Keywords: cGMP; Retinal ganglion cell; Glaucoma; Nitric oxide; PDE5;
مقالات ISI (ترجمه نشده)
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Keywords: testicular neoplasms; erectile dysfunction; radiotherapy; drug therapy; survivors; BEP; bleomycin, etoposide and cisplatin; DaTeCa; Danish Testicular Cancer; HADS; Hospital Anxiety and Depression Scale; IIEF-15; International Index of Erectile Function-15
Keywords: PDE5; Phosphodiesterase 5; PDE5C; Phosphodiesterase 5 catalytic domain; PDE5C-TC; phosphodiesterase 5 catalytic domain modified with a tetracysteine tag; PDE5C-TC-FlAsH; complex obtained by conjugation of the FlAsH fluorophore to Phosphodiesterase 5 Catal
Keywords: CAD; coronary artery diseases; DIC; disseminated intravascular coagulation, I/R, ischemia/reperfusion; MPI; myocardial perfusion imaging; SCI; spinal cord injury; ED; erectile dysfunction; AUC; area under the concentration-time curve; cAMP; cyclic adenosi
Keywords: PDE5; phosphodiesterase type 5; BDNF; brain derived neurotrophic factor; NE; norepinephrine; 5-HIAA; 5-hydroxyindoleacetic acid; ROS; reactive oxygen species; Noise; Sildenafil; Phosphodiesterase type 5 inhibitors; Oxidative stress; Cognition; Behavior; M
Keywords: ADMA; asymmetric dimethylarginine; cAMP; cyclic adenosine monophosphate; CD73; cluster of differentiation 73; CDC2; cell division cycle 2; CFTR; cystic fibrosis transmembrane conductance regulator; cGMP; cyclic guanosine monophosphate; CH; chronic hypoxia
Keywords: CDDP; cisplatin; GSH; reduced glutathione; MDA; malondialdehyde; NO; nitric oxide; cTn-I; cardiac troponin; PDE5; phosphodiesterase-5 enzyme; i.p.; intraperitoneally; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CAD; coronar
Keywords: PDE5; PDE6; Erectile dysfunction; Pseudo-ring; Intramolecular hydrogen bond
Keywords: testis; spermatic cord torsion; reperfusion injury; sildenafil; udenafil; I/R; ischemia and reperfusion; MDA; malondialdehyde; NO; nitric oxide; PDE5; phosphodiesterase-5; T/D; testicular torsion and detorsion; T-SH; total sulfhydryl;
Keywords: AA; arachidonic acid; NSAID; non-steroidal anti-inflammatory drug; FAP; familial adenomatous polyposis; TA; tolfenamic acid; SS; sulindac sulfide; EGR-1; early growth response-1; NAG-1; NSAID-activated gene-1; EMT; epithelial-mesenchymal transition; bZIP;
Keywords: Erectile dysfunction; PDE5; Hypogonadism; Aging; Sexual function; 5α-reductase inhibitors
Keywords: 6MWD; 6-min walk distance; AHRQ; Agency for Healthcare Research and Quality; ARIES; Ambrisentan in Pulmonary Arterial Hypertension, Randomized Double-Blind, Placebo-Controlled, Multicenter, Efficacy Study; BNP; brain natriuretic peptide; CB; consensus-bas
The oligomeric assembly of the phosphodiesterase-5 is a mixture of dimers and tetramers: A putative role in the regulation of function
Keywords: PDE5; cGMP; SAXS; Native PAGE-WB; Quaternary assembly; Platelets;
An immunohistochemical and ultrastructural analysis of the retina in tadalafil (Cialis) treated rats
Keywords: Retina; Tadalafil; Cialis; PDE5; Bcl-2; Immunohistochemistry; Ultrastructure;
Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis
Keywords: Ovarian follicle; Oocyte; Cyclic GMP; Phosphodiesterase; PDE5; Meiosis;
Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension
Keywords: ADRF; adipocyte-derived relaxing factor; AE; anion exchanger; ATP; adenosine triphosphate; BH4; tetrahydrobiopterin; BKCa; big conductance Ca2+-sensitive K+ channel; CaM; calmodulin; cAMP; cyclic adenosine monophosphate; CAT; cysteine aminotransferase; CB
Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation
Keywords: AE; adverse event; AI; augmentation index; AUC; area under the curve; BID; twice daily; Cavg; average concentration; Cmax; maximal concentration; mg; milligrams; mL; milliliters; MPI; myocardial performance index; ng; nanograms; PAT; peripheral arterial t
Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis
Keywords: ACE2; angiotensin I converting enzyme 2; AGT; angiotensinogen; ATI; alveolar epithelial cells type I; ATII; alveolar epithelial cells type II; BALF; bronchial alveolar lavage fluid; BMP2; bone morphogenetic protein 2; BMPR1A; bone morphogenetic protein re
Riociguat: Mode of Action and Clinical Development in Pulmonary Hypertension
Keywords: chronic thromboembolic pulmonary hypertension; pulmonary arterial hypertension; sGC stimulator; 6MWD; 6-minute walking distance; ADMA; asymmetric dimethylarginine; AE; adverse event; BH4; tetrahydrobiopterin; BMPR-2; bone morphogenetic protein receptor-2;
The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma
Keywords: cGMP; PKG; sGC; PDE5; HNSCC; Tadalafil;
l-Cys/CSE/H2S pathway modulates mouse uterus motility and sildenafil effect
Keywords: Sildenafil; l-Cysteine; Sodium hydrogen sulfide; PDE5; phosphodiesterase type 5; H2S; hydrogen sulfide; l-Cys; l-Cysteine; CBS; cystathionine-β-synthase; CSE; cystathionine-γ-lyase; PAG; DL-propargilglycine; AOAA; aminooxiacetic acid; Emax; maximum effe
Determination of phosphodiesterase type V inhibitors in wastewater by direct injection followed by liquid chromatography coupled to tandem mass spectrometry
Keywords: PDE5; phosphodiesterase type V; ED; erectile dysfunction; API; active pharmaceutical ingredient; WWTP; wastewater treatment plant; ILIS; isotopically labeled internal standard; WBE; wastewater-based epidemiology; Wastewater-based epidemiology; Phosphodies
Phosphodiesterase-5 Inhibitor PF-03049423 Effect on Stroke Recovery: A Double-Blind, Placebo-Controlled Randomized Clinical Trial
Keywords: Stroke; PDE5; neurorestoration; clinical trial;
ReviewRight sided heart failure and pulmonary hypertension: New insights into disease mechanisms and treatment modalities
Keywords: cGMP; cyclic guanosine monophosphate; PDE5-I; Prosphodiesterase type 5 inhibitor; PDE5; Prosphodiesterase type 5; 5â²GMP; 5â² Guanosine monophosphate; cAMP; cyclic adenosine monophosphate; ETRA; Endothelin receptor antagonist; AC; adenylate cyclase;
MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions
Keywords: Ago2; Argonaute 2; DIV; day in vitro; DPN; diabetic peripheral neuropathy; DRG; dorsal root ganglia; GAPDH; glyceraldehyde-3-phosphatedehydrogenase; HG; high glucose; IRAK1; interleukin-1 receptor-associated kinase 1; miRNA; MicroRNA; PDE5; phosphodiester
Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway
Keywords: Cancer stem cells; Stemness; PDE5; Hippo pathway; TAZ5'-GMP, guanosine-5'-monophosphate; cGMP, cyclic guanosine monophosphate; CSCs, cancer stem cells; ED, erectile dysfunction; eNOS, endothelial NOS; GC, guanylyl cyclase; iNOS, inducible NOS; LATS, nucle
Group 2 PH: Medical Therapy
Keywords: Cpc; combined pre and post capillary; ET1; endothelin-1; HFpEF; heart failure preserved ejection fraction; Ipc; isolated post capillary; LV; left ventricle; mPAP; mean pulmonary pressure; NO; nitric oxide; PDE5; phosphodiesterase 5; PCWP; pulmonary capill
Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits
Keywords: Metabolic syndrome; Tadalafil; PDE5; Insulin-resistance;
8-(3-Chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors
Keywords: PDE5; PDE6; Erectile dysfunction
Distinct patterns of compartmentalization and proteolytic stability of PDE6C mutants linked to achromatopsia
Keywords: PDE6; photoreceptor phosphodiesterase-6; PDE5; cGMP-binding, cGMP-specific phosphodiesterase-5; ACHM; autosomal recessive achromatopsia; GAF; domains, termed for their presence in cGMP-regulated PDEs, adenylyl cyclases, and the E. coli protein Fh1A; OS; o
S-nitrosylation of PDE5 increases its ubiquitin-proteasomal degradation
Keywords: cGMP; cyclic guanosine monophosphate; DETA-NO; diethylenetriamine NONOate; GSNO; S-nitrosoglutathione; KT5823; 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3â²,2â²,1â²-kl]pyrrolo[3][1,6]benzodiazocine-10-car
Effect of the Novel BKCa Channel Opener LDD175 on the Modulation of Corporal Smooth Muscle Tone
Keywords: Erectile Dysfunction; BKCa Channel; Corpus Cavernosum; LDD175; PDE5
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels
Keywords: ADT-OH; anethole dithiolethione, 5-[p-methoxyphenyl]3H-1,2-dithiole-3-thione; AP219; 9-(Carboxynonyl)triphenylphosphonium bromide; AP39; (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide; ApoE; apolioprotein E; ARRIVE;
Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors
Keywords: ABC-transporters; ABCC5; PDE5; PDE inhibitors; cGMP; cAMP;
The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor
Keywords: PDE5; PDE6; Erectile dysfunction; Avanafil;
Embolization of the Periprostatic Venous Plexus for Erectile Dysfunction Resulting from Venous Leakage
Keywords: AEPV; anterograde embolization of the periprostatic venous plexus; DDV; deep dorsal vein; ED; erectile dysfunction; EDV; end-diastolic velocity; IIEF-6; International Index of Erectile Function questionnaire; NBCA; N-butyl cyanoacrylate; PDE5; phosphodies
The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy
Keywords: cDNA; complementary DNA; DAPI; 4â²,6-diamidino-2-phenylindole; db/db; BKS.Cg-m+/+Leprdb/J; db/m; heterozygote mice; DIG; digoxin; DRG; dorsal root ganglion; HG; high glucose; IRAK1; interleukin-1 receptor-activated kinase; LNA; locked nucleic acid; MCID;
Research reportPDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats
Keywords: Sensory gating; PDE2; PDE5; PDE10; Auditory information processing; Schizophrenia;
Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD
Keywords: PDE5; Tadalafil; Alzheimer's disease; Blood-brain barrier; Memory;
Appraisal of sildenafil binding on the structure and promiscuous esterase activity of native and histidine-modified forms of carbonic anhydrase II
Keywords: hCA; human carbonic anhydrase; PDE5; phosphodiesterase-5; CD; circular dichroism; PSH; protein surface hydrophobicity; ANS; 1,8-anilinonaphtalene sulfonate; PDB; protein data bank; ED; erectile dysfunction; CAIs; CA inhibitors; DEPC; diethyl pyrocarbonate
Urodynamic Effects of Once Daily Tadalafil in Men With Lower Urinary Tract Symptoms Secondary to Clinical Benign Prostatic Hyperplasia: A Randomized, Placebo Controlled 12-Week Clinical Trial
Keywords: prostatic hyperplasia; phosphodiesterase inhibitors; urodynamics; urinary bladder neck obstruction; BOOI; bladder outlet obstruction index; BPH; benign prostatic hyperplasia; BPH-LUTS; LUTS secondary to clinical BPH; ED; erectile dysfunction; I-PSS; Inter
Exploring the Association Between Erectile Rigidity and Treatment Adherence With Sildenafil
Keywords: PDE5; Erectile Dysfunction; Erection Hardness; Compliance; Adherence; Persistence;
Increased Phosphodiesterase Type 5 Levels in a Mouse Model of Type 2 Diabetes Mellitus
Keywords: Type 2 Diabetes; Erectile Dysfunction; PDE5
Dysfonction érectile
Keywords: Dysfonction érectile; Épidémiologie; Physiopathologie; Traitement médical; Prise en charge; Inhibiteurs de phosphodiestérase de type 5; Effets secondaires sexuels; RecommandationsEpidemiology; Physiopathology; Pharmacological treatment; Management; PDE5;
The Role of Initial Success Rates and Other Factors in Determining Reliability of Outcomes of Phosphodiesterase Inhibitor Therapy for Erectile Dysfunction: A Pooled Analysis of 17 PlaceboâControlled Trials of Tadalafil for Use as Needed
Keywords: Erectile Dysfunction; Phosphodiesterase Type 5 Inhibitors; PDE5; Tadalafil; Reliability of Efficacy; Pooled Analysis;
Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the activity of two atypical antidepressant drugs, mianserin and tianeptine, in the forced swim test in mice
Keywords: HPLC; high-performance liquid chromatography; PDE5; phosphodiesterase type 5; NO; nitric oxide; GC; guanylate cyclase; cGMP; guanosine 3´,5´-monophosphate; GABA; γ-aminobutyric acid; NMDA; N-methyl-d-aspartate; SERT; serotonin transporter; Antidepressa
Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries
Keywords: Sildenafil; Tadalafil; Cerebral artery; PDE5; Phosphodiesterase; Migraine;
Dropout in the Treatment of Erectile Dysfunction with PDE5: A Study on Predictors and a Qualitative Analysis of Reasons for Discontinuation
Keywords: Erectile Dysfunction; PDE5; Dropout; Vardenalfil; Sildenafil; Tadalafil;
A Systematic Review and Meta-analysis on the Use of Phosphodiesterase 5 Inhibitors Alone or in Combination with α-Blockers for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia
Keywords: Benign prostatic hyperplasia; Lower urinary tract symptoms; Erectile dysfunction; Prostate; BPH; LUTS; ED; PDE5; PDE5-I; IPSS; IIEF
A Randomized, Placebo-Controlled Study to Assess Safety and Efficacy of Vardenafil 10 mg and Tamsulosin 0.4 mg vs. Tamsulosin 0.4 mg Alone in the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
Keywords: Benign Prostatic Hyperplasia; Lower Urinary Tract Symptoms; Erectile Dysfunction; Tamsulosin; Vardenafil; PDE5