Keywords: N-acetylcysteine; Antioxidants; MEF; Adipogenesis; Kinases; Lipids
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A validated LC-MS/MS method for simultaneous determination of linagliptin and metformin in spiked human plasma coupled with solid phase extraction: Application to a pharmacokinetic study in healthy volunteers
Keywords: ALG; alogliptin; AUC0-t and AUC0-â; the areas under the plasma concentration-time curve; Cmax; maximum plasma concentration; DPP-IV; dipeptidyl peptidase; ER; extraction recovery; GIP; glucose-dependent insulinotropic polypeptide; GLP 1; glucagon-
Characterization of epimerization and composition of heparin and dalteparin using a UHPLC-ESI-MS/MS method
Keywords: HONO; nitrous acid; IdoA; iduronic acid; GlcA; glucuronic acid; GlcN; glucosamine; SAX; strong anion exchange; RP-IP; reverse phase ion pairing; HILIC; hydrophilic interaction chromatography; WAX; weak anion exchange; LMWHs; low molecular weight heparins;
Optimal human iPS cell culture method for efficient hepatic differentiation
Keywords: AK02N method; StemFit AK02N medium with iMatrix-511; ALB; albumin; BMP; bone morphogenetic protein; DE; definitive endoderm; E8 medium; Essential 8 medium; E8 method; E8 medium with vitronectin N; ES cells; embryonic stem cells; FBS; fetal bovine serum; F
Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
Keywords: Akt; Protein kinase B; AP-1; Activator protein-1; ASK1; Apoptosis signal-regulating kinase 1; ATF2; activating transcription factor 2;; ChIP; Chromatin immunoprecipitation;; DEN; Diethyl nitrosamine;; EGFR; Epidermal growth factor receptor; G6PDH; Glucose
Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient
Keywords: RFLP; restriction fragment length polymorphism; TUNEL; TdT-mediated dUTP nick end labeling; PBMC; peripheral blood mononuclear cell; MEF; mouse embryonic fibroblast; BSA; bovine serum albumin; Fabry disease; Fabry cardiomyopathy; Induced pluripotent stem
The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes
Keywords: α-MEM; alpha minimum essential medium; bFGF; basic fibroblast growth factor; BIO; 6-bromoindirubin-3â²-oxime; BM-MSCs; bone marrow-derived MSCs; BMP4; bone morphogenetic protein 4; C57BL/6; C57BL/6 mouse; CM; conditioned medium; DAPI; 4â²,6-diamidino-2
ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine
Keywords: MEF; mouse embryonic fibroblast; UPR; unfolded protein response; ER; endoplasmic reticulum; DKO; double knock out; ROS; reactive oxygen species; GFP; green fluorescent protein; Bcl-2; B-cell lymphoma 2; Bax; Bcl-2 associated X protein; Bak; Bcl-2 antagoni
Comprehensive analysis of lncRNAs and mRNAs with associated co-expression and ceRNA networks in C2C12 myoblasts and myotubes
Keywords: lncRNAs; long non-coding RNAs; ceRNAs; competing endogenous RNAs; TFs; specific transcription factors; MyoD; myogenic differentiation antigen; Myf; myogenic factor; myog; myogenin; MEF; myocyte enhancer factor; bHLH; basic helix loop helix; GO; Gene ontol
Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells
Keywords: mESCs; mouse embryonic stem cells; iPSCs; induced pluripotent stem cells; CRISPR; clustered regularly interspaced short palindromic repeat; Cas9; CRISPR- associated protein 9; MEF; mouse embryonic fibroblast; EBs; embryoid bodies; EPL; early primitive ect
The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids
Keywords: Enteroid; Intestinal stem cells; Lgr5; LPA; Octadecyl thiophosphate; Radiation; Radioprotection; Radiomitigation; LPA; lysophosphatidic acid; ARS; acute radiation syndrome; Lgr5; leucine-rich repeat-containing G protein-coupled receptor 5; OTP; octadecyl
TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter
Keywords: ATF; activating transcription factor; C/EBP; CCAAT/enhancer-binding protein; ER; endoplasmic reticulum; FGF21; fibroblast growth factor 21; MEF; mouse embryonic fibroblast; PPARα; peroxisome proliferator-activated receptor α; TRIB3; Tribbles homolog 3;
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
Keywords: Diabetic retinopathy; Reactive metabolites; TRPC cation channels; MethylGlyoxal; Vasoregression; Glyoxalase1; DR; Diabetic Retinopathy; GLO1; Glyoxalase 1; GSH; Glutathione; GSSG; Glutathione disulfide; HTA; Hemithioacetal; MEF; Mouse Embryonic Fibroblast
Isolation of primitive mouse extraembryonic endoderm (pXEN) stem cell lines
Keywords: Stem cells; Blastocyst; Mice; Rats; Extraembryonic endoderm; ExEn; extraembryonic endoderm; LIF; leukemia inhibitory factor; MEF; mouse embryo fibroblasts; PDGF; platelet-derived growth factor; PrE; primitive endoderm; pXEN cells; primitive (mouse) ExEn s
Electrotechnologies applied to microalgal biotechnology - Applications, techniques and future trends
Keywords: AC; Alternating current; DC; Direct Current; DEP; Dielectrophoresis; DMSP; dimethylsulfoniopropionate; EC; Electrocoagulation; ECF; Electro-coagulation-flotation; ECH; Electrochemical harvesting; EF; Electric Field; HVED; High Voltage Electric Discharge;
Molecular and functional characterization of tumor-induced factor (TIF): Hamster homolog of CXCL3 (GROγ) displays tumor suppressive activity
Keywords: CXCL1; CXCL3; CXCR2; GRO; IL-8; MAS; Tumor-induced factor; Chemokine; Ab; antibody; CHO-K1; Chinese hamster ovary-K1; CNV; copy number variation; CXCR2; CXC chemokine receptor 2; CRE; cAMP-response elements; DCIP1; dendritic cell inflammatory protein 1; D
Regulation of inflammation by β-arrestins: Not just receptor tales
Keywords: βarr; β-arrestin; IL; interleukin; IκBα; inhibitor α of NFκB; IKK; IκB kinase; MEF; mouse embryo fibroblast; LPA; lysophosphatidic acid; TLR4; Toll-like receptor-4; TNF; tumor necrosis factor; TNFR1; TNF receptor-1; TRAF; TNFR-associated factor; 7T
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease
Keywords: AGEs; advanced glycation end-products; ARE; antioxidant-response element; AP; argpyrimidine (Náº-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine); BBB; blood-brain barrier; Casp-3; Caspase-3; CCM; Cerebral Cavernous Malformation; CNS; central nervous
Mechanism of MEN1 gene in radiation-induced pulmonary fibrosis in mice
Keywords: H&E; hematoxylin and eosin; ECM; extracellular matrix; EMT; epithelial stromal cell transformation; IP; immunoprecipitation; IR; Ionizing radiation; MEF; mouse embryonic fibroblast cell; MLE-12; mouse lung epithelial cell; NEM; N-ethylmaleimide; qRT-PCR;
Effects of Class II-Selective Histone Deacetylase Inhibitor on Neuromuscular Function and Disease Progression in SOD1-ALS Mice
Keywords: CMAPs; Compound muscle action potentials; FGFBP; fibroblast growth factor binding protein; HDACs; histone deacetylases; MEF; myocyte enhancer factor; PBS; phosphate-buffered saline; amyotrophic lateral sclerosis; HDAC inhibitor; SOD1G93A mice; skeletal mu
Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion
Keywords: OPA1; optic atrophy 1; IM; inner membrane; OM; outer membrane; CL; cardiolipin; KO; knockout; Mfns; mitofusins; MEF; mouse embryonic fibroblast; mtDNA; mitochondrial DNA; Drp1; dynamin-related protein 1; Mff; mitochondrial fission factor; MiD49/MIEF2; mit
Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation
Keywords: AKR1C1; aldo-keto reductase family 1 member C1; DMEM; sodium pyruvate free Dulbecco's modified Eagle's medium; DMNQ; 2,3-dimethoxy-1,4-naphthoquinone; dtBHQ; 2,5-di-tert-butylhydroquinone; EGCG; epigallocatechin-3-gallate; FBS; fetal bovine serum; HEPES;
Enhancing the sensitivity of DNA microarrays by metal-enhanced fluorescence using vertical nanorod structures
Keywords: MEF; metal-enhanced fluorescence; NR; nanorods; VNR; vertical nanorod; SNRs; slanted nanorods; GLAD; glancing angle deposition; KLK7; Kallikrein-related peptidase 7; SERS; surface enhanced Raman scattering; LSPR; localized surface plasmon resonance; FE-SE
Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses
Keywords: ALS; amyotrophic lateral sclerosis; BMDM; bone marrow-derived macrophages; C9orf72; chromosome 9 open-reading frame 72; CNS; central nervous system; CXCL; CXC chemokine ligand; DAMPs; damage-associated molecular patterns; DMEM; Dulbecco's Modified Eagle
Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention
Keywords: 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; 8-oxoGua; 8-oxo-7,8-dihydroguanine, BER, base excision repair; AP; apurinic/apyrimidic; APE1; AP endonuclease-1; DMSO; dimethyl sulfoxide; FRET; fluorescence resonance energy transfer; MEF; mouse embryonic f
N-terminal acetylation modulates Bax targeting to mitochondria
Keywords: MEF; mouse embryonic fibroblasts; MOMP; mitochondrial outer membrane permeabilization; OMM; outer mitochondrial membrane; cyt c; cytochrome c; tBid; truncated Bid; ART; apoptosis regulating targeting; Nt-acetylation; N-terminal acetylation; NATs; N-termin
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
Approach for the Derivation of Melanocytes from Induced Pluripotent Stem Cells
Keywords: FBS; fetal bovine serum; FGF2; fibroblast growth factor 2; iDMM; iPS cell-derived melanocyte medium; iPS; induced pluripotent stem; MEF; mouse embryonic fibroblast; MITF; microphthalmia-associated transcription factor; siRNA; small interfering RNA; TYRP1;
High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype
Keywords: TPP1; protein encoded by adrenocortical dysplasia gene; Acd; adrenocortical dysplasia gene; acd; adrenocortical dysplasia mutation; p53; transformation related protein 53; DNA; Deoxyribonucleic acid; DC; Dyskeratosis congenita; HHS; Hoyeraal-Hreidarsson s
Mitochondrial function requires NGLY1
Keywords: C. elegans; Caenorhabditis elegans; CDG; congenital disorders of glycosylation; ER; endoplasmic reticulum; ERAD; ER-associated degradation; ERAF; ER-associated folding; FCCP; carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; FCL; fibroblast cell line
Marliolide inhibits skin carcinogenesis by activating NRF2/ARE to induce heme oxygenase-1
Keywords: HO-1; Heme oxygenase-1; NRF2; NF-E2-related factor 2; KEAP1; Kelch-like ECH-Associated protein 1; ARE; Antioxidant response element; GCLC; glutamate-cysteine ligase modifier catalytic unit; MEF; Mouse embryonic fibroblast; DMBA; 12-Dimethylbenz[a]anthrace
Modelling the pathogenesis of Myotonic Dystrophy type 1 cardiac phenotype through human iPSC-derived cardiomyocytes
Keywords: Myotonic Dystrophy type 1 (DM1); Human induced pluripotent stem cells; Cardiomyocytes; Electrophysiological analysis; Antiarrhytmic drugs; ACTN2; sarcomeric alpha actinin; AFM; atomic force microscopy; AP; action potential; APD; action potential duration;
Supramolecular zippers elicit interbilayer adhesion of membranes producing cell death
Keywords: Fibroblasts; Mitochondria; Giant vesicles; H-aggregate; NAO; 2P-FLIM; two-photon fluorescence-lifetime imaging microscopy; AO; acridine orange; ATP; adenosine triphosphate; CL; cardiolipin; DFT; density functional theory; DMEM; Dulbecco Modified Eagle Med
FLCN: The causative gene for Birt-Hogg-Dubé syndrome
Keywords: AEC; alveolar epithelial type II cell; AKT; protein kinase B; AMPK/Ampk; 5â²-AMP activated protein kinase; AMPKα (also AAK-2); AMPKα subunit; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BHD; Birt-Hogg-Dubé; BAT; brown adipose tissue; C. ele
CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition
Keywords: E-cadherin; epithelial cadherin; N-cadherin; neuronal cadherin; EMT; epithelial-mesenchymal transition; EMT-TF; EMT transcriptional factor; TGF-β; transforming growth factor-β; BMP; bone morphogenetic protein; MEF; mouse embryonic fibroblast; WT; wild t
Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways
Keywords: ATG; autophagy-related gene; DMEM; Dulbecco's Modified Eagle Medium; GFP; green fluorescent protein; HFD; high fat diet; Ho-1; heme oxygenase-1; Keap1; Kelch-like ECH-associated protein 1; LC3; microtubule-associated protein 1 light chain 3 (MAP1LC3); MCP
JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice
Keywords: Tumor Microenvironment; Drug Development; Targeted Therapy; Pancreas; AE; anion exchanger; CA; carbonic anhydrase; GPCR; G protein-coupled receptor; GPX; glutathione peroxidase; GSH; glutathione; HCQ; hydroxychloroquine; HMGB1; high mobility group box 1;
Validation of the electronic version of the BREAST-Q in the army of women study
Keywords: BREAST-Q; PROMS; Patient reported outcome measures; Patient reported outcomes; Psychometrics; Electronic questionnaires; Breast surgery; AOW; Army of Women; MEF; maximum endorsement frequency; PCL-C; PTSD Checklist-Civilian version; PROM; patient-report
The novel mef(C)-mph(G) macrolide resistance genes are conveyed in the environment on various vectors
Keywords: Macrolide; Resistance; mef; mph; Asian waters;
Simple and effective generation of transgene-free induced pluripotent stem cells using an auto-erasable Sendai virus vector responding to microRNA-302
Keywords: SeV; Sendai virus; SeVdp; replication-defective and persistent Sendai virus; PSC; pluripotent stem cell; RdRp; RNA-dependent RNA polymerase; MEF; mouse embryonic fibroblast; UTR; untranslated region; Cluc; Cypridina noctiluca luciferase; LNA; locked nucle
The good and the bad faces of STAT1 in solid tumours
Keywords: BAD; Bcl2-associated agonist of cell death; Bcl; B-cell lymphoma; CD; cluster of differentiation; CDK; cyclin-dependent kinase; CTL; cytotoxic T lymphocyte; CUG; cancer upregulated gene; CXCL; C-X-C motive ligand; DC; dendritic cells; DAMP; danger-associa
Nucleolin is a nuclear target of heparan sulfate derived from glypican-1
Keywords: anMan/AM; anhydromannose; DAPI; 4,6-diamidino-2-phenylindole; Gpc; glypican; HS; heparan sulfate; mAb; monoclonal antibody; MEF; mouse embryonic fibroblast; NO; nitric oxide; SH; thiol; SNO; S-nitrosothiol; Tg2576; transgenic Alzheimer mouse; WT; wild-typ
Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1
Keywords: Aβ; amyloid β peptide; anMan; anhydromannose; APP; amyloid precursor protein; β-CTF; C-terminal fragment of APP generated by β-cleavage; γ-CTF; C-terminal fragment of APP generated by γ-cleavage; CYB561A3; A3 variant of cytochrome b561; GAG; glycosa
MicroRNA-29 impairs the early phase of reprogramming process by targeting active DNA demethylation enzymes and Wnt signaling
Keywords: microRNA; miR; OKS.dT; hOCT4-hKLF4-hSOX2-dTom; OKSM.dT; hOCT4-hKLF4-hSOX2-hC-MYC-dTom; MEF; mouse embryonic fibroblasts; iPSC; induced pluripotent stem cells; ESC; embryonic stem cells; shRNA; short-hairpin RNA; siRNA; small interfering RNA; OG2; Oct4 pro
Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein â ring finger protein 4 dependent pathway
Keywords: AEC; Airway epithelial cell; AOE; Antioxidant enzyme; ARE; Antioxidant response element; CBP; CREB-binding protein; HDAC; Histone deacetylase; IFN; Interferon; IP; Immunoprecipitation; KEAP1; Kelch like-ECH-associated protein 1; MEF; Mouse embryonic fibro
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Original ArticleAspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition
Keywords: Aspirin; mTORC1; AMPK; Sorafenib; Proliferation; AMPK; Adenosine 5'-monophosphate (AMP)-activated protein kinase; mTOR; mammalian target of rapamycin; MEF; mouse embryonic fibroblast; TSC2; Tuberous sclerosis 1; NSAID; non-steroidal anti-inflammatory dr
Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification
Keywords: ChIP; Chromatin Immuno-Precipitation; Dpc; Day post coitum; MEF; Mouse embryonic fibroblast; Men1; Multiple endocrine neoplasia type1; PanNET; Pancreatic NeuroEndocrine Tumour; PcG; Polycomb Gene; PCR; Polymerase Chain Reaction; PRC; Polycomp Repressing C
NF-κB p65 Overexpression Promotes Bladder Cancer Cell Migration via FBW7-Mediated Degradation of RhoGDIα Protein
Keywords: BC; bladder cancer; BBN; N-butyl-N-(4-hydroxybutyl)-nitrosamine; CHX; cycloheximide; RT-PCR; reverse transcription-polymerase chain reaction; NF-κB; transcription factors of the nuclear factor kappa B; RhoGDI; RHO guanosine diphosphate dissociation inhib
Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor
Keywords: Q; Coenzyme Q; 2,4-DHB; 2,4-dihydroxybenzoic acid; DOD; drop-out-dextrose medium; FBS; fetal bovine serum; 4HB; 4-Hydroxybenzoic acid; 4HPAA; 4-hydroxyphenylacetic acid; MEF; mouse embryonic fibroblast; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetraz