کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1364390 | 981535 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
In an effort to minimize side effects associated with low selectivity against PDE isozymes, we have successfully identified a series of 6,7,8-substituted quinzaolines as potent inhibitors of PDE5 with high level of isozyme selectivity, especially against PDE6 and PDE11. PDE5 potency and isozyme selectivity of quinazolines were greatly improved with substitutions both at 6- and 8-position. The synthesis, structure–activity relationships and in vivo efficacy of this novel series of potent PDE5 inhibitors are described.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 23, 1 December 2008, Pages 6279–6282
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 23, 1 December 2008, Pages 6279–6282
نویسندگان
Young Hoon Kim, Hojin Choi, Jaekwang Lee, In-Chang Hwang, Seung Kee Moon, Soo Jin Kim, Hong Woo Lee, Dai Sig Im, Sung Sook Lee, Soon Kil Ahn, Sang Woong Kim, Cheol Kyu Han, Jeong Hyeok Yoon, Kyung Joo Lee, Nam Song Choi,