Molecular analysis of mucinous nonneoplastic cyst of the pancreas
Keywords: از دست دادن هتروزیگوتیسم; MNNC; KRAS; Loss of heterozygosity; Histomorphology; Molecular analysis;
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Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma
Keywords: از دست دادن هتروزیگوتیسم; cSCC; cutaneous squamous cell carcinoma; KA; keratoacanthoma; LOH; loss of heterozygosity; VSL; vemurafenib-induced squamous lesion;
The molecular pattern of histopathological progression to anaplastic meningioma – A case report
Keywords: از دست دادن هتروزیگوتیسم; Meningioma; Anaplastic meningioma; Molecular biology; Loss of heterozygosity; Tumour progression
Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer
Keywords: از دست دادن هتروزیگوتیسم; INPP4B; PTEN; Loss of heterozygosity; Breast cancer; Triple-negative breast cancerLOH, loss of heterozygosity; ROH, retention of heterozygosity; INPP4B, Inositol polyphosphate 4-phosphatase type II; PI3K, phosphoinositide 3-kinase; PTEN, phosphatase and t
Clonal and genetic relationship between individual components of mucoepidermoid carcinoma: X-chromosome inactivation assay and microsatellite analysis
Keywords: از دست دادن هتروزیگوتیسم; Individual components; Heterogeneity; Laser-capture microdissection; Loss of heterozygosity; Mucoepidermoid carcinoma; X-chromosome inactivation
Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships
Keywords: از دست دادن هتروزیگوتیسم; Massively parallel sequencing; Invasive lobular carcinoma; Lobular carcinoma in situ; Clonality; Somatic genetic alterations; LCIS; lobular carcinoma in situ; TCGA; The Cancer Genome Atlas; ILC; invasive lobular carcinoma; LOH; loss of heterozygosity; MSK
Revertant Mosaicism in Ichthyosis with Confetti Caused by a Frameshift Mutation in KRT1
Keywords: از دست دادن هتروزیگوتیسم; IWC; ichthyosis with confetti; IWC-K1; ichthyosis with confetti caused by frameshift mutations in KRT1; IWC-K10; ichthyosis with confetti caused by frameshift mutations in KRT10; KRT1; keratin 1; LOH; loss of heterozygosity;
Biomarkers for Wilms Tumor: A Systematic Review
Keywords: از دست دادن هتروزیگوتیسم; biomarkers; kidney neoplasms; pediatrics; prognosis; Wilms tumor; COG; Children's Oncology Group; GOF; gain of function; LOH; loss of heterozygosity; NWTS; National Wilms Tumor Study; PRISMA; Preferred Reporting Items for Systematic Reviews and Meta-An
Concordant B-cell precursor acute lymphoblastic leukemia in non-twinned siblings
Keywords: از دست دادن هتروزیگوتیسم; ALL; acute lymphoblastic leukemia; BCP-ALL; B-cell precursor acute lymphoblastic leukemia; BFM; Berlin-Frankfurt-Münster; BM; bone marrow; CNS-f; central nervous system fluids; EGIL; European group for the immunological characterization of leukemias;
Hepatic carcinosarcoma: evidence of polyclonal origin based on microsatellite analysis
Keywords: از دست دادن هتروزیگوتیسم; Hepatic carcinosarcoma; Microsatellite; Loss of heterozygosity; Microsatellite instability; Clonal origin
Identifying the similarities and differences between single nucleotide polymorphism array (SNPa) analysis and karyotyping in acute myeloid leukemia and myelodysplastic syndromes
Keywords: از دست دادن هتروزیگوتیسم; Acute myeloid leukemia; Myelodysplastic syndromes; Loss of heterozygosity; Single nucleotide polymorphism; Karyotype
The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers
Keywords: از دست دادن هتروزیگوتیسم; Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2; ACK1/TNK2; activated CDC42-associated kinase 1; AR; androgen receptor; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated related; BF; biochemical failure; DCC; deleted in colorectal cance
Hypermethylation of potential tumor suppressor miR-34b/c is correlated with late clinical stage in patients with soft tissue sarcomas
Keywords: از دست دادن هتروزیگوتیسم; A; adenine; ASPS; alveolar soft part sarcoma; ASS1; argininosuccinate synthetase 1; BMP2; bone morphogenetic protein 2; C; cytosine; Da; Dalton; DFSP; dermatofibrosarcoma protuberan; DNA; deoxyribonucleic acid; EDTA; ethylenediaminetetraacetic acid; ES/pP
Widespread Non-Canonical Epigenetic Modifications in MMTV-NeuT Breast Cancer
Keywords: از دست دادن هتروزیگوتیسم; SNP; single nucleotide polymorphism; LOH; loss of heterozygosity; ASO; allele-specific oligonucleotide probe; LSO; locus-specific oligonucleotide probe;
Runx3 at the interface of immunity, inflammation and cancer
Keywords: از دست دادن هتروزیگوتیسم; Ab; antibody; CD; Crohn's disease; CGH; comparative genomic hybridization; DC; dendritic cell; DMBA; 7, 12-dimethylbez(a)anthracene; DRG; dorsal root ganglia; FISH; fluorescent in-situ hybridization; FL; fetal liver; GC; gastric cancer; GIT; gastrointesti
Structural perspective of ARHI mediated inhibition of STAT3 signaling: An insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ
Keywords: از دست دادن هتروزیگوتیسم; ARHI; Aplasia Ras Homologue member I; STAT3; Signal Transducer and Activator of Transcription 3; NTD; N-terminal domain; CCD; Coiled-coil domain; DBD; DNA binding domain; LD; Linker domain; SH2; Src-homology-2 domain; TAD; transactivation domain; LOH; los
Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer
Keywords: از دست دادن هتروزیگوتیسم; Genomic Instability; Microsatellite Instability; Chromosomal Instability; CIMP; ACF; aberrant crypt focus; CIMP; CpG island methylator phenotype; CIN; chromosomal instability; Cox-2; cyclo-oxygenase-2; CRC; colorectal cancer; EGFR; epithelial growth facto
Targeting the TGFβ pathway for cancer therapy
Keywords: از دست دادن هتروزیگوتیسم; Angiogenesis; Fibrosis; Metastasis; Microenvironment; TGFβ inhibitors; Tumor-stroma interactions; bFGF; basic fibroblast growth factor; bi-shRNAi; bi-functional short hairpin RNAi; CAF; cancer-associated fibroblasts; CR; complete response; CTGF; connecti
Microsatellite instability, promoter methylation and protein expression of the DNA mismatch repair genes in epithelial ovarian cancer
Keywords: از دست دادن هتروزیگوتیسم; EOC; epithelial ovarian cancer; IHC; immunohistochemistry; LOH; loss of heterozygosity; LMP; low malignant potential; MSP; methylation specific PCR; MMR; mismatch repair; MSI; microsatellite instability; MSI-H; microsatellite instability - high; MSI-L;
PTPLAD2 is a tumor suppressor in esophageal squamous cell carcinogenesis
Keywords: از دست دادن هتروزیگوتیسم; ESCC; esophageal squamous cell carcinoma; JAK; Janus kinase; LOH; loss of heterozygosity; MTT; 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; PTPLAD; protein tyrosine phosphatase-like A domain; SOCS3; suppressor of cytokine signaling 3; STAT
p53: The barrier to cancer stem cell formation
Keywords: از دست دادن هتروزیگوتیسم; Stem cells; p53; Loss of heterozygosity; Cancer stem cells; Tumorigenesis;
PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele
Keywords: از دست دادن هتروزیگوتیسم; BCCs; Basal cell carcinomas; Hh; Hedgehog; HWE; Hardy-Weinberg equilibrium; LOH; Loss of heterozygosity; MHC; Major histocompatibility complex; OC; Ovarian carcinoma; OD; Ovarian dermoid; OF; Ovarian fibroma; PTCH1; Patched; SSD; Sterol-sensing domain;
Detection of transfluthrin and metofluthrin genotoxicity in the ST cross of the Drosophila Wing Spot Test
Keywords: از دست دادن هتروزیگوتیسم; flr3; flare-3 (Drosophila strain); m; multiplication factor; mwh; multiple wing hairs (Drosophila strain); c; Frequency of clone formation per 105 cells; LOH; Loss of Heterozygosity; SMART; Somatic Mutation and Recombination Test; ST cross; Standard cross
Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
Keywords: از دست دادن هتروزیگوتیسم; Nitroxide; Mouse lymphoma assay; Micronucleus assay; Loss of heterozygosity; Glutathione; Oxidative stress;
Identification of chromosomal copy number variations and novel candidate loci in hereditary nonpolyposis colorectal cancer with mismatch repair proficiency
Keywords: از دست دادن هتروزیگوتیسم; HNPCC; hereditary non-polyposis colorectal cancers; MMR; mismatch repair; MSS; microsatellite stable; MSI; microsatellite instability; CNV; copy number variation; LOH; loss of heterozygosity; cnLOH; copy-neutral loss of heterozygosity; qPCR; quantitative
Loss of Heterozygosity Analysis at Different Chromosome Regions in Wilms Tumor Confirms 1p Allelic Loss as a Marker of Worse Prognosis: A Study from the Italian Association of Pediatric Hematology and Oncology
Keywords: از دست دادن هتروزیگوتیسم; kidney neoplasms; loss of heterozygosity; pediatrics; Wilms tumor; A; dactinomycin; AIEOP; Italian Association of Pediatric Hematology and Oncology; AIEOP-TW-2003; Italian Association of Pediatric Hematology and Oncology-Wilms Tumor-2003 study; D; doxorub
The advantage of using SNP array in clinical testing for hematological malignancies-a comparative study of three genetic testing methods
Keywords: از دست دادن هتروزیگوتیسم; SNP array; myelodysplastic syndrome; chronic lymphocytic leukemia; loss of heterozygosity;
Accumulation of genomic alterations in 2p16, 9q33.1 and 19p13 in lung tumours of asbestos-exposed patients
Keywords: از دست دادن هتروزیگوتیسم; Lung cancer; Asbestos exposure; Pulmonary epithelium; Allelic imbalance; DNA copy number alteration; LC; lung cancer; AI; allelic imbalance; CNA; copy number alteration; LOH; loss of heterozygosity; FF; fresh frozen; FFPE; formalin-fixed paraffin-embedded
Allelotyping analysis suggesting a consecutive progression from intratubular germ cell neoplasia to seminoma and then to embryonal carcinoma of the adult testis
Keywords: از دست دادن هتروزیگوتیسم; Testis; Germ cell tumor; Microdissection; Loss of heterozygosity; Carcinogenesis; Embryonal carcinoma
Genetics and pharmacogenomics of diffuse gliomas
Keywords: از دست دادن هتروزیگوتیسم; Companion diagnostics; Glioma; 1p/19q co-deletion; IDH1; Pharmacogenomics; EGFRvIII; CGH; comparative genomic hybridization; CNA; copy number aberrations; CRC; colorectal carcinoma; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FF
Analysis of genomic abnormalities in tumors: a review of available methods for Illumina two-color SNP genotyping and evaluation of performance
Keywords: از دست دادن هتروزیگوتیسم; Tumor abnormalities; spectral karyotyping; copy number estimation; loss of heterozygosity; ploidy
Biomarkers and Targeted Therapeutics in Colorectal Cancer
Keywords: از دست دادن هتروزیگوتیسم; Colorectal cancer; Molecular biology; APC; p53; Loss of heterozygosity; Microsatellite instability; CPG-island methylation;
Loss of heterozygosity of the PTCH gene in ameloblastoma
Keywords: از دست دادن هتروزیگوتیسم; Ameloblastoma; Loss of heterozygosity; PTCH; GLI1; GLI2; Sonic Hedgehog pathway
Loss of heterozygosity of the Mutated in Colorectal Cancer gene is not associated with promoter methylation in non-small cell lung cancer
Keywords: از دست دادن هتروزیگوتیسم; Non-small cell lung cancer; APC; MCC; DNA methylation; Loss of heterozygosity
The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma
Keywords: از دست دادن هتروزیگوتیسم; APC (adenomatous polyposis coli); WNT (wingless-type) gene; Loss of heterozygosity; Mutations; Epigenetic alterations
Short CommunicationTarget genes of microsatellite sequences in head and neck squamous cell carcinoma: Mononucleotide repeats are not detected
Keywords: از دست دادن هتروزیگوتیسم; MSI; Microsatellite instability; HNSCC; head and neck squamous cell carcinoma; MMR; mismatch repair; LOH; loss of heterozygosity; bp; base pair; TGFBR2; TGF-beta type II receptor 2; Microsatellite sequences; Microsatellite instability; Target genes; Head
High frequency of allelic loss at the BRCA1 locus in ovarian cancers: clinicopathologic and molecular associations
Keywords: از دست دادن هتروزیگوتیسم; BRCA1 germline mutations; loss of heterozygosity; methylation; TP53; PIK3CA
Mutational profiling of sporadic versus toxin-associated brain cancer formation: Initial findings using loss of heterozygosity profiling
Keywords: از دست دادن هتروزیگوتیسم; Sporadic cancer; Genotoxin-associated cancer; Occupational and environmental cancer; Glioma; Hemangioblastoma; Mutagenesis; Chlorinated solvents; Trichloroethylene; Vinyl chloride; Mutation; Point mutation; Allelic imbalance; Loss of heterozygosity; Micro
Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress
Keywords: از دست دادن هتروزیگوتیسم; Reactive oxygen species; Loss of heterozygosity; Peroxiredoxin 1; Mutations
Deciphering the molecular genetic basis of NPC through functional approaches
Keywords: از دست دادن هتروزیگوتیسم; TSG; tumor suppressor gene; NPC; nasopharyngeal carcinoma; MCH; microcell hybrid; MMCT; microcell-mediated chromosome transfer; YAC; yeast artificial chromosome; P1; bacteriophage P1 cloning system; PAC; P1-derived artificial chromosome; BAC; bacterial ar
Identification and Clinical Implementation of Biomarkers for Barrett's Esophagus
Keywords: از دست دادن هتروزیگوتیسم; HGD; high-grade dysplasia; IVDs; in vitro diagnostic devices; LGD; low-grade dysplasia; LOH; loss of heterozygosity; RFA; radiofrequency ablation;
Downregulation of Metallothionein 1F, a putative oncosuppressor, by loss of heterozygosity in colon cancer tissue
Keywords: از دست دادن هتروزیگوتیسم; Microarray; Metallothionein; Colon carcinogenesis; Epigenetics; Loss of heterozygosity
Loss of heterozygosity at chromosomes 1p35-pter, 4q, and 18q and protein expression differences between adenocarcinomas of the distal stomach and gastric cardia
Keywords: از دست دادن هتروزیگوتیسم; Adenocarcinoma; Distal stomach; Adenocarcinoma; Gastric cardia; Loss of heterozygosity; Tumor suppressor genes
The role of pseudokinases in cancer
Keywords: از دست دادن هتروزیگوتیسم; ALL; Acute Lymphoblastic Leukaemia; AML; Acute Myeloid Leukaemia; AMPK; 5â²-Adenosine Monophosphate Activated Protein Kinase; ATF4; Activating Transcriptional Factor 4; ATP; Adenosine-5â²-Triphosphate; BTICs; Brain Tumour-Initiating Cells; C/EBPα; CCAA
Pathology of fore and midgut neuroendocrine tumours
Keywords: از دست دادن هتروزیگوتیسم; foregut; gastrointestinal tract; midgut; molecular markers; neuroendocrine tumour; pathology; DNES; diffuse neuroendocrine system; GI; gastrointestinal; LOH; loss of heterozygosity; NE; neuroendocrine; NEC; neuroendocrine carcinoma; NET; neuroendocrine tu
Clinically Relevant Subsets Identified by Gene Expression Patterns Support a Revised Ontogenic Model of Wilms Tumor: A Children's Oncology Group Study
Keywords: از دست دادن هتروزیگوتیسم; WT; Wilms tumor; ICR1; imprint control region 1; ICR2; imprint control region 2; MM; metanephric mesenchyme; LOI; loss of imprinting; LOH; loss of heterozygosity; ROI; retention of imprinting; UPD; uniparental disomy;
Field Cancerization in the Intestinal Epithelium of Patients With Crohn's Ileocolitis
Keywords: از دست دادن هتروزیگوتیسم; Inflammatory Bowel Disease; Tumor Progression; Clonal Ordering; Oncogene; CRC; CD; Crohn's disease; LOH; loss of heterozygosity; PCR; polymerase chain reaction; UC; ulcerative colitis;
Single Nucleotide Polymorphism Microarray Analysis in Cortisol-Secreting Adrenocortical Adenomas Identifies New Candidate Genes and Pathways
Keywords: از دست دادن هتروزیگوتیسم; ACA; adrenocortical adenoma; ACC; adrenocortical carcinoma; CGH; comparative genomic hybridization; CNA; copy number alteration; cnLOH; copy-neutral loss of heterozygosity; FISH; fluorescence in situ hybridization; LOH; loss of heterozygosity; qRT-PCR; qu
Monitoring of Loss of Heterozygosity in Serum Microsatellite DNA Among Patients with Gastrointestinal Stromal Tumors Indicates Tumor Recurrence
Keywords: از دست دادن هتروزیگوتیسم; gastrointestinal stromal tumor; loss of heterozygosity; microsatellite alterations; recurrence
Ionizing radiation is a potent inducer of mitotic recombination in mouse embryonic stem cells
Keywords: از دست دادن هتروزیگوتیسم; Mouse embryonic stem cells; Ionizing radiation; Mitotic recombination; Loss of heterozygosity