دانلود مقالات ISI درباره Jak1 + ترجمه فارسی

پیشرفت در ایمنی اولیه و بالینی در سال 2016

Advances in basic and clinical immunology in 2016

Keywords: Immunology; primary immunodeficiency; whole-exome sequencing; hematopoietic stem cell transplantation; common variable immunodeficiency; severe combined immunodeficiency; hyper-IgE syndrome; AIP1; Actin-interacting protein 1; APDS; Activated PI3Kδ syndro

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

نقش ظهور عامل کنترل کننده اینترفرون 9 در پاسخ میزبان ضد ویروسی و فراتر از آن

The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

Keywords: OASL; 2'-5'-oligoadenylate synthetase; PKR; double-stranded RNA-dependent protein kinase; GAS; gamma-activated site; HCMV; human cytomegalovirus; ISG; IFN-I-stimulated genes; IFNAR; interferon alpha receptor; IFNGR; interferon gamma receptor; IRF; interfe

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

مکانیسم های مولکولی اثرات ضد سرطانی میریستین

Molecular mechanisms underlying anticancer effects of myricetin

Keywords: Myricetin; Cdk1; Akt; Erk1 and Erk2; Mek1; Jak1; Stat3; Ap-1; Apoptosis; Metastasis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

تریازولو-پیرولوپیریدین های جدید به عنوان مهارکننده یونوس کیناز 1

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Keywords: Janus kinase; JAK1; JAK2; JAK1 inhibitor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes

Keywords: Quercetin; IL (interleukin)-18; AIM (absent in melanoma) 2; Inflammasome; Keratinocytes; JAK/STAT pathway; IL-18; Interleukin (IL)-18; HEKn; Human primary epidermal keratinocytes from neonatal foreskin; IFN-γ; interferon-γ; AIM2; absent in melanoma 2; A

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Src promotes anti-inflammatory (M2) macrophage generation via the IL-4/STAT6 pathway

Keywords: Macrophage polarization; Inflammation; Src; STAT6; Arg1; Arginase; BMDMs; Bone Marrow-Derived Macrophages; C/EBPβ; CCAAT/enhancer-binding Protein beta; CREB; cAMP-Response Element Binding protein; DSS; Dextran Sulfate Sodium; Fizz1; Found in inflammatory

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Inhibition of JAK1 by microRNA-708 promotes SH-SY5Y neuronal cell survival after oxygen and glucose deprivation and reoxygenation

Keywords: MiR-708; JAK1; OGD/R; Cell apoptosis; SH-SY5Y;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

A Placebo-Controlled Phase II Study of Ruxolitinib in Combination With Pemetrexed and Cisplatin for First-Line Treatment of Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer and Systemic Inflammation

Keywords: Janus kinase (JAK); JAK1; JAK2; Modified Glasgow prognostic score; Signal transducers and activators of transcription (STAT);

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype

Keywords: TPP1; protein encoded by adrenocortical dysplasia gene; Acd; adrenocortical dysplasia gene; acd; adrenocortical dysplasia mutation; p53; transformation related protein 53; DNA; Deoxyribonucleic acid; DC; Dyskeratosis congenita; HHS; Hoyeraal-Hreidarsson s

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Sustained anti-inflammatory effects of TGF-β1 on microglia/macrophages

Keywords: bFGF; basic fibroblast growth factor; Contra; contralateral cortex; DAMPs; damage-associated molecular patterns; dpr; days post-reperfusion; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HGF; hepatocyte growth factor; HMGB1; high mobility group box 1;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

Interleukin 6 inhibits the differentiation of rat stem Leydig cells

Keywords: IL-6; Stem Leydig cells; Proliferation; Differentiation; JAK1; STAT;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases

Keywords: AUClast; Area under concentration-time curve; CL; Total clearance; COLO205; Intestinal epithelial cells; Cmax; Maximal serum concentration; DC; Dendritic Cells; DMEM; Dulbecco's modified Eagle's medium; DSS; Dextran sulfate sodium salt; EC50; Half max

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of hypnotic bromovalerylurea on microglial BV2 cells

Keywords: NO; ATP; Microglia; Macrophage; Rotenone; ALI; acute lung injury; AMs; alveolar macrophages; BU; bromovalerylurea; JNK; c-Jun N-terminal kinases; cDNA; complementary DNA; Dex; dexamethasone; DMEM; Dulbecco's Modified Eagle Medium; E. coli; Escherichia col

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer

Keywords: Antrodia cinnamomea; Tamoxifen; Anti-angiogenesis; ER+ T47D breast cancer; Dehydroeburicoic acid; Akt; protein kinase B; CAM; chorioallantoic membrane; COX-2; cyclooxygenase-2; ER; estrogen receptor; Jak1; Janus kinase 1; mTOR; mammalian target of rapamyc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleAnti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients

Keywords: Multiple myeloma; JAK/STAT; Ruxolitinib; JAK1; JAK2; Small molecule inhibitor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Nonsteroidal anti-inflammatory-induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phosphorylation in aspirin-exacerbated respiratory disease

Keywords: Aspirin-exacerbated respiratory disease; IL-4 signaling inhibition; pSTAT6 inhibition; mechanism of aspirin desensitization; AERD; Aspirin-exacerbated respiratory disease; LTE4; Leukotriene E4; MFI; Mean fluorescence intensity; NSAID; Nonsteroidal anti-in

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of azabenzimidazoles as potent JAK1 selective inhibitors

Keywords: Azabenzimidazoles; JAK1; JAK selectivity; JAK1 inhibitors

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity

Keywords: NKLAM; natural killer lytic-associated molecule; STAT1; signal transducer and activator of transcription 1; RBR; RING in between RING; JAK1; Janus kinase 1; IFNγ; interferon gamma; IFNGR; interferon gamma receptor; GAS; gamma interferon activation sequen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Ensemble docking-based virtual screening yields novel spirocyclic JAK1 inhibitors

Keywords: AUC; area under the (ROC) curve; EF; enrichment factor; FDA; Food and Drug Administration; FPR; false positive rate; HTVS; high throughput virtual screening; JAK; Janus kinase; LLE; lipophilic ligand efficiency; LELP; lipophilicity-corrected ligand effici

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental myelodysplastic syndrome

Keywords: Bone marrow; MDS; JAK1; STAT5; CD 45; CD71;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewIL-6 pathway in the liver: From physiopathology to therapy

Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Fc; constant portion of an IgG antibody; gp130; glycoprotein 130 kDa; IL; interleukin; JAK1; Janus kinase 1; JNK1; Jun amino-terminal kinase 1; LPS; lipopolysaccharide; R; receptor; s;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis

Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5′AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long

دانلود رایگان متن کامل مقاله ISI 80 صفحه سال انتشار : 2016 سفارش ترجمه

9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors

Keywords: JAK2; JAK; JAK family selectivity; JAK1; JAK3; TYK2; Myeloproliferative disorders; Myeloproliferative neoplasms

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Investigation of genetic susceptibility to nonspecific digestive disorder between TYK2, JAK1, and STAT3 genes in rabbits

Keywords: TYK2; JAK1; STAT3; Genetic susceptibility; MDR; Rabbit;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Mutations leading to constitutive active gp130/JAK1/STAT3 pathway

Keywords: Inflammatory hepatocellular adenomas; gp130; STAT3; FRK; GNAS; JAK1; HCA; hepatocellular adenoma; IHCA; inflammatory HCA; HCC; hepatocellular carcinoma; STATs; ignal transducer and activator of transcription; JAK; Janus kinase; LGL; large granular lymphoc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

17β-Estradiol enhances the activation of IFN-α signaling in B cells by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p that target IKKε

Keywords: SLE; systemic lupus erythematosus; IFN-α; interferon-α; TLR; Toll like receptor; ER; estrogen receptor; IKKε; inhibitor of kappa B kinase epsilon; UTR; untranslated region; si-ERα; small interfering RNA specific to ERα; si-ERβ; small interfering RNA

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

A novel JAK-STAT inhibitor, 2-[(3-Carbamoyl-2-thienyl)amino]-2-oxoethyl(2,6-dichlorophenyl)acetate, suppresses helper T cell differentiation in vitro and collagen-induced arthritis in vivo

Keywords: Helper T cells; Cytokine signaling; Th17; JAK1; STAT3;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

Requirement of the eukaryotic translation initiation factor 4F complex in hepatitis E virus replication

Keywords: Hepatitis E virus; Eukaryotic translation initiation factor 4F complex; eIF4E-binding protein 1; Ribavirin; IFN-α; HEV; hepatitis E virus; eIF4F; eukaryotic translation initiation factor 4F; eIF4A; eukaryotic initiation translation factor 4A; eIF4G; euka

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2015 سفارش ترجمه

Selective inhibitors of the Janus kinase Jak3—Are they effective?

Keywords: Jak3; Jak1; Janus kinase inhibitors; Selectivity; Immunosuppression

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Investigation of JAK1 and STAT3 polymorphisms and their gene-gene interactions in nonspecific digestive disorder of rabbits

Keywords: JAK1; Janus kinase 1; STAT3; signal transducer and activator of transcription 3; cSNPs; coding single nucleotide polymorphisms; SH2; Src homology-2 domains; NSDD; nonspecific digestive disorder; IBD; inflammatory bowel disease; CD; Crohn's disease; UC; ul

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1/STAT6 pathway

Keywords: Progesterone; Progesterone receptor; PIBF; Astrocytomas; IL-4 receptor; JAK1; STAT6; Gliomas;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Short CommunicationInterleukin-10 prevents epithelial cell apoptosis by regulating IFNγ and TNFα expression in rhesus macaque colon explants

Keywords: AC-3; active caspase-3; IL-10; interleukin-10; HIV; human immunodeficiency virus; Th1; T-helper 1; JAK1; janus kinase 1; Tyk2; tyrosine kinase 2; SCID; severe combined immunodeficiency; EC; epithelial cells; RM; rhesus macaque; MAb; monoclonal antibody; r

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

STAT1 requirement for PKR-induced cell cycle arrest in vascular smooth muscle cells in response to heparin

Keywords: IFN; interferon; PKR; protein kinase, RNA-activated; VSMC; vascular smooth muscle cell; Cdk2; cyclin-dependent kinase 2; STAT1; signal transducer and activator of transcription-1; ds; double-stranded; JAK1; janus kinase 1; ATRA; all-trans retinoic acid; F

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Transcriptomic profiling of progesterone in the male fathead minnow (Pimephales promelas) testis

Keywords: 11-KT; 11-ketotestosterone; AKT1; RAC-α serine/threonine-protein kinase; APOE; apolipoprotein E; APP; amyloid β (A4) precursor protein; AR; androgen receptor; BCL2L1; BCL2-like 1; BCL6; B-cell CLL/lymphoma 6; BMP2; bone morphogenetic protein 2; BMP4; bo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes

Keywords: AICAR; 5-amino-4-imidazole-carboxamideriboside; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; CRP; C-reactive protein; HP; haptoglobin; IKK; IkappaB kinase; IL-6; Interleukin-6; IL6Rα; IL-6 receptor subun

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification

Keywords: AKR1Cs; aldo-keto reductase family members (e.g. AKR1C1, AKR1C2, or AKR1C3); ARE; antioxidant response element; cisplatin; cis-diamminedichloroplatinum(II) (CDDP); ERCC-1; excision repair cross-complementing-1; ERK; extracellular signal-related kinase; FF

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice

Keywords: 25-Hydroxyvitamin D3; Diabetes; Periodontitis; TLR4; JAK1; STAT3

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors

Keywords: JAK1; JAK2; JAK3; 4-Aryl-2-aminoalkylpyrimidine;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.)

Keywords: Interleukin-10 receptor; IL10R1; Interleukin-10 receptor, alpha chain; Bony fish; Goldfish; Inflammation; Gene expression; Macrophages; STAT3; JAK1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Analiza ekspresji JAK1, STAT3, STAT1 i SOCS1 w jednojądrzastych komórkach krwi obwodowej u chorych z rakiem krtani

Keywords: rak krtani; ekspresia mRNA JAK1; STAT3; STAT1 i SOCS1; jednojądrzaste komórki krwi; cytokiny pozapalne i regulatorowe; carcinoma of the larynx; JAK1; STAT3; STAT1 and SOCS1 mRNA expression; peripheral blood mononuclear cells; proinflammatory and regulat

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3

Keywords: Tyrosine kinase 2; TYK2; Janus associated kinase; JAK1; JAK2; JAK3

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors

Keywords: Janus kinase; JAK1; JAK2; JAK3; Tyk2; Kinase inhibitors; JAK2 inhibitor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors

Keywords: Janus kinase; JAK1; JAK2; JAK3; Tyk2; Kinase inhibitors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Tumor Necrosis Factor alpha (TNFα) regulates CD40 expression through SMAR1 phosphorylation

Keywords: SMAR1; CD40; STAT1; TNFα; MAR; JAK1; HDAC1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Myricetin directly targets JAK1 to inhibit cell transformation

Keywords: Myricetin; EGF; JAK1; STAT3; JB6 cells

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Computational analyses of JAK1 kinase domain: Subtle changes in the catalytic cleft influence inhibitor specificity

Keywords: Jak1; Homology modeling; Kinase inhibitor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-α/β signaling

Keywords: Measles; Virus; V; IFN-α/β; Jak1; STAT1

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Initial conditions of psychotropic drug response: Studies of serotonin transporter long promoter region (5-HTTLPR), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome

Keywords: ATP; adenosine triphosphate; ADR; antidepressant response; ADT; antidepressant treatment; cAMP; cyclic adenosine monophosphate; 5-HT; 5-hydroxtrytamine (serotonin); HPA; hypothalamic-pituitary-adrenal; IL; interleukin; ICE; interleukin converting enzyme;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه