کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3000293 | 1180325 | 2009 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pulmonary Hypertension: Diagnosis and Management
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کلمات کلیدی
IPAHTGF-βFDA5-hydroxytryptamine transporterBMPR2PCWPPASPmPAPPAHPDE55-HTTTransforming growth factor β - تبدیل فاکتور رشد βWorld Health Organization - سازمان بهداشت جهانیFood and Drug Administration - سازمان غذا و داروPhosphodiesterase 5 - فسفودی استراز 5Pulmonary arterial hypertension - فشار خون شریانی ریویPulmonary arterial systolic pressure - فشار سیستولیک شریانی ریویmean pulmonary arterial pressure - فشار متوسط شریان ریویpulmonary capillary wedge pressure - فشار گوه مویرگی ریویPulmonary hypertension - پرفشاری خون ریویIdiopathic pulmonary arterial hypertension - پرفشاری خون شریانی ریوی ایدیوپاتیکWHO - که
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pulmonary arterial hypertension is a progressive, symptomatic, and ultimately fatal disorder for which substantial advances in treatment have been made during the past decade. Effective management requires timely recognition and accurate diagnosis of the disorder and appropriate selection among therapeutic alternatives. Despite progress in treatment, obstacles remain that impede the achievement of optimal outcomes. The current article provides an overview of the pathobiologic mechanisms of pulmonary arterial hypertension, including genetic substrates and molecular and cellular mechanisms, and describes the clinical manifestations and classification of pulmonary arterial hypertension. The article also reviews established approaches to evaluation and treatment, with emphasis on the appropriate application of calcium channel blockers, prostacyclin analogues, endothelin receptor antagonists, and phosphodiesterase 5 inhibitors. In addition, the authors discuss unresolved issues that may complicate patient management, such as the clinical importance of mild or exercise-related pulmonary arterial hypertension, and they identify avenues by which treatment may advance in the future through the use of combination treatment, outcomes assessment, and exploration of alternative pharmacologic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 84, Issue 2, February 2009, Pages 191-207
Journal: Mayo Clinic Proceedings - Volume 84, Issue 2, February 2009, Pages 191-207
نویسندگان
Michael D. MD, Garvan C. MD, PhD,