Keywords: هدف پستانداران مجتمع رپامایسین; aging; cellular senescence; cyclin-dependent kinase; DNA damage; fetal death; fetal growth restriction; mammalian target of rapamycin complex; membrane rupture; mitogen-activated protein kinase; oxidative stress; phosphoinositide 3-kinase; placental aging
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Keywords: هدف پستانداران مجتمع رپامایسین; T2DM; Type 2 diabetes mellitus; NG; normal glucose concentration; HG; high glucose concentration; mTORC; mammalian target of rapamycin complex; GLUT; glucose transporters; LKB1; Liver kinase B1; AMPK; AMP-activated protein kinase; AKT; Protein kinase B; A
Keywords: هدف پستانداران مجتمع رپامایسین; antiphospholipid antibodies; atherosclerosis; epidemiology; thrombophilia; vascular endothelium; warfarin; aCL; anticardiolipin antibody; aPL; antiphospholipid antibody; apoER2; apolipoprotein E receptor 2; APS; antiphospholipid syndrome; β2-GP1; β2-gly
Keywords: هدف پستانداران مجتمع رپامایسین; ACLY; ATP citrate lyase; AKT; protein kinase B; ATP; adenosine triphosphate; ANT; adenine nucleotide translocator; AMPK; AMP-activated protein kinase; COX; cytochrome c oxidase; EGFR; epidermal growth factor receptor; ERRα; estrogen-related receptor alph
Keywords: هدف پستانداران مجتمع رپامایسین; CDP-DAG; cytidine diphosphate diacylglycerol; DAG; diacylglycerol; ER; endoplasmic reticulum; mTORC; mammalian target of rapamycin complex; NES; nuclear export signal; NLS; nuclear localization signal; NEBD; nuclear envelope breakdown; PA; phosphatidic ac
Mechanisms controlling the anti-neoplastic functions of FoxO proteins
Keywords: هدف پستانداران مجتمع رپامایسین; ATM; ataxia telangiectasia mutated; cHL; classical hodgkin lymphoma; CML; chronic myelogenous leukemia; CSC; cancer stem cell; ERK; the extracellular signal-regulated kinase; ERα; the nuclear receptor estrogen receptor α; FoxO; forkhead box O; G6PC; glu
TRPM7 functions in non-neuronal and neuronal systems: Perspectives on its role in the adult brain
Keywords: هدف پستانداران مجتمع رپامایسین; TRPM7; transient receptor potential melastatin like 7; PI3K; phosphatidyl inositol 3-kinase; Akt; serine-threonine kinase; S6K1; S6 kinase 1; mTORC; mammalian target of rapamycin complex; HEK; human embryonic kidney; TRPM6; transient receptor potential me
The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy
Keywords: هدف پستانداران مجتمع رپامایسین; Epilepsy; Rapamycin; Everolimus; Pharmacokinetics; Tolerability; Levetiracetam; AKT; protein kinase B; ASD; anti-seizure drug; 4E-BP1; initiation factor 4E binding protein; HPβCD; hydroxypropyl-Ã-cyclodextrin; MTD; maximal tolerated dose; MES-T; maximal
Autophagy as a pharmacological target in hematopoiesis and hematological disorders
Keywords: هدف پستانداران مجتمع رپامایسین; 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5â²-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;
The role of T cells in the pathogenesis of Parkinson's disease
Keywords: هدف پستانداران مجتمع رپامایسین; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APC; antigen-presenting cell; AQP4; Aquaporin-4; BBB; blood-brain barrier; BCL6; B cell lymphoma 6; BCR; B cell receptor; BEC; brain endothelial cells; CCL20; C-C motif ligand 20; CCR2; C-C
Research reportTRPC3- and ETB receptor-mediated PI3K/AKT activation induces vasogenic edema formation following status epilepticus
Keywords: هدف پستانداران مجتمع رپامایسین; 3CAI; 3-chloroacetyl indole; ANOVA; analysis of variance; BBB; brain-blood barrier; DAB; 3,3-diaminobenzidine; eNOS; endothelial nitric oxide synthase; ETB receptor; endothelin B receptor; LMB; leptomycin B; mTORC2; mammalian target of rapamycin complex
ReviewPushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression
Keywords: هدف پستانداران مجتمع رپامایسین; NMDA receptors; Major Depressive Disorder; MRNA translation; Homeostasis; Mammalian target of rapamycin complex; RNA binding protein;
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: هدف پستانداران مجتمع رپامایسین; AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: Role of mTORC2/SGK1 pathway
Keywords: هدف پستانداران مجتمع رپامایسین; AFC; alveolar fluid clearance; AGC; protein kinase A, protein kinase G and protein kinase C; AKT; protein kinase B; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; AT II; type II alveolar epithelial cell; ENaC; epithelial sodium channel
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
Keywords: هدف پستانداران مجتمع رپامایسین; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos
MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond
Keywords: هدف پستانداران مجتمع رپامایسین; APP; amyloid precursor protein; CHO; Chinese hamster ovary; DRP; dynamin-related protein; ER; endoplasmic reticulum; MAM; mitochondria-associated membranes; MFN; mitofusin; mTORC; mammalian target of rapamycin complex; PACS; phosphofurin acidic cluster pr
Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer
Keywords: هدف پستانداران مجتمع رپامایسین; AKT; phosphoinositide 3-kinase; phosphatase and tensin homolog deleted on chromosome 10; SMA- and MAD-related protein (SMAD) transforming growth factor-β; mammalian target of rapamycin complex
mTOR inhibitors in cancer therapy
Keywords: هدف پستانداران مجتمع رپامایسین; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC; mammalian target of rapamycin complex; Raptor; regulatory-associated protein of mTOR; S6K1; S6 kinase 1, 4E-BP1, 4E-binding protein 1; Rictor; rapamycin-insensitive companion
Tumor necrosis factor-α mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter
Keywords: هدف پستانداران مجتمع رپامایسین; ANOVA; analysis of variance; G-CSF; granulocyte colony-stimulating factor; JNK; c-Jun N-terminal kinase; IL; interleukin; IP; interferon gamma-induced protein; LPS; lipopolysaccharide; MCP; monocyte chemoattractant protein; MIG; monokine induced by interf
14-3-3 proteins in neurodegeneration
Keywords: هدف پستانداران مجتمع رپامایسین; TH; tyrosine hydroxylase; 3â²UTR; three prime untranslated region; CSF; cerebrospinal fluid; 2D-PAGE; two-dimensional polyacrylamide gel electrophoresis; PD; Parkinson disease; AD; Alzheimer disease; CJD; Creutzfeldt-Jakob disease; MSA; multiple system a
Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer
Keywords: هدف پستانداران مجتمع رپامایسین; Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro