ORIGINAL RESEARCH: Phosphodiesterase Type 5 Regulation in the Penile Corpora Cavernosa

PDE5 can be regulated at protein and gene levels. In the penis, changes of PDE5 activity have been linked to its phosphorylation status, and downregulation of PDE5 expression has been associated with hypoxia. Lin CS. PDE5 regulation in the penile corpora nervosa.