کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016305 | 1128087 | 2005 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Initial conditions of psychotropic drug response: Studies of serotonin transporter long promoter region (5-HTTLPR), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome
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کلمات کلیدی
5-HTTLPRpKaJAK1ADTSAPKRT-PCRADRRDPSSRIsinterleukin receptor-associated kinasePKC5-HTJanus kinase - کیناز جانوس cAMP - cAMPNa+ - Na +Adenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPCyclic adenosine monophosphate - آدنوزین مونوفسفات Cyclicstress activated protein kinase - استرس فعال پروتئین کینازribonucleic acid - اسید ریبونوکلئیکRNA - اسید ریبونوکلئیکDepression - افسردگیinterleukin - اینترلوکین5-HT uptake - جذب 5-HTAntidepressants - داروهای ضد افسردگیAntidepressant treatment - درمان ضد افسردگیSERT - سختSodium - سدیم Serotonin - سروتونینserotonin transporter - سروتونین حمل کنندهCytokine - سیتوکینInitial conditions - شرایط اولیهIRAK - عراقLymphocyte - لنفوسیتselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیHPA - میلی بار یا هکتوپاسکالhypothalamic-pituitary-adrenal - هیپوتالاموس-هیپوفیز-آدرنالReverse transcriptase-polymerase chain reaction - واکنش زنجیره ای واکنش زنجیره ای واکنش زنجیره ایAntidepressant response - پاسخ ضددردیPotassium - پتاسیمprotein kinase A - پروتئین کیناز AProtein kinase C - پروتئین کیناز سیPlatelet - پلاکتKinase - کینازIce - یخ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The Hypothesis of Initial Conditions posits that differences in psychotropic drug response result from individual differences in receptor site kinetics, and differences in the sensitivity of downstream receptor-linked responses. This work examines data consistent with the hypothesis, specific to genetic and kinetic differences of the serotonin (5-HT) transporter (SERT), as they may be linked to divergent antidepressant response (ADR). The mechanisms for divergent ADR in association with different initial SERT function are considered within the context of SERT trafficking as sensitive to various different kinase and cytokine signals, some of which are dependent on the 5-HTTLPR polymorphism of the SERT gene. Pilot data suggest that human lymphocytes show kinase changes similar to those found in rat brain with ADT. These studies additionally suggest that ADT prompts a shift in cytokine gene expression toward a greater anti-inflammatory/inflammatory ratio. These latter findings are discussed within the context of a literature suggesting increased inflammatory cytokine levels in depression, and recent observations of increased temperature associated with depression. In sum, the data suggest the opportunity to identify response dependent protein (RDP) expression patterns that may differ with dichotomous ADR, and suggest new insights into understanding the mechanisms of psychotropic drug response through an understanding of initial differences in potential for psychotropic drug target regulation during therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 6, July 2005, Pages 1046-1061
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 6, July 2005, Pages 1046-1061
نویسندگان
Jeffrey L. Rausch,