Intracellular signaling pathways that regulate behavioral responses to ethanol
Keywords: کیناز; Alcohol; Neuron; Brain; Behavior; Kinase
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Regulatory properties of adenylate cyclases type 5 and 6: A progress report
Keywords: کیناز; Adenylate cyclase; Cyclic AMP; G protein-coupled receptor; Kinase; Signaling
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Keywords: کیناز; LRRK2; Kinase; Parkinson's disease; α-Synuclein; Substantia nigra
The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6
Keywords: کیناز; Arf; ADP-ribosylation factor; Kinase; Phospholipase; Phosphatidylinositol; Membrane; GTPase; PtdIns4P; PLD; PtdInsP; phosphatidylinositol phosphate; DAG; 1,2 diacylglycerol; Ins(1,4,5)P3; inositol 1,4,5-trisphosphate; PtdIns(3,4,5)P3; phosphatidylinositol
The Drosophila orthologue of xPlkk1 is not essential for Polo activation and is necessary for proper contractile ring formation
Keywords: کیناز; Polo; dPlkk; Cytokinesis; Kinase; Mitosis; Drosophila
The sea urchin kinome: A first look
Keywords: کیناز; Kinase; Signal transduction; Genome; Kinome
A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases
Keywords: کیناز; PAK, p21-activated kinase; TROSY, transverse relaxation optimized spectroscopyP21 activated kinase; autophosphorylation; NMR; protein kinase substrate; kinase
Up-regulation and increased phosphorylation of protein kinase C (PKC) δ, μ and θ in the degenerating rd1 mouse retina
Keywords: کیناز; Apoptosis; Kinase; Microarray; Photoreceptor; Signaling pathways
QSAR modeling of the inhibition of Glycogen Synthase Kinase-3
Keywords: کیناز; Kinase; Inhibitory activity IC50; Stepwise regression; Artificial neural network; CODESSA PRO
Uncoupling of RNA Binding and PKR Kinase Activation by Viral Inhibitor RNAs
Keywords: کیناز; RNA; PKR; kinase; inhibitionPKR, protein kinase RNA-activated; dsRNA, double-stranded RNA; eIF2α, eukaryotic initiation factor 2α; dsRBD, double-stranded RNA-binding domain; ITC, isothermal titration calorimetry; NOESY, nuclear Overhauser effect spectrosc
Regulation of wingless signaling by the CKI family in Drosophila limb development
Keywords: کیناز; Wg; Wnt; CKI; Kinase; β_catenin; Limb development; Signaling; Cancer;
Therapeutic role of beta-interferons in multiple sclerosis
Keywords: کیناز; Multiple sclerosis; Interferon-β; IFNAR; STAT; Kinase; Immunology; Lymphocytes; Pivotal trials; MRI; Natalizumab; SLE; NAbAPC, antigen presenting cell; BBB, blood–brain barrier; CNS, central nervous system; DMA, disease modifying agent; EC, endothelial ce
New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors
Keywords: کیناز; c-Src; Kinase; Inhibitor; 5,7-Disubstituted quinazoline;
Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor
Keywords: کیناز; Src; Kinase; 3-Quinolinecarbonitriles;
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
Keywords: کیناز; Pyridine; Tetrazole; Akt; Inhibitor; Kinase;
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction
Keywords: کیناز; GTPase; Kinase; Signal transduction; Protein transduction;
Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice
Keywords: کیناز; K channel; Kinase; Pseudohypoaldosteronism; Hypertension; Hyperkalemia; Transgenic mice;
Molecular profile of hyalinizing trabecular tumours of the thyroid: High prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations
Keywords: کیناز; Thyroid; Oncogene; Kinase; RAF; RET; Papillary carcinoma;
Second nature: Biological functions of the Raf-1 “kinase”
Keywords: کیناز; Raf; Kinase; Knock-out; Survival; Motility
Isolation and functional analysis of a chk2 homologue from Entamoeba histolytica
Keywords: کیناز; Entamoeba histolytica; Chk2; Kinase; Cell division;
EGF receptor activity is essential for adhesion-induced stress fiber formation and cofilin phosphorylation
Keywords: کیناز; Adhesion; Cytoskeleton; Integrin; Kinase; Signaling;
Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3
Keywords: کیناز; MST3; Zinc; Cofactor; Kinase; Cobalt; Autophosphorylation;
Truncated deoxynivalenol-induced splenic immediate early gene response in mice consuming (n-3) polyunsaturated fatty acids
Keywords: کیناز; Mycotoxin; Fish oil; Inflammation; Cytokine; Chemokine; Kinase;
Expression and purification of active PKB kinase from Escherichia coli
Keywords: کیناز; PKB; Co-expression; His-tag; FLAG-tag; E. coli; Kinase; Recombinant protein;
Coupling phosphoryl transfer and substrate interactions in protein kinases
Keywords: کیناز; Cbp; Csk binding protein; Cbp peptide; phosphotyrosine peptide derived from Cbp with sequence ISAMpYSSVMK; Csk; COOH terminal Src kinase; Kemptide; peptide substrate with sequence LRRASLG; Npl3; nuclear protein localization 3; PKA; cAMP-dependent protein
HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases
Keywords: کیناز; NDR; nuclear Dbf2 related; HIV-1; human immunodeficiency virus type 1; PR; protease; WT; wild type; CA; capsid; CIP; calf intestinal alkaline phosphatase; C-PKA; cAMP-dependent protein kinase; DMSO; dimethyl sulfoxide; GFP; green fluorescent protein; PMSF
Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control
Keywords: کیناز; Cortactin; Src; Erk; Kinase; Phosphorylation; Actin cytoskeleton;
Cloning and characterization of a novel human Aurora C splicing variant
Keywords: کیناز; Aurora C-SV; Kinase; Splicing variant; Phosphorylation; Mitosis;
Enhanced JNK activation by NESK without kinase activity upon caspase-mediated cleavage during apoptosis
Keywords: کیناز; NIK; Nck-interacting kinase; NESK; NIK-like embryo-specific kinase; GCK; Germinal center kinase; JNK; c-Jun N-terminal kinase; TNF-α; Tumor necrosis factor-α; CNH; Citron and NIK homology; GFP; Green fluorescence protein; CHX; Cycloheximide; PARP; Poly
Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle
Keywords: کیناز; Cyclin; Cdk; Kinase; Roscovitine; CYC202; Flavopiridol;
The conditional kinase ÎMEKK1:ER* selectively activates the JNK pathway and protects against serum withdrawal-induced cell death
Keywords: کیناز; Bad; Bcl-2 antagonist of cell death; BH; Bcl-2 homology domain; Bim; Bcl-2 interacting modulator; BimEL; Bim extra long; ERK; Extracellular signal-regulated kinase; FBS; Fetal bovine serum; JNK; c-Jun N-terminal kinase; MAPK; Mitogen-activated protein kin
Agonist-induced up-regulation of human somatostatin receptor type 1 is regulated by β-arrestin-1 and requires an essential serine residue in the receptor C-tail
Keywords: کیناز; AC; adenylyl cyclase; CaM; calcium calmodulin; CHO-KI; Chinese hamster ovary cell line; FBS; fetal bovine serum; GPCR; G protein-coupled receptor; GRK; GPCR kinase; hSSTR; human somatostatin receptor; MAPK; mitogen activated protein kinase; PKA; protein k
Evidence for lectin activity of a plant receptor-like protein kinase by application of neoglycoproteins and bioinformatic algorithms
Keywords: کیناز; Agglutinin; Kinase; Lectin; Neoglycoprotein; Rhamnose; Signaling;
New insights into cyclins, CDKs, and cell cycle control
Keywords: کیناز; Cyclin; CDK; Cell cycle; Kinase; Substrate;
Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid
Keywords: کیناز; Neurotransmitters, modulators, transporters and receptors; Uptake and transporters; Docosahexaenoic acid; Calcium; Glutamate; Transport; Kinase;
Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes
Keywords: کیناز; AG; AG1478; ASM; acidic sphingomyelinase; ca; constitutively active; CD533; dominant negative ERBB1; DCA; deoxycholic acid; dn; dominant negative; EGF; epidermal growth factor; ERK; extracellular regulated kinase; FADD; FAS associating death domain protei
Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: Molecular yardsticks for analyzing catalytic mechanism and inhibitor design
Keywords: کیناز; Kinase; Peptide; Protein; Inhibitor; Nucleotide;
Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure
Keywords: کیناز; Kinase; Centrosome; Mitosis; Cytokinesis;
Pedicel development in Arabidopsis thaliana: Contribution of vascular positioning and the role of the BREVIPEDICELLUS and ERECTA genes
Keywords: کیناز; Stem; Homeobox; Kinase; Sepal; Architecture; Node; Internode; Radial symmetry; Vascular bundle;
Inhibition of the cell cycle with chemical inhibitors: A targeted approach
Keywords: کیناز; Cell cycle; Cyclin; Kinase; Inhibitors; p53;
Insights into heme-based O2 sensing from structure-function relationships in the FixL proteins
Keywords: کیناز; FixL; Oxygen; Sensor; Heme; Kinase; Regulation;
Initial conditions of psychotropic drug response: Studies of serotonin transporter long promoter region (5-HTTLPR), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome
Keywords: کیناز; ATP; adenosine triphosphate; ADR; antidepressant response; ADT; antidepressant treatment; cAMP; cyclic adenosine monophosphate; 5-HT; 5-hydroxtrytamine (serotonin); HPA; hypothalamic-pituitary-adrenal; IL; interleukin; ICE; interleukin converting enzyme;
Functional identification of kinases essential for T-cell activation through a genetic suppression screen
Keywords: کیناز; GSE; genetic suppressor element; STE; homologs to yeast sterile7, sterile 11, and sterile 20 kinases; CAMK; calcium/calmodulin-dependent-like protein kinases; AGC; containing PAK, PKG, and PKC kinase families; CMGC; containing CDK, MAPK, GSK3, and CLK kin
Tau phosphorylation: physiological and pathological consequences
Keywords: کیناز; Tau; Tauopathy; Phosphorylation; Filament; Kinase; Phosphatase;
Bacterial resistance to antibiotics: Enzymatic degradation and modification
Keywords: کیناز; Antibiotic; Resistance; Hydrolase; Acetyltransferase; Kinase; Nucleotidyltransferase; Ribosyltransferase; Redox;
Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α
Keywords: کیناز; NAC; N-acetyl-l-cysteine; AP; activating protein; ARDS; acute respiratory distress syndrome; AD; Alzheimer's disease; ARNT; aryl-hydrocarbon receptor nuclear translocator; bHLH-PAS; basic-helix-loop-helix-PAS; CREB; cyclic AMP-response element binding pro
c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention
Keywords: کیناز; c-Met; HGF; Kinase; Oncogene;
N-methyl-d-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: A revolving neurochemical axis for therapeutic intervention?
Keywords: کیناز; AA; arachidonic acid; AIDS; acquired immunodeficiency syndrome; ALS; amyotrophic lateral sclerosis; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APV; 2-amino-5-phosphonovalerate; 2-AP5; 2-amino-5-phosphonopentanoic acid; ATF; activating tr