کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8305911 | 1538434 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ca2+ signaling in taste bud cells and spontaneous preference for fat: Unresolved roles of CD36 and GPR120
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کلمات کلیدی
SFKcalcium influx factorPTKCa2+-independent phospholipase A2iPLA2TRPM5lyso-PCCIFGPR120SOCESTIM1TRCcPLA2PLCTBCLCFAGPCRCD36G protein-coupled receptors - G گیرنده های پروتئینی همراهSrc family kinases - kinases خانواده Src[Ca2+]i - [Ca2 +] iArachidonic acid - اسید آراشیدونیکLong-chain fatty acid - اسید چرب طولانی مدتFatty acids - اسیدهای چربCAM - ساخت به کمک کامپیوترtaste receptor cells - سلول های گیرنده طعمSOC - سیستم روی یک تراشهtaste bud cells - طعم جوانه های سلولیglossopharyngeal nerve - عصب glossopharyngealfree intracellular calcium concentration - غلظت کلسیم داخل سلولی آزادcytosolic phospholipase A2 - فسفولیپاز A2 سیتوزولphospholipase C - فسفولیپاز CLyso-phosphatidylcholine - لیسو فسفاتیدیل کولینStromal interaction molecule 1 - مولکول تعامل استروما 1Store-operated Ca2+ entry - ورودی Ca2 + ذخیره شدهProtein tyrosine kinase - پروتئین تیروزین کینازLipids - چربیهاCalmodulin - کالمودولینStore-operated Ca2+ channel - کانال Ca2 + ذخیره شده
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ca2+ signaling in taste bud cells and spontaneous preference for fat: Unresolved roles of CD36 and GPR120 Ca2+ signaling in taste bud cells and spontaneous preference for fat: Unresolved roles of CD36 and GPR120](/preview/png/8305911.png)
چکیده انگلیسی
Recent compelling evidences from rodent and human studies raise the possibility for an additional sixth taste modality devoted to oro-gustatory perception of dietary lipids. Understanding the mechanisms underlying oro-gustatory detection of dietary fat is critical for the prevention and treatment of obesity. A number of studies have suggested that lingual CD36, a glycoprotein, highly expressed by circumvallate papillae of the tongue, is implicated in the perception of dietary fat taste. G protein-coupled receptors (GPCRs) are important signaling molecules for many aspects of cellular functions. It has been shown that these receptors, particularly GPR120, are also involved in lipid taste perception. We have shown that dietary long-chain fatty acids (LCFAs), in CD36-positive taste bud cells (TBC), induce increases in free intracellular Ca2+ concentrations, [Ca2+]i, by recruiting Ca2+ from endoplasmic reticulum (ER) pool via inositol 1,4,5-triphosphate production, followed by Ca2+ influx via opening of store-operated Ca2+ (SOC) channels. GPR120 is also coupled to increases in [Ca2+]i by dietary fatty acids. We observed that stromal interaction molecule 1 (STIM1), a sensor of Ca2+ depletion in the ER, mediated fatty acid-induced Ca2+ signaling and spontaneous preference for fat in the mouse. In this review article, we discuss the recent advances and unresolved roles of CD36 and GPR120 in lipid taste signaling in taste bud cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 96, January 2014, Pages 8-13
Journal: Biochimie - Volume 96, January 2014, Pages 8-13
نویسندگان
Souleymane Abdoul-Azize, Subramaniam Selvakumar, Hassimi Sadou, Philippe Besnard, Naim Akhtar Khan,