Keywords: Legumain; Asparaginyl endopeptidase; Vector; Ticks; Hemoglobin;
مقالات ISI (ترجمه نشده)
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Keywords: Biomarkers; Carotid plaque; Atherosclerosis; Legumain; Protease;
Keywords: Asparaginyl endopeptidase (AEP); Atherosclerosis; Carotid; Cholesterol crystals; Cystatins; Inflammation; Legumain; Macrophage polarization; Plaque; Proteases;
Keywords: Polymer; Platinum-based drugs; Controlled-release; Legumain;
Keywords: nRGD; iRGD; Legumain; Tumor associated macrophage; Tumor microenvironment;
Keywords: ABP; activity-based probe; ACPP; activatable cell-penetrating peptide; BD; blocking domain; ECM; extracellular matrix; MMP; matrix metalloproteinase; MMPI; MMP inhibitor; NP; nanoparticle; PAP; Protease-Activated Prodrug; PEG; polyethylene glycol; Prodrug
Keywords: Legumain; Cancer; Cyano warhead; Cellular active inhibitor;
Keywords: Legumain; Colorectal cancer; Asparaginyl endopeptidase (AEP); Cell nuclei; Cysteine proteinase; Prodrugs; S100A4;
Keywords: Legumain; VPE; Caspase-like; Rice; Plant development;
Keywords: HEK293 cells; human embryonic kidney 293 cells; M38L; monoclonal legumain over-expressing HEK293 cells; M4C; monoclonal cystatin E/M over-expressing HEK293 cells; Asparaginyl endopeptidase; Colchicine; Colorectal cancer; Cystatin E/M; Legumain; Prodrug;
Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors
Keywords: Legumain; Pichia pastoris; Enzyme activity; Small molecule inhibitor;
Proteases catalyzing vicilin cleavage in developing pea (Pisum sativum L.) seeds
Keywords: AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride; DAI; days after imbibition; DTT; 1,4-dithiothreitol; E-64; N-[N-(L-3-transcarboxyirane-2-carbonyl)-l-leucyl]-agmatine; PCMPS; p-choromercuriphenylsulfonic acid; PSV; protein storage vacuole; Pisum sativum;
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy
Keywords: legumain; M2 macrophage; renal interstitial fibrosis; UUO;
Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart
Keywords: MHC; major histocompatibility complex; AMC; 7-amino-4-methylcoumarin; Z; benzyloxycarbonyl; MCA; methylcumarinamide; Legumain; DJ-1; Cystatin E/M;
Expression of the enzymatically active legumain-like cysteine proteinase TvLEGU-1 of Trichomonas vaginalis in Pichia pastoris
Keywords: Cysteine proteinases; Legumain; Trichomonas vaginalis; Pichia pastoris; Protein expression; Alpha-amylase signal peptide of Aspergillus niger;
Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions
Keywords: Activity-based probe; Asparaginyl endopeptidase (AEP); Cystatin E/M; Internalization; Glycosylation; Legumain; ABP; activity-based probe; AEP; asparaginyl endopeptidase; GAG; glycosaminoglycan; C4S; chondroitin-4-sulfate; HS; heparan sulfate; SDS; sodium
Full length articleLegumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release
Keywords: Legumain; PEG; Doxorubicin; Conjugate; Drug delivery;
Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors
Keywords: Legumain; Cancer; SAR; Small molecule protease inhibitor;
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells
Keywords: Legumain; DJ-1; p53; Annexin A2; Z; benzyloxycarbonyl; MCA; methylcumarinamide;
Digestive proteases in bodies and faeces of the two-spotted spider mite, Tetranychus urticae
Keywords: Phytophagous mites; Cathepsin; Legumain; Cystatin; Protease inhibitors; Proteomics
Full length articleCharacterization of a gut-associated asparaginyl endopeptidase of Clonorchis sinensis
Keywords: Clonorchis sinensis; Asparaginyl endopeptidase; Legumain; Intestine;
P3 SAR exploration of biphenyl carbamate based Legumain inhibitors
Keywords: Legumain; Cancer; Cyano warhead; Protease inhibitor;
Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidney
Keywords: Ketone body; Acetoacetyl-CoA synthetase; Legumain; Kidney; Proteolytic degradation
Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection
Keywords: Legumain; MRI; Optical imaging; Contrast agent
Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney
Keywords: Z; benzyloxycarbonyl; MCA; methylcumarinamide; siRNA-lipoplex; siRNA-cationic liposome complex; NEM; N-ethyl maleimide; 2-ME; 2-mercaptoetanol; PBS; phosphate buffered saline; Legumain; Annexin A2; Cationic liposome; siRNA; Invivo; Mouse kidney;
Alginates induce legumain activity in RAW 264.7 cells and accelerate autoactivation of prolegumain
Keywords: M; mannuronic acid; G; guluronic acid; PolyM; polymannuronate; PolyG; polyguluronate; dp; degree of polymerization; SDS; sodium dodecyl sulphate; DMEM; Dulbeccoâ²s modified Eagle medium; DTT; dithiothreitol; T-TBS; Tween-Tris-buffered saline; BSA; bo
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain
Keywords: Legumain; Protease inhibitors; Covalent inhibitors; Cysteine protease; Asparaginyl endopeptidase; Activity-based probes
Characterization of two cysteine proteases secreted by Blastocystis ST7, a human intestinal parasite
Keywords: Blastocystis; Secreted proteases; Cathepsin; Legumain; Pathogenicity; Proteomics
Recombinant expression and biochemical characterization of sugarcane legumain
Keywords: Vacuolar processing enzyme; Legumain; Sugarcane; Cystatin; Expression analysis; Sugarcane development; Phytohormone responseABA, abscisic acid; AMC, 7-amino-4-methylcoumarin; DAP, days after planting; E-64, trans-epoxysuccinyl-l-leucylamido(4-guanidino)bu
Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity
Keywords: Ligand-targeting; Liposome; Legumain; Cancer;
Research ArticleNucleoplasmic calcium regulates cell proliferation through legumain
Keywords: RaSH; Rapid Subtraction Hybridization; PV; parvalbumin; LGMN; legumain; BrdU; 5-bromo-2â²-deoxyuridine; HCC; hepatocellular carcinoma; Nuclear calcium; Legumain; Hepatocellular carcinoma;
Two cysteine proteinases respond to bacterial and WSSV challenge in Chinese white shrimp Fenneropenaeus chinensis
Keywords: Cathepsin L; Legumain; Innate immunity; Fenneropenaeus chinensis
Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo
Keywords: Schistosome; Cathepsin; Legumain; Peptidase; RNAi; Digestion;
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis
Keywords: Asparaginyl endopeptidase; Legumain; Opisthorchis viverrini; Liver fluke; Cholangiocarcinoma; Immunodiagnosis; Protease
HlLgm2, a member of asparaginyl endopeptidases/legumains in the midgut of the ixodid tick Haemaphysalis longicornis, is involved in blood-meal digestion
Keywords: Ixodid tick; Asparaginyl endopeptidase; Legumain; Haemoglobin; Blood-meal digestion
Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis
Keywords: Cysteine protease; Legumain; Atherosclerosis; Macrophages; Microarray analysis; Chemotaxis;
Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain
Keywords: Activity-based probes; Cysteine protease; Fluorescent labeling; Legumain
Carboxy terminal extended phytocystatins are bifunctional inhibitors of papain and legumain cysteine proteinases
Keywords: PhyCys, phytocystatinsBarley; Cystatin; Cysteine proteinase inhibitor; Legumain; Papain
Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells
Keywords: Extracellular matrix remodeling; Fibronectin; Legumain; Lysosomal peptidase; Renal proximal tubular cell; Unilateral ureteral obstruction;
Comparison of natural and recombinant clitocypins, the fungal cysteine protease inhibitors
Keywords: Clitocybe nebularis; Mushroom; Basidiomycete; Clitocypin; Cysteine protease inhibitor; Heterologous expression; Cysteine protease; Cathepsins; Legumain; Escherichia coli
IrAE – An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus
Keywords: Asparaginyl endopeptidase; Legumain; Protease; Tick; Midgut; Hemoglobin digestion; Ixodes ricinus
Characterization of asparaginyl endopeptidase, legumain induced by blood feeding in the ixodid tick Haemaphysalis longicornis
Keywords: Ixodid tick; Haemaphysalis longicornis; Asparaginyl endopeptidase; Legumain; Hydrolysis activity; Blood-meal digestion
Comparative molecular analysis of two asparaginyl endopeptidases and encoding genes from Fasciola gigantica
Keywords: Fasciola gigantica; Legumain; Asparaginyl endopeptidase; Southern analysis; Northern analysis; Stage-specific reverse transcriptase PCR; In situ hybridization; Immunolocalization; Proteolytic activity
Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion
Keywords: Cystatin M; siRNA; Cathepsins; Legumain; Oral cancer