دانلود مقالات ISI درباره Pde5 + ترجمه فارسی

Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis

Keywords: PDE5; Pyrazinone-based inhibitors; 3D-QSAR; Molecular docking; Molecular dynamics

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics

Keywords: PDE5; Caco-2; Phosphodiesterase; Oral bioavailability;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Keywords: ABI; ankle-brachial index; ACCF; American College of Cardiology Foundation; AHA; American Heart Association; BMI; body mass index; BP; blood pressure; CACS; coronary artery calcium scoring; CAD; coronary artery disease; CCTA; coronary computed tomographic

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Testosterone/Estradiol Ratio Regulates NO‐Induced Bladder Relaxation and Responsiveness to PDE5 Inhibitors

Keywords: Bladder; PDE5; Vardenafil

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil

Keywords: PDE; cyclic nucleotide phosphodiesterase; PAGE; polyacrylamide gel electrophoresis; SDS; sodium dodecyl sulfate; KPEM; 10 mM potassium phosphate (pH 6.8) containing 1 mM EDTA and 25 mM β-mercaptoethanol; GAF; cGMP-binding PDE, Anabaenaadenylyl cyclase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Sinusoidal electromagnetic field stimulates rat osteoblast differentiation and maturation via activation of NO-cGMP-PKG pathway

Keywords: NOS; nitric oxide synthase; NO; nitric oxide; ALP; alkaline phosphatase; SEMF; sinusoidal electromagnetic field; ROB; rat osteoblast; OSX; osterix; PBS; phosphate buffered saline; a-MEM; a-minimal essential medium; FBS; fetal bovine serum; ROD; relative o

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Phosphodiesterase-5 is a therapeutic target for peripheral neuropathy in diabetic mice

Keywords: sildenafil; PDE5; peripheral neuropathy; function; diabetes; miceBDNF, brain-derived neurotrophic factor; bFGF, basic fibroblast growth factor; BrdU, bromodeoxyuridine; cGMP, cyclic guanosine monophosphate; DAPI, 4′, 6′-diamidino-2-phenylindole; db/db, BK

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Critical Analysis of the Relationship Between Sexual Dysfunctions and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia

Keywords: LUTS; ED; BPH; PDE5; PDE5-i; Prostate; Benign prostatic hyperplasia; EjD; IPSS; IIEF; Age

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533)

Keywords: PDE5; PDE6; PDE11; Enzyme inhibitor; Metabolic stability; Quinazoline; Male erectile dysfunction

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Urodynamic Effects of Once Daily Tadalafil in Men With Lower Urinary Tract Symptoms Secondary to Clinical Benign Prostatic Hyperplasia: A Randomized, Placebo Controlled 12-Week Clinical Trial

Keywords: prostatic hyperplasia; phosphodiesterase inhibitors; urodynamics; urinary bladder neck obstruction; BOOI; bladder outlet obstruction index; BPH; benign prostatic hyperplasia; BPH-LUTS; LUTS secondary to clinical BPH; ED; erectile dysfunction; I-PSS; Inter

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Efficacy of Udenafil for the Treatment of Erectile Dysfunction up to 12 Hours after Dosing: A Randomized Placebo-Controlled Trial

Keywords: Erectile Dysfunction; PDE5; Long-Acting PDE5 Inhibitor; Udenafil; Clinical Trial;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Effects of Phosphodiesterase Inhibitors on the Inflammatory Response of Endothelial Cells Stimulated by Myeloperoxidase-Modified Low-Density Lipoprotein or Tumor Necrosis Factor Alpha

Keywords: Erectile dysfunction; Atherosclerosis; PDE5; PDE5 inhibitors; Myeloperoxidase; LDL; Mox-LDL

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Heart Failure and Pulmonary Hypertension

Keywords: Heart failure; Pulmonary hypertension; Nitric oxide; PDE5; BMPR2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Efficacy and Safety of Oral Mirodenafil in the Treatment of Erectile Dysfunction in Diabetic Men in Korea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Keywords: Erectile Dysfunction; PDE5; Mirodenafil; Diabetes: Diabetes Mellitus and Erectile Dysfunction;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

The interplay between chromogranin A-derived peptides and cardiac natriuretic peptides in cardioprotection against catecholamine-evoked stress

Keywords: CgA; chromogranin A; CAs; catecholamines; NPs; natriuretic Peptides; VS-1; vasostatin 1; Cts; catestatin; rCgA1-64; rat CgA1-64; hrSTACgA1-78; human recombinant STACgA1-78; VSs; vasostatins; ET-1; endothelin 1; HPA; hypothalamus-pituitary-adrenal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Tratamiento basado en la evidencia de la insuficiencia cardiaca derecha: una revisión sistemática de un campo empírico

Keywords: Insuficiencia cardiaca; Insuficiencia cardiaca aguda; Corazón derecho; Hipertensión pulmonar; Revisión sistemática; Heart failure; Acute heart failure; Right heart; Pulmonary hypertension; Systematic review; BRDH; bloqueo de rama derecha del haz; BRE;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2010 سفارش ترجمه

ORIGINAL RESEARCH-BASIC SCIENCE: The PDE5 Inhibitor Sildenafil Increases Circulating Endothelial Progenitor Cells and CXCR4 Expression

Keywords: Endothelial Progenitor Cells; Endothelial Function; PDE5; CXCR4; Sildenafil;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Keywords: PDE5; PDE6; PDE11; Inhibitors;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Lack of direct androgen regulation of PDE5 expression

Keywords: Penis; PDE5; Androgen; Cavernous smooth muscle;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system

Keywords: PDE5; Pi-pi interaction; Aminopyrazinone; Lead optimization;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Keywords: PDE5; Aminopyrazinone; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

ORIGINAL RESEARCH: Phosphodiesterase Type 5 Regulation in the Penile Corpora Cavernosa

Keywords: Penis; cAMP; cGMP; Promoter; Priapism; Hypoxia; Nitric Oxide Synthase; PDE5;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

Keywords: PDE; cyclic nucleotide phosphodiesterase; IBMX; 3-isobutyl-1-methylxanthine; C domain; catalytic domain; R domain; regulatory domain; PAGE; polyacrylamide gel electrophoresis; KP; 10 mM potassium phosphate (pH 6.8); GAF; cGMP-binding PDE, Anabaenaadenyly

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Intravenous Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension

Keywords: cAMP; Cyclic adenosine monophosphate; cGMP; Cyclic guanosine monophosphate; ECMO; Extracorporeal membrane oxygenation; FiO2; Fraction of inspired oxygen; iNO; Inhaled nitric oxide; IV; Intravenous; OI; Oxygenation index; PaO2; Partial pressure of oxygen i

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

Keywords: PDE5; pressure overload; hypertrophy; myocyte; cardiac functioncGMP, cyclic guanosine monophosphate; Cn, calcineurin; ISO, isoproterenol; LV, left ventricular; NOS, nitric oxide synthase; PDE5A, phosphodiesterase 5A; PKCα, protein kinase C-α; PKG, protein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Erectile Dysfunction and Cardiovascular Disease: Efficacy and Safety of Phosphodiesterase Type 5 Inhibitors in Men With Both Conditions

Keywords: BPH; benign prostatic hyperplasia; CAD; coronary artery disease; CI; confidence interval; CVD; cardiovascular disease; ED; erectile dysfunction; EF; ejection fraction; HbA1c; hemoglobin A1c; HDL-C; high-density lipoprotein cholesterol; IIEF; International

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Phosphodiesterase Type 5 Inhibitors Facilitate Noncontact Erections in Male Rats: Site of Action in the Brain and Mechanism of Action

Keywords: PDE5; Noncontact Erections; Sexual Arousal; Ventral Tegmental Area; Dopamine; Nitric Oxide;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Laboratory Forum: Experimental Models of Peyronie's Disease. Implications for New Therapies

Keywords: Fibrosis; TGFβ; Penis; Myofibroblast; PDE5; Myostatin;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes

Keywords: PDE5; Compartmentalization; Contraction; Cyclic GMP; L-type Ca channel

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

The ENDOTRIAL Study: A Spontaneous, Open-Label, Randomized, Multicenter, Crossover Study on the Efficacy of Sildenafil, Tadalafil, and Vardenafil in the Treatment of Erectile Dysfunction

Keywords: Sildenafil; Tadalafil; Vardenafil; Doppler; Erectile Dysfunction; PDE5;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Pulmonary Hypertension: Diagnosis and Management

Keywords: 5-HTT; 5-hydroxytryptamine transporter; BMPR2; bone morphogenetic protein receptor, type II; FDA; Food and Drug Administration; IPAH; idiopathic pulmonary arterial hypertension; mPAP; mean pulmonary arterial pressure; PAH; pulmonary arterial hypertension;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2009 سفارش ترجمه

Highly potent and selective chiral inhibitors of PDE5: An illustration of Pfeiffer’s rule

Keywords: Pfeiffer’s rule; Eudismic analysis; Eudismic; PDE5; PDE5 inhibitor; Sildenafil; UK-343,664; UK-371,800; Non-linear pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction

Keywords: PDE5; PDE6; PDE11; Inhibitor; Quinazoline; MED

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Effect of Vardenafil on Blood Pressure Profile of Patients With Erectile Dysfunction Concomitantly Treated With Doxazosin Gastrointestinal Therapeutic System for Benign Prostatic Hyperplasia

Keywords: adrenergic alpha-antagonists; phosphodiesterase inhibitors; prostatic hyperplasia; erectile dysfunction; α1-AR blocker; α1-adrenergic receptor blocker; BP; blood pressure; BPH; benign prostatic hyperplasia; DBP; diastolic blood pressure; ED; erectile dy

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Keywords: San-Huang-Xie-Xin-Tang; Cardiovascular effects; U46619; PDE5; ROCK-II; COX-2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The Efficacy and Safety of Udenafil, a New Selective Phosphodiesterase Type 5 Inhibitor, in Patients with Erectile Dysfunction

Keywords: Erectile Dysfunction; PDE5; Udenafil; Clinical Trial;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Sexual incentive motivation in old male rats: The effects of sildenafil and a compound (Impaza) stimulating endothelial NO synthase

Keywords: Proerectile drugs; Sexual incentive motivation; Copulatory behavior; Aging rats; NO; PDE5; Sildenafil;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

ORIGINAL RESEARCH-ED PHARMACOTHERAPY: Efficacy and Safety of Mirodenafil, A New Oral Phosphodiesterase Type 5 Inhibitor, for Treatment of Erectile Dysfunction

Keywords: Erectile Dysfunction; PDE5; Mirodenafil;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Effect of Statin Therapy on Early Return of Potency After Nerve Sparing Radical Retropubic Prostatectomy

Keywords: prostate; prostatic neoplasms; prostatectomy; impotence; hydroxymethylglutaryl-CoA reductase inhibitors; ED; erectile dysfunction; IIEF; International Index of Erectile Function; LDL; low density lipoprotein; PDE5; phosphodiesterase 5; PSA; prostate speci

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil

Keywords: PDE5; Tadalafil; Tetrahydrobetacarboline; N-arylation; Cuprous iodide; Epimerisation

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Time-dependent involvement of cAMP and cGMP in consolidation of object memory: Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors

Keywords: Learning and memory; Object recognition; Phosphodiesterase; Vardenafil; Rolipram; PDE2; PDE4; PDE5

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

The Efficacy and Safety of Vardenafil in East Asian Men with Erectile Dysfunction

Keywords: Erectile Dysfunction; Vardenafil; PDE5;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Relationship Between Vascular Damage Degrees and Endothelial Progenitor Cells in Patients with Erectile Dysfunction: Effect of Vardenafil Administration and PDE5 Expression in the Bone Marrow

Keywords: Bone marrow; Erectile dysfunction; EPCs; PDE5; PDE5 inhibitors

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Molecular modeling studies of pyridopurinone derivatives—Potential phosphodiesterase 5 inhibitors

Keywords: PDE5; CoMFA; CoMSIA; CODESSA; Docking

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Nocturnal Tumescence: A Parameter for Postoperative Erectile Integrity After Nerve Sparing Radical Prostatectomy

Keywords: impotence; prostatectomy; prostatic neoplasms; penile erection; ED; erectile dysfunction; IIEF; International Index of Erectile Function; NPTR; nocturnal penile tumescence and rigidity; PDE5; phosphodiesterase type 5; RP; radical prostatectomy;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Phosphodiesterase type 5 inhibitor sildenafil citrate does not potentiate the vasodilative properties of nebivolol in rat aorta

Keywords: Nebivolol; Sildenafil; PDE5; Vasodilation; Erectile dysfunction; eNOS

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Analysis of PDE6 function using chimeric PDE5/6 catalytic domains

Keywords: Phototransduction; Phosphodiesterase; PDE5; PDE6; cGMP

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

ORIGINAL RESEARCH-COUPLES' SEXUAL DYSFUNCTION: Vardenafil Improves Sexual Function and Treatment Satisfaction in Couples Affected by Erectile Dysfunction (ED): A Randomized, Double‐Blind, Placebo‐Controlled Trial in PDE5 Inhibitor‐Naïve Men with ED

Keywords: Erectile Dysfunction; Vardenafil; PDE5;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Local anti-inflammatory effect and behavioral studies on new PDE4 inhibitors

Keywords: PDE2; PDE3; PDE4; PDE5; Phosphodiesterase inhibitor; Inflammation; Pain; Locomotor activity; Pyridazinone derivatives

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Physiology of Erectile Function: An Update on Intracellular Molecular Processes

Keywords: Erectile function; Penile smooth muscle tone; NO/cGMP signalling; RhoA/ROK pathway; PDE5; Androgens; Erectile dysfunction

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه