Keywords: Idiopathic ventricular fibrillation; Genetics; Catecholaminergic polymorphic ventricular tachycardia; RYR2; Genetic testing;
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Keywords: Monozygotic twins; Down syndrome; Discordance; Exome sequencing; TGFBR2; ITPR1; RYR2;
Keywords: AM; Atrial cardiomyocyte; AP; Action potential; APA; Action potential amplitude; APD; Action potential duration; CICR; Ca2+-induced Ca2+ release; CK; Creatine kinase; CM; Cardiomyocyte; cTNI; Troponin I, cardiac type; cTnT; Cardiac troponin T; CÂ ÃÂ 40;
Keywords: CM; cardiomyocyte; Fab; the Fab fragment of the monoclonal anti-PLB antibody 2D12; IP3R; inositol 1,4,5-trisphosphate receptor; nCa2Â +; Â perinuclear/nuclear Ca2Â +; Â NE; nuclear envelope; NM; perinuclear/nuclear membranes; PLB; phospholamban; RyR2; rya
Keywords: PP1; protein phosphatase type 1; PP2A; protein phosphatase type 2; PP2B; protein phosphatase type 2B; RyR2; ryanodine receptor type 2; SR; sarcoplasmic reticulum; SERCa; SR Ca2+ ATPase; CaMKII; calcium-calmodulin dependent protein kinase type 2; PKA; prot
Keywords: BG; blood glucose; BW; body weight; CaMKII; Calcium/calmodulin-dependent protein kinase II; CRP; C-reactive protein; CVD; cardiovascular disease; DM; diabetes mellitus; EC; exercise control; ECG; electrocardiogram; ED; exercise diabetic; eNOS; endothelial
Keywords: AMA; amantadine; BFM; bond fluctuation method; BST-2; bone marrow stromal cell antigen 2; CD; circular dichroism; CGMD; coarse-grained molecular dynamics; ClyA; cytolysin A; DHPC; dihexanoylphosphocholine; DPC; dodecylphosphocholine; E. coli; Escherichia
Keywords: Nifedipine (PubChem CID: 4485); E4031 (PubChem CID: 3185); Dofetilide (PubChem CID: 71329); Lidocaine (PubChem CID: 3676); ZD7288 (PubChem CID: 123983); Verapamil (PubChem CID: 2520); Azimilide (PubChem CID: 9571004); Ranolazine (PubChem CID: 56959); Tert
Keywords: Heart; Tissue engineering; Myocardium; Biophysical properties; Force of contraction; Force frequency relationship; Calcium handling; T-tubulation; Maturation; AAV; adenovirus-associated virus; CSQ2; Calsequestrin 2; DMS; dynamic mechanical stimulation; EH
Keywords: Hypoxia; Trimetazidine; Cardioprotection; RyR2; SERCA2a; NCX
Keywords: 2D12; anti-PLB monoclonal antibody; CaMKII; Ca2Â +/calmodulin-dependent protein kinase; CPVT; catecholaminergic polymorphic ventricular tachycardia; DAD; delay afterdepolarizations; Fab; fab fragment of 2D12; KCa; Ca concentration for half-maximal effect;
Keywords: AS; arrhythmia score; cAMP; cyclic adenosine monophosphate; CPVT; catecholaminergic polymorphic ventricular tachycardia; CVA; complex ventricular arrhythmia; ECG; electrocardiogram; EC50; half maximal effective concentration; ETT; exercise treadmill test;
Keywords: AP; action potential; APD; action potential duration; [Ca2+]i; intracellular Ca2+ concentrations; CM; cardiomyopathy; CON; control; E-C; excitation-contraction; ICaL; L-type Ca current; IK1; inward rectifier current; IKr; rapid delayed rectifier current;
Keywords: AKAPs; A-kinase anchoring proteins; AKT; protein kinase b; Ang-II; angiotensin II; ASK1; apoptosis signal-regulating kinase 1; BH4; tetrahydrobiopterin; CaMKII; Ca/calmodulin-dependent kinase II; cGMP; cyclic guanosine monophosphate; CHF; chronic heart fa
Keywords: CaMKII; Ca2Â +/calmodulin dependent protein kinase II; cAMP; cyclic adenosine monophosphate; cTn; cardiac Troponin; DAD; delayed afterdepolarization; EAD; early afterdepolarization; ECC; excitation-contraction coupling; H2O2; hydrogen peroxide; HNO; Nit
Keywords: AF; atrial fibrillation; AKAP; A-kinase-anchoring protein; AP; action potential; β-AR; β-adrenoceptor; CaMKII; Ca2 +/calmodulin-dependent protein kinase type-II; CKIP-1; casein kinase-2 interacting protein-1; cMyBP-C; cardiac myosin-binding protein-C;
Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes
Keywords: AP; action potential; BAPTA; 1,2-bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid; BVT; bidirectional ventricular tachycardia; CPVT; catecholaminergic polymorphic ventricular tachycardia; DAD; delayed afterdepolarization; EAD; early afterdepolariz
Differentially DNA methylation changes induced in vitro by traffic-derived nanoparticulate matter
Keywords: nPM; nanoparticulate matter; PM; particulate matter; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; DMP; differential methylated probes; GO; gene ontology; DMGs; differential methylated genes; KEGG; Kyoto encyclopedia of gen
A novel variant in RyR2 causes familiar catecholaminergic polymorphic ventricular tachycardia
Keywords: Sudden cardiac death; Catecholaminergic polymorphic ventricular tachycardia; Genetics; RyR2;
The chemical biology of HNO signaling
Keywords: Nitroxyl; Azanone; Thiols; Nitrogen oxides; RSSH; hydropersulfides; DTT; dithiothreitol; GPx; glutathione peroxidase; BDE; bond dissociation energy; NHE; normal hydrogen electrode; metmyoglobin; MbFe3+; methemoglobin; HbFe3+; ferrous myoglobin; MbFe2+; sG
Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2)
Keywords: Hyperemesis gravidarum; Nausea; Vomiting; Pregnancy; RYR2;
A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia
Keywords: Torsades de pointes; Catecholaminergic polymorphic ventricular tachycardia; Idiopathic ventricular fibrillation; RyR2; Long QT;
Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models
Keywords: CPVT; MCU; MiCUp; mitochondria; RyR2; VDAC2; CPVT; catecholaminergic polymorphic ventricular tachycardia; epi/caff; epinephrine/caffeine; iPSC; induced pluripotent stem cell; ISO; isoproterenol; MCU; mitochondrial calcium uniporter; MiCUp; mitochondrial c
Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F4t-neuroprostane protects the heart against reperfusion injury
Keywords: ÎΨm; mitochondrial membrane potential; 4-F4t-NeuroP; 4(RS)-4-F4t-neuroprostane; n-3 PUFA; n-3 polyunsaturated fatty acids; Ca2+; Calcium; CsA; cyclosporine A; CypD; cyclosphilin D; DHA; docosahexaenoic acid; ECG; electrocardiogram; EPA; eicosapentaenoic
Insight into the contribution of isoprostanoids to the health effects of omega 3 PUFAs
Keywords: AA; arachidonic acid; ALA; α-linolenic acid; APCI; atmospheric pressure chemical ionization; ApoB100; apolipoprotein B100; BHT; butylated hydroxytoluene; BSTFA; bis-(trimethylsilyl)trifluoroacetamide; CCl4; tetrachloromethane; CNS; central nervous system
Effective cascade screening through identification of a mutation in RYR2 in a large family with a history of sudden death
Keywords: Catecholaminergic polymorphic ventricular tachycardia (CPVT); RYR2; Sudden death;
Roles and regulation of protein phosphatase 2A (PP2A) in the heart
Keywords: PP2A; protein phosphatase 2A; NCX1; Na/Ca exchanger; MI; myocardial infarction; cMyBP-C; cardiac myosin binding protein-C; TnI; inhibitory subunit of troponin; RyR2; ryanodine receptor 2; PKA; protein kinase A; CaMKII; Ca2Â +/calmodulin-dependent protein
Nadolol decreases the incidence and severity of ventricular arrhythmias during exercise stress testing compared with β1-selective β-blockers in patients with catecholaminergic polymorphic ventricular tachycardia
Keywords: CPVT; catecholaminergic polymorphic ventricular tachycardia; ECG; electrocardiogram/electrocardiographic; ICD; implantable cardioverter-defibrillator; NSVT; nonsustained ventricular tachycardia; RyR2; ryanodine receptor 2; SCA; sudden cardiac arrest; VES;
JPH-2 interacts with Cai-handling proteins and ion channels in dyads: Contribution to premature ventricular contraction-induced cardiomyopathy
Keywords: Ab; antibody; BIN-1; bridging integrator-1; Cavβ2; voltage-gated Ca channel β subunit 2; CICR; Ca-induced Ca release; CON; control; CSQ2; calsequestrin 2; ICaL; L-type Ca channel current; IKs; slow delayed rectifier current; IP; immunoprecipitate; JPH-2
CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift
Keywords: AIP; autocamtide-2 related inhibitory peptide; Bmax; binding maximum; CaM; calmodulin; CaMKII; calcium/calmodulin-dependent protein kinase II; CaSpF; calcium spark frequency; CPVT; catecholaminergic polymorphic ventricular tachycardia; DAN; dantrolene; F;
The HNO donor Angeli's salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia-reperfusion injury in the rat heart ex vivo
Keywords: AC; adenylyl cyclase; AS; Angeli's salt; β1-AR; β1-adrenoceptor; CGRP; calcitonin gene-related peptide; CK; creatine kinase; DEA/NO; diethylamine NONOate; DOB; dobutamine; DRC; dose-response curve; HF; heart failure; HNO; nitroxyl; I-R; ischaemia-
ReviewRole of the dysfunctional ryanodine receptor - Na+-Ca2+exchanger axis in progression of cardiovascular diseases: What we can learn from pharmacological studies?
Keywords: RyR2; Ryanodine receptor Ca2+-Release channel type 2; NCX1; Na+-Ca2+-exchanger type 1; SR; Sarco(endo)plasmic reticulum; TRPC6; Transient receptor potential-like channel 6; NKA; Na+-K+-ATP-ase; ATP; Adenosine-triphosphate; CamKII; Ca2+/calmodulin-dependen
Role of SERCA and the sarcoplasmic reticulum calcium content on calcium waves propagation in rat ventricular myocytes
Keywords: Calcium waves; SERCA; Ryanodine receptors; Ventricular myocytes; Beta-adrenergic stimulation; Calcium-triggered arrhythmias; SR; sarcoplasmic reticulum; RyR2; ryanodine receptors type 2; CICR; Ca2+-induced Ca2+ release; Êwave; Ca2+ wave propagation rate;
Modeling Na+-Ca2Â + exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling
Keywords: NCX1; Na+/Ca2Â + exchanger; RyR2; ryanodine receptor; CICR; Ca2Â +-induced Ca2Â + release; AP; action potential; PD; peri-dyad; fd, fpd, and fcyto; fraction of NCX1 in dyad, PD, and cytosol; Cardiac myocyte; Sodium-calcium exchanger; Calcium micro-domains
Medicinal effect and its JP2/RyR2-based mechanism of Smilax glabra flavonoids on angiotensin II-induced hypertrophy model of cardiomyocytes
Keywords: Smilax glabra; Flavonoids; Cardiac hypertrophy; JP2; RyR2
Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity
Keywords: Ï; time constant; Ïwash-in; wash-in time constant; Ïwash-out; wash-out time constant; AIP; autocamtide-2 related inhibitory peptide; Bmax; binding maximum; CaM; calmodulin; CaSpF; calcium spark frequency; DAN; dantrolene; F; fluorescent; FDHM; full dur
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels
Keywords: ADT-OH; anethole dithiolethione, 5-[p-methoxyphenyl]3H-1,2-dithiole-3-thione; AP219; 9-(Carboxynonyl)triphenylphosphonium bromide; AP39; (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide; ApoE; apolioprotein E; ARRIVE;
A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes
Keywords: ARVC; arrhythmogenic right ventricular cardiomyopathy; CPVT; catecholaminergic polymorphic ventricular tachycardia; RyR2; caridiac ryanodine receptor gene; Arrhythmia; Model mouse; Sudden death; Calcium;
A novel RyR2 mutation in a 2-year-old baby presenting with atrial fibrillation, atrial flutter, and atrial ectopic tachycardia
Keywords: AET; atrial ectopic tachycardia; AF; atrial fibrillation; AFL; atrial flutter; CASQ2; calsequestrin 2; CPVT; catecholaminergic polymorphic ventricular tachycardia; JTC; junctin; RyR2; cardiac ryanodine receptor 2; TRDN; triadin; Atrial arrhythmia; Catecho
Subcellular Mechanisms Underlying Digitalis-Induced Arrhythmias: Role of Calcium/Calmodulin-Dependent Kinase II (CaMKII) in the Transition from an Inotropic to an Arrhythmogenic Effect
Keywords: Cardiotonic glycosides; CaMKII; RyR2; Arrhythmia; Calcium handling
Voltage-gated calcium channels function as Ca2+-activated signaling receptors
Keywords: transmitter release; synaptotagmin; syntaxin; SNAREs; ryanodine receptor; cardiac channel; cardiac contraction; RyR2
Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium
Keywords: [Ca2 +]; free Ca2 + concentration; DTT; dithiothreitol; EGTA; ethyleneglycol-bis(β-aminoethyl ether) N, N, Nâ², Nâ²-tetraacetic acid; ER; endoplasmic reticulum; GSH; glutathione; HEDTA; N-(2-hydroxyethyl)-ethylenediamine-triacetic acid; I5R1; 5 min
How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity
Keywords: APD; action potential duration; EAD; early afterdepolarization; ICa,L; L-type Ca2+ current; IK1; inward rectifier K+ current; IKr; rapid delayed rectifier K+ current; IKs; slow delayed rectifier K+ current; KCNE1; β-subunit to KvLQT1 to form slow delayed
CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury
Keywords: AC3-I; Ca2+-calmodulin kinase II-inhibitory peptide; Ca2+; Calcium; CaMKII; Ca2+-calmodulin kinase II; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; I/R; Ischemia/reperfusion; LAD; Left anterior descending; LDH; Lactodehydrogenase; MI; Myocardial infar
KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia
Keywords: ATS; Andersen-Tawil syndrome; CASQ2; calsequestrin-2; CPVT; catecholaminergic polymorphic ventricular tachycardia; ECG; electrocardiogram; IK1; inward rectifier current; LQT7; long QT syndrome type 7; OSH; outside hospital; PBS; phosphate buffer solution;
Sex differences in SR Ca2Â + release in murine ventricular myocytes are regulated by the cAMP/PKA pathway
Keywords: cAMP; cyclic adenosine monophosphate; DMSO; dimethyl sulfoxide; EC; excitation-contraction; Fura-2 AM; fura-2 acetoxymethyl; FR; fractional release; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; IV; current-voltage; PCR; polymerase chain reaction;
Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca2+ release in cardiomyoblast cells
Keywords: SGF; flavonoids of Smilax glabra; ANP; atrial natriuretic peptide; SR; sarcoplasmic reticulum; ER; endoplasmic reticulum; IP3; inositol trisphosphate; IP3R; inositol trisphosphate receptor; RyR; ryanodine receptor; RyR2; ryanodine receptor 2; CICR; Ca2+-i
Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure
Keywords: EC; excitation-contraction; RGK; Rad-Rem-Rem2-Gem/Kir protein; RyR2; type 2 ryanodine-sensitive intracellular Ca2+ release channel; SR; sarcoplasmic reticulum; Rad; RGK protein; CaV1.2; CaV1.3; L-type; Heart failure;
Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy
Keywords: ADPKD; autosomal dominant polycystic kidney disease; APD; action potential duration; AV; atrioventricular; bpm; beats per minute; dpf; days post fertilization; CICR; calcium-induced calcium release; ER; endoplasmic reticulum; hpf; hours post fertilization
STIM1 participates in the contractile rhythmicity of HL-1 cells by moderating T-type Ca2Â + channel activity
Keywords: [Ca2Â +]i; concentration of intracellular free Ca2Â +; AFM; atomic force microscopy; CICR; Ca2Â +-induced Ca2Â + release; CRAC; Ca2Â +-release activated Ca2Â + channel; ICa; Ca2Â + current; ICa,T; T-type Ca2Â + current; L-VDCC; L-type voltage-dependent ca