Keywords: mAbs، آنتیبادیهای تک سلولی; LC–MS, liquid chromatography–mass spectrometry; CHO, Chinese hamster ovary; Fc, crystalline fragment; Fab, antigen-binding fragment; mAbs, monoclonal antibodies; PTMs, posttranslational modifications; CQAs, critical quality attributes; Lys-C, endoproteina
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Keywords: mAbs، آنتیبادیهای تک سلولی; DCs, Dendritic cells; MSCs, Mesenchymal stromal cells; NSG, NOD scid gamma; BM, Bone marrow; mAbs, Monoclonal antibodies; HSCs, Hematopoietic stem cells; LPS, Lipopolysaccharide; PBMCs, Peripheral blood mononuclear cells; NK cells, Nature killer cellsMese
Keywords: mAbs، آنتیبادیهای تک سلولی; dsDNA, double-stranded DNA; MPs, microparticles; mAbs, monoclonal antibodies; SLE, systemic lupus erythematosus; ssDNA, single-stranded DNAMicrovesicle;; Anti-DNA;; Lupus;; Autoimmunity;; Apoptosis
HLA-G and classical HLA class I expression in primary colorectal cancer and associated liver metastases
Keywords: mAbs، آنتیبادیهای تک سلولی; β2m, β2-microglobulin; DAB, 3,3′-diaminobenzidine; HLA, Human leukocyte antigen; IHC, Immunohistochemistry; mAbs, Monoclonal antibodies; MSI, Microsatellite instable; NK cells, Natural killer cells; PBS, Phosphate buffered salineColorectal cancer; Liver m
Combination of neutralizing monoclonal antibodies against Hepatitis C virus E2 protein effectively blocks virus infection
Keywords: mAbs، آنتیبادیهای تک سلولی; ELISA, enzyme-linked immunosorbent assay; EDTA, ethylenediaminetetra-acetic acid; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HCV, hepatitis C virus; HCV-LPs, hepatitis C virus-like particles; mAbs, monoclonal antibodies; PBS, phosphate buffered sali
A novel method for measuring cellular antibody uptake using imaging flow cytometry reveals distinct uptake rates for two different monoclonal antibodies targeting L1
Keywords: mAbs، آنتیبادیهای تک سلولی; mAbs, monoclonal antibodies; EpCAM, epithelial cell adhesion molecule; ADCC, antibody-dependent cellular cytotoxicity; LSCM, laser-scanning confocal microscopy; L1, L1 cell adhesion molecule; WGA, wheat-germ agglutinin; ISX, ImageStreamXAntibody internali
MicroRNAs are implicated in the suppression of CD4+CD25− conventional T cell proliferation by CD4+CD25+ regulatory T cells
Keywords: mAbs، آنتیبادیهای تک سلولی; Tregs, CD4+CD25+ regulatory T cells; Tcons, CD4+CD25− conventional T cells; miRNA, microRNA; WT, wild-type; GFP-Tg, green fluorescent protein transgenic; mAbs, monoclonal antibodies; PBS, phosphate-buffered saline; PI, propidium iodide; FCM, flow cytometr
An extended range generic immunoassay for total human therapeutic antibodies in preclinical pharmacokinetic studies
Keywords: mAbs، آنتیبادیهای تک سلولی; ELISA, enzyme linked immunosorbent assay; Fc, fragment crystallizable region; PBS, isotonic phosphate buffered saline pH 7.4; mAbs, monoclonal antibodies; TMB, 3,3′,5,5′ tetramethylbenzidine; ART, ambient room temperature; ULOQ, upper limit of quantitatio
CD4 detected from Lactobacillus helps understand the interaction between Lactobacillus and HIV
Keywords: mAbs، آنتیبادیهای تک سلولی; CD4, cluster of differentiation 4; RT–PCR, reverse transcriptase/polymerase chain reaction; LAB, lactic acid bacteria; BSA, bovine serum albumin; mAbs, monoclonal antibodies; ELISA, enzyme-linked immunosorbent assay; PBS, phosphate buffered saline; Taq, T
Effect of filgrastim (recombinant human granulocyte colony stimulating factor) on IgE responses in human asthma: A case study
Keywords: mAbs، آنتیبادیهای تک سلولی; Ig, immunoglobulin; Th, T helper; rhG-CSF, recombinant human granulocyte colony-stimulating factor; mAbs, monoclonal antibodies; Ab, antibody; EDTA, ethylenediaminotetraacetic; PBSC, peripheral blood stem cells; WBC, white blood cellIgE; Filgrastim; Asthm
High sensitivity chemiluminescence enzyme immunoassay for detecting staphylococcal enterotoxin A in multi-matrices
Keywords: mAbs، آنتیبادیهای تک سلولی; CLEIA, chemiluminescence enzyme immunoassay; mAbs, monoclonal antibodies; SEA, detection of staphylococcal enterotoxin A; LOD, low limit of detection; SEs, staphylococcal enterotoxins; SFP, staphylococcal food poisoningStaphylococcal enterotoxin A; Chemil
Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody
Keywords: mAbs، آنتیبادیهای تک سلولی; IgG, immunoglobulin G; FcγR, Fc receptors for IgG; ITP, immune thrombocytopenic purpura; mAbs, monoclonal antibodies; PK, pharmacokinetics; PD, pharmacodynamics; AUC, area under the concentration vs. time profiles; CL, clearance; Vss, volume of distributi
Cancer Genetics and the Cardiotoxicity of the Therapeutics
Keywords: mAbs، آنتیبادیهای تک سلولی; cardio-oncology; cardiotoxicity; kinase inhibitorsABL, Abelson leukemia virus tyrosine kinase; ATP, adenosine triphosphate; CML, chronic myeloid leukemia; KIs, kinase inhibitors; LV, left ventricular; mAbs, monoclonal antibodies; RAF, rapidly accelerated
Production, purification and biological characterization of mono-PEGylated anti-IL-17A antibody fragments
Keywords: mAbs، آنتیبادیهای تک سلولی; PEG, polyethylene glycol; mAbs, monoclonal antibodies; AUC, area under the curve; BHR, bronchial hyperreactivity; HSFM, hybridoma serum free medium; LPS, lipopolysaccharide; PBS, phosphate buffered saline; PVDF, polyvinylidene fluoride; FPLC, fast protein
Different regulatory and cytotoxic CD4+ T lymphocyte profiles in renal transplants with antibody-mediated chronic rejection or long-term good graft function
Keywords: mAbs، آنتیبادیهای تک سلولی; Tregs, regulatory T cells; CTL, cytotoxic T lymphocytes; mAbs, monoclonal antibodies; GzmA, granzyme A; GzmB, granzyme B; Perf, perforin; NHS, normal healthy subjects; LTKT, long-term kidney transplants; MTKT, middle-term kidney transplants; AMCR, antibod
Development and evaluation of a sandwich ELISA method for the detection of human CD306
Keywords: mAbs، آنتیبادیهای تک سلولی; LAIR, leukocyte-associated Ig-like receptor; PBMCs, peripheral blood mononuclear cells; HFRS, hemorrhagic fever with renal syndrome; mAbs, monoclonal antibodies; ABTS, 2,2′-azino-bis-[3-ethylbenzthiazoline-6-sulfonic acid]; TMB, 3,3′,5,5′-tetramethylbenzi
Evaluation of mixed-mode chromatographic resins for separating IgG from serum albumin containing feedstock
Keywords: mAbs، آنتیبادیهای تک سلولی; BSA, bovine serum albumin; CIP, clean-in-place; CV, column volume; HCIC, hydrophobic charge induction chromatography; IgG, immunoglobulin G; mAbs, monoclonal antibodies; SEC-HPLC, size exclusion chromatography–high performance liquid chromatographyMixed-m
Selection of a monoclonal antibody for detection of gliadins and glutenins: A step towards reliable gluten quantification
Keywords: mAbs، آنتیبادیهای تک سلولی; Monoclonal antibodies; ELISA; Prolamin; Deamidated glutenLMW, low molecular weight; HMW, high molecular weight; GS, glutenin subunits; ELISA, enzyme-linked immunosorbent assay; mAbs, monoclonal antibodies; IgG, immunoglobulin G; IgM, immunoglobulin M
Ipilimumab (Yervoy) and the TGN1412 catastrophe
Keywords: mAbs، آنتیبادیهای تک سلولی; APC, antigen-presenting cell; CTLA-4, cytotoxic T lymphocyte-associated antigen-4; gp100, glycoprotein 100; irAEs, immune-related adverse events; mAbs, monoclonal antibodies; MHC, major histocompatibility complex; TCR, T cell receptor; Treg, regulatory T
Adverse pulmonary reactions associated with the use of monoclonal antibodies in cancer patients
Keywords: mAbs، آنتیبادیهای تک سلولی; Adverse pulmonary reaction; Anticancer chemotherapy; Rituximab; Cetuximab; Trastuzumab; BevacizumabEGFR, epidermal growth factor receptor; ILD, interstitial lung disease; NHL, non-Hodgkin’s lymphoma; mAbs, monoclonal antibodies; VEGF, vascular endothelial
Development of highly sensitive chemiluminescence enzyme immunoassay based on the anti-recombinant HC subunit of botulinum neurotoxin type A monoclonal antibodies
Keywords: mAbs، آنتیبادیهای تک سلولی; CLEIA, chemiluminescence enzyme immunoassay; mAbs, monoclonal antibodies; rAHC, recombinat C-terminal of heavy chain of botulinum neurotoxin type A; BoNT/A, botulinum neurotoxin type ABotulinum neurotoxin type A; Chemiluminescence enzyme immunoassay; Reco
In vivo immunoregulatory properties of the novel mitochondria-targeted antioxidant SkQ1
Keywords: mAbs، آنتیبادیهای تک سلولی; ROS, reactive oxygen species; DC, dendritic cells; mAbs, monoclonal antibodies; PBMC, peripheral blood mononuclear cellsReactive oxygen species; SkQ1; Immune cells
Activation of the immune response against Infectious Bursal Disease Virus after intramuscular inoculation of an intermediate strain
Keywords: mAbs، آنتیبادیهای تک سلولی; ConA, concanavalin A; dpi, days post-inoculation; EID, egg infectious dose; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; IBDV, Infectious Bursal Disease Virus; IFN, interferon; IL, interleukin; i.m., intramuscular; mAbs, monoclonal antibodies; PBS, ph
Oral complications of targeted cancer therapies: A narrative literature review
Keywords: mAbs، آنتیبادیهای تک سلولی; EGFR(I), epidermal growth factor receptor (inhibitors); TKIs, tyrosine kinase inhibitors; mAbs, monoclonal antibodies; RT, radiotherapy; HNSCC, head and neck squamous cell carcinoma; HNC, head and neck cancer; CRC, colorectal cancer; RCC, renal cell carci
The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton
Keywords: mAbs، آنتیبادیهای تک سلولی; TEM8, tumor endothelial marker 8; CMG2, capillary morphogenesis protein 2; IgG, immunoglobulin G; mAbs, monoclonal antibodies; α-SMA, alpha-smooth muscle actin; PA, protective antigenAngiogenesis; Endothelial; Actin cytoskeleton; TEM8; ANTXR1
Prevention of Pseudomonas aeruginosa infection in cystic fibrosis patients
Keywords: mAbs، آنتیبادیهای تک سلولی; KLH, keyhole limpet hemocyanin; LPS, lipopolysaccharide; mAbs, monoclonal antibodies; MEP, mucoid exopolysaccharide; Opr, outer membrane proteins; PS, polysaccharidesCystic fibrosis; Pseudomonas aeruginosa; Infection; Prevention; Vaccines; Antibiotics; Hy
A new ELISA plate based microtiter well assay for mycobacterial topoisomerase I for the direct screening of enzyme inhibitory monoclonal antibody supernatants
Keywords: mAbs، آنتیبادیهای تک سلولی; MAbs, Monoclonal antibodies; PAb, Polyclonal antibody; Ms, Mycbacterium smegmatis; topo I, topoisomerase IRapid screening; Microtiter plate; Monoclonal antibody; Topoisomerase I; Mycobacteria
Ex vivo expansion protocol for human tumor specific T cells for adoptive T cell therapy
Keywords: mAbs، آنتیبادیهای تک سلولی; CTLs, cytotoxic T cell lines; cGMP, current good manufacturing practice; DCs, dendritic cells; LCL-B cells, EBV-transformed B lymphoblastoid cell line; mAbs, monoclonal antibodies; PBMC, Peripheral blood mononuclear cells; SD, standard deviation; TAA, tum
Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412
Keywords: mAbs، آنتیبادیهای تک سلولی; ELISA, enzyme-linked immunoabsorbent assay; mAbs, monoclonal antibodies; PP, polypropylene; PS, polystyrene; PBMCs, peripheral blood mononuclear cellsTGN1412; Therapeutic monoclonal antibodies; Pro-inflammatory cytokines; Immobilised antibody
Quantitative measurement of F-actin accumulation at the NK cell immunological synapse
Keywords: mAbs، آنتیبادیهای تک سلولی; F-actin, filamentous actin; KIR, killer cell immunoglobulin-like receptor; mAbs, monoclonal antibodies; MTOC, microtubule organizing center; NK, natural killer; NKIS, NK cell immunological synapse; SMAC, supramolecular activation clusterNK cells; Immunolo
Characterization and in vitro activities of cell-free antigens from Histoplasma capsulatum-loaded biodegradable microspheres
Keywords: mAbs، آنتیبادیهای تک سلولی; CFAgs, cell-free antigens; LT, leukotrienes; MS, microspheres; BMDMϕ, bone marrow-derived macrophages; LPS, lipopolysaccharide; FBS, foetal bovine serum; mAbs, monoclonal antibodies; PLGA, poly(d,l-lactide-co-glycolide); PVA, poly(vinyl-alcohol); LAL, Lim
Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: Prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations
Keywords: mAbs، آنتیبادیهای تک سلولی; actinic keratosis; Bowen disease; cyclin A; phenol; squamous cell carcinoma; treatment; tumor thicknessAK, actinic keratosis; BD, Bowen disease; CR, complete response; LI, labeling index; mAbs, monoclonal antibodies; PCNA, proliferating cell nuclear antig
Anthraquinones of edible wild vegetable Cassia tora stimulate proliferation of human CD4+ T lymphocytes and secretion of interferon-gamma or interleukin 10
Keywords: mAbs، آنتیبادیهای تک سلولی; BrdU, 5-bromo-2′-deoxyuridine; Con A, concanavalin A; DMSO, dimethylsulfoxide; ELISA, enzyme-linked immunosorbent assay; FITC, isothiocyanate; IFN-γ, interferon-gamma; IL-10, interleukin 10; mAbs, monoclonal antibodies; PBMC, peripheral blood mononuclear
Design and optimization of a multiplex anti-influenza peptide immunoassay
Keywords: mAbs، آنتیبادیهای تک سلولی; HA, hemagglutinin; NA, neuraminidase; DMSO, dimethyl sulfoxide; OMPC, outer membrane protein complex; CP, consistency panel; MAbs, monoclonal antibodies; OMPC, N. meningitides outer membrane protein complex; MFI, median fluorescent intensity; WB, wash buf
A scFv antibody fragment as a therapeutic candidate to neutralize a broad diversity of human IFN-alpha subtypes
Keywords: mAbs، آنتیبادیهای تک سلولی; hIFN-α, human interferon alpha; mAbs, monoclonal antibodies; scFv, single-chain antibodies; IFN-β, interferon beta; IFN-ω, interferon omega; HIV, human immunodeficiency virus; SLE, systemic lupus erythematosus; IDDM, insulin-dependent diabetes mellitus; P
Vaccines and immunotherapy against Pseudomonas aeruginosa
Keywords: mAbs، آنتیبادیهای تک سلولی; KLH, keyhole limpet hemocyanin; LPS, lipopolysaccharide; mAbs, monoclonal antibodies; MEP, mucoid exopolysaccharide; Opr, outer membrane proteins; PS, polysaccharidesPseudomonas aeruginosa; Vaccines; Monoclonal antibodies
Prospective study of human metapneumovirus infection: Diagnosis, typing and virus quantification in nasopharyngeal secretions from pediatric patients
Keywords: mAbs، آنتیبادیهای تک سلولی; hMPV, human metapneumovirus; MAbs, monoclonal antibodies; ARTI, acute respiratory tract infections; RT-PCR, reverse transcription-PCR; NPA, nasopharyngeal aspirateHuman metapneumovirus; Acute viral respiratory infections; RT-PCR; hMPV RNA quantification
Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients
Keywords: mAbs، آنتیبادیهای تک سلولی; hCoVs, human coronavirus; DFA, direct fluorescent antibody staining; MAbs, monoclonal antibodies; RT-PCR, reverse transcription-PCR; NPA, nasopharyngeal aspirate; SVC, shell-vial cultures; ARTI, acute respiratory tract infections; BAL, bronchoalveolar lav
Physiological concentrations of transforming growth factor β1 selectively inhibit human dendritic cell function
Keywords: mAbs، آنتیبادیهای تک سلولی; DC, dendritic cells; hMo-DC, human monocyte derived DC; GM-CSF, granulocyte macrophage colony stimulating factor; IFN, interferon; IL, interleukin; LC, Langerhans cells; LPS, lipopolysaccharide; mAbs, monoclonal antibodies; PG, prostaglandin; TGFβ1, trans
Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparum
Keywords: mAbs، آنتیبادیهای تک سلولی; 6-cys, 6-cysteine; GPI, glycosyl-phosphatidylinositol; IFA, immuno-fluorescence assay; mAbs, monoclonal antibodies; SIFA, suspension IFAMalaria; Plasmodium falciparum; Gametocytes; Pfs47; P47; Sex-specific protein; Transfection
Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets
Keywords: mAbs، آنتیبادیهای تک سلولی; C-type lectins; Dendritic cells; Macrophages; Plasmacytoid DCAPC, antigen presenting cell; ASGP-R, asialoglycoprotein receptor; DC, dendritic cell; GILZ, glucocorticoid-induced leucine zipper; GC, glucocorticoids; mAbs, monoclonal antibodies; MGL, macroph
Detection and pathogenicity of human metapneumovirus respiratory infection in pediatric Italian patients during a winter–spring season
Keywords: mAbs، آنتیبادیهای تک سلولی; RT-PCR, reverse transcription-PCR; CPE, cytopathic effect; NPA, nasopharyngeal aspirates; MAbs, monoclonal antibodies; sAGMK, secondary African green monkey kidney; HELF, human embryonic lung fibroblasts; ELISA, enzyme-linked immunosorbent assayHuman meta