دانلود مقالات ISI درباره Mtorc + ترجمه فارسی

متفورمین ترویج تکثیر و تمایز پوزوستوب بلاست های مغز با تنظیم بیان سیرت 6 و اکتبر

Metformin promotes the proliferation and differentiation of murine preosteoblast by regulating the expression of sirt6 and oct4

Keywords: T2DM; Type 2 diabetes mellitus; NG; normal glucose concentration; HG; high glucose concentration; mTORC; mammalian target of rapamycin complex; GLUT; glucose transporters; LKB1; Liver kinase B1; AMPK; AMP-activated protein kinase; AKT; Protein kinase B; A

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

اسیدهای چرب غیر اشباع امگا 3 به عنوان یک استراتژی درمان برای بیماری کبد چرب غیرقرآل

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

Keywords: ACC; acetyl CoA carboxylase; ACYL; ATP citrate lyase; Akt2; rac-β-serine-threonine kinase; ALA; α-linolenic acid; ALT; alanine aminotransferase; ARA; arachidonic acid, 20:4,ω6; AST; aspartate aminotransferase; ATGL; adipocyte triglyceride lipase; CD36;

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2018 سفارش ترجمه

سندرم ضد فسفولیپید

Antiphospholipid Syndrome

Keywords: antiphospholipid antibodies; atherosclerosis; epidemiology; thrombophilia; vascular endothelium; warfarin; aCL; anticardiolipin antibody; aPL; antiphospholipid antibody; apoER2; apolipoprotein E receptor 2; APS; antiphospholipid syndrome; β2-GP1; β2-gly

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

پتانسیل های درمانی کربوهیدرات ها به عنوان تنظیم کننده های فعال سازی ماکروفاژ

Therapeutic potential of carbohydrates as regulators of macrophage activation

Keywords: 2-DG; 2-deoxy glucose; Akt; protein kinase B; ARDS; acute respiratory distress syndrome; Arg; arginase; BALF; broncho-alveolar lavage fluid; BCG; Bacillus Calmette-Guérin; CD; cluster of differentiation; cGAS; cyclic GMP-AMP synthase; COX-2; cyclooxyge

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

فعال سازی ماتریکس مؤثر است که فعالیت میتوکندری را افزایش می دهد و باعث کاهش چربی رحمی در موش می شود

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice

Keywords: 4E-BP; eukaryotic initiation factor 4E-binding protein;; ATscKO; Tsc1Lox/Lox adiponectin-cre+/− mice; ATscWT; Tsc1Lox/Lox adiponectin-cre−/− mice; C/EBP; CCAAT/enhancer-binding protein; CYC1; cytochrome c-1; DEPTOR; DEP domain-containing mTOR-intera

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

مفاهیم جدید در تحقیقات سرطان و بیوفرهنگی: انعطاف پذیری متابولیک، اتصال، همزیستی، سوئیچ، تومورهای اکسید کننده، بازسازی متابولیک، درمان سیگنالینگ و بیو انرژی

Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy

Keywords: ACLY; ATP citrate lyase; AKT; protein kinase B; ATP; adenosine triphosphate; ANT; adenine nucleotide translocator; AMPK; AMP-activated protein kinase; COX; cytochrome c oxidase; EGFR; epidermal growth factor receptor; ERRα; estrogen-related receptor alph

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

متابولیسم فسفولیپید و عملکرد هسته ای: نقش خانواده لپین فسفاتید اسید فسفاتاز

Phospholipid metabolism and nuclear function: Roles of the lipin family of phosphatidic acid phosphatases

Keywords: CDP-DAG; cytidine diphosphate diacylglycerol; DAG; diacylglycerol; ER; endoplasmic reticulum; mTORC; mammalian target of rapamycin complex; NES; nuclear export signal; NLS; nuclear localization signal; NEBD; nuclear envelope breakdown; PA; phosphatidic ac

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Re-evaluating the role of FOXOs in cancer

Keywords: RTK; receptor tyrosine kinase; GF; growth factor; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; PKB; protein kinase B; AKT; RAC-alpha serine/threonine-protein kinase; FOXO; forkhead box O; GFR; growth factor receptor; PDPK1; Phosphoinositide-depen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanisms controlling the anti-neoplastic functions of FoxO proteins

Keywords: ATM; ataxia telangiectasia mutated; cHL; classical hodgkin lymphoma; CML; chronic myelogenous leukemia; CSC; cancer stem cell; ERK; the extracellular signal-regulated kinase; ERα; the nuclear receptor estrogen receptor α; FoxO; forkhead box O; G6PC; glu

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

TRPM7 functions in non-neuronal and neuronal systems: Perspectives on its role in the adult brain

Keywords: TRPM7; transient receptor potential melastatin like 7; PI3K; phosphatidyl inositol 3-kinase; Akt; serine-threonine kinase; S6K1; S6 kinase 1; mTORC; mammalian target of rapamycin complex; HEK; human embryonic kidney; TRPM6; transient receptor potential me

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Keywords: Epilepsy; Rapamycin; Everolimus; Pharmacokinetics; Tolerability; Levetiracetam; AKT; protein kinase B; ASD; anti-seizure drug; 4E-BP1; initiation factor 4E binding protein; HPβCD; hydroxypropyl-ß-cyclodextrin; MTD; maximal tolerated dose; MES-T; maximal

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy as a pharmacological target in hematopoiesis and hematological disorders

Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5′-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;

دانلود رایگان متن کامل مقاله ISI 80 صفحه سال انتشار : 2018 سفارش ترجمه

The role of T cells in the pathogenesis of Parkinson's disease

Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APC; antigen-presenting cell; AQP4; Aquaporin-4; BBB; blood-brain barrier; BCL6; B cell lymphoma 6; BCR; B cell receptor; BEC; brain endothelial cells; CCL20; C-C motif ligand 20; CCR2; C-C

دانلود رایگان متن کامل مقاله ISI 87 صفحه سال انتشار : 2018 سفارش ترجمه

A review of the mechanism of action and clinical applications of sorafenib in advanced osteosarcoma

Keywords: Sorafenib; Advanced osteosarcoma; Denosumab; Everolimus; Novel therapy; Second line; RANKL; Tyrosine kinase; Nexavar; MTORC; Italian Sarcoma Group; Primary bone cancer; MAPK; ERK; Temsirolimus; Bevacizumab;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Original contributionExpression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma★

Keywords: ADC; adenocarcinoma; AKT; protein kinase B; ALK; anaplastic lymphoma kinase; BM; brain metastasis; EGFR; epidermal growth factor receptor; IGFR-1; insulin-like growth factor receptor-1; IHC; immunohistochemistry; mTOR; mammalian target of rapamycin; mTORC

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection

Keywords: TSC1; Raptor; Differentiation; EGF; epidermal growth factor; IHC; immunohistochemistry; i-TSC-/-; intestinal epithelial cell-specific tuberous sclerosis complex 1 null mice; MMP; matrix metalloproteinase; mTOR; mammalian target of rapamycin; mTORC; mamm

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissue

Keywords: ACM; Adipocyte-conditioned medium; BET; Bromodomain and extraterminal; Brd2; Bromodomain-containing protein 2; WT; Wild-type; SWI/SNF; Switch mating type/sucrose non-fermenting; Deptor; DEP domain containing mTOR-interacting protein; mTOR; Mechanistic tar

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Keywords: 4E-BP-1; eukaryotic initiation factor 4E binding protein-1; ATF4; activating transcription factor 4; Bcl2; B-cell lymphoma 2; C/EBP; CAAT/enhancer binding protein; cdc-2; cyclin-dependent kinase 1 (cell division cycle protein 2); CHOP; CAAT/enhancer bindi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex

Keywords: CNS; central nervous system; FCD; focal cortical dysplasia; HME; hemimegalencephaly; IPC; intermediate progenitor cell; mTORC; mechanistic target of rapamycin complex; NSC; neural stem cell; RGC; radial glial cell; SEGA; subependymal giant cell astrocytom

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease

Keywords: Lysosome; Acidification; pH; v-ATPase; Endocytosis; Autophagy; Lysosomal storage disease; Alzheimer's disease; Parkinson's disease; mTORC; Calcium; TFEB; Cathepsin; Caloric restriction;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2016 سفارش ترجمه

Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation

Keywords: Mammalian target of rapamycin; Hippocampus; Kaplan-Meier; Forebrain-specific Tsc2 Knock-out; mTOR overactivation; mTORC; mechanistic Target of Rapamycin Complex; Rheb; Ras-homolog enriched in brain; S6; ribosomal protein S6; S6K; ribosomal protein S6 ki

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

Keywords: CCC; clear cell carcinoma; SAC; serous adenocarcinoma; mTOR; mammalian target of rapamycin; mTORC; mTOR complex; S6K-1; ribosomal S6 kinase-1; 4E-BP1; elF4E binding protein 1; PI3K; phosphatidylinositol 3-kinase; cisplatin; cis-diaminodichloroplatinum; PT

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Dual treatments targeting IGF-1R, PI3K, mTORC or MEK synergize to inhibit cell growth, induce apoptosis, and arrest cell cycle at G1 phase in MDA-MB-231 cell line

Keywords: Triple-negative breast cancer; IGF-1R; PI3K; mTORC; MEK; Synergism

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1α pathway

Keywords: CS; citrate synthase; ECAR; extracellular acidification rate; FGF21; fibroblast growth factor; MELAS; mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes; mtDNA; mitochondrial DNA; mTOR; mammalian target of rapamycin; mTORC; mTOR co

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice

Keywords: Liver Cancer; Mouse Model; Drug; Signal Transduction; DEN; diethylnitrosamine; GP73; Golgi protein 73; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; MEF; mouse embryonic fibroblast; MMP; matrix metalloproteinase; mTOR; mec

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2015 سفارش ترجمه

Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis

Keywords: AAR; Area at risk; ADP; adenosine diphosphate; AKT; Protein kinase B; ANOVA; Analysis of variance; cTnI; Cardiac troponin I; dP/dT Max; left ventricular maximum contractility; dV/dT max; Left ventricular maximum filling; ECL; Enhanced chemiluminescense; E

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells

Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; caRags; constitutively active Rags B and C; caRheb; constitutively active Rheb; caRhoA; constitutively active RhoA; mTOR; mechanistic target of rapamycin; mTORC; mechanistic target of rapamycin co

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

Keywords: APP; amyloid precursor protein; CHO; Chinese hamster ovary; DRP; dynamin-related protein; ER; endoplasmic reticulum; MAM; mitochondria-associated membranes; MFN; mitofusin; mTORC; mammalian target of rapamycin complex; PACS; phosphofurin acidic cluster pr

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes

Keywords: 4SU; 4-thiouridine; ARVC; adult rat ventricular cardiomyocytes; CH; cardiac hypertrophy, ChIP, chromatin immunoprecipitation; ERK; extracellular ligand-regulated kinase; MEK; mitogen-activated protein kinase kinase; mTOR; mammalian target of rapamycin; mT

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

β-Arrestin signal complex plays a critical role in adipose differentiation

Keywords: GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleInactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways

Keywords: AKT; v-akt murine thymoma viral oncogene homolog; ERK; extracellular-related kinase; GLUT; glucose transporter; HCC; hepatocellular carcinoma; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; mTORC; mTOR complex; RPS6; ribosoma

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR inhibitors in cancer therapy

Keywords: PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC; mammalian target of rapamycin complex; Raptor; regulatory-associated protein of mTOR; S6K1; S6 kinase 1, 4E-BP1, 4E-binding protein 1; Rictor; rapamycin-insensitive companion

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Tumor necrosis factor-α mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter

Keywords: ANOVA; analysis of variance; G-CSF; granulocyte colony-stimulating factor; JNK; c-Jun N-terminal kinase; IL; interleukin; IP; interferon gamma-induced protein; LPS; lipopolysaccharide; MCP; monocyte chemoattractant protein; MIG; monokine induced by interf

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

14-3-3 proteins in neurodegeneration

Keywords: TH; tyrosine hydroxylase; 3′UTR; three prime untranslated region; CSF; cerebrospinal fluid; 2D-PAGE; two-dimensional polyacrylamide gel electrophoresis; PD; Parkinson disease; AD; Alzheimer disease; CJD; Creutzfeldt-Jakob disease; MSA; multiple system a

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer

Keywords: Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors

Keywords: kidney; carcinoma; renal cell; D 21266; 1-phosphatidylinositol 3-kinase; mTOR protein; 17-HWT; 17-hydroxy-wortmannin; APC; alkylphosphocholine; ERK; extracellular regulated kinase; GSK3; glycogen synthase kinase-3; HIF; hypoxia-inducible factor; IC50; hal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه