Differential programming of p53-deficient embryonic cells during rotenone block
Keywords: p53; Mitochondria; Rotenone; miRNA; Embryo; MEF; Mouse
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Uncovering the role of hypoxia inducible factor-1α in skin carcinogenesis
Keywords: Bax; Bcl-2-associated X protein; BCC; Basal cell carcinoma; Bcl-2; B cell lymphoma; Bcl-xL; B-cell lymphoma-extra large; BNIP3; BCL2/adenovirus E1B 19Â kDa protein-interacting protein 3; CMM; Cutaneous malignant melanoma; CBP; cyclic-AMP response element
Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer
Keywords: Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro
Directed differentiation of porcine epiblast-derived neural progenitor cells into neurons and glia
Keywords: AA; Ascorbic acid; BDNF; Brain-derived neurotrophic factor; bFGF; Basic fibroblast growth factor; ESC; Embryonic stem cell; FGF8; Fibroblast growth factor 8; GDNF; Glial cell line-derived neurotrophic factor; ICM; Inner cell mass; iPSC; Induced pluripoten
Human embryonic fibroblasts support single cell enzymatic expansion of human embryonic stem cells in xeno-free cultures
Keywords: hESC; human embryonic stem cell; iPS; induced pluripotent stem cell; MEF; mouse embryonic fibroblast; SR; serum replacement; XHEF; xeno-free human embryonic fibroblast; XHFF; xeno-free human foreskin fibroblast; ROCK; rho-associated kinase;
Inactivation of Brca2 Promotes Trp53-Associated but Inhibits KrasG12D-Dependent Pancreatic Cancer Development in Mice
Keywords: Pancreas; Cancer Genetics; Oncogene; Neoplasia; B2; Brca2; C; Cre; CK19; cytokeratin 19; K; Kras; MEF; mouse embryonic fibroblast; P; Trp53; PanIN; pancreatic intraepithelial neoplasia; PARP; poly-adenosine diphosphate-ribose polymerase; PCR; polymera
Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation
Keywords: Aqp; aquaporin; ATII; alveolar epithelial type II; BMP; bone morphogenetic protein; Ccsp; clara cell secretary protein; C/EBP; CCAAT-enhancer binding protein; CRIB; cdc42 and rac interactive binding; ECL; enhanced chemiluminescence; EGF; epidermal growth
Inhibition of REV3 Expression Induces Persistent DNA Damage and Growth Arrest in Cancer Cells
Keywords: TLS; DNA translesion synthesis; Pol ζ; DNA translesion synthesis polymerase ζ; REV3; the mammalian REV3L gene; MEF; mouse embryonic fibroblast; DDR; DNA damage response; DSBs; DNA double-strand breaks; ATM; ataxia-telangiectasia mutated; γH2AX; phospho
Stem cell cultivation in bioreactors
Keywords: 2D; Two-Dimensional; 3D; Three-Dimensional; BFU-E; Burst-Forming Units-Erythrocyte; CFCs; Colony-Forming Cells; CFU-F; Colony-Forming Units-Fibroblast; CFU-GEMM; Colony-Forming Units-Granulocyte-Erythrocyte-Macrophage-Megakaryocyte; CFU-GM; Colony-Forming
A model of enteric fermentation in dairy cows to estimate methane emission for the Dutch National Inventory Report using the IPCC Tier 3 approach
Keywords: CP; crude protein; D; potentially degradable fraction in the rumen; DM; dry matter; FPCM; fat and protein corrected milk; GE; gross energy; GHG; greenhouse gas; IPCC; Intergovernmental Panel on Climate Change; MCF; CH4 energy conversion factor; MEF; CH4 e
Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice
Keywords: MPT; Mouse Model; Aging; Liver Injury; ALLM; N-acetyl-leucine-leucine-methionine; Atg; autophagy-related protein; I/R; ischemia/reperfusion; KO; knockout; KRH; Krebs-Ringer-HEPES; MEF; mouse embryonic fibroblast; ÎΨm; mitochondrial membrane potentia
Caspase-7: A protease involved in apoptosis and inflammation
Keywords: DISC; death-inducing signalling complex; FasL; Fas ligand; LPS; lipopolysaccharide; MEF; mouse embryonic fibroblast; TRAIL; TNF-related apoptosis-inducing ligand; UV; ultraviolet; Caspase-7; Caspase-3; Apoptosis; Inflammation;
Metal-enhanced PicoGreen® fluorescence: Application to fast and ultra-sensitive pg/ml DNA quantitation
Keywords: PG; PicoGreen® dsDNA intercalating fluorescent probe; MEF; Metal Enhanced Fluorescence; SiFs; Silver Island Films; NP; silver nanoparticles; CW; Continuous Wave; LoD; Limit of Detection; Metal-enhanced fluorescence; PicoGreen®; DNA; Intercalation; Plasm
The gene expression of the myocardial lipid droplet protein is highly regulated by PPARγ in adipocytes differentiated from MEFs or SVCs
Keywords: MEF; SVC; MLDP; Adipocyte; SREBP-1; PPARγ;
Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation
Keywords: hESC; human embryonic stem cells; ES cells; embryonic stem cells; IR; ionizing radiation; qRT-PCR; quantitative real-time polymerase chain reaction; EMEM; Earle's modified Eagle's medium; DMEM; Dulbecco's modified Eagle's medium; MEF; murine embryonic fib
An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1
Keywords: BKCa; big conductance Ca2+-activated K+-channel (KCa1.1); Clotrimazole; 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole; CsA; Cyclosporin A; DC-EBIO; 5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one; DMEM; Dulbecco's modified Eagle medium; ER; endopla
Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism
Keywords: AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; autophagy-related; ATP; adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2 associated X protein; Bcl-2; B-cell leukemia/lymphoma 2; Cvt; cytoplasm-to-vacuole t
Malt1 and cIAP2-Malt1 as effectors of NF-κB activation: Kissing cousins or distant relatives?
Keywords: MALT; mucosa associated lymphoid tissue; cIAP2; cellular inhibitor of apoptosis 2; IKK complex; inhibitor of κB kinase; TCR; T cell receptor; BCR; B cell receptor; Bcl10; B cell lymphoma 10; CARD; caspase associated recruitment domain; BIR; baculovirus I
Hepatoblast-Like Progenitor Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice
Keywords: Hepatic Differentiation; Bipotency; Cell Transplantation; Liver Injury; Aat; α1-antitrypsin; Afp; α-fetoprotein; Alb; albumin; BSA; bovine serum albumin; CDM; chemically defined medium; DE; definitive endoderm; DMEM; Dulbecco's modified Eagle medium; ES
Metal-enhanced ethidium bromide emission: Application to dsDNA detection
Keywords: EB; ethidium bromide; MEF; Metal-Enhanced Fluorescence; SiFs; Silver-Island Films; NP; silver nanoparticles; CW; continuous wave;
Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes
Keywords: MEF; mouse embryonic fibroblast; MMP-; matrix metalloproteinase-; MCP-1; monocyte chemotactic protein-1; GCP-2; granulocyte chemotactic protein-2; Chemokine; Fibroblast; Monocyte chemotactic protein-1; Interleukin-17; Matrix metalloproteinase; Tissue inhi
Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung Maturation
Keywords: JNK; c-Jun kinase; MEF; murine embryonic fibroblast; NF-κB; nuclear factor κB; NSCLC; non-small cell lung cancer; TNF; tumor necrosis factor; TRAF; TNF-receptor-associated factor;
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis
Keywords: AIF; apoptosis-inducing factor; BHK; Baby Hamster Kidney; CAD; caspase-activated DNase; LEI; leukocyte elastase inhibitor; L-DNase II; LEI-derived DNase II; MEF; mouse embryonic fibroblasts; MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; PAR; poly-ADP-ribo
Reduced amyloidogenic processing of the amyloid β-protein precursor by the small-molecule Differentiation Inducing Factor-1
Keywords: Aβ; amyloid beta peptide; AD; Alzheimer's disease; ALLN; Acetyl-l-Leucyl-l-Leucyl-l-Norleucinal; APP; amyloid-β protein precursor; APLP1; amyloid precursor-like protein 1; APLP2; amyloid precursor-like protein 2; αCTF (C83); C-terminal fragment of APP
Novel channels of the inner mitochondrial membrane
Keywords: ANT; Adenine Nucleotide Translocator; BHT; 3,5-di-t-Butyl-4-HydroxyToluene; BKCa; Big Ca-dependent K+ channel; CaM; Calmodulin; CLIC; Chloride-selective Intracellular Channel; CSA; Cyclosporin A; diCl-DHAA; 12,14-dichlorodehydroabietic acid; ÎÏm; mitoch
Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses
Keywords: Fas; RIP1; ROS; Caspase; JNK; MEF; Inflammation; Free radicals
Loss of p53 Induces Tumorigenesis in p21-Deficient Mesenchymal Stem Cells
Keywords: CDK; cyclin-dependent kinase; CIN; chromosome instability; CPT; camptothecin; HSC; hematopoietic stem cell; MEF; mouse embryonic fibroblast; MSC; mesenchymal stem cell;
Silver island nanodeposits to enhance surface plasmon coupled fluorescence from copper thin films
Keywords: MEF; metal-enhanced fluorescence; SIFs; silver island films; SPCF; surface plasmon coupled fluorescence;
Metal-enhanced excimer (P-type) fluorescence
Keywords: MEF; metal enhanced fluorescence; MEPTE; metal enhanced P-type excimer Emission; MEPTm; metal enhanced P-type monomer emission;
Differentiation of endothelial cells derived from mouse embryoid bodies: A possible in vitro vasculogenesis model
Keywords: mES cells; mouse embryonic stem cells; EBs; embryoid bodies; EGM-2; endothelial growth medium-2; LIF; leukaemia inhibitory factor; VEGF; vascular endothelial growth factor; bFGF; basic fibroblast growth factor; IL-6; interleukin-6; EPO; erythropoietin; IG
Linker region of Akt1/protein kinase Bα mediates platelet-derived growth factor-induced translocation and cell migration
Keywords: PDGF; platelet-derived growth factor; PKB; protein kinase B; PI3K; phosphatidylinositol 3-kinase; MEF; mouse embryo fibroblast; P-Rex1; PIP3-dependent Rac exchanger1; Girdin; girders of actin filaments; Migration; PI3K; Akt/PKB; Linker region; PDGF;
βγ subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced
Keywords: BDNF; brain-derived neurotrophic factor; CTX; cholera toxin; DMEM; Dulbecco's modified Eagle's medium; EGF; epidermal growth factor; EPAC; exchange protein activated by cAMP; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; G3
Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells
Keywords: AMI; acute myocardial infarction; BLI; bioluminescence imaging; Ees; end-systolic elastance; EMax; maximal elastance; fluc; firefly luciferase gene; GFP; green fluorescent protein; LAD; left anterior descending coronary artery; LVEF; left ventricular ejec
Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis
Keywords: CA-074; N-(l-3-trans-propylcarbamoyloxirane-2-carbonyl)-l-isoleucyl-l-proline; CREG; Cellular repressor of E1A-stimulated genes; E-64; N-(l-3-trans-carboxyoxirane-2-carbonyl)-l-leucyl-(4-guanidino)-butane; endo H; endo-β-N-acetyl-glucosaminidase H; ER; e
Genome dynamics and transcriptional deregulation in aging
Keywords: single cell; cell-to-cell variation; genome instability; somatic mutations; gene regulation; Actb; β-actin; Actc1; cardiac α-actin; B2m; β-2 microglobulin; Gapd; glyceraldehyde-3-phosphate dehydrogenase; H2O2; hydrogen peroxide; Lpl; lipoprotein lipase
β-Arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression
Keywords: β-Arrestin; Endotoxin shock; MEF; RNAi
Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum
Keywords: ATF; activation of transcription factor; [Ca2+]i; intracellular [Ca2+]; CNX; calnexin; CBB; Coomassie brilliant blue; CPA; cyclopiazonic acid; CRT; calreticulin; eIF; eukaryotic translation initiation factor; ER; endoplasmic reticulum; GST; glutathione S-
Action of Pasteurella multocida toxin on Gαq is persistent and independent of interaction with G-protein-coupled receptors
Keywords: GPCR; G protein coupled receptor; IP; inositol phosphates; MEF; mouse embryonic fibroblasts; PMT; Pasteurella multocida toxin; PLC-β; phospholipase CβHeterotrimeric G protein; Gαq; Pasteurella multocida toxin; GTPase cycle; GPCR; Adrenoceptor
A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC)
Keywords: HPLC; high-performance liquid chromatography; HUVEC; human umbilical vein endothelial cells; IMAC; immobilized metal affinity chromatography; MEEC; mouse embryonic endothelial cells; MEF; mouse embryonic fibroblast; S1P; sphingosine 1-phosphate; S1Px; sph
TGF-β modulates β-Catenin stability and signaling in mesenchymal proliferations
Keywords: TGF; transforming growth factor; APC; adenomatous polyposis coli; FCS; fetal calf serum; MEF; mouse embryonic fibroblast; BrdU; 5-bromo-2â²-deoxyuridine; IP; immunoprecipitation; TCF; T cell factor; α-SMA; alpha smooth muscle actin; CM; conditioned medi
Intracellular trafficking of raft/caveolae domains: Insights from integrin signaling
Keywords: DRM; detergent resistant membranes; ECM; extracellular matrix; Pak; p21 activated kinase; MEF; mouse embryo fibroblast; FRET; fluorescence resonance energy transfer; EM; electron microscopy; GPI-AP; glycosylphosphatidylinositol-achored proteins; Integrins
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Keywords: 1O2; singlet oxygen; ÎÏm; mitochondrial transmembrane potential; [Ca2+]cyt; cytosolic Ca2+-concentration; AlPc; aluminum phthalocyanine; ALA; 5-aminolevulinic acid; AIF; apoptosis inducing factor; ANT; adenine nucleotide translocator; Apaf-1; apoptosis
The Ras-association domain family (RASSF) members and their role in human tumourigenesis
Keywords: AP-1; activation protein 1; APC; anaphase-promoting complex; ATM; ataxia telagectasia mutant; C1; protein kinase C conserved region; CIMP; CpG island methylator phenotype; CRC; colorectal cancer; DAG; diacylglycerol; HCC; hepatocellular carcinoma; Hpo; hi
Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences
Keywords: AAI; aristolochic acid I (CAS No. 313-67-7); B(a)P; benzo(a)pyrene (CAS No. 50-32-8); CHN; Chinese herbal nephropathy; DB; database; HUF; Hupki embryonic fibroblast; Hupki; Human P53-Knock-In; IARC; International Agency for Research on Cancer; MEF; mouse
TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-α-induced cell death: Involvement of reactive oxygen species
Keywords: TRAF6; TNF-α; Actinomycin D; Cell death; TRAF6KO; MEF; ROS; Antioxidant; BHA
Toward xeno-free culture of human embryonic stem cells
Keywords: Human embryonic stem cells; MEF; Feeder-free cell culture; Matrigel
Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?
Keywords: ACS; acyl-CoA synthase; BAT; brown adipose tissue; CPT; carnitine palmitoyltransferase; CRE; cyclic AMP response element; DNP; 2,4-dinitrophenol; FCCP; carbonylcyanide p-trifluoromethoxyphenylhydrazone (an uncoupling reagent); KO; knock-out (animals); MEF
shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts
Keywords: GMP; guanosine monophosphate; GMPS; GMP synthetase; HPRT1; hypoxanthine-guanine phosphoribosyl transferase 1; shRNA; short hairpin RNA; MEF; mouse embryo fibroblasts; Synthetic lethality screen; RNA interference; Genetic suppressor elements;
Rapid and reliable real-time PCR assay for detection of the macrolide efflux gene and subsequent discrimination between its distinct subclasses mef(A) and mef(E)
Keywords: Real-time PCR assay; mef; PCR-RFLP approach;
NK cells in innate immunity
Keywords: CMV; cytomegalovirus; DC; dendritic cell; HCMV; human CMV; HCV; hepatitis C virus; IFN; interferon; IL; interleukin; IL-15R; IL-15 receptor; MCMV; mouse CMV; MEF; myeloid elf-like factor; NK; natural killer;