دانلود مقالات ISI درباره Logp + ترجمه فارسی

درمان سرطان موثر بر اساس تحویل داروهای انتخابی به سلول ها در سراسر غشاء خود با استفاده از گیرنده گیرنده اندوسیتوز

Effective cancer therapy based on selective drug delivery into cells across their membrane using receptor-mediated endocytosis

Keywords: MW; molecular weight; MDR1; multiple drug resistance 1; P-gp; P-glycoprotein; ABC-transporter; ATP-binding cassette transporter; ATP; adenosine triphosphate; BBB; blood brain barrier; SLC transporter; solute carrier transporter; logP; partition coefficien

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

طراحی و ترکیب عوامل ضد تومور جدید با چارچوب 1،7-اپوکسی سکلونونان. بررسی مکانیسم عمل ضد سرطان توسط یک ترکیب مدل

Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound

Keywords: AFM; atomic force microscopy; ATR; Attenuated total reflectance (IR system); CCC; covalently closed circular DNA; CD; circular dichroism; CT DNA; calf thymus DNA; DEPT; distortionless enhancement by polarization transfer; DMF; Dimethylformamide; DMSO; Dim

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

بررسی مقایسه ای از جذب های پلی (4-وینیل بنزیل کلرید / اتیلن گلیکول دی متیکریلات) برای غنی سازی داروهای انتخاب شده و استروژن ها از نمونه های آبی

Comparative study of substituted poly(4-vinylbenzyl chloride/ethylene glycol dimethacrylate) sorbents for enrichment of selected pharmaceuticals and estrogens from aqueous samples

Keywords: ATR-IR; attenuated total reflection infrared; DVB; divinylbenzene; EGDMA; ethylene glycol dimethacrylate; LOD; limit of detection; logP; logarithmic ratio of the octanol-water partitioning coefficient; LOQ; limit of quantitation; SPE; solid-phase extracti

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

سنتز و خواص پایگاه های فسفاتاز بسیار لیپوفیلی

Synthesis and properties of highly lipophilic phosphazene bases

Keywords: Phenylphosphazenes; Lipophilicity; LogP; pKa; Staudinger reaction;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

تاثیر چربی مصنوعی بر جذب پوست در مواد شیمیایی پوست انسان: یک مطالعه اثبات مفهومی

Influence of artificial sebum on the dermal absorption of chemicals in excised human skin: A proof-of-concept study

Keywords: CAS; chemical abstract service; CV; relative coefficient of variation; GC; gas chromatography; KOH; potassium hydroxide; LogP; decadic logarithm of the octanol/water partition coefficient; NaCl; sodium chloride; o/w; oil in water emulsion; SD; standard de

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

خواص بیولوژیکی متنوعی از گازهای نجیب شیمیایی غیر فعال

The diverse biological properties of the chemically inert noble gases

Keywords: Noble gases; Chemically inert; Clinical applications; In vitro and in vivo studies; Drug delivery; CNS; central nervous system; logP; log of the octanol-water partition coefficient; L1; L2, Ostwald coefficients; DMPC; 1,2-dimyristoyl-sn-glycero-3-phosphoc

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

پیشرفت در محاسبه مدل سازی دستیابی زیستی دهان و دندان

Advances in computationally modeling human oral bioavailability

Keywords: ADME-Tox; Absorption, distribution, metabolism, excretion, and toxicity; HOBA; Human oral bioavailability; HIA; Human intestinal absorption; QSAR; Quantitative structure-activity relationship; MLR; Multiple linear regressions; GA; Genetic algorithm; L

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Aminoguanidine hydrazones (AGH's) as modulators of norfloxacin resistance in Staphylococcus aureus that overexpress NorA efflux pump

Keywords: Staphylococcus aureus; Efflux pump inhibitors; Docking; Aminoguanidine hydrazones; EPIs; efflux pump inhibitors; AGH's; aminoguanidine hydrazones; MICs; minimum inhibitory concentrations; MTT; 1-(4,5-dimethylthiazol-2-yl)-3,5-diphenyl formazan; MDR; multi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs

Keywords: Bioaccumulation; Perfluorinated compounds; PFOS; Cationic amphiphilic drugs; Adipocytes; Phospholipid binding; ACC; compound's accumulation in cells; ACE; acetaminophen; ACN; acetonitrile; AMIO; amiodarone; AMIT; amitriptyline; AZI; azithromycin; AZAG; az

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents

Keywords: Teicoplanin; Lipoglycopeptide; Maleimide; Sulfonamide; Influenza virus inhibitor; Coronavirus; DCM; dichloromethane; DMF; dimethylformamide; CPE; cytopathic effect; Et3N; triethylamine; Galp; galactopyranose; HA; hemagglutinin; HIV; human immunodeficiency

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Drug release studies from lipid nanoparticles in physiological media by a new DSC method

Keywords: Lipid nanoparticles; Drug release; Differential scanning calorimetry; Physiological conditions; Crystallization; logP;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Preclinical evaluation of melanocortin-1 receptor (MC1-R) specific 68Ga- and 44Sc-labeled DOTA-NAPamide in melanoma imaging

Keywords: α-MSH; alpha-melanocyte stimulating hormone; ACN; acetonitrile; DOTA; 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; DOTA-NAPamide; Ac-Nle-Asp-His-d-Phe-Arg-Trp-Gly-Lys(DOTA)-NH2; EtOH; ethanol; i.v.; intravenous(ly); logP; octanol-water par

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Towards a chromatographic similarity index to establish localised Quantitative Structure-Retention Relationships for retention prediction. III Combination of Tanimoto similarity index, logP, and retention factor ratio to identify optimal analyte training

Keywords: QSRR; Ion chromatography; Retention factor ratio; Tanimoto similarity; LogP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis

Keywords: Natural product analogues; Drug design; Isoxazole; Trypanosoma cruzi; Leishmania amazonensis; Trypanothione reductase; %GI; percentage of growth inhibition; AB; amphotericin B; BZN; benznidazol; logP; partition coefficient octanol/water; MW; microwave; ND

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Keywords: AG; andrographolide; ATM; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; DLS; Dynamic Light Scattering; DMSO; dimethyl sulfoxide; ECA; ethylcyanoacrylate; EE; encapsulation efficiency; E

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Keywords: API; active pharmaceutical ingredient; AUC; area under the curve; BCS; biopharmaceutics classification system; BP; blood-to-plasma ratio; Cmax; maximum concentration; CL; clearance; Do; dose number according to BCS; DDI; drug-drug interaction; EFPIA; Euro

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Keywords: AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Keywords: API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies

Keywords: Pyridazine-3-carboxamides; CB2 agonist; Structure-activity relationships; Molecular docking; logP;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2017 سفارش ترجمه

Retention data of bile acids and their oxo derivatives in characterization of pharmacokinetic properties and in silico ADME modeling

Keywords: logP; logarithm of partition coefficient; RM0; intercept; b; slope of the linear plot; C; volume fraction of the organic solvent in the mobile phase; TPSA; total polar surface area; natoms; number of atoms; Mw; molecular weight; nOH; number of hydrogen bo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewStrategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: State-of-the-art and challenges

Keywords: PLGA; poly(d,l-lactide-co-glycolide); logP; partition coefficient; Mw; molecular weight; W1/O/W2; water/oil/water; O/W; oil/water; W2; outer water phase; W1; inner water phase; S/O1/O2; solid/oil/oil; S/O/W; solid/oil/water; W/O1/O2; water/oil/oil; ME; me

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies

Keywords: 4-HPAA; 4-hydroxyphenyl acetic acid; ACN; acetonitrile; BSA; bovine serum albumin; Cal; calibrator; CCl; cell layer capacitance; CNS; central nervous system; CV%; coefficient of variation; CPT-cAMP; 8-(4-chlorophenylthio)-adenosine-3′,5′-cyclic monoph

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels

Keywords: ADT-OH; anethole dithiolethione, 5-[p-methoxyphenyl]3H-1,2-dithiole-3-thione; AP219; 9-(Carboxynonyl)triphenylphosphonium bromide; AP39; (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide; ApoE; apolioprotein E; ARRIVE;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2

Keywords: Saccharomyces cerevisiae; Leucine permease Bap2; Homology modeling; logP;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry

Keywords: PK; pharmacokinetic; PD; pharmacodynamic; PK/PD; pharmacokinetic/pharmacodynamic; RES; reticuloendothelial system; EPR effect; enhanced permeability and retention effect; ADMET; absorption, distribution, metabolism, excretion and toxicity; logP; octanolâ€

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

GroESL overexpression imparts Escherichia coli tolerance to i-, n-, and 2-butanol, 1,2,4-butanetriol and ethanol with complex and unpredictable patterns

Keywords: LogP; Biofuels; Tolerance engineering; Heat shock proteins; Molecular chaperones

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Neurosteroids, stress and depression: Potential therapeutic opportunities

Keywords: 5α-DHP; 5α-dihydroprogesterone; 3α-HSD; 3α-hydroxysteroid dehydrogenase; 3α5β-PC; 3α,5β-20-oxo-pregnane-3-carboxylic acid; 17-PA; 3α5α-17-phenylandrost-16-en-3-ol; ANT; adenine nucleotide transporter; ACTH; adrenocorticotrophic hormone; alloP; a

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

On Quantitative Relationships Between Drug-Like Compound Lipophilicity and Plasma Free Fraction in Monkey and Human

Keywords: Protein binding; drug-like properties; physicochemical properties; logP; structure-property relationship; lipophilicity; drug; radiotracer; logD; plasma free fraction;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs

Keywords: MOR; Mu opioid receptor; DOR; delta opioid receptor; KOR; kappa opioid receptor; DAMGO; (d-Ala2, N-MePhe4, Gly-ol)-enkephalin; GPCR; G-protein coupled receptors; FDA; Food and Drug Administration; Ki; equilibrium dissociation constant for the test compoun

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The role of a conserved tyrosine in the 49-kDa subunit of complex I for ubiquinone binding and reduction

Keywords: ACMA; 9-amino-6-chloro-2-methoxyacridine; BN-PAGE; blue-native polyacrylamide gel electrophoresis; C12E8; n-alkyl-polyoxyethylene-ether; DBQ; n-decylubiquinone; dNADH; deamino-nicotinamide-adenine-dinucleotide (reduced form); DQA; 2-decyl-4-quinazolinyl a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Antihypertensive and antiarrhythmic properties of a para-hydroxy[bis(ortho-morpholinylmethyl)]phenyl-1,4-DHP compound: Comparison with other compounds of the same kind and relationship with logP values

Keywords: Cardiovascular effects; Antihypertensives; Bis(morpholinylmethyl)phenols; DHP; pKa values; logP

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Cytotoxic effects of propiconazole and its metabolites in mouse and human hepatoma cells and primary mouse hepatocytes

Keywords: MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; cLogP, calculated LogP (log of the octanol–water partition coefficient)Propiconazole; Conazole; Hepa1c1c7; HepG2; Primary mouse hepatocytes; Cytotoxicity; LogP; MTT; Neutral red

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Cell spreading correlates with calculated logP of amino acid-modified surfaces

Keywords: Amino acid; LogP; Surface; Osteoblast; Surface functionalization

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

On stalling in LogP

Keywords: BSP; LogP; Parallel computation; Bridging models; Stalling;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Comparison of a Miniaturized Shake-Flask Solubility Method with Automated Potentiometric Acid/Base Titrations and Calculated Solubilities

Keywords: solubility; high throughput; logP; physicochemical properties; druglike properties; pH‐profile; calculation; potentiometric titration; solubility measurement;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه