کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4350520 | 1296988 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α2-Adrenergic receptor subtype-specific activation of NF-κB in PC12 cells
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کلمات کلیدی
GPCRMAPK/ERK kinase 1MEK1PI-3KPTXAP-1NF-κBNGFERKFBSERK1/2 - ERK1 / 2G-protein coupled receptor - G-پروتئین همراه گیرندهMAPK - MAPKCNS - دستگاه عصبی مرکزیfetal bovine serum - سرم جنین گاوpertussis toxin - سموم سورافنیcentral nervous system - سیستم عصبی مرکزیnerve growth factor - فاکتور رشد عصبnuclear factor-kappaB - فاکتور هسته ای - kappaBknock-out - ناک اوتactivator protein-1 - پروتئین فعال کننده-1mitogen-activated protein kinase - پروتئین کیناز فعال با mitogenextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیα2-adrenergic receptor - گیرنده α2-adrenergicα2-adrenergic receptors - گیرنده های α2-adrenergic
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
In the present study we sought to investigate the signal transduction mechanisms that underlie the α2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. α2-ARs induced NF-κB transcriptional activity and p21waf-1 gene transcription in the same subtype-specific manner (α2A < α2B < α2C) as the neuronal differentiation induced by these receptors. Following pretreatment with the MEK1 inhibitor PD98059, the NF-κB response to epinephrine becomes uniform with loss of subtype specificity. In contrast, there is complete abolishment of epinephrine-induced transcription by NF-κB after pretreatment with the PI3-K inhibitor LY294002. These data imply that induction of transcription by NF-κB is PI-3K-dependent; however, the subtype-specific induction of transcription by NF-κB is ERK1/2-dependent. Taken together, these results suggest that the three α2-adrenoceptors promote an interaction between PI-3K and ERK1/2 in a subtype-specific way, leading to subtype-specific induction of transcription by NF-κB and p21waf-1 gene transcription, which might underlie the subtype-specific differentiation of PC12 cells induced by these receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 402, Issue 3, 24 July 2006, Pages 210-215
Journal: Neuroscience Letters - Volume 402, Issue 3, 24 July 2006, Pages 210-215
نویسندگان
Anastasios Lymperopoulos, Georgios Karkoulias, Walter J. Koch, Christodoulos S. Flordellis,