Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD

► We report that tadalafil crosses the blood-brain barrier. ► The amount fo tadalafil that reached the brain at the dose administered, is enough to inhibit PDE5. ► The administration of PDE5 inhibitors reverses memory deficits in an AD mice model. ► PDE5 inhibitors induced a decrease in Tau pathology but no effect was observed in amyloid burden.