کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8345208 | 1541613 | 2015 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels
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کلمات کلیدی
TRISNADPHEGTAHEK3-MSTCav3.1logPeNOSCav3.2Potassium cationBLMCBSEndothelium-derived hyperpolarising factorEDHFGYY4137PDE5Nitric oxide deficiencyHEPESCsClKClCaCl2H2SNa2S•NOCSENaClMgCl2RyR2Cl-Calcium cation2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid - 2- [4- (2-hydroxyethyl) piperazin-1-yl] ethanesulfonic acid3-mercaptopyruvate sulfurtransferase - 3-merkaptopyruvate sulfurransferaseCa(OH)2 - Ca (OH) 2Ca2+ - Ca2 +cystathionine-γ-lyase - cystationine-g-lyaseDMSO - DMSOH2O - H2OI/R - I / Rl-NAME - L-NAMETEA-Cl - TEA-CLATP - آدنوزین تری فسفات یا ATPApoe - آپوischaemia-reperfusion - ایسکمی-رپرفوزیسARRIVE - برگرفته ازMin - حداقلminute - دقیقهDimethyl sulfoxide - دیمتیل سولفواکسیدSarcoplasmic reticulum - رتیکولوم سارکوپلاسمیکSodium chloride - سدیم کلریدPulse wave velocity - سرعت موج پالسSodium sulfide - سولفید سدیمHydrogen sulfide - سولفید هیدروژنcystathionine-β-synthase - سیستاتیونین بتا سنتازbilayer lipid membrane - غشای چربی دو طرفهPhosphodiesterase 5 - فسفودی استراز 5Blood pressure - فشارخونPhen - فینNitrogen monoxide - منوکسید نیتروژنPulse wave - موج پالسNash - نوشNitric oxide synthase 3 - نیتریک اکساید سنتاز 3Sodium hydrosulfide - هیدرو سولفید سدیمCesium hydroxide - هیدروکسید سزیمCalcium hydroxide - هیدروکسید کلسیم، آهک آب خورده، آهک شکفته، آهک مردهChloride - کلریدcesium chloride - کلرید سزیمMagnesium chloride - کلرید منیزیمPotassium chloride - کلرید پتاسیمCalcium chloride - کلسیم کلریدhuman embryonic kidney - کلیه جنین انسانRyanodine receptor 2 - گیرنده رایانودین 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
H2S donor molecules have the potential to be viable therapeutic agents. The aim of this current study was (i) to investigate the effects of a novel triphenylphosphonium derivatised dithiolethione (AP39), in the presence and absence of reduced nitric oxide bioavailability and (ii) to determine the effects of AP39 on myocardial membrane channels; CaV3, RyR2 and Cl-. Normotensive, L-NAME- or phenylephrine-treated rats were administered Na2S, AP39 or control compounds (AP219 and ADT-OH) (0.25-1âµmol kg-1i.v.) and haemodynamic parameters measured. The involvement of membrane channels T-type Ca2+ channels CaV3.1, CaV3.2 and CaV3.3 as well as Ca2+ ryanodine (RyR2) and Cl- single channels derived from rat heart sarcoplasmic reticulum were also investigated. In anaesthetised Wistar rats, AP39 (0.25-1âµmol kg-1 i.v) transiently decreased blood pressure, heart rate and pulse wave velocity, whereas AP219 and ADT-OH and Na2S had no significant effect. In L-NAME treated rats, AP39 significantly lowered systolic blood pressure for a prolonged period, decreased heart rate and arterial stiffness. In electrophysiological studies, AP39 significantly inhibited Ca2+ current through all three CaV3 channels. AP39 decreased RyR2 channels activity and increased conductance and mean open time of Cl- channels. This study suggests that AP39 may offer a novel therapeutic opportunity in conditions whereby
- NO and H2S bioavailability are deficient such as hypertension, and that CaV3, RyR2 and Cl- cardiac membrane channels might be involved in its biological actions.
- NO and H2S bioavailability are deficient such as hypertension, and that CaV3, RyR2 and Cl- cardiac membrane channels might be involved in its biological actions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 46, 30 April 2015, Pages 131-144
Journal: Nitric Oxide - Volume 46, 30 April 2015, Pages 131-144
نویسندگان
Lenka Tomasova, Michaela Pavlovicova, Lubica Malekova, Anton Misak, Frantisek Kristek, Marian Grman, Sona Cacanyiova, Milan Tomasek, Zuzana Tomaskova, Alexis Perry, Mark E. Wood, Lubica Lacinova, Karol Ondrias, Matthew Whiteman,