Keywords: فعال سازی متابولیک; Susceptibility; Circadian; Xenobiotics; Disinfection; Cosinor; Liver clock; Toxication; Metabolic activation;
مقالات ISI فعال سازی متابولیک (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: فعال سازی متابولیک; Pyrrolizidine alkaloids; Hepatotoxicity; Metabolic activation; Reactive metabolites; Hepatic sinusoidal endothelial cell damage; Pyrrole-protein adductsCYP, cytochrome P450; DABA, 4-(dimethylamino)benzaldehyde; DHPA, dehydropyrrolizidine alkaloid; DHR, de
Keywords: فعال سازی متابولیک; Methyleugenol; Metabolic activation; Glutathione conjugates; Cysteine conjugates; Reactive metabolites; Mechanism actionME, methyleugenol; GSH, glutathione; GS-1′OME, 3′-(glutathione-S-yl)-1′-oxo-2′,3′-dihydromethyleugenol; GSTs, glutathione-S -transferas
Keywords: فعال سازی متابولیک; Metabolic activation; Reactive metabolite; Cytochrome P450; Drug-induced toxicity; Structural alerts
Keywords: فعال سازی متابولیک; Genotoxicity; Mutagenicity; Dose-response; Metabolic activation; Threshold; Micronucleus assay; HPRT assay
Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies
Keywords: فعال سازی متابولیک; 2D; two-dimensional; 3D; three-dimensional; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; BCG; bromocresol green; CBMN; cytokinesis-blocked micronucleus; CBPI; cytokinesis-block proliferation index; CYP; cytochrome P450; DMSO; dimethyl sulfoxide;
A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies
Keywords: فعال سازی متابولیک; 2D; two-dimensional; 3D; three-dimensional; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; BCG; bromocresol green; CBMN; cytokinesis-blocked micronucleus; CBPI; cytokinesis-block proliferation index; CYP; cytochrome P450; DMSO; dimethyl sulfoxide;
Assessment of the predictive capacity of the optimized in vitro comet assay using HepG2 cells
Keywords: فعال سازی متابولیک; In vitro comet assay; Predictivity; HepG2 cell line; Metabolic activation; Post-incubation;
Simultaneous determination of gemcitabine prodrug, gemcitabine and its major metabolite 2â², 2â²-difluorodeoxyuridine in rat plasma by UFLC-MS/MS
Keywords: فعال سازی متابولیک; Gemcitabine; Prodrug; Metabolic activation; UFLC-MS/MS; Nucleoside;
Identification of 5-hydroxymethylfurfural in cigarette smoke extract as a new substrate metabolically activated by human cytochrome P450 2A13
Keywords: فعال سازی متابولیک; CYP; cytochrome P450; CYP2A13; cytochrome P450 2A13; CYP2A5; cytochrome P450 2A5; 8-MOP; 8-methoxypsoralen; BEAS-2B; immortalized human bronchial epithelial cells; B-2A13; BEAS-2B cells stably expressing CYP2A13; CSE; cigarette smoke extract; TSNA; tobacc
Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells
Keywords: فعال سازی متابولیک; AP; Acetaminophen; CCK; 2H-Tetrazolium,5-(2,4-disulfophenyl)-3-(2-methoxy-4-nitrophenyl)-2-(4-nitrophenyl)-,innersalt,sodium salt; CYP450; Cytochrome P450; DB; Diosbulbin B; DMEM; Dulbecco's Modified Eagle Medium; DMF; N,N-Dimethylformamide; DMSO; D
One electron oxidation of 3-methylcholanthrene: A chemical model for its mechanism of carcinogenesis
Keywords: فعال سازی متابولیک; 3-Methylcholanthrene; Polycyclic aromatic hydrocarbons; One-electron oxidation; Carcinogenesis; Metabolic activation;
Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4â²-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells
Keywords: فعال سازی متابولیک; Resveratrol; DMU-212; DMU-214; Metabolic activation; CYP1A1;
The immature rat as a potential model for chemical risks to children: Ontogeny of selected hepatic P450s
Keywords: فعال سازی متابولیک; Animal model; Children’s risk assessment; Cytochrome P450 ontogeny; Carbon tetrachloride; Metabolic activation; Hepatotoxicity
On the origins and development of the 32P-postlabelling assay for carcinogen–DNA adducts
Keywords: فعال سازی متابولیک; Carcinogens; DNA adducts; Metabolic activation; Biomonitoring
Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma
Keywords: فعال سازی متابولیک; PCB; 32P-postlabeling; Metabolic activation; Gene mutation; Genotoxicity
Development and validation of an in vitro micronucleus assay platform in TK6 cells
Keywords: فعال سازی متابولیک; In vitro micronucleus assay; Aneugen; Clastogen; Metabolic activation; Lymphoblastoid cell line; TK6;
A carbamate-based approach to primaquine prodrugs: Antimalarial activity, chemical stability and enzymatic activation
Keywords: فعال سازی متابولیک; Malaria; Primaquine; Prodrugs; Carbamates; Chemical stability; Metabolic activation;
Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: Results with model toxicants aflatoxin B1, cyclo
Keywords: فعال سازی متابولیک; Animal alternatives; In vitro toxicology; Metabolic activation; Detoxification; Human hepatocytes
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I
Keywords: فعال سازی متابولیک; AHR; aryl hydrocarbon receptor; AA; aristolochic acid; AAI; aristolochic acid I; AAIa; aristolochic acid Ia; AAN; aristolochic acid nephropathy; ARE; antioxidant response element (also known as EpRE, electrophile response element); BEN; Balkan endemic nep
Effects of general and local fatigue on postural control: A review
Keywords: فعال سازی متابولیک; Fatigue; Exercise; Muscle; Muscular contraction; Muscle strength; Metabolic activation; Muscle acidity; Postural control; Balance; Posture; Somatosensory afferences; Proprioception; Visual information; Vestibular information; Postural sway; Centre of foot
The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells
Keywords: فعال سازی متابولیک; Silver nanoparticles; Titanium dioxide nanoparticles; Cellular binding/uptake; Metabolic activation; Cell death; Agglomeration
Ipso substitution of bisphenol A catalyzed by microsomal cytochrome P450 and enhancement of estrogenic activity
Keywords: فعال سازی متابولیک; Bisphenol A; Cytochrome P450; Estrogenic activity; Metabolic activation
Isolation and structural identification of a direct-acting mutagen derived from N-nitroso-N-methylpentylamine and Fenton's reagent with copper ion
Keywords: فعال سازی متابولیک; N-Nitrosodialkylamine; Metabolic activation; Nitric oxide; Hydroxyl radical; Fenton's reagent; Pyrazoline;
A viability assay for Candida albicans based on the electron transfer mediator 2,6-dichlorophenolindophenol
Keywords: فعال سازی متابولیک; Complex I activity; Respiratory chain inhibitors; Candida glabrata; Saccharomyces cerevisiae; NADH dehydrogenases; Metabolic activation
Astaxanthin can alter CYP1A-dependent activities via two different mechanisms: Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer
Keywords: فعال سازی متابولیک; Ax; astaxanthin; B[a]P; benzo[a]pyrene; CYP; cytochrome P450; DCNB; 1,2-dichloro-4-nitrobenzene; EROD; ethoxyresorufin O-deethylase; GSH; reduced glutathione; GST; glutathione S-transferase; UDPGA; glucuronic acid trisodium salt; UGT; UDP-glucuronosyltran
Different sensitivity of BALB/c 3T3 cell clones in the response to carcinogens
Keywords: فعال سازی متابولیک; Cell transformation assay; Alternative methods; Carcinogens; Metabolic activation; REACHACE, absolute clonal efficiency; B(a)P, benzo(a)pyrene; 1,2-DBE, 1,2 dibromoethane; CTA, cell transformation assay; GSH, glutathione; 3-MCA, 3-methylcholanthrene; MEL,
Zebrafish (Danio rerio) embryos as a model for testing proteratogens
Keywords: فعال سازی متابولیک; Zebrafish; Metabolic activation; Proteratogen; Teratogenic; Embryotoxic
Herbal bioactivation, molecular targets and the toxicity relevance
Keywords: فعال سازی متابولیک; Herbal medicine; Metabolic activation; Target; Cytochrome P450; ToxicityAA, aristolochic acids; CYP, cytochrome P450; GSH, glutathione; GST, glutathione S-transferase; HPA, hydroxyphenylacetaldehyde; Ki, apparent inhibition constant; SULT, sulfotransferas
Activation mechanism for N-nitroso-N-methylbutylamine mutagenicity by radical species
Keywords: فعال سازی متابولیک; N-Nitroso-N-methylbutylamine; Metabolic activation; Nitric oxide; Hydroxyl radical; Fenton's reagent;
In vivo estrogenic potential of 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, an active metabolite of bisphenol A, in uterus of ovariectomized rat
Keywords: فعال سازی متابولیک; Bisphenol A; Estrogenic activity; Metabolic activation; Uterotrophic assay; OVX rat
Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing
Keywords: فعال سازی متابولیک; Embryonic stem cell test; Alternative test method; Co-culture; Metabolic activation; Proteratogen
Air pollution particulate matter (PM2.5)-induced gene expression of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in an in vitro coculture lung model
Keywords: فعال سازی متابولیک; Healthy outpatients; Bronchoalveolar lavage; Alveolar macrophage; L132 cell; Coculture; Particulate matter; Metabolic activation; Volatile organic compounds; Polycyclic aromatic hydrocarbons
Application of a metabolizing system as an adjunct to the rat whole embryo culture
Keywords: فعال سازی متابولیک; Whole embryo culture; Biotransformation; Metabolic activation; Rat
Metabolic activation of PCBs to carcinogens in vivo—A review
Keywords: فعال سازی متابولیک; PCB; Carcinogenesis; In vivo; Mutation; Transgenic rat; 4-monochlorobiphenyl; Metabolic activation
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice
Keywords: فعال سازی متابولیک; AhR receptor; Gene targeting; Chemical carcinogenesis; CYP1A1; AhR; Transcription; Metabolic activation; Polyaromatic hydrocarbon; Super-induction; Transcription repression
Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay
Keywords: فعال سازی متابولیک; Comet assay; Human hepatoma cells; Genotoxic carcinogens; Metabolic activation; Enzyme expression
Metabolic activation promotes estrogenic activity of the phytoestrogen-rich plant
Keywords: فعال سازی متابولیک; Phytoestrogen; Isoflavonoid; Pueraria mirifica; MCF-7; Metabolic activation; S9 mixture
Gene expression induction of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in isolated human alveolar macrophages in response to airborne particulate matter (PM2.5)
Keywords: فعال سازی متابولیک; Healthy outpatients; Bronchoalveolar lavage; Alveolar macrophage; Particulate matter; Cytotoxicity; Metabolic activation; Volatile organic compounds; Polycyclic aromatic hydrocarbons
The metabolic activation of 2-aminofluorine, 4-aminobiphenyl, and benzidine by cytochrome P-450-107S1 of Pseudomonas aeruginosa
Keywords: فعال سازی متابولیک; Pseudomonas aeruginosa; Metabolic activation; Cytochrome P-450; Procarcinogens
No induction of structural chromosomal aberrations in cylindrospermopsin-treated CHO-K1 cells without and with metabolic activation
Keywords: فعال سازی متابولیک; Cylindrospermopsin; Metabolic activation; Chromosomal aberrations; Mitotic index; Apoptosis; Necrosis; CHO-K1 cells
Ambient particulate matter (PM2.5): Physicochemical characterization and metabolic activation of the organic fraction in human lung epithelial cells (A549)
Keywords: فعال سازی متابولیک; A549 cells; Particulate matter; Physical and chemical characteristics; Cytotoxicity; Metabolic activation; Volatile organic compounds; Polycyclic aromatic hydrocarbons
In vitro basal and metabolism-mediated cytotoxicity of flavonoids
Keywords: فعال سازی متابولیک; Flavonols; Cytotoxicity; S9; Metabolic activation
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1
Keywords: فعال سازی متابولیک; Anti-cancer drugs; Metabolic activation; Colon cancer; Lung cancer; Arachidonic acid;
The combined use of human neural and liver cell lines and mouse hepatocytes improves the predictability of the neurotoxicity of selected drugs
Keywords: فعال سازی متابولیک; Neurotoxicity in vitro; Metabolic activation; Amitriptyline; Selegiline; Paracetamol; Carbamazepine
Metabolic activation of bladder procarcinogens, 2-aminofluorene, 4-aminobiphenyl, and benzidine by Pseudomonas aeruginosa and other human endogenous bacteria
Keywords: فعال سازی متابولیک; Procarcinogens; Metabolic activation; Human endogenous bacteria; Cytochrome P450
Evaluation of DNA damage induced by atrazine and atrazine-based herbicide in human lymphocytes in vitro using a comet and DNA diffusion assay
Keywords: فعال سازی متابولیک; Atrazine; Genotoxicity; Apoptosis; Human lymphocytes; Comet assay; DNA diffusion assay; Metabolic activation
CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons
Keywords: فعال سازی متابولیک; MC; Atherosclerosis; Metabolic activation; AHR; siRNA; Quantitative RT-PCR; Luciferase assay;
Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108
Keywords: فعال سازی متابولیک; Areca nut; Betel leaf; 3-(N-Nitrosomethylamino)propionitrile; 3-(N-Nitrosomethylamino)propionaldehyde; N-Nitrosoguvacoline; Metabolic activation; Genetically engineered S. typhimurium; CPR; NADPH-cytochrome P450 reductase (EC 1.6.2.4, NADPH:ferrihemoprote
Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene
Keywords: فعال سازی متابولیک; Polycyclic aromatic hydrocarbons; Chemiluminescence immunoassay; Metabolic activation; Cell culture; Carcinogenesis; DNA damage; BP; benzo[a]pyrene; BP-7,8-oxide; benzo[a]pyrene-7,8-epoxide; BP-7,8-dihydrodiol; trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyren