S6K1 controls autophagosome maturation in autophagy induced by sulforaphane or serum deprivation
Keywords: S6K1; S6K2; Autophagy flux; Sulforaphane; LC3; PC-3; MEF
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Liver maturation deficiency in p57Kip2â/â mice occurs in a hepatocytic p57Kip2 expression-independent manner
Keywords: Afp; α-fetoprotein; Bmp; bone morphogenic proteins; C/EBPα; CCAAT/enhancer-binding protein α; CK; cytokeratin; CKI; cyclin-dependent kinase inhibitor; Cyp; cytochrome P450; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; Dlk1; delta-like 1 homol
CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop
Keywords: MEF; mouse embryonic fibroblasts; MSF; mouse skin fibroblasts; NAC; N-acetylcysteine, NHFs, normal human fibroblasts; OS; oxidative stress; ROS; reactive oxygen species; SA-β-gal; senescence-associated β-galactosidase.; Senescence; p53; Reactive oxygen
Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
Keywords: Sirtuin 1 (SIRT1); skin barrier; filaggrin; AD; Atopic dermatitis; AhR; Aryl hydrocarbon receptor; ARNT; Aryl hydrocarbon receptor nuclear translocator; BaP; Benzo(a)pyrene; cHet; Epidermis-specific heterozygous SIRT1 deletion; cKO; Epidermis-specific hom
The Nuclear Factor κB pathway: A link to the immune system in the radiation response
Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP
TGF-β/BMP proteins as therapeutic targets in renal fibrosis. Where have we arrived after 25 years of trials and tribulations?
Keywords: Kidney fibrosis; Smad proteins; TGF-β1; Bone morphogenetic proteins; Inhibitors; micro-RNAs; ALK1-6; activin receptor-like kinase 1-6; BAMBI; BMP and activin receptor membrane bound inhibitor; BMP; bone morphogenetic protein; CKD; chronic kidney disease;
A fluorescent aptasensor for H5N1 influenza virus detection based-on the core-shell nanoparticles metal-enhanced fluorescence (MEF)
Keywords: H5N1; Anti-rHA aptamer; Core-shell nanoparticles; MEF; POC diagnostic;
1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose
Keywords: ERR; estrogen-related receptor; WAT; white adipose tissue; BAT; brown adipose tissue; PET; positron-emission-tomography; FGF21; fibroblast growth factor 21; MOA; mechanisms of action; UCP1; uncoupling protein 1; SHP; small heterodimer partner; ATP5b; ATP
Nuclear glutaredoxin 3 is critical for protection against oxidative stress-induced cell death
Keywords: anti-PCNA; antibody against proliferating cell nuclear antigen; AP1; activator protein 1; CDNB; 1-chloro-2,4-dinitrobenzene; CS; calf serum; DEM; diethyl maleate; DHE; dihydroethidium; DMEM; Dulbecco׳s modified Eagle medium; DTT; dithiothreitol; eGFP; en
Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; EpRE; electrophile response element; HO-1; heme oxygenase-1; ROS; reactive oxygen species; (PhSe)2; diphenyl diselenide; GSTP
mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice
Keywords: Liver Cancer; Mouse Model; Drug; Signal Transduction; DEN; diethylnitrosamine; GP73; Golgi protein 73; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; MEF; mouse embryonic fibroblast; MMP; matrix metalloproteinase; mTOR; mec
LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR
Keywords: ACC; Acetyl-CoA-Carboxylase; FCS; fetal calf serum; LPS; lipopolysaccharide; MEF; mouse embryonic fibroblasts; ox-LDL; oxidized low density lipoprotein; PDGF; platelet derived growth factor; SRB; sulforhodamine B; TLR; Toll-like receptor; ZMP; 5-aminoimid
Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling
Keywords: ANOVA; analysis of variance; CUL7; Cullin7; CRL7; Cullin RING E3 ubiquitin ligase 7; FBXW8; F-box/WD repeat-containing protein 8; GLUT4; glucose transporter 4; HSP90; heat shock protein 90; IRS; insulin receptor substrate; IGF-1; insulin-like growth hormo
Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1β and regulates the cellular PDH activity
Keywords: PDH; pyruvate dehydrogenase; PDC; pyruvate dehydrogenase complex; HIF; Hypoxia-Inducible Factor; PHD; prolyl-hydroxylase domain containing protein; MEF; mouse embryonic fibroblast; ROS; reactive oxygen species; GST; glutathione S-transferase; DFO; deferox
Research ArticlePin1 induction in the fibrotic liver and its roles in TGF-β1 expression and Smad2/3 phosphorylation
Keywords: TGF-β1; transforming growth factor-β1; HSC; hepatic stellate cell; RT-PCR; real-time-polymerase chain reaction; MEF; mouse embryonic fibroblast; DMN; dimethylnitrosamine; α-SMA; α-smooth muscle actin; ERK; extracellular signal-regulated kinase; AP-1;
The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation
Keywords: CCT; cytoplasmic carboxyl terminal; EBV; Epstein-Barr virus; IFNAR1; interferon- alpha/beta receptor alpha chain; IKK; IκB kinase; IL17R; interleukin-17 receptor; IFλR1; interferon-λ receptor chain 1; Jak3; Janus kinase 3; JNK; cJun kinase; LMP1; l
Podoplanin is a substrate of presenilin-1/γ-secretase
Keywords: PDPN; podoplanin; fl-PDPN; full-length PDPN; EC; extracellular; TM; transmembrane; CT; cytoplasmic; ERM; ezrin radixin moesin; CTF; C-terminal fragment; ICD; intracellular domain; PS; presenilin; MEF; mouse embryonic fibroblast; RIP; regulated intramembra
EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368
Keywords: AGJ; annular gap junction; CME; clathrin mediated endocytosis; EGF; epidermal growth factor; GJ; gap junction; GJIC; gap junction intercellular communication; LY; lucifer yellow; MAPK; mitogen activated protein kinase; MEF; mouse embryonic fibroblast; mES
mTOR and autophagy: A dynamic relationship governed by nutrients and energy
Keywords: Akt1; v-akt murine thymoma viral oncogene homolog 1; AMBRA; Autophagy/Beclin-1 regulator 1; AMPK; AMP-dependent protein kinase; ATG; autophagy-related; BECN1; beclin 1; DEPTOR; DEP domain containing mTOR-interacting protein; EGFR; epidermal growth factor
Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation
Keywords: Elmo; engulfment and cell motility; GEF; guanine nucleotide exchange factor; IP; immunoprecipitation; GST; glutathione S-transferase; AG16; Arhgef16; E1; Elmo1; D-ISP; Dock1-ISP; DC; dendritic cell; TEC; thymic epithelial cell; PEC; peritoneal exudate cel
Map2k4δ - Identification and functional characterization of a novel Map2k4 splice variant
Keywords: AKT; protein kinase B; ATF-2; activating transcription factor 2; BrdU; 5-bromo-2-deoxyuridine; DVD; domain of versatile docking; E; embryonic day; ERK; extracellular signal-regulated kinase; Fas-L; Fas ligand; ID; immunodepletion; IP; immunoprecipitation;
Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game
Keywords: ADAMTS; A Disintegrin And Metalloproteinase with Thrombospondin Motifs; BMP; bone morphogenic protein; CaMK; Ca2Â +/calmodulin-dependent protein kinase; CaN; calcineurin; CNA, CNB; calcineurin catalytic (A) and regulatory (B) subunits; COX; cyclooxygenase
Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation
Keywords: JAK; Janus kinase; STAT; Signal Transducer and Activator of Transcription; TC-PTP; T-cell protein tyrosine phosphatase; SOCS3; suppressor of cytokine signalling 3; H2O2; hydrogen peroxide; LIF; leukemia inhibitory factor; OSM; oncostatin M; MAPK; mitogen-
Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis
Keywords: EGFR; epidermal growth factor receptor; CIN85; Cbl interacting protein of 85Â kDa; Cbl; casitas B-lineage lymphoma; EEA1; early endosome antigen 1; FACS; fluorescence-activated cell sorting; PFA; paraformaldehyde; mAb; monoclonal antibody; pAb; polyclonal
Caveolin-1 limits human influenza A virus (H1N1) propagation in mouse embryo-derived fibroblasts
Keywords: A549; adenocarcinomic human alveolar basal epithelial cells; Cav-1; caveolin-1; CBM; caveolin-1 binding motif; CMV-IE; cytomegalovirus immediate early promoter enhancer; ESCRT; Endosomal sorting complexes required for transport; HA; hemagglutinin; IAV; in
Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1
Keywords: Rho GDIα; Rho GDP-dissociation inhibitor α; GFP; green fluorescence protein; BrdU; bromodeoxyuridine; 7-AAD; 7-amino-actinomycin D; CDK; cyclin-dependent kinase; CKI; cyclin-dependent kinase inhibitor; siRNA; small interfering RNA; Siah1; seven in absen
Compositional complexity of the mitochondrial proteome of a unicellular eukaryote (Acanthamoeba castellanii, supergroup Amoebozoa) rivals that of animals, fungi, and plants
Keywords: BN-PAGE; blue native polyacrylamide gel electrophoresis; ERMES; ER-mitochondria encounter structure; ICL; isocitrate lyase; LC; liquid chromatography; ML; maximum likelihood; MRO; mitochondrion-related organelle; MalS; malate synthase; MEF; membrane-prote
Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
Keywords: Liver-Specific Disruption of Sirt1; Hepatocyte-Derived Hormone; Metabolic Homeostasis; Obesity; Ad; adenovirus; BAT; brown adipose tissue; CPT1α; carnitine palmitoyltransferase 1α; FAS; fatty acid synthase; FGF21; fibroblast growth factor 21; MCAD; medi
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives
Keywords: Heart; MAPK; Cardiac diseases; Mitochondria; Cell signaling; AngII; angiotensin II; CA; constitutively active; CHIP; C terminus of Hsc70-interacting protein; CT-1; cardiotrophin-1; ÎΨmit; mitochondrial membrane potential; DN; dominant negative; ERK1/2;
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Akt1 as a putative regulator of Hox genes
Keywords: Hox; homeobox gene; Akt; v-akt murine thymoma viral oncogene homolog; PKB; protein kinase B; PI3K; phosphatidylinositol 3-kinase; RT-PCR; reverse transcription-polymerase chain reaction; MEF; mouse embryonic fibroblast; GEO; gene expression omnibus; COBRA
Contiguous RNA editing sites in the mitochondrial nad1 transcript of Arabidopsis thaliana are recognized by different proteins
Keywords: GFP; green fluorescent protein; GUS; β-glucuronidase; MEF; mitochondrial editing factor; MORF; multiple organellar editing factor; PPR; pentatricopeptide repeat; RNA editing factor; Plant mitochondria; Pentatricopeptide repeat protein; PPR protein; nad1;
Co-treatment with the anti-malarial drugs mefloquine and primaquine highly sensitizes drug-resistant cancer cells by increasing P-gp inhibition
Keywords: VIN; vinblasitne; ATO; atovaquone; CHL; chloroquine; PRL; primaquine; MEF; mefloquine; ART; artesunate; DOY; doxycycline; VER; verapamil; P-gp; p-glycoprotein; DMSO; dimethylsulfoxide; C-PARP; cleaved ploy ADP ribose polymerase; FACS; fluorescence-activat
Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells
Keywords: Neuron regeneration; Human iPS cells; Cholinergic neuron; GABAergic neuron; Retinoic acid; PDAPP mouse; Aβ; amyloid β protein; APP; amyloid precursor protein; ChAT; choline acetyltransferase; DG; dentate gyrus; EB; embryoid bodies; FN; fibronectin; iPS;
The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
Keywords: ATF-4; activating transcription factor 4; CB1; cannabinoid type-1 receptor; CB2; cannabinoid type-2 receptor; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; MEF; mouse embryonic fibroblast; mTORC1; mammalian target of rapamycin complex 1; mTOR
Specific expression pattern of a novel Otx2 splicing variant during neural differentiation
Keywords: ORF; open reading frame; MEF; mouse embryonic fibroblast; ESC; embryonic stem cell; FBS; fetal bovine serum; eGFP; enhanced green fluorescence protein; lncRNA; long non-protein coding RNA; Otx2; Alternative splicing; Non-coding RNA; Neural differentiation
Honokiol: A non-adipogenic PPARγ agonist from nature
Keywords: AMPK; AMP-activated kinase; ANOVA; analysis of variance; ATCC; American type culture collection; BADGE; bisphenol A diglycidyl ether; BMP; bone morphogenic protein 4; BSA; bovine serum albumin; CMCNa; sodium carboxymethyl cellulose; DMEM; Dulbecco's modif
Downregulation of the small GTPase Ras-related nuclear protein accelerates cellular ageing
Keywords: HDF; human diploid fibroblast; HGPS; Hutchinson-Gilford progeria syndrome; MEF; mouse embryonic fibroblast; MnSOD; manganese superoxide dismutase; Ran; Ras-related nuclear protein; ROS; reactive oxygen species; SA-β-gal; senescence-associated β-galact
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic à cell exhaustion
Keywords: Ins2; Insulin 2 protein; ER; endoplasmic reticulum; ASK1; apoptosis signal-regulating kinase 1; UPR; unfolded protein response; PERK; protein kinase RNA-like ER kinase; ATF6; activating transcription factor 6; IRE1; inositol-requiring enzyme 1; ERAD; ER-a
Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence
Keywords: OIS; oncogene-induced senescence; MEF; mouse embryonic fibroblast; ERK; extracellular signal-regulated kinase; MEK; mitogen-activated protein kinase kinase; PI3K; phosphatidylinositol 3-kinase; pRb; retinoblastoma tumor suppressor protein; SA-β-Gal; sene
Significant differences in genotoxicity induced by retrovirus integration in human T cells and induced pluripotent stem cells
Keywords: iPSCs; induced pluripotent stem cells; ESC; embryonic stem cell; LTR; long terminal repeat; SMA; spinal muscular atrophy; DMEM; Dulbecco's modified Eagle medium; FBS; fetal bovine serum; MEF; mouse embryonic fibroblasts; EB; embryoid bodies; FACS; fluores
DNA doubleâstrand break response in stem cells: Mechanisms to maintain genomic integrity
Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; BRCA1; breast cancer type 1 susceptibility protein; CtBP; C-terminal binding protein; CtIP; CTBP interacting protein; DDR; DNA damage response; DNA-PK; DNA-dependent
Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers
Keywords: ATRP; Atom transfer radical polymerization; POEM; Poly(oxyethylene methacrylate); PVC; Poly(vinyl chloride); PVC-g-POEM; Poly(vinyl chloride)-g-poly(oxyethylenemethacrylate); PVPO11; PVC:POEMÂ =Â 1:1; PVPO13; PVC:POEMÂ =Â 1:3; PVPO16; PVC:POEMÂ =Â 1:6; FT
Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells
Keywords: BSA; bovine serum albumin; CMV; cytomegalovirus; DAPI; 4,6-diamidio-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; Dox; doxycycline; EBs; embryoid bodies; ES-FCS; ES-qualified fetal calf serum; Fndc5; fibronectin type III domain-containing
Src kinases are important regulators of mitochondrial functions
Keywords: OXPHOS; oxidative phosphorylation; ETS; electron transport system; PKA; cAMP-dependent protein kinase; ROS; reactive oxygen species; Y; tyrosine; MEF; mouse embryonic fibroblasts; ER; endoplasmic reticulum; PKCδ; protein kinase C δ; RBM; rat brain mitoc
Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects
Keywords: DCM-CD; Dilated Cardiomyopathy with Conduction System Disease; EDMD; Emery-Dreifuss Muscular dystrophy; LGMD; Limb-Girdle Muscular Dystrophy; Cx43; Connexin43; MAPK; Mitogen-Activated Protein Kinase; ERK; Extracellular Signal-Regulated Kinase; MEF; Mous
Nek7 kinase accelerates microtubule dynamic instability
Keywords: Bgap; backward gaps; Fgap; forward gaps; MEF; mouse embryonic fibroblast; MT; microtubule; Nek; NIMA-related kinase; siRNA; small interfering RNA; +Â TIP; plus end binding protein; NIMA kinase; Nek7; Microtubule dynamics; siRNA; Gene targeting;
Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2
Keywords: AIF; Apoptosis Inducing Factor; ALLN; N-Acetyl-Leu-Leu-Nle-CHO; AP; Alkaline Phosphatase; BCA; Bicinchoninic Acid; BSA; Bovine Serum Albumin; CAD; Caspase Activated DNase; CA; Cornu Ammonis; CMA; chaperon mediated autophagy; DMEM; Dulbecco's Modified Ea
Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions
Keywords: 8-oxoG or Go; 7,8-dihydro-8-oxoguanine; 9-1-1; Rad9-Rad1-Hus1; AP; apurinic/apyrimidinic; APE1; AP-endonuclease 1; BSA; bovine serum albumin; BER; base excision repair; BstMutY; Bacillus stearothermophilus MutY; Ec-cMutY; Escherichia coli MutY cat
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis
Keywords: AP1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; CBB; Coomassie brilliant blue; DMEM; Dulbecco's modified Eagle's medium; DNCB; dinitrochlorobenzene; DTNB; dithiobisnitrobenzoic acid; GRs; glutathione reductases; HIF-1α; hypoxia-indu