کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030720 1071240 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voltage-gated calcium channels function as Ca2+-activated signaling receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Voltage-gated calcium channels function as Ca2+-activated signaling receptors
چکیده انگلیسی


• The Ca2+-bound voltage-gated channel operates as a Ca2+ binding receptor.
• A Ca2+-bound channel triggers synchronous release prior to Ca2+ influx.
• A conformational change is conveyed from the channel to syntaxin 1A via intramembrane signaling.
• A Ca2+-bound channel drives cardiac contraction in neonate cardiomyocytes independent of Ca2+ influx.

Voltage-gated calcium channels (VGCCs) are transmembrane cell surface proteins responsible for multifunctional signals. In response to voltage, VGCCs trigger synaptic transmission, drive muscle contraction, and regulate gene expression. Voltage perturbations open VGCCs enabling Ca2+ binding to the low affinity Ca2+ binding site of the channel pore. Subsequent to permeation, Ca2+ targets selective proteins to activate diverse signaling pathways. It is becoming apparent that the Ca2+-bound channel triggers secretion in excitable cells and drives contraction in cardiomyocytes prior to Ca2+ permeation. Here, I highlight recent data implicating receptor-like function of the Ca2+-bound channel in converting external Ca2+ into an intracellular signal. The two sequential mechanistic perspectives of VGCC function are discussed in the context of the prevailing and long-standing current models of depolarization-evoked secretion and cardiac contraction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 39, Issue 2, February 2014, Pages 45–52
نویسندگان
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