Keywords: Myricetin; Cdk1; Akt; Erk1 and Erk2; Mek1; Jak1; Stat3; Ap-1; Apoptosis; Metastasis
مقالات ISI (ترجمه نشده)
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Keywords: Langerhans cell histiocytosis; LCH; BRAF; MAP2K1; MEK1;
Keywords: A. mylitta; Antheraea mylitta; AA; amino acid; aP2; adipocyte fatty acid-binding; ASC; human-derived adipose stem cells; B. mori; Bombyx mori; BMSC; bone marrow stem cells; BSA; bovine serum albumin; Da; Dalton; DMSO; dimethyl sulfoxide; ECM; extracellula
Cyclin-dependent kinase 5 regulates MAPK/ERK signaling in the skin of mice
Keywords: CDK5; MAP3K6; MEK1; Pigment; CDK5-Knockdown mouse;
The histone demethylase PHF8 promotes adult acute lymphoblastic leukemia through interaction with the MEK/ERK signaling pathway
Keywords: PHF8; MEK1; MEK/ERK pathway; PD184352; Acute lymphoblastic leukemia;
Strategies of biochemical adaptation for hibernation in a South American marsupial Dromiciops gliroides: 1. Mitogen-activated protein kinases and the cell stress response
Keywords: CREB; cAMP response element binding protein; ERK; extracellular signal-regulated protein kinase; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; MAPKK; MAPK kinase; MAPKKK; MAPKK kinase; p38; p38 protein kinase; TNF-α; tumor necrosi
Suspended graphene oxide nanosheets maintain the self-renewal of mouse embryonic stem cells via down-regulating the expression of Vinculin
Keywords: Graphene oxide; Mouse embryonic stem cell; Self-renewal; Focal adhesion; Vinculin; MEK1;
MicroRNAs link chronic inflammation in childhood to growth impairment and insulin-resistance
Keywords: ALS; acid-labile subunit; APC; antigen-presenting cell; CXCL2; chemokine (C-X-C motif) ligand 2; ESR; erythrocyte sedimentation rate; FGFR1; fibroblast growth factor receptor 1; FOXO1; Forkhed box O1; FOXP3; forkhead box P3; GH; growth hormone; GHR; growt
ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK
Keywords: 2-NBDG; 2-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]amino)-2-deoxyglucose; AICAR; 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt Substrate of 160â¯kDa; ATF4; Activating Transcription Factor 4; AUC; area un
Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation
Keywords: Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b
Molecular and cellular pharmacologyNoradrenaline increases intracellular glutathione in human astrocytoma U-251 MG cells by inducing glutamate-cysteine ligase protein via β3-adrenoceptor stimulation
Keywords: AD; Alzheimer's disease; ERK; extracellular signal-regulated kinase; GCLc; catalytic subunit of glutamate-cysteine ligase; CNS; central nervous system; DTNB; 5,5â²-dithio-bis(2-nitrobenzoic acid); JNK; c-Jun N-terminal kinase; GSH; glutathione; MEK1; mit
Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication
Keywords: TLR3; HIV; Viral transactivation; LTR; NFκB; JNK; STAT1; Histone acetylation; Epigenetics; Human monocyte-derived macrophages; TZM-bl; U38 cells; AP-1; activator protein-1; B2M; beta-2-microglobulin; BCA; bicinchoninic acid; CAT; chloramphenicol acetyltr
Is diagnosing cardio-facio-cutaneous (CFC) syndrome still a challenge? Delineation of the phenotype in 15 Polish patients with proven mutations, including novel mutations in the BRAF gene
Keywords: Cardio-facio-cutaneous syndrome; CFC; BRAF; MEK1; MEK2; KRAS; Genotype–phenotype; Novel mutation
Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms
Keywords: BRAF; Vemurafenib; Dabrafenib; Resistance; Acquired; MAPK; NRAS; Splice; MEK1; Meta-analysis
MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages
Keywords: Macrophages; ERK; MEK1; MEK2; STAT/JAK; IL-12; IL-10;
Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor
Keywords: Dual inhibition; Akt; ERK; PI-3 Kinase; MEK1; MAP Kinase; Oncogenic signaling; KRAS; Driven oncogenesis;
p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling
Keywords: Akt1; Mek1; mTOR; p70 S6-kinase; Extracellular matrix; Integrin;
ERK1/2 can feedback-regulate cellular MEK1/2 levels
Keywords: 4-HT; 4-hydroxytamoxifen; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; MEK; mitogen-activated protein kinase kinase; UTR; untranslated region; Raf; MEK1; MEK2; ERK1/2; Feedback regulation;
Saururus chinensis (Lour.) Baill blocks enterovirus 71 infection by hijacking MEK1-ERK signaling pathway
Keywords: Saururus chinensis (Lour.) Baill; Enterovirus 71; MEK1; ERK; NF-κB; Antiviral;
Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy
Keywords: miRNAs; microRNAs; DG; dentate gyrus; PHC; parahippocampal cortex; MAPK; mitogen-activated protein kinase; TGFβ; transforming growth factor beta; mTOR; mammalian target of rapamycin; TLE; temporal lobe epilepsy; SE; status epilepticus; RIN; RNA Integrity
Activation of the MEK pathway is required for complete scattering of MCF7 cells stimulated with heregulin-β1
Keywords: Scattering; p38 MAK kinase; MEK1; Rac1; F-actin;
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1
Keywords: Fragment screening; Virtual screening; Differential scanning fluorimetry; MEK1;
Increased levels of microRNA-424 are associated with the pathogenesis of fetal growth restriction
Keywords: Fetal growth restriction; Placenta; miRNA-424; MEK1; FGFR1
Truncated MEK1 is required for transient activation of MAPK signalling in G2 phase cells
Keywords: MAPK; G2 phase; MEK1; p90RSK
MEK1-ERKs signal cascade is required for the replication of Enterovirus 71 (EV71)
Keywords: EV71; Viral replication cycle; MEK1; MEK2; ERK; siRNAs;
MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway
Keywords: IL; interleukin; MAPK; mitogen-activated protein kinase; NFκB; nuclear factor κB; AP-1; jun proto-oncogene; ERK; extracellular signal-regulated kinase; JNK; c-Jun amino-terminal kinase; P38; mitogen-activated protein kinase 14; MEK; MAP Kinase kinase; R
Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts
Keywords: AITC; allyl isothiocyanate; ARE; antioxidant response element; BITC; butyl isothiocyanate; CpG; cytosine-phospho-guanine; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; γGCS; γ-glutamyl cysteine synthetase; HO-1; heme oxygenase-1; IT
The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins
Keywords: KDEL receptor; ER stress; neurodegenerative disease-related proteins; autophagy; ALS; amyotrophic lateral sclerosis; ARF1; ADP ribosylation factor 1; ARF1-GAP; ARF1 GTPase-activating protein; ATG5; autophagy-related gene 5; BIP; binding immunoglobulin pro
MEK1 and AKT2 Mutations in Japanese Lung Cancer
Keywords: MEK1; Lung cancer; AKT2; Mutation
Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2
Keywords: HSV-2; Viral replication; MEK1; MEK2; ERK; siRNA
Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1
Keywords: COX-2; Cyanidin; MEK1; MKK4; Raf-1; UVB
Molecular characterisation of MEK1/2- and MKK3/6-like mitogen-activated protein kinase kinases (MAPKK) from the fox tapeworm Echinococcus multilocularis
Keywords: Echinococcus; Cestode; Parasite; MAP kinase cascade; MEK1; MKK3; 14-3-3; Raf;
Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead
Keywords: MEKK1; MEK1; Resorcylic acid; Anti-inflammatory; ER-803064
Scaffolding actions of membrane-associated progesterone receptors
Keywords: Progesterone receptor; CD domain; Scaffold; Rapid kinase activation; c-Src; MEK1
MEK1 plays contrary stage-specific roles in skeletal myogenic differentiation
Keywords: ERK; extracellular signal-regulated kinase; Id2; inhibitor of DNA binding (differentiation)2; MAPK; mitogen-activated protein kinase; MEK1; mitogen-activated protein kinase kinase 1; MKP-1; mitogen-activated protein kinase phosphatase-1; MRF; myogenic reg
The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression
Keywords: APR; acute-phase reaction; APP; acute-phase protein; IL; interleukin; EGFR; epidermal growth factor receptor; AR; amphiregulin; OSM; oncostatin M; STAT; signal transducer and activator of transcription; TNF; tumour necrosis factor; JAK; Janus-activated ki
DNA double-strand breaks in meiosis: Checking their formation, processing and repair
Keywords: Double-strand breaks; Meiosis; Checkpoint; CDK; Mek1; Rad53
MAP kinase: It’s been longer than fifteen minutes
Keywords: MAP kinase; Cell cycle; MEK1; MEK2; ERK1; ERK2
Sodium selenite inhibits γ-secretase activity through activation of ERK
Keywords: Alzheimer's disease; Amyloid-β; MEK1; Nicastrin; Presenilin-1; C99; Phosphorylation
WNK2 modulates MEK1 activity through the Rho GTPase pathway
Keywords: ERK1/2; MAP kinase pathway; MEK1; PAK1; Rac1; RhoA; WNK protein kinases; WNK2;
Thrombocytes respond to lipopolysaccharide through Toll-like receptor-4, and MAP kinase and NF-κB pathways leading to expression of interleukin-6 and cyclooxygenase-2 with production of prostaglandin E2
Keywords: Thrombocytes; Toll-like receptor-4; Interleukin-6; Cyclooxygenase-2; Prostaglandin E2; MEK1; NF-κB
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors
Keywords: Anticancer; MEK1; Kinase inhibitor; 3-Quinolinecarbonitriles
Constitutive CXCL12 Expression Induces Anoikis in Colorectal Carcinoma Cells
Keywords: ECM; extracellular matrix; eGFP; enhanced green fluorescent protein; ERK1/2; extracellular-regulated kinase-1/2; FAK; focal adhesion kinase; MEK1; mitogen-activated protein kinase kinase 1; poly-HEMA; polyhydroxyethylmethacrylate; SCID; severe combined im
Surveillance mechanisms monitoring chromosome breaks during mitosis and meiosis
Keywords: Checkpoint; Double-strand breaks; Mitosis; Meiosis; Rad53; Mek1
SMAD3 expression is regulated by mitogen-activated protein kinase kinase-1 in epithelial and smooth muscle cells
Keywords: TGF; transforming growth factor; MEK1; mitogen-activated protein kinase kinase-1; ERK; extracellular signal-regulated protein kinase.; MEK1; SMAD3; Inflammation; Fibrosis; Airway epithelium; Smooth muscle;
Expression and purification of phosphorylated and non-phosphorylated human MEK1
Keywords: MEK1; MAPK; Kinase; Raf-BXB; Phosphorylation; Circular dichroism; Baculovirus
Pyrrolopyridazine MEK inhibitors
Keywords: MEK inhibitor; MEK1; Pyrrolopyridazine
Regulation of PrPC expression: Nerve growth factor (NGF) activates the prion gene promoter through the MEK1 pathway in PC12 cells
Keywords: Prnp gene; Expression; Rat brain; PC12 cells; NGF; MEK1
Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors
Keywords: Isothiazoles; 3-Hydroxy-isothiazoles; Cancer; MEK1; MAPK; Protein kinases
α2-Adrenergic receptor subtype-specific activation of NF-κB in PC12 cells
Keywords: α2-ARs; α2-adrenergic receptors; GPCR; G-protein coupled receptor; CNS; central nervous system; KO; knock-out; MAPK; mitogen-activated protein kinase; AP-1; activator protein-1; NF-κB; nuclear factor-kappaB; PI-3K; phosphatidyl inositol-3â²OH kinase;