کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5826960 | 1558915 | 2015 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardioprotective role of tadalafil against cisplatin-induced cardiovascular damage in rats
ترجمه فارسی عنوان
نقش محافظتی تادالافیل در برابر آسیب های قلبی عروقی ناشی از سیس پلاتین در موش صحرایی
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کلمات کلیدی
MDAPDE5i.p.CDDPcTn-IcGMPGSHDOXcAMP - cAMPCyclic adenosine monophosphate - آدنوزین مونوفسفات CyclicVascular damage - آسیب عروقیa-smooth muscle actin - آکتین عضله ای صافErectile dysfunction - اختلال نعوظcoronary artery disease - بیماری عروق کرونرTadalafil - تادالافیلCardiac troponin - تروپونین قلبیIntraperitoneally - داخل صفاقیDoxorubicin - دوکسوروبیسینcisplatin - سیس پلاتینatherogenic index - شاخص آتروژنیکCAD - طراحی به کمک رایانه یا کَدCardiac - قلبmalondialdehyde - مالون دی آلدهیدRats - موش صحراییcyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایNitric oxide - نیتریک اکسیدreduced glutathione - کاهش گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
The present study investigated the possible cardioprotective effect of tadalafil (Tad) on cisplatin (CDDP)-induced cardiac and vascular damages in rats. A total number of seventy two healthy male albino rats initially weighting between 200 and 220 g were used and randomly divided into four groups,18 rats in each. The control group received no treatment; CDDP group received a single dose of CDDP (4 mg/kg) intraperitoneal (i.p.) per week for 4 weeks the duration of the experiment; Tad group received 0.4 mg/kg BW Tad i.p. daily and Tad +CDDP group received 0.4 mg/kg BW Tad i.p. +4 mg/kg BW CDDP i.p. The results showed that Tad was able to decrease blood pressure, heart rate, levels of serum cardiac troponin (cTn-I), malondialdehyde (MDA) and increased levels of reduced glutathione (GSH) and nitric oxide (NO) in the heart homogenate sample from CDDP treated rats. Semi-quantitative analysis showed that Tad was able to decrease the histopathological scores of cardiac muscular hyalinzation and fibrosis in three sacrifices in CDDP treated rats. CDDP treated rats showed significantly increased thickening in wall of aorta with an irregular luminal layer of endothelial cell linings in three sacrifices when it was compared to other groups. Moreover, immunohistochemical labeling of α- smooth muscle actin (α-SMA) in aorta revealed significant lower scores in Tad +CDDP group when they were compared to CDDP group. In conclusion, Tad alone did not induce any harmful effects on blood pressure, selective antioxidant, peroxidation markers or cardiac histology, in addition, Tad has a cardio-protective role against CDDP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 765, 15 October 2015, Pages 574-581
Journal: European Journal of Pharmacology - Volume 765, 15 October 2015, Pages 574-581
نویسندگان
Rasha M. Saleh, Walaa F. Awadin, Reham A. El-Shafei, Yousef Y. Elseady, Faheim E. Wehaish, Mohamed F. Elshal,