کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2019366 | 1068589 | 2006 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?
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کلمات کلیدی
CREMTERXRRetinoid X receptorRMRDNPFCCPPPARBATACSMEFCPT2,4-Dinitrophenol - 2،4-دینیتروفنلMitochondrial DNA - DNA میتوکندریاROS - ROSResting metabolic rate - استراحت سرعت متابولیسمbrown adipose tissue - بافت چربی قهوه ایmtDNA - دیانای میتوکندریاییTRE - سهcyclic AMP response element - عنصر پاسخ AMP cyclicCarnitine palmitoyltransferase - کارنتین پالمیتیل ترانسفرازReactive oxygen species - گونههای فعال اکسیژنPeroxisome proliferator activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism? Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?](/preview/png/2019366.png)
چکیده انگلیسی
The discovery of the human homologue of the thermogenic protein UCP1, named uncoupling protein 3 (UCP3), boosted research on the role of this skeletal muscle protein in energy metabolism and body weight regulation. Nowadays, 9 years after its discovery emerging data indicate that the primary physiological role of UCP3 may be the mitochondrial handling of fatty acids rather than regulating energy expenditure via thermogenesis. UCP3 has been proposed to export fatty acid anions or fatty acid peroxides away from the matrix-side of the mitochondrial inner membrane to prevent their deleterious accumulation. In this way, UCP3 could protect mitochondria against lipid-induced oxidative mitochondrial damage, a function especially important under conditions of high fatty acid supply to skeletal muscle mitochondria. Such function may be clinically relevant in the development of type 2 diabetes mellitus, a condition characterized by muscular fat accumulation, mitochondrial damage and low levels of UCP3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 45, Issue 1, January 2006, Pages 17-41
Journal: Progress in Lipid Research - Volume 45, Issue 1, January 2006, Pages 17-41
نویسندگان
Patrick Schrauwen, Joris Hoeks, Matthijs K.C. Hesselink,