کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4272299 | 1610960 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Laboratory Forum: Experimental Models of Peyronie's Disease. Implications for New Therapies
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
اورولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
These models have: (i) clarified the role of microtrauma, myofibroblasts, and oxidative stress in plaque development; (ii) demonstrated that this tissue is under sustained turnover by fibrotic and antifibrotic mechanisms; (iii) showed the interplay of collagenolytic and fibrinolytic systems and their inhibitors; (iv) detected an endogenous antifibrotic process consisting of the expression of inducible nitric oxide synthase that counteracts oxidative stress, collagen synthesis, and myofibroblast generation; (v) characterized the antifibrotic effects of chronic treatment with phosphodiesterase type 5 (PDE5) inhibitors; (vi) discovered the cytogenetic instability of PD cells and alterations in their gene expression; and (vii) detected stem cells in the tunica albuginea with a potential role in fibrosis and ossification. Gonzalez-Cadavid NF, and Rajfer J. Experimental models of peyronie's disease. Implications for new therapies. J Sex Med 2009;6:303-313.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Sexual Medicine - Volume 6, Issue 2, February 2009, Pages 303-313
Journal: The Journal of Sexual Medicine - Volume 6, Issue 2, February 2009, Pages 303-313
نویسندگان
Nestor F. PhD, Jacob MD,