کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837937 | 1612895 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TRPM7 functions in non-neuronal and neuronal systems: Perspectives on its role in the adult brain
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کلمات کلیدی
PI3KNipAS6 kinase 1Magnesium transporterACDPTRPM6TRPM7mTORCeEF2S6K1N-methyl-d-aspartic acidTrkBNMDAGTPHEKBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Adenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPBrain injuries - آسیب مغزیAkt - آکتamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکIschemia - ایسکمیALS - بیماری اسکلروز جانبی آمیوتروفیکCognitive functions - توابع شناختیBrain development - رشد مغز Mental health - سلامت روانeukaryotic elongation factor-2 - ضریب کشش یوکاریوتی 2Brain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزPhosphatidyl Inositol 3-kinase - فسفاتیدیل آنزیم 3-کینازMammalian target of rapamycin complex - هدف پستانداران مجتمع رپامایسینtropomyosin-related kinase B - وابسته به tropomyosin kinase BSerine-threonine kinase - کرین ترئونین کینازhuman embryonic kidney - کلیه جنین انسانGuanosine triphosphate - گوانوزین تری فسفات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Transient receptor potential melastatin-like 7 (TRPM7) has a unique dual protein structure. It is an ion channel that has biophysical characteristics enabling divalent cations transport and a kinase domain involved in molecular events starting from modulating signaling pathways to inducing chromatin remodeling. Over the past 15 years, significant progress in the molecular and functional characterization of TRPM7 has been made in peripheral tissue and/or cell lines. TRPM7 appears to be involved in a plethora of physiological and pathological processes including embryonic development, organogenesis, cell proliferation and survival, and cell death following certain triggers. In the post-mitotic neuronal cells, however, the functional role of TRPM7 remains unclear. Majority of the progress in this area of research has focused on the potential role of TRPM7 in mediating neuronal death following ischemia-like and neuronal injuries-like conditions. Here, we summarize major progress on the biological roles of the TRPM7 during development and in mitotic systems (cell lines). Then, we address the recent developments made in neuronal systems. Besides its role in neuronal death, we emphasize on direct and indirect evidences that could link TRPM7 to fundamental neurobiological processes such as synaptic transmission, synapse remodeling, plasticity, cognitive functions as well as to some mental disorders. Therefore, we propose that an equivalent effort is demanded to systematically characterize the role of TRPM7 in healthy neural system before presenting it as a potential molecular target to treat neurodegenerative disorders or to prevent neuronal death following ischemia and/or neuronal injuries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 340, 15 March 2018, Pages 81-86
Journal: Behavioural Brain Research - Volume 340, 15 March 2018, Pages 81-86
نویسندگان
Nashat Abumaria, Wei Li, Yuqiang Liu,