Keywords: MW; molecular weight; MDR1; multiple drug resistance 1; P-gp; P-glycoprotein; ABC-transporter; ATP-binding cassette transporter; ATP; adenosine triphosphate; BBB; blood brain barrier; SLC transporter; solute carrier transporter; logP; partition coefficien
مقالات ISI (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: AFM; atomic force microscopy; ATR; Attenuated total reflectance (IR system); CCC; covalently closed circular DNA; CD; circular dichroism; CT DNA; calf thymus DNA; DEPT; distortionless enhancement by polarization transfer; DMF; Dimethylformamide; DMSO; Dim
Keywords: ATR-IR; attenuated total reflection infrared; DVB; divinylbenzene; EGDMA; ethylene glycol dimethacrylate; LOD; limit of detection; logP; logarithmic ratio of the octanol-water partitioning coefficient; LOQ; limit of quantitation; SPE; solid-phase extracti
Keywords: Phenylphosphazenes; Lipophilicity; LogP; pKa; Staudinger reaction;
Keywords: CAS; chemical abstract service; CV; relative coefficient of variation; GC; gas chromatography; KOH; potassium hydroxide; LogP; decadic logarithm of the octanol/water partition coefficient; NaCl; sodium chloride; o/w; oil in water emulsion; SD; standard de
Keywords: Noble gases; Chemically inert; Clinical applications; In vitro and in vivo studies; Drug delivery; CNS; central nervous system; logP; log of the octanol-water partition coefficient; L1; L2, Ostwald coefficients; DMPC; 1,2-dimyristoyl-sn-glycero-3-phosphoc
Keywords: ADME-Tox; Absorption, distribution, metabolism, excretion, and toxicity; HOBA; Human oral bioavailability; HIA; Human intestinal absorption; QSAR; Quantitative structure-activity relationship; MLR; Multiple linear regressions; GA; Genetic algorithm; L
Aminoguanidine hydrazones (AGH's) as modulators of norfloxacin resistance in Staphylococcus aureus that overexpress NorA efflux pump
Keywords: Staphylococcus aureus; Efflux pump inhibitors; Docking; Aminoguanidine hydrazones; EPIs; efflux pump inhibitors; AGH's; aminoguanidine hydrazones; MICs; minimum inhibitory concentrations; MTT; 1-(4,5-dimethylthiazol-2-yl)-3,5-diphenyl formazan; MDR; multi
Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs
Keywords: Bioaccumulation; Perfluorinated compounds; PFOS; Cationic amphiphilic drugs; Adipocytes; Phospholipid binding; ACC; compound's accumulation in cells; ACE; acetaminophen; ACN; acetonitrile; AMIO; amiodarone; AMIT; amitriptyline; AZI; azithromycin; AZAG; az
Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents
Keywords: Teicoplanin; Lipoglycopeptide; Maleimide; Sulfonamide; Influenza virus inhibitor; Coronavirus; DCM; dichloromethane; DMF; dimethylformamide; CPE; cytopathic effect; Et3N; triethylamine; Galp; galactopyranose; HA; hemagglutinin; HIV; human immunodeficiency
Drug release studies from lipid nanoparticles in physiological media by a new DSC method
Keywords: Lipid nanoparticles; Drug release; Differential scanning calorimetry; Physiological conditions; Crystallization; logP;
Preclinical evaluation of melanocortin-1 receptor (MC1-R) specific 68Ga- and 44Sc-labeled DOTA-NAPamide in melanoma imaging
Keywords: α-MSH; alpha-melanocyte stimulating hormone; ACN; acetonitrile; DOTA; 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; DOTA-NAPamide; Ac-Nle-Asp-His-d-Phe-Arg-Trp-Gly-Lys(DOTA)-NH2; EtOH; ethanol; i.v.; intravenous(ly); logP; octanol-water par
Towards a chromatographic similarity index to establish localised Quantitative Structure-Retention Relationships for retention prediction. III Combination of Tanimoto similarity index, logP, and retention factor ratio to identify optimal analyte training
Keywords: QSRR; Ion chromatography; Retention factor ratio; Tanimoto similarity; LogP;
Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis
Keywords: Natural product analogues; Drug design; Isoxazole; Trypanosoma cruzi; Leishmania amazonensis; Trypanothione reductase; %GI; percentage of growth inhibition; AB; amphotericin B; BZN; benznidazol; logP; partition coefficient octanol/water; MW; microwave; ND
Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line
Keywords: AG; andrographolide; ATM; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; DLS; Dynamic Light Scattering; DMSO; dimethyl sulfoxide; ECA; ethylcyanoacrylate; EE; encapsulation efficiency; E
IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds
Keywords: API; active pharmaceutical ingredient; AUC; area under the curve; BCS; biopharmaceutics classification system; BP; blood-to-plasma ratio; Cmax; maximum concentration; CL; clearance; Do; dose number according to BCS; DDI; drug-drug interaction; EFPIA; Euro
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
Keywords: AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
Keywords: API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti
Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies
Keywords: Pyridazine-3-carboxamides; CB2 agonist; Structure-activity relationships; Molecular docking; logP;
Retention data of bile acids and their oxo derivatives in characterization of pharmacokinetic properties and in silico ADME modeling
Keywords: logP; logarithm of partition coefficient; RM0; intercept; b; slope of the linear plot; C; volume fraction of the organic solvent in the mobile phase; TPSA; total polar surface area; natoms; number of atoms; Mw; molecular weight; nOH; number of hydrogen bo
ReviewStrategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: State-of-the-art and challenges
Keywords: PLGA; poly(d,l-lactide-co-glycolide); logP; partition coefficient; Mw; molecular weight; W1/O/W2; water/oil/water; O/W; oil/water; W2; outer water phase; W1; inner water phase; S/O1/O2; solid/oil/oil; S/O/W; solid/oil/water; W/O1/O2; water/oil/oil; ME; me
Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
Keywords: 4-HPAA; 4-hydroxyphenyl acetic acid; ACN; acetonitrile; BSA; bovine serum albumin; Cal; calibrator; CCl; cell layer capacitance; CNS; central nervous system; CV%; coefficient of variation; CPT-cAMP; 8-(4-chlorophenylthio)-adenosine-3â²,5â²-cyclic monoph
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels
Keywords: ADT-OH; anethole dithiolethione, 5-[p-methoxyphenyl]3H-1,2-dithiole-3-thione; AP219; 9-(Carboxynonyl)triphenylphosphonium bromide; AP39; (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide; ApoE; apolioprotein E; ARRIVE;
Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2
Keywords: Saccharomyces cerevisiae; Leucine permease Bap2; Homology modeling; logP;
Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry
Keywords: PK; pharmacokinetic; PD; pharmacodynamic; PK/PD; pharmacokinetic/pharmacodynamic; RES; reticuloendothelial system; EPR effect; enhanced permeability and retention effect; ADMET; absorption, distribution, metabolism, excretion and toxicity; logP; octanolâ
GroESL overexpression imparts Escherichia coli tolerance to i-, n-, and 2-butanol, 1,2,4-butanetriol and ethanol with complex and unpredictable patterns
Keywords: LogP; Biofuels; Tolerance engineering; Heat shock proteins; Molecular chaperones
Neurosteroids, stress and depression: Potential therapeutic opportunities
Keywords: 5α-DHP; 5α-dihydroprogesterone; 3α-HSD; 3α-hydroxysteroid dehydrogenase; 3α5β-PC; 3α,5β-20-oxo-pregnane-3-carboxylic acid; 17-PA; 3α5α-17-phenylandrost-16-en-3-ol; ANT; adenine nucleotide transporter; ACTH; adrenocorticotrophic hormone; alloP; a
On Quantitative Relationships Between Drug-Like Compound Lipophilicity and Plasma Free Fraction in Monkey and Human
Keywords: Protein binding; drug-like properties; physicochemical properties; logP; structure-property relationship; lipophilicity; drug; radiotracer; logD; plasma free fraction;
Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs
Keywords: MOR; Mu opioid receptor; DOR; delta opioid receptor; KOR; kappa opioid receptor; DAMGO; (d-Ala2, N-MePhe4, Gly-ol)-enkephalin; GPCR; G-protein coupled receptors; FDA; Food and Drug Administration; Ki; equilibrium dissociation constant for the test compoun
The role of a conserved tyrosine in the 49-kDa subunit of complex I for ubiquinone binding and reduction
Keywords: ACMA; 9-amino-6-chloro-2-methoxyacridine; BN-PAGE; blue-native polyacrylamide gel electrophoresis; C12E8; n-alkyl-polyoxyethylene-ether; DBQ; n-decylubiquinone; dNADH; deamino-nicotinamide-adenine-dinucleotide (reduced form); DQA; 2-decyl-4-quinazolinyl a
Antihypertensive and antiarrhythmic properties of a para-hydroxy[bis(ortho-morpholinylmethyl)]phenyl-1,4-DHP compound: Comparison with other compounds of the same kind and relationship with logP values
Keywords: Cardiovascular effects; Antihypertensives; Bis(morpholinylmethyl)phenols; DHP; pKa values; logP
Cytotoxic effects of propiconazole and its metabolites in mouse and human hepatoma cells and primary mouse hepatocytes
Keywords: MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; cLogP, calculated LogP (log of the octanol–water partition coefficient)Propiconazole; Conazole; Hepa1c1c7; HepG2; Primary mouse hepatocytes; Cytotoxicity; LogP; MTT; Neutral red
Cell spreading correlates with calculated logP of amino acid-modified surfaces
Keywords: Amino acid; LogP; Surface; Osteoblast; Surface functionalization
On stalling in LogP
Keywords: BSP; LogP; Parallel computation; Bridging models; Stalling;
Comparison of a Miniaturized Shake-Flask Solubility Method with Automated Potentiometric Acid/Base Titrations and Calculated Solubilities
Keywords: solubility; high throughput; logP; physicochemical properties; druglike properties; pHâprofile; calculation; potentiometric titration; solubility measurement;