Keywords: کوبس; A2Ms; α-2- macroglobulins; AFLEI; elastase inhibitor from Aspergillus flavus; AFUEI; elastase inhibitor from Aspergillus fumigatus; AP; α-2-antiplasmin; AT; antithrombin; bFGF; basic fibroblast growth factor; BSuPI; Bacillus subtilis protease inhibitor;
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Keywords: کوبس; ABC; ATP-binding cassette; GSH; glutathione; IC50; half-maximal inhibitory concentration; IFN-γ; interferon-gamma; iNOS; inducible NO synthase; IRF-1; interferon regulatory factor-1; ITC; isothiocyanate; Kobs; Pseudo-first order reaction rate constant; L
Mechanistic insights into F420-dependent glucose-6-phosphate dehydrogenase using isotope effects and substrate inhibition studies
Keywords: کوبس; FGD; F420-dependent glucose-6-phosphate dehydrogenase; G6P; glucose-6-phosphate; G6P-d1; glucose-6-phosphate-d1; G6PD; glucose-6-phosphate dehydrogenase; F420 cofactor; 7,8-didemethyl-8-hydroxy-5-deazariboflavin-5â²-phosphoryllactyl(glutamyl)nglutamate;
Kinetic and Mechanistic Study of the pH-Dependent Activation (Epoxidation) of Prodrug Treosulfan Including the Reaction Inhibition in a Borate Buffer
Keywords: کوبس; chemical stability; complexation; HPLC; kinetics; prodrugs; B; boric acid (unionized); Bâ; borate anion; CB; total concentration of a borate buffer; CT; total concentration of T; DEB; (2S,3S)-1,2:3,4-diepoxybutane; EBDM; (2S,3S)-1,2-epoxybutane-3,4-diol
Rapid green synthesis of gold nanocatalyst for high-efficiency degradation of quinclorac
Keywords: کوبس; Au NPs; gold nanoparticles; Au/SCM; gold nanoparticles immobilized on NaOH-pretreated yeast; SPR; surface plasmon resonance; kobs; rate constant; Quinclorac; Saccharomyces cerevisiae; Nanoparticle; Catalyst; Reductive dechlorination;
Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism
Keywords: کوبس; PTP1B; protein tyrosine phosphatase 1B; IC50; the inhibitor concentration leading 50% activity loss; Ki; inhibition constant; Kiapp; apparent Ki; Vmax; maximum velocity; Km; Michaelis-Menten constant; Kobs; apparent first-order rate constant for the trans
Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand
Keywords: کوبس; BH; Bolton-Hunter; Bmax; maximal number of the binding sites; BSA; bovine serum albumin; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EC50; half maximal effective concentration; Emax; maximal stimulation (Efficacy); GDP; guanosine 5â²-
β-Cyclodextrin complexation as an effective drug delivery system for meropenem
Keywords: کوبس; DPH-I; dehydropeptidase-I; MER-β-CD; meropenem-β-cyclodextrin inclusion complex; β-CD; β-cyclodextrin; MER; meropenem; UHPLC; Ultra High-Performance Liquid Chromatography; HPLC; High-Performance Liquid Chromatography; FT-IR; Fourier Transform Infrared
In vitro and in vivo toxicological studies of V nerve agents: Molecular and stereoselective aspects
Keywords: کوبس; GA; tabun; GB; sarin; GD; soman; GF; cyclosarin; VX; O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiate; VR; O-isobutyl S-[2-(diethylamino)ethyl] methylphosphonothiate; EA-2192; S-[2(diisopropylamino)ethyl] methylphosphonothioic acid; OP; organop
Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast
Keywords: کوبس; 3â²-dRP; 3â²-α,β-unsaturated aldehyde; 8-oxoG or G°; 7,8-dihydro-8-oxoguanine; 9-1-1; Rad9-Rad1-Hus1; AP; apurinic/apyrimidinic; APE1 or Apn1; AP-endonuclease 1; Apn2; AP-endonuclease 2; BER; base excision repair; BSA; bovine serum albumin; D
External loops at the ferredoxin-NADP+ reductase protein-partner binding cavity contribute to substrates allocation
Keywords: کوبس; FNR; ferredoxin-NADP+ reductase; FNRox; FNR in the fully oxidized state; FNRsq; FNR in the partially reduced state; FNRhq; FNR in the anionic hydroquinone (fully reduced) state; Fd; ferredoxin; Fdrd; ferredoxin in the reduced state; dRf; 5-deazariboflavin
Degradation of antipyrine by heat activated persulfate
Keywords: کوبس; AP; antipyrine; AOT; advanced oxidation technology; DO; dissolved oxygen; DOC; dissolved organic carbon; E0; redox potential; ISCO; in situ chemical oxidation; kobs; pseudo-first-order degradation rate; kobs-original; pseudo-first-order degradation rate i
Extraction of ursolic acid from Ocimum sanctum leaves: Kinetics and modeling
Keywords: کوبس; UA; ursolic acid; OA; oleanolic acid; OS; Ocimum sanctum; Cl,exp,i; experimental concentration of the component in the liquid phase at time t; Cl,pre,i; predicted concentration of the component in the liquid phase at time t; N; number of observations; PE(
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
Keywords: کوبس; IC50; the inhibitor concentration leading to 50% activity loss; Ki; inhibition constant; Kiapp; apparent Ki; k; rate constant; Vmax; maximum velocity; Km; Michaelis-Menten constant; kobs; apparent first-order rate constant for the transition from vi to vs
Chemical reactivity and microbicidal action of bethoxazin
Keywords: کوبس; Cys; cysteine; DTT; dithiotreitol; ESI; electrospray ionization; GSH; glutathione; HRMS; high resolution mass spectrometry; HSA; human serum albumin; kDNA; kinetoplast plasmid DNA; kobs; pseudo first order rate constant; LC; liquid chromatography; MS; mas
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation
Keywords: کوبس; Pol β; DNA polymerase β; BER; base excision repair; AP; apurinic/apyrimidinic; APE1; AP endonuclease 1; dRP; deoxyribose phosphate; NEIL; Nei-like; WT; wild-type; Tet; tetracycline; MEF; mouse embryonic fibroblast; Hyg; hygromycin; SDS; sodium dodecyl s
Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation
Keywords: کوبس; ACN; acetonitrile; APAP; acetaminophen; CYP1A2; cytochrome P450 1A2 enzyme; CYP2B6; cytochrome P450 2B6 enzyme; CYP2C19; cytochrome P450 2C19 enzyme; CYP2D6; cytochrome P450 2D6 enzyme; CYP3A4; cytochrome P450 3A4 enzyme; CYP450; cytochrome P450 enzymes;
Refolding of the non-specific neutral protease from Bacillus stearothermophilus proceeds via an autoproteolytically sensitive intermediate
Keywords: کوبس; Abz-AGLA-Nba; 2-aminobenzoyl-Ala-Gly-Leu-Ala-4-nitrobenzylamide; GdnHCl; guanidine hydrochloride; kobs; observed rate constant; pWT; pseudo-wild type; TCA; trichloroacetic acid; Tris; tris(hydroxymethyl)aminomethane; ÎG#; Gibbs free energy of activation;
Dual role of FMN in flavodoxin function: Electron transfer cofactor and modulation of the protein-protein interaction surface
Keywords: کوبس; AnFld; flavodoxin from Anabaena; ApoFld; apoflavodoxin; DDM; β-dodecyl maltoside; ET; electron transfer; ox; oxidised; sq; semiquinone; hq; hydroquinone; Eox/sq; midpoint reduction potential for the ox/sq couple; Esq/hq; midpoint reduction potential for
Human H9 cells proliferation is differently controlled by Vasoactive Intestinal Peptide or Peptide Histidine Methionine: implication of a GTP-insensitive form of VPAC1 receptor
Keywords: کوبس; PHM; Peptide Histidine Methionine; VIP; Vasoactive Intestinal Peptide; cAMP; cyclic AMP; AC; Adenylate Cyclase; PHI; Peptide Histidine Isoleucine; PACAP; Pituitary Adenylate Cyclase-Activating Peptide; PHV; Peptide Histidine Valine; GPCRs; G protein-coupl