کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10815199 1058459 2014 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1
چکیده انگلیسی
p27 has essential roles in cellular proliferation and migration, and reduced or cytoplasmic p27 is associated with poor clinical outcomes in a variety of human tumours. Jun activation domain-binding protein (Jab1)/constitutive photomorphogenic-9 signalosome 5 (CSN5) directly interacts with p27 promoting its translocation and cytoplasmic degradation. Sec6 is a component of the exocyst complex. Recently, several studies revealed that Sec6 has specific functions in migration, adhesion, and cell differentiation. However, how Sec6 is involved in the regulation of cell cycle progression is unknown. The present study shows that Sec6 regulates cytoplasmic translocation of p27 through p27 phosphorylation at Thr157, thereby promoting p27 degradation in the cytoplasm via interaction with Jab1 and Siah1 and suppressing cell cycle progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 26, Issue 10, October 2014, Pages 2071-2085
نویسندگان
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