Transcriptomic profiling of progesterone in the male fathead minnow (Pimephales promelas) testis

- Progesterone plays multiple roles in teleost reproduction but is understudied in males.
- Progesterone increased testosterone, but not 11-ketotestosterone, production from testis explants.
- Progesterone regulated gene networks that included fibronectin and amino acid metabolism.
- A gene network that included insulin growth factor 1 signaling was depressed by progesterone.
- New insight is gained on gene regulation by progesterone in the teleost mature testis.