Keywords: ESCC; esophageal squamous cell carcinoma; 2D LC-MS; two-dimensional liquid chromatography-mass spectrometry; FFA; free fat acids; PC; phosphatidylcholines; Chok; choline kinase; ESI; electrospray ionization; PCA; principal component analysis; PLS-DA; pa
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Keywords: atopic dermatitis; eicosanoids; leukotrienes; montelukast; pharmacology; prostaglandins; timapiprant; zileuton; COX; cyclooxygenase; CPLA2; cytosolic phospholipase A2; CRTH2; chemoattractant receptor homologous molecule expressed on T helper type 2; LT; l
Keywords: AD; Alzheimer's disease; ARA; arachidonic acid; CD; cluster of differentiation; iPLA2; calcium independent phospholipase A2; cPLA2; cytosolic phospholipase A2; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; HDHA; hydroxy DHA; HETE; hydroxyeicosa
Keywords: ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotropic factor; CerS; ceramide synthase; CNS; central nervous system; CPL; cecal ligation and puncture; cPLA2; cytosolic phospholipase A2; CSA; cyclosporine A; CTL; cytotoxic T lymphocytes; CYP45
Keywords: ACSL4; acyl-CoA synthetase long-chain family member 4; AD; Alzheimer's disease; ARE; antioxidant-responsive element; ANT; adenine nucleotide translocase; AP-1; activator protein-1; ATP; adenosine triphosphate; Bak; Bcl-2 antagonist/killer; BCEC; brain c
Keywords: Ginger; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Therapeutic potentials; AP-1; Activator protein 1; APCs; Antigen-presenting cells; ASC; apoptosis speck-like protein containing CARD; BAFF; B cell-activating factor belonging to the TN
Keywords: 4-HNE; (4-hydroxynonenal); ABTS; (2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CAT; (catalase); CE; (capillary electrophoresis); CMH; (1-hydroxy-3-methoxy-carbonyl-2,2,5,5-tetrame-thylpyrrolidine); COX; (cyclooxygenase); cPLA2; (cytosolic ph
Keywords: 2OAA; 2-hydroxyarachidonic acid; 4-HNE; 4-hydroxynonenal; AA; arachidonic acid; C-Pu; caudate-putamen; CCA; common carotid artery; cPLA2; cytosolic phospholipase A2; COX; cyclooxygenase; DHA; docosahexaenoic acid; ECA; external carotid artery; FFA; free f
Keywords: AA; arachidonic acid; AKR; aldo-keto reductase; AOS; allene oxide synthase; CX; carbon numbers; COX; cyclooxygenase; cPGES; cytosolic PGE synthase; cPLA2; cytosolic phospholipase A2; CYP; cytochrome P450; DGLA; dihomo-γ-linolenic acid; DP; prostaglandin
Keywords: Arachidonic acid; Alzheimer's disease; Diet; Synaptic function; Neuroinflammation; Prevention; Aβ; amyloid-β; ABCA7; ATP-binding cassette, subfamilly A member 7; ACSL; acyl-CoA synthetase; AD; Alzheimer's disease; ARA; arachidonic acid; COX; cyclooxygen
Keywords: AA; arachidonic acid; Akt (PKB); protein kinase; BMDM; bone marrow-derived macrophages; CerK; ceramide kinase; C1P; ceramide 1-phosphate; cPLA2; calcium-dependent cytosolic phospholipase 2; ERK; extracellularly regulated kinases; GLUT; glucose transporter
Keywords: Phospholipid asymmetry; Lysophosphatidic; Platelet-activating factor; Phosphoinositides; PLRP2; Phospholipase B; 2-AG; 2-arachidonoyl-glycerol; ATX; autotaxin; cPLA2; cytosoluble phospholipase A2; DAG; diacylglycerol; ECs; endocannabinoids; IP3; inositol
Keywords: Azithromycin; Macrolide antibiotic; Mechanisms of action; Pharmacokinetics; Immunomodulation; Clinical efficacy; AECOPD; acute exacerbations of COPD; AP-1; activator protein-1; ARDS; acute respiratory distress syndrome; AUC; area under the plasma concentr
Keywords: MDD; major depressive disorder; BD; bipolar disorder; ASA; acetyl-salicylic acid; WHO; World Health Organization; TCAs; tricyclic antidepressants; MAOIs; monoamine oxidase inhibitors; SSRIs; selective serotonin reuptake inhibitors; PAMPs; pathogen associa
Keywords: LT; leukotriene; FABP; fatty acid binding protein; AFABP; adipocyte fatty acid binding protein; EFABP; epithelial fatty acid binding protein; HFABP; heart fatty acid binding protein; HETE; hydroxyeicosatetraenoic acid; PG; prostaglandin; MCP-1; monocyte c
Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration
Keywords: 2-AG; 2-arachidonoylglycerol; 4-HNE; 4-hydroxynonenal; 8-isoPGF2α; F2 -isoprostanes; 8-OHdG; 8-hydroxy-2'-deoxyguanosine; AA; arachidonic acid; AEA; N-arachidonoylethanolamine, anandamide; AM3506; 5-(4-hydroxyphenyl) pentanesulfonyl fluoride; Bach1; ba
Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β; PrPC; cellular prion protein; cPLA2; cytoplasmic phospholipase A2; CSP; cysteine-string protein; ELISA; enzyme-linked immunoassay; Fab; fragment antigen-binding; GPI; glycosylphosph
cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures
Keywords: BACE1; Hyperphosphorylated tau; Excitotoxicity; cPLA2; Desaturases; Inflammation;
Lipopolysaccharide (LPS)-mediated priming of toll-like receptor 4 enhances oxidant-induced prostaglandin E2 biosynthesis in primary murine macrophages
Keywords: ONS; oxidative/nitrosative stress; TLR; toll-like receptor; LPS-EK (Ultrapure); lipopolysaccharide from E. coli K12; TLR4-WT macrophages; macrophages derived from wild-type mice; TLR4-KO macrophages; macrophages derived from complete TLR4 knock-out mice;
Anti-neuroinflammatory effects of Ginkgo biloba extract EGb761 in LPS-activated primary microglial cells
Keywords: Neurodegeneration; Prostaglandin E2; Cyclooxygenase; Cytokines; Neuroinflammation; Alzheimer's disease; EGb 761; Extract Ginkgo biloba 761; PG; prostaglandin; COX; cyclooxygenase; cPLA2; cytosolic phospholipase A2; IkappaBalpha; inhibitor of kappa B alpha
Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication
Keywords: AA; arachidonic acid; ALA; α-linolenic acid; CD81; cluster of differentiation 81; CE; cholesterol ester; Cer; ceramides; Chol; cholesterol; CoA; coenzyme A; cPLA2; cytosolic phospholipases A2; DAG; diglycerides; DHA; docosahexaenoic acid; DMV; double-mem
Valnoctamide, which reduces rat brain arachidonic acid turnover, is a potential non-teratogenic valproate substitute to treat bipolar disorder
Keywords: AA; arachidonic acid; AA-CoA; arachidonoyl-CoA; VPA; Valproic acid; VCD; Valnoctamide; ChoGpl; choline glycerophospholipid; cPLA2; cytosolic phospholipase A2, EtnGpl, ethanolamine glycerophospholipid; FAME; fatty acid methyl esters; PtdIns; phosphatidylin
Research reportHeterozygous knockout of cytosolic phospholipase A2α attenuates Alzheimer's disease pathology in APP/PS1 transgenic mice
Keywords: Cytosolic phospholipase A2; cPLA2; Alzheimer's disease; Knockout mouse; APPswe/PS1 transgenic mouse;
Research reportNeuroprotective effects of N-adamantyl-4-methylthiazol-2-amine against amyloid β-induced oxidative stress in mouse hippocampus
Keywords: Aβ; amyloidβ; AD; Alzheimer's disease; cPLA2; cytosolic phospholipase A2; DCF; DA 2â²,7â²-dichlorofluorescin diacetate; CAT; catalase; DMSO; dimethyl-sulfoxide; EDTA; ethylenediaminetetraacetic acid; GPx; glutathione peroxidase; GSH; reduced glutath
Too much of a good thing: How modulating LTB4 actions restore host defense in homeostasis or disease
Keywords: LT; leukotriene; PAMP; pathogen associated molecular patterns; PRR; pattern recognition receptor; AA; arachidonic acid; LO; lipoxygenase; cPLA2; cytosolic phospholipase A2; FLAP; 5-lipoxygenase-activating protein; cysLT; cysteinyl LT; BLT; B leukotriene r
The role of cPLA2 in Methylglyoxal-induced cell apoptosis of HUVECs
Keywords: MGO; Methylglyoxal; cPLA2; cytosolic phospholipase A2; ECs; endothelial cells; HUVEC; Human umbilical vascular endothelial cells; AGEs; advanced glycation end products; MAPKs; Mitogen-activated protein kinases; NAC; N-acetyl cysteine; ROS; reactive oxygen
Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation
Keywords: Anx; annexin; ATGL; adipose triglyceride lipase; Ca2+; calcium; CE; cholesteryl ester; cPLA2; cytoplasmic phospholipase A2; ER; endoplasmic reticulum; FA; fatty acid; HA; human influenza hemagglutinin; KD; knockdown; LD; lipid droplet; MAFP; methyl arachi
Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction
Keywords: ANOVA; one-way analysis of variance; CCA; Common carotid artery; cPLA2; Cytosolic phospholipase A2; ECA; external carotid artery; ICA; internal carotid artery; lncRNAs; Long non-coding RNAs; MCA; middle cerebral artery; MCAO; middle cerebral artery occlus
DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression
Keywords: DXA3; 8-hydroxy-9, 10-dioxolane A3; PE; phosphatidylethanolamine; COX; cyclooxygenase; PAR; protease-activated receptors; cPLA2; cytosolic phospholipase A2; TXA2; thromboxane A2; HETE; hydroxyeicosatetraenoic acid; PGE2; prostaglandin E2; OOEPC; oleyloxye
Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation
Keywords: AKT; protein kinase B; AP-1; activator protein-1; BV-2; immortalized murine microglia cell line; CD11b; cluster of differentiation 11b; CD36; cluster of differentiation 36; CD44; cluster of differentiation 44; CD68; cluster of differentiation 68; CNS; cen
G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux
Keywords: G0S2; G0/G1 switch gene 2; HSL; hormone-sensitive lipase; ATGL; adipose triglyceride lipase; TG; triacylglycerol/triglyceride; FA; fatty acid; BAT; brown adipose tissue; WAT; white adipose tissue; PPAR; peroxisome proliferator-activated receptor; PPRE; PP
Lipid metabolism in Rhodnius prolixus: Lessons from the genome
Keywords: 4CL; 4-coumarate:CoA ligase; ACS; acyl-CoA synthetases; ACSBG; ACS bubblegum; ACSL; ACS long-chain; ACSM; ACS medium-chain; ACSS; ACS short-chain; ACSVL; ACS very long-chain; Bmm; brummer; iPLA2; calcium-independent PLA2; CPT; carnitine palmitoyltransfera
Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures
Keywords: Ketogenic diet; Cpla2; Clusterin; Autophagy; Neonatal seizure
Research articleAnnexin A10 is involved in the development and maintenance of neuropathic pain in mice
Keywords: ASIC1a; acid-sensing ion channel 1a; cPLA2; cytosolic phospholipaseA2; COX; cyclo-oxygen-ase; NC; negative control; PB; phosphate buffer; PGE2; prostaglandin E2; PWL; paw withdrawal latency; RNAi; RNA interference; TASK-1; WIK-related acid-sensitive K+ ch
Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca2+ release
Keywords: AACOCF3; arachidonyl trifluoromethyl ketone; AUDA; 12-(3-adamantan-1-yl-ureido)dodecanoic acid; CP85; Na-1-ethylsulfoxide-2-methyl-3-hyroxypyridin-4-one; CP94; 1,2-diethyl-3-hyroxypyridin-4-one; CPA; Cyclopiazonic Acid; DFO; Desferrioxamine; EC; endotheli
Mitochondria-localized phospholipase A2, AoPlaA, in Aspergillus oryzae displays phosphatidylethanolamine-specific activity and is involved in the maintenance of mitochondrial phospholipid composition
Keywords: CL; cardiolipin; cPLA2; cytosolic phospholipase A2; EGFP; enhanced green fluorescent protein; ESI-MS/MS; electrospray ionization-tandem mass spectrometry; MTS; mitochondrial targeting signal; PC; phosphatidylcholine; PE; phosphatidylethanolamine; PG; phos
UCN enhances TGF-beta-mediated mitoinhibition of VSMCs via counteracting TGF-beta-induced cPLA2 expression and activation
Keywords: Ast; astressin; cPLA2; cytosolic phospholipase A2; CRF; corticotrophin-releasing factor; CRFR; corticotrophin-releasing factor receptor; PYR; pyrrophenone; UCN; urocortin; mitoinhibition; mitosis inhibition; UCN; TGF-beta; cPLA2; VSMCs; Mitoinhibition;
BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly
Keywords: 5-LO; 5-lipoxygenase; AA; arachidonic acid; COX; cyclooxygenase; cPLA2; cytosolic phospholipase A2; FLAP; 5-lipoxygenase-activating protein; fMLP; N-formyl-methionyl-leucyl-phenylalanine; H(P)ETE; hydro(pero)oxyeicosatetraenoic acid; HHT; hydroxyheptadeca
The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
Keywords: NO; nitric oxide; NO2; dioxide radical; O2; superoxide; ONO2â; Â peroxynitrite; 15-dPGJ2; 15-deoxy-Î12,14-prostaglandin J2; AA; arachidonic acid; ADH; alcohol dehydrogenase; AF-1; ligand-independent activation function; AF-2; ligand-dependent activatio
Balancing proportions of competing omega-3 and omega-6 highly unsaturated fatty acids (HUFA) in tissue lipids
Keywords: AA; arachidonic acid, 20:4n-6; ALA; alpha-linolenic acid, 18:3n-3; CoA; coenzyme A; cPLA2; cytosolic phospholipase A2; EPA; eicosapentaenoic acid, 20:5n-3; DPA; docosapentaenoic acid, 22:5n-3; DHA; docosahexaenoic acid, 22:6n-3; HUFA; 20- and 22-carbon hi
PKCδ-iPLA2-PGE2-PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells
Keywords: CLDN1; claudin 1; TJ; tight junctions; PPARγ; peroxisome proliferator-activated receptor γ; TRAF-2; TNF-associated factor 2; FADD; Fas-associated protein with death domain; sPLA2; secreted phospholipase 2; cPLA2; cytosolic calcium dependent PLA2; iPLA2;
Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells
Keywords: AMs; alveolar macrophages; ARDS; Acute Respiratory Distress Syndrome; BAL; bronchoalveolar lavage; C12-NBD-FA; 12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoic acid; C12-NBD-PC; 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-
Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells
Keywords: CRF receptors; cPLA2; Sphk1; S1PR; Cell motility;
Ca2+ signaling in taste bud cells and spontaneous preference for fat: Unresolved roles of CD36 and GPR120
Keywords: Lipids; Taste receptor cells; CD36; GPR120; Stim1; Ca2+ influx factor; Fatty acids; AA; arachidonic acid; [Ca2+]i; free intracellular calcium concentration; CaM; calmodulin; CIF; calcium influx factor; cPLA2; cytosolic phospholipase A2; GL; glossopharynge
Ethanol dose-dependently elicits opposing regulatory effects on hippocampal AMPA receptor GluA2 subunits through a zeta inhibitory peptide-sensitive kinase in adolescent and adult Sprague-Dawley rats
Keywords: ANOVA; analysis of variance; aPKC; atypical protein kinase C; cPLA2; cytoplasmic phospholipase A2; EDTA; ethylenediaminetetraacetic acid; LTP; long-term potentiation; NSF; N-ethylmaleimide-sensitive factor; PBS; phosphate-buffered saline; PKC; protein kin
Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy
Keywords: ChT; chymotrypsin-like; cPLA2; cytosolic phospholipase A2; NOX; NADPH oxidase; HETE; hydroxyeicosatetraenoic acid; LT; leukotriene; f-ALS; familial amyotrophic lateral sclerosis; LO; lipoxygenase; UPS; ubiquitin-proteasome system; GA; gastrocnemius; TA;
ReviewMembrane lipid interactions in intestinal ischemia/reperfusion-induced Injury
Keywords: AA; arachidonic acid; ATP; adenosine tri-phosphate; β2-GPI; beta2-glycoprotein 1; cAMP; cyclic adenosine mono-phosphate; Cox; cyclooxygenase; cPLA2; cytosolic phospholipase A2; CR2; complement receptor 2; ESI-MS/MS; electrospray ionization-tandem mass sp
Class specific peptide inhibitors for secretory phospholipases A2
Keywords: AMP; antimicrobial peptides; bv; bee venom; C28-O-PHPM; 1-octosanyl-2-(pyren-1-yl)hexanoyl-sn-glycero-3-phospho-monomethyl ester; cPLA2; cytosolic PLA2; CSSP; continuum secondary structure predictor; EM; electron microscopy; FFA; free fatty acid; Hsp70; h
Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo
Keywords: DHA; Docosahexaenoic acid; AA; Arachidonic acid; LA; Linoleic acid; α-LNA; α-linolenic acid; DPA; Docosapentaenoic acid; EDP; Epoxy-docosapentaenoic acid; EPA; Eicosapentaenoic acid; PLA2; Phospholipase A2; cPLA2; Cytosolic PLA2; sPLA2; Secretory PLA2;
Leptin attenuates lipopolysaccharide-induced apoptosis of thymocytes partially via down-regulation of cPLA2 and p38 MAPK activation
Keywords: Leptin; cPLA2; p38 MAPK; Thymocytes; Apoptosis;