کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5888440 | 1568019 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Balancing proportions of competing omega-3 and omega-6 highly unsaturated fatty acids (HUFA) in tissue lipids
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کلمات کلیدی
EPALTB5docosahexaenoic acid, 22:6n-3arachidonic acid, 20:4n-6HUFALTB4cPLA2COAALADPAArachidonic acid - اسید آراشیدونیکalpha-linolenic acid - اسید آلفا لینولنیکEicosapentaenoic acid - اسید ایکوزاپنتانوئیکLinoleic acid - اسید لینولئیکDHA - دوکوساهگزائنوئیک اسیدPhospholipase - فسفولیپازcytosolic phospholipase A2 - فسفولیپاز A2 سیتوزولLeukotriene B4 - لوکوترین B4Leukotriene - لکوترینcoenzyme A - کوآنزیم A
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
People eating different balances of omega-3 and omega-6 nutrients develop predictably different proportions of competing highly unsaturated fatty acids (HUFA) in their tissue lipids. While epidemiological studies have associated wide differences in HUFA balance with disease severity, some clinical studies that did not examine wide differences failed to confirm the association. We examined the degree to which the relative amount of arachidonic acid, the major precursor of omega-6 eicosanoids, differs among people who have widely different dietary intakes of omega-3 and omega-6 nutrients. Gas chromatographic analyses of human blood samples describe the balance among n-3 and n-6 HUFA for different individuals. The proportion of the omega-6 arachidonic acid, from which potent eicosanoids are formed, is not constant. It ranges from 30% to 70% of HUFA while the competing n-3 HUFA range from 60% to 10% of HUFA. Significant differences in clinical outcomes between control and intervention groups have been seen when using dietary interventions that shift the balance of n-3 and n-6 nutrients far enough to create a biologically significant difference in the HUFA balance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 99, August 2015, Pages 19-23
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 99, August 2015, Pages 19-23
نویسندگان
Doug Bibus, Bill Lands,