کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735289 | 1612914 | 2017 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroprotective effects of sildenafil against oxidative stress and memory dysfunction in mice exposed to noise stress
ترجمه فارسی عنوان
اثرات عصبی محافظتی سیلدنافیل در برابر استرس اکسیداتیو و اختلال عملکرد حافظه در موشهای تحت تاثیر استرس نویز
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کلمات کلیدی
5-HIAAPDE55-Hydroxyindoleacetic acid - 5-هیدروکسی سدیم اسیدBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز ROS - ROSPhosphodiesterase type 5 inhibitors - بازدارنده های نوع 5 فسفودی استرازOxidative stress - تنش اکسیداتیوMemory - حافظهBehavior - رفتارNoise - سر و صداSildenafil - سیلدنافیلCognition - شناختbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استphosphodiesterase type 5 - فسفودی استراز نوع 5norepinephrine - نوراپی نفرینReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Noise exposure has been well characterized as an environmental stressor, and is known to have auditory and non-auditory effects. Phosphodiesterase 5 (PDE5) inhibitors affect memory and hippocampus plasticity through various signaling cascades which are regulated by cGMP. In this study, we investigated the effects of sildenafil on memory deficiency, neuroprotection and oxidative stress in mice caused by chronic noise exposure. Mice were exposed to noise for 4Â h every day up to 14Â days at 110Â dB SPL of noise level. Sildenafil (15Â mg/kg) was orally administered 30Â min before noise exposure for 14Â days. Behavioral assessments were performed using novel object recognition (NOR) test and radial arm maze (RAM) test. Higher levels of memory dysfunction and oxidative stress were observed in noise alone-induced mice compared to control group. Interestingly, sildenafil administration increased memory performance, decreased oxidative stress, and increased neuroprotection in the hippocampus region of noise alone-induced mice likely through affecting memory related pathways such as cGMP/PKG/CREB and p25/CDK5, and induction of free radical scavengers such as SOD1, SOD2, SOD3, Prdx5, and catalase in the brain of stressed mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 319, 15 February 2017, Pages 37-47
Journal: Behavioural Brain Research - Volume 319, 15 February 2017, Pages 37-47
نویسندگان
Hu Erxidan Sikandaner, So Young Park, Min Jung Kim, Shi Nae Park, Dong Won Yang,