دانلود مقالات ISI درباره اسید کینورنیک + ترجمه فارسی

Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition

Keywords: اسید کینورنیک; Major depressive disorder; Oxidative and nitrosative stress; Kynurenine; Aryl hydrocarbon; Immune-inflammation; Mitochondria; Pathophysiology; Melatonin; Treatment; Classification; Cognition; 3-OH-ANA; 3-hydroxyanthranillic acid; 3-OH-Kyn; 3-hydroxykynure

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor

Keywords: اسید کینورنیک; 1MDT; 1-Methy-D-Tryptophan; 1MLT; 1-Methyl-l-Tryptophan; AHR; Aryl Hydrocarbon Receptor; DMSO; dimethylsulfoxide; DPBS; Dulbecco's Phosphate Buffered Saline; IDO; indoleamine 2,3-dioxygenase; INCB; INCB024360; Kyn; kynurenine; KA; kynurenic acid; NLG; NLG

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

N-Methyl-D aspartate receptor-mediated effect on glucose transporter-3 levels of high glucose exposed-SH-SY5Y dopaminergic neurons

Keywords: اسید کینورنیک; Glucose toxicity; Oxidative stress; GLUT3; Kynurenic acid; SH-SY5Y cells; NMDA receptors;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Systemic administration of l-kynurenine sulfate induces cerebral hypoperfusion transients in adult C57Bl/6 mice

Keywords: اسید کینورنیک; l-KYN; l-kynurenine; KYNA; kynurenic acid; α7nACh; α7 nicotinic acetylcholine; GPR35; G-protein-coupled receptor 35; NMDA; N-methyl-d-aspartate; l-KYNs; l-kynurenine sulfate; CBF; cerebral blood flow; MABP; mean arterial blood pressure; rCBFx; cerebrova

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum

Keywords: اسید کینورنیک; KYNA; Opioid receptor; [35S]GTPγS binding; G-protein; MK-801; 3-NLT; 3-nitro-l-tyrosine; CNS; central nerve system; CSF; cerebrospinal fluid; BBB; blood-brain barrier; DAMGO; Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol; DOPr; δ opioid peptide receptor; EGTA; ethylene

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex

Keywords: اسید کینورنیک; glutamate; KAT II; Kynurenic acid; Microelectrode array; Prefrontal cortex; Schizophrenia; ACh; acetylcholine; α7nAChR; alpha7 nicotinic acetylcholine receptor; Gluox; glutamate-sensitive; HPBCD; hydroxyl-propyl-beta-cyclodextrin; KYNA; kynurenic acid; K

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Archival ReportAdaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders

Keywords: اسید کینورنیک; Anxiety; Cognition; Kynurenic acid; Locomotor activity; Schizophrenia; Social interaction;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

The emerging pharmacology and function of GPR35 in the nervous system

Keywords: اسید کینورنیک; GPR35; Kynurenic acid; Zaprinast; Pain; CNS; Synaptic transmission; AHO; Albright's hereditary osteodystrophy; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; CNS; central nervous system; cGMP; cyclic guanosine 3′5′ monophosphate; DRG; d

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences

Keywords: اسید کینورنیک; Kynurenine pathway; Indoleamine 2,3-dioxygenase; Kynurenine 3-monooxygenase; Kynurenine aminotransferase; Kynurenine; Kynurenic acid; Quinolinic acid; TRP; l-tryptophan; KP; kynurenine pathway; NAD+; nicotinamide adenine nucleotide; TDO; tryptophan 2,3-di

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Dimerization and oxidation of tryptophan in UV-A photolysis sensitized by kynurenic acid

Keywords: اسید کینورنیک; UV-A light; Tryptophan; Kynurenic acid; Radicals; Oxidation; Ditryptophan crosslinks;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain

Keywords: اسید کینورنیک; 3-HK; 3-hydroxy-kynurenine; FST; forced swim test; HAAO; 3-hydroxyanthralinic acid dioxygenase; i.c.v; intracerebroventricular; IDO; indoleamine 2,3-dioxygenase; IL; interleukin; KMO; kynurenine 3-monooxygenase; KYN; kynurenine; KYNA; kynurenic acid; KYNU

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons

Keywords: اسید کینورنیک; Kynurenic acid; Dopamine; Ventral tegmental area; Firing; Kynurenine transferase; GABA-receptor; NMDA-receptor; PF-04859989; d-Cycloserine; CGP-52432; Picrotoxin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

In vitro and in silico evaluation of transactivation potencies of avian AHR1 and AHR2 by endogenous ligands: Implications for the physiological role of avian AHR2

Keywords: اسید کینورنیک; Bird; Aryl hydrocarbon receptor; FICZ; l-Kynurenine; Kynurenic acid; Indoxyl sulfate;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation

Keywords: اسید کینورنیک; GPR35; HCN; DRG; Kynurenic acid; Zaprinast; Pain; Zaprinast (Pubchem CID; 5722); Kynurenic acid (Pubchem CID; 3845); CID 2745687 (Pubchem CID; 2745687); ZD7288 (Pubchem CID; 123983);

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction

Keywords: اسید کینورنیک; BPnd; non-displacable binding potential; CG; cingulate cortex; CP; caudate putamen; CT; computed tomography; Ctrl; control; Ctrl-PBO; placebo-treated control cohort; Ctrl-NAc; NAc-treated control cohort; FOV; field of view; GSH; glutathion; HC; hippocampu

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2016 سفارش ترجمه

Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/− mice, using liquid chromatography-tandem mass spectrometry

Keywords: اسید کینورنیک; Kynurenine; Kynurenic acid; Quinolinic acid; Tryptophan metabolism; Rett syndrome;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease

Keywords: اسید کینورنیک; Kynurenine; Kynurenic acid; Inhibitor; Huntington's disease; Quinolinic acid; Pharmacodynamic; Neurodegeneration; Q175; R6/2;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2016 سفارش ترجمه

Pipa carvalhoi skin secretion profiling: Absence of peptides and identification of kynurenic acid as the major constitutive component

Keywords: اسید کینورنیک; Anura; Granular glands; Pipa carvalhoi; Pipidae; Kynurenic acid; Xenopus laevis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Quinaldic acid inhibits proliferation of colon cancer HT-29 cells in vitro: Effects on signaling pathways

Keywords: اسید کینورنیک; Quinaldic acid (PubChem CID: 7124)Quinaldic acid; Kynurenic acid; Colon cancer; Cancer cells proliferation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Determination of binding capacity and adsorption enthalpy between Human Glutamate Receptor (GluR1) peptide fragments and kynurenic acid by surface plasmon resonance experiments. Part 2: Interaction of GluR1270-300 with KYNA

Keywords: اسید کینورنیک; Kynurenic acid; Glutamate receptor; Binding enthalpy; Molecular docking; SPR; AFM;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality

Keywords: اسید کینورنیک; Suicide; Glutamate; Quinolinic acid; Kynurenic acid; Interleukin-6; Cerebrospinal fluid;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias

Keywords: اسید کینورنیک; GA; glutaric acid; GA I; glutaric acidemia type I; GDD; glutaryl-CoA dehydrogenase; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; KA; kynurenic acid; KP; kynurenine pathway; l-NAME; l-nitro-l-arginine methyl ester; MDA; Malondialdehyde; MMA;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine

Keywords: اسید کینورنیک; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; CED; Cambridge Electronic Design; DCX; doublecortin; DISC1; Disrupted in Schizophrenia-1; fEPSPs; field excitatory postsynaptic potentials; HRP; horseradish peroxidase; IDO; indolamine-2,3

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Pulmonary, gastrointestinal and urogenital pharmacologyEffects of systemic administration of kynurenic acid and glycine on renal haemodynamics and excretion in normotensive and spontaneously hypertensive rats

Keywords: اسید کینورنیک; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; CBF; cortical blood flow; D-AP5; D-2-amino-5-phosphonopentanoic acid; GFR; glomerular filtration rate; IMBF; inner medullary blood flow; KYNA; kynurenic acid; MAP; mean arterial pressure; NMDA; N-me

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

d-cycloserine lowers kynurenic acid formation-New mechanism of action

Keywords: اسید کینورنیک; KAT; kynurenine aminotransferase; KYNA; kynurenic acid; NMDA; N-methyl-d-aspartate; AMPOL; 2-amino-2-methyl-1-propanol; HIV-1; human immunodeficiency virus type-1; HIV; CO control; N; number; EAA; excitatory amino acid; Kynurenic acid; Kynurenine aminotra

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats

Keywords: اسید کینورنیک; Kynurenic acid; l-Kynurenine; KAT II; PF-04859989; Schizophrenia; Cognition;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway

Keywords: اسید کینورنیک; Kynurenines; Kynurenic acid; Neurodevelopment; Glutamate transport; GABA transport; Doublecortin; Sonic hedgehog;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Decreased levels of kynurenic acid in the intestinal mucosa of IBS patients: Relation to serotonin and psychological state

Keywords: اسید کینورنیک; Irritable bowel syndrome; Kynurenic acid; Serotonin; Small intestine; Psychiatric comorbidity;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Paradox effects of kynurenines on LTP induction in the Wistar rat. An in vivo study

Keywords: اسید کینورنیک; Long-term potentiation; LTP; Hippocampus; Kynurenic acid; KYNA; Cognitive functions;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain

Keywords: اسید کینورنیک; HD; Huntington's disease; Ido1; indoleamine 2,3-dioxygenase (gene); Tdo2; tryptophan 2,3-dioxygenase (gene); Ido2; indoleamine 2,3-dioxygenase 2 (gene); KP; kynurenine pathway; SP; serotonin pathway; Kyn; kynurenine; LC-MS/MS; liquid chromatography tandem

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Psychopharmacological effects of acute exposure to kynurenic acid (KYNA) in zebrafish

Keywords: اسید کینورنیک; Kynurenic acid; Zebrafish; Novel tank test; 3D reconstructions of locomotion; Anxiety;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Post-ischemic treatment with L-kynurenine sulfate exacerbates neuronal damage after transient middle cerebral artery occlusion

Keywords: اسید کینورنیک; 3-HK; 3-hydroxykynurenine; CNS; central nervous system; dMCA; distal middle cerebral artery; dMCAO; distal middle cerebral artery occlusion; EEG; electroencephalography; I/H; ischemic/hypoxic; KYNA; kynurenic acid; L-KYNs; L-kynurenine sulfate; NDS; norma

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2013 سفارش ترجمه

Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: Facts and challenges

Keywords: اسید کینورنیک; Kynurenic acid; α7 Nicotinic receptors; Neurotransmission; Glutamate receptor antagonists

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Synergistic effect of the l-tryptophan and kynurenic acid with dipyrone or paracetamol in mice

Keywords: اسید کینورنیک; Dipyrone; Paracetamol; l-Tryptophan; Kynurenic acid; Nociception; Synergism

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Concurrent quantification of tryptophan and its major metabolites

Keywords: اسید کینورنیک; Kynurenine pathway; Serotonin; Kynurenic acid; Tryptophan metabolites; HPLC

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus

Keywords: اسید کینورنیک; Kynurenines; Kynurenic acid; Tryptophan; Neurodevelopment; Rho proteins; Sonic hedgehog; Doublecortin

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

Keywords: اسید کینورنیک; Mitochondrial dysfunction; Glutamate excitotoxicity; Neuroinflammation; Kynurenine system; Kynurenic acid; Neurodegeneration; Cerebral ischemia; Huntington's disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Kynurenic acid enhances expression of p21 Waf1/Cip1 in colon cancer HT-29 cells

Keywords: اسید کینورنیک; kynurenic acid; colon cancer; p21 Waf1/Cip1; proliferation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis

Keywords: اسید کینورنیک; 5-HT; 5-hydroxytryptamine; 5-HTP; 5-hydroxytryptophan; ALAC; α-lactoalbumin; dSWDs; mean total duration of SWDs; EEG; Electroencephalography; i.p.; intraperitoneally; LNAAs; large neutral amino acids; nSWDs; mean number of SWDs; NMDA; N-methyl-d-aspartat

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Intracerebroventricular injection of kynurenic acid attenuates corticotrophin-releasing hormone-augmented stress responses in neonatal chicks

Keywords: اسید کینورنیک; 5-HT; serotonin; CRH; corticotrophin-releasing hormone; KYN; kynurenine; KYNA; kynurenic acid; NMDA; N-methyl-d-aspartate; TRP; l-tryptophan; kynurenic acid; l-tryptophan; intracerebroventricular injection; social separation stress; neonatal chick;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3

Keywords: اسید کینورنیک; hOAT; human organic anion transporter; NMDA; N-methyl d-aspartate; NSAID; nonsteroidal anti-inflammatory drug; hOAT1; hOAT3; Tryptophan metabolites; Kynurenic acid; Transport;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat

Keywords: اسید کینورنیک; CSD; cortical spreading depression; DC; direct current; FHM; familial hemiplegic migraine; HPLC; high performance liquid chromatography; IDO; indoleamine 2,3-dioxygenase; KAT; kynurenine aminotransferases; KYNA; Kynurenic acid; L-KYN; l-kynurenine; nAChR;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment

Keywords: اسید کینورنیک; Tryptophan metabolism; Social isolation rearing; Clozapine; Schizophrenia; Quinolinic acid; Kynurenic acid; Anti-inflammatory; AntioxidantSIR, social isolation rearing; DA, dopamine; ROS, reactive oxygen species; KYNA, kynurenic acid; QA, quinolinic acid;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Effect of kynurenic acid on the viability of probiotics in vitro

Keywords: اسید کینورنیک; probiotics; kynurenic acid; viability; in vitro

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Time-course of kynurenic acid concentration in mouse serum following the administration of a novel kynurenic acid analog

Keywords: اسید کینورنیک; Kynurenic acid; Kynurenic acid analog; Pharmacokinetic study; High-performance liquid chromatography; Mass spectrometry

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast

Keywords: اسید کینورنیک; GPR35; Kynurenic acid; Zaprinast; Pain; Analgesia; KynurenineDRG, dorsal root ganglia; GPR35, G-protein coupled receptor 35; KYNA, Kynurenic acid; PBS, phosphate buffered saline

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Kynurenic acid: a new effector of valproate action?

Keywords: اسید کینورنیک; PTZ-kindling; microdialysis; valproate; kynurenic acid; GABA; steady state; epilepsy; neuroprotection;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Simultaneous determination of urinary tryptophan, tryptophan-related metabolites and creatinine by high performance liquid chromatography with ultraviolet and fluorimetric detection

Keywords: اسید کینورنیک; Tryptophan; Kynurenine; Kynurenic acid; 5-Hydroxyindole-3-acetic acid; Urine; High performance liquid chromatography

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients

Keywords: اسید کینورنیک; Schizophrenia; Kynurenine; Kynurenic acid; 3-Hydroxykynurenine; Antipsychotics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Decreased plasma tryptophan and tryptophan/large neutral amino acid ratio in patients with neuroleptic-resistant schizophrenia: Relationship to plasma cortisol concentration

Keywords: اسید کینورنیک; Serotonin; Kynurenine; Kynurenic acid; Immune activation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه