Keywords: متیل لیکاکونیتین; APD; antipsychotic drugs; NOR; novel object recognition; nAChR; nicotinic acetylcholine receptor; SGA; second-generation antipsychotics; FGA; first-generation antipsychotics; MLA; methyllycaconitine; MRM; multiple reaction monitoring; Antipsychotic; Cogni
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Keywords: متیل لیکاکونیتین; Larkspur; Delphinium; Goats; Methyllycaconitine; Deltaline; Toxicokinetics; IV dosing; Oral dosing;
Keywords: متیل لیکاکونیتین; ACh; acetylcholine; ALS; amyotrophic lateral sclerosis; DHβE; dihydro-beta-erythroidine; DHR 123; dihydrorhodamine; EAATs; excitatory amino acid transporters; HMs; hypoglossal motoneurons; MLA; methyllycaconitine; MTT; mitochondrial toxicity test; nAChR;
Keywords: متیل لیکاکونیتین; α7 nAChR; alpha-7 nicotinic acetylcholine receptor; AKT; protein kinase B; ANOVA; analysis of variance; CNS; central nervous system; CREB; cAMP response element-binding protein; DMSO; dimethylsulfoxide; ELISA; enzyme-linked immuno sorbent assay; GFAP; gl
Keywords: متیل لیکاکونیتین; 4-AP; 4-aminopyridine; ACC; anterior cingulate cortex; aCSF; artificial cerebral spinal fluid; ANOVA; analysis of variance; APV; D-1-2-amino-5-phosphonopentanoic acid; ATP; adenosine triphosphate; BDNF; brain-derived neurotrophic factor; CSD; current-sour
Keywords: متیل لیکاکونیتین; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; one-way analysis of variance; APV; DL-2-amino-5-phosphonopentanoic acid; BSA; bovine serum albumin; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; DHβE; dihydro-β-erythroidine; EPSCs; exci
Keywords: متیل لیکاکونیتین; Memory; Memory consolidation; Memory reconsolidation; Mice; Inhibitory avoidance; Acetylcholine; Alpha7 nicotinic receptors; Choline; Methyllycaconitine; Hippocampus
Keywords: متیل لیکاکونیتین; α7nAChR; α7 nicotinic acetylcholine receptor; α-SMA; α smooth muscle actin; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BDL; bile duct ligated; DAB; diaminobenzidine; ISPP; intrasplenic pulp pressure; MLA; methyllycaconitine; MCP-1
Keywords: متیل لیکاکونیتین; [125I]-αBGT; [125I]-α-bungarotoxin; ACh; acetylcholine; AChE; acetylcholinesterase; ANOVA; analysis of variance; ATR; atropine; CA1; cornus ammonis 1 of hippocampus; DAPC; dystrophin-associated glycoprotein complex; DHBE; dihydro-β-erythroidine; DMD; D
Keywords: متیل لیکاکونیتین; Neuroprotection; Retina; Excitotoxicity; Retinal ganglion cells; Tropisetron; Pig; ACh; acetylcholine; AEBSF; 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride; α7 nAChR; alpha7 nicotinic acetylcholine receptor; ANOVA; analysis-of-variance; EDTA; e
Keywords: متیل لیکاکونیتین; Larkspur; Delphinium; Cattle; Goats; Sheep; Methyllycaconitine; Deltaline; Toxicokinetics
3,4-Methylenedioxymethamphetamine (MDMA) Alters Synaptic Dopamine Release in the Dorsal Striatum Through Nicotinic Receptors and DAT Inhibition
Keywords: متیل لیکاکونیتین; CPA; constant potential amperometry; DA; dopamine; DAT; dopamine transporter; DHβE; dihydroβerythroidine; MDMA; 3,4-methylenedioxymethamphetamine; MLA; methyllycaconitine; nAchR; nicotinic acetylcholine receptor; SNpc; substantia nigra pars compact; 3,4
Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms
Keywords: متیل لیکاکونیتین; AChR; nicotinic acetylcholine receptor; ACh; acetylcholine; TCAs; tricyclic antidepressants; α-BTx; α-bungarotoxin; MLA; methyllycaconitine; RT; room temperature; IC50; ligand concentration that produces 50% inhibition (of binding or of agonist activati
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice
Keywords: متیل لیکاکونیتین; Major depression; Nicotinic receptor; Microglia; α7 positive allosteric modulator; Neuroinflammation; Mice; MDD; major depressive disorder; CNS; central nervous system; LPS; lipopolysaccharide; nAChR; nicotinic acetylcholine receptor; PAM; positive allos
The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-β-erythroidine
Keywords: متیل لیکاکونیتین; Nicotine; Rhesus monkey; Drug discrimination; Varenicline; Schild analysis; DHβE; dihydro-β-erythroidine; FR; fixed ratio; nAChR; nicotinic acetylcholine receptor; MLA; methyllycaconitine;
Varenicline promotes endothelial cell migration by lowering vascular endothelial-cadherin levels via the activated α7 nicotinic acetylcholine receptor-mitogen activated protein kinase axis
Keywords: متیل لیکاکونیتین; nAChR; nicotinic acetylcholine receptor; HUVECs; human umbilical vein endothelial cells; VE-cadherin; vascular endothelial-cadherin; MLA; methyllycaconitine; DHβE; dihydro-β-erythroidine hydrobromide; ERK; extracellular signal-regulated kinase; MAPK; mi
Thujone inhibits the function of α7-nicotinic acetylcholine receptors and impairs nicotine-induced memory enhancement in one-trial passive avoidance paradigm
Keywords: متیل لیکاکونیتین; ACh; Acetylcholine; ANOVA; analysis of variance; BAPTA; 1,2-bis (o-aminophenoxy) ethane-N N N' N'-tetraacetic acid; HEPES; 4-(2-hydroxyethyl) piperazineethane sulfonic acid; MLA; methyllycaconitine; MBS; modified Barth's solution; Nicotinic receptor
Evidence of BrdU-positive retinal neurons after application of an Alpha7 nicotinic acetylcholine receptor agonist
Keywords: متیل لیکاکونیتین; BrdU; bromodeoxyuridine; IOP; intraocular pressure; IPL; interplexiform layer; MLA; methyllycaconitine; ONH; optic nerve head; RGCs; retinal ganglion cells; alpha7 nAChRs; Müller glia; retinal ganglion cells; BrdU; retina; Long Evans rats;
Varenicline enhances oxidized LDL uptake by increasing expression of LOX-1 and CD36 scavenger receptors through α7 nAChR in macrophages
Keywords: متیل لیکاکونیتین; nAChR; nicotinic acetylcholine receptor; oxLDL; oxidized low-density lipoprotein; LOX-1; lectin-like oxidized LDL receptor-1; CD36; cluster of differentiation 36; SR-A; scavenger receptor class A; MLA; methyllycaconitine; DHβE; dihydro-β-erythroidine hy
Tropisetron sensitizes α7 containing nicotinic receptors to low levels of acetylcholine in vitro and improves memory-related task performance in young and aged animals
Keywords: متیل لیکاکونیتین; Alzheimer's disease; Aging; Cognition; Non-human primate; Rat; Xenopus oocytes; ACh; acetylcholine; AChEI; acetylcholinesterase inhibitor; DMTS; delayed match to sample; MCI; mild cognitive impairment; MLA; methyllycaconitine; nAChR; nicotinic acetylcholi
α4β2â nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex
Keywords: متیل لیکاکونیتین; 5-IA; 5-iodo-3-[2(S)-azetidinylmethoxy]pyridine; ACh; acetylcholine; ADNFLE; autosomal dominant nocturnal frontal lobe epilepsy; AHP; after-hyperpolarization; AP; action potential; AP5; d(â)-2-amino-5-phosphono-pentanoic acid; BSA; bovine serum albumin;
Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
Keywords: متیل لیکاکونیتین; ACh; acetylcholine; AP; action potential; APV; (2R)-amino-5-phosphonovaleric acid; DHβE; dihydro-β-erythroidine; DNQX; 6,7-dinitroquinoxaline-2,3-dione; EK; potassium equilibrium potential; GABA; γ-aminobutyric acid; HM; hypoglossal motoneuron; Ih; hyp
BAG2 expression dictates a functional intracellular switch between the p38-dependent effects of nicotine on tau phosphorylation levels via the α7 nicotinic receptor
Keywords: متیل لیکاکونیتین; CHRNA7; SH-SY5Y; Primary cell culture; Hippocampus; Methyllycaconitine; Mecamylamine; SB203580; Alzheimer's disease
Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content
Keywords: متیل لیکاکونیتین; 5-HT; 5-hydroxytryptamine (serotonin); m5-HT3AR; murine serotonin type 3A receptor; AChR; nicotinic acetylcholine receptor; ACh; acetylcholine; NMDAR; N-methyl-D-aspartate receptor; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; NI
Enantioselective synthesis of BE ring analogues of methyllycaconitine
Keywords: متیل لیکاکونیتین; Multi-component reaction; Quinolones; Methyllycaconitine; Enantioselective synthesis;
Administration of nicotinic receptor antagonists during the period of memory consolidation affects passive avoidance learning and modulates synaptic efficiency in the CA1 region in vivo
Keywords: متیل لیکاکونیتین; DHβE; dihydro-β-erythroidine; fEPSP; field excitatory postsynaptic potential; i.c.v.; intracerebroventricular; LLP; long-lasting potentiation; MLA; methyllycaconitine; mecamylamine; dihydro-β-erythroidine (DHβE); hippocampus; nAChR; consolidation; mem
Induction of long-term oscillations in the γ frequency band by nAChR activation in rat hippocampal CA3 area
Keywords: متیل لیکاکونیتین; γ oscillation; neural network oscillation at γ frequency band; ACSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; D-AP5; D-(â)-2-amino-5-phosphonopentanoic acid; DhβE; dihydro-β-erythroidine; GABA; gamma-aminobutyric acid; KA; kainate;
The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors
Keywords: متیل لیکاکونیتین; Nicotinic acetylcholine receptor; Ion channel; Allosteric modulation; Pharmacology; 4BP-TQS; cis-cis-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide; MLA; methyllycaconitine; nAChR; nicotinic acetylcholine receptor; NS-1738;
Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice
Keywords: متیل لیکاکونیتین; ACh; acetylcholine; AChEI; acetylcholine-esterase inhibitor; AD; Alzheimer's disease; ASC; alcoholic-saturated sodium chloride; Aβ; beta-amyloid; cDNA; complementary DNA; Gal; Galantamine; MLA; Methyllycaconitine; MWM; Morris water maze; nAChRs; nicoti
Varenicline aggravates plaque formation through α7 nicotinic acetylcholine receptors in ApoE KO mice
Keywords: متیل لیکاکونیتین; nAChRs; nicotinic acetylcholine receptors; ApoE KO mice; apolipoprotein E knockout mice; MLA; methyllycaconitine; Varenicline; Adverse cardiovascular effect; Atherosclerosis; α7 nAChR;
Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction
Keywords: متیل لیکاکونیتین; ACh; acetylcholine; nAChR; nicotinic acetylcholine receptor; cyt c; cytochrome c; DhβE; dihydro-β-erythroidine; MLA; methyllycaconitine; MPTP; mitochondria permeability transition pore; CaMKII; calcium-calmodulin-dependent kinase; PI3K; phosphatidylinos
SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity
Keywords: متیل لیکاکونیتین; Acetylcholine; Mononuclear cells; Methyllycaconitine; Proliferation; T cells
Review articleTargeting the α7 nicotinic acetylcholine receptor to prevent progressive dementia and improve cognition in adults with Down's syndrome
Keywords: متیل لیکاکونیتین; DS; Down's syndrome; AD; Alzheimer's disease; α7nAChRs; α7 nicotinic acetylcholine receptor; PAM; Positive allosteric modulator; APP; Amyloiod precursor protein; MLA; Methyllycaconitine; 3H-MLA; 3H-methyllycaconitine; RAGE; Receptor for advanced gly
Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice
Keywords: متیل لیکاکونیتین; I/R; ischemia-reperfusion; 5-HT; 5-hydroxytryptamine; IPC; ischemic preconditioning; SERT; serotonin re-uptake transporter; nAchR; nicotinic receptor; MLA; methyllycaconitine; SMA; superior mesenteric artery; MPO; myeloperoxidase; MDA; malondialdehyde;
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade
Keywords: متیل لیکاکونیتین; AChE; acetylcholinesterase; AD; Alzheimer's disease; B12H; bis(12)-hupyridone; CGNs; cerebellar granule neurons; DHβE; dihydro-β-erythroidine; GSK3β; glycogen synthase kinase 3β; mAChR; muscarinic acetylcholine receptor; MLA; methyllycaconitine; NMD
The effect of low larkspur (Delphinium spp.) co-administration on the acute toxicity of death camas (Zigadenus spp.) in sheep
Keywords: متیل لیکاکونیتین; Death camas; Larkspur; Zigadenus; Delphinium; Methyllycaconitine; Zygacine; Sheep;
Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells
Keywords: متیل لیکاکونیتین; nAChR; nicotinic acetylcholine receptor; MLA; methyllycaconitine; MEC; mecamylamine; d-Ser; d-serine; m-SR; monomeric serine racemase; d-SR; dimeric serine racemase; DHNK; dehydronorketamine; Serine racemase; d-Serine; Nicotinic acetylcholine receptors; m
Effect of α7 nicotinic acetylcholine receptor agonists and antagonists on motor function in mice
Keywords: متیل لیکاکونیتین; MLA, methyllycaconitineNicotine; Anabasine; Methyllycaconitine; Deltaline; Motor function; Alpha 7 nicotinic acetylcholine receptor
Methyllycaconitine: A non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors — In vivo target localization and biodistribution in rat brain
Keywords: متیل لیکاکونیتین; ABBF (N-[(3R)-1-azabicyclo [2.2.2] oct-3-yl]-7-[2-(methoxy) phenyl]-1-benzofuran-2-carboxamide); α7 nAChRs; LC–MS/MS; Methyllycaconitine; Nicotine; PNU282987 (N-[(3R)-1-azabicyclo [2.2.2] oct-3-yl]-4-chlorobenzamide)
The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia
Keywords: متیل لیکاکونیتین; LPS; lipopolysaccharide; MLA; methyllycaconitine; MAPK; mitogenâactivated protein kinase; nAChR; nicotinic acetylcholine receptor; PAM; positive allosteric modulator; HFIP; 1,1,1,3,3,3âhexafluoroâ2âpropanol; Nicotinic acetylcholine receptor; Infla
Anti-amnesic effect of neurosteroid PREGS in Aβ25-35-injected mice through Ï1 receptor- and α7nAChR-mediated neuroprotection
Keywords: متیل لیکاکونیتین; Pregnenolone sulfate (PREGS); β-Amyloid (Aβ); α7 nicotinic acetylcholine receptor (α7nAChR); Sigma-1 receptor (Ï1R); AD; Alzheimer's disease; Aβ; β-amyloid; DMXB; 3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride; LY294002; 2-(4-morpholinyl)-
An efficient synthesis of 3-alkyl-1,5,3-dioxazepanes and their use as electrophiles in double-Mannich reactions
Keywords: متیل لیکاکونیتین; Methyllycaconitine; Double-Mannich reactions; Dioxazepanes; Azabicyclo[3.3.1]nonanes; Bis(aminol)ethers;
Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo
Keywords: متیل لیکاکونیتین; Cigarette smoke; nicotine; nicotinic acetylcholine receptors; γ-aminobutyric acid receptors; acetylcholine; airway mucus; AB/PAS; Alcian blue/periodic acid-Schiff; ALI; Air-liquid interface; GABAAR; γ-Aminobutyric acid type A receptor; GAPDH; Glycera
Different presynaptic nicotinic receptor subtypes modulate in vivo and in vitro the release of glycine in the rat hippocampus
Keywords: متیل لیکاکونیتین; AUC; area under the curve; Ch; choline; DHβE; dihydro-β-erythroidine; GLY; glycine; GLYRs; glycine receptors; 5IA85380; 5-IA85380 dihydrochloride; MLA; methyllycaconitine; nAChR; nicotinic ACh receptor; PHA543613; PHA-543613 hydrochloride; Synaptosomes;
The enantioselective synthesis of tetracyclic methyllycaconitine analogues
Keywords: متیل لیکاکونیتین; Methyllycaconitine; Diels-Alder reaction; Enantioselective; Semi-synthesis; Cobalt(III) salen catalyst;
Activation of the α7-Nicotinic Acetylcholine Receptor Reverses Complete Freund Adjuvant–Induced Mechanical Hyperalgesia in the Rat Via a Central Site of Action
Keywords: متیل لیکاکونیتین; α7-Nicotinic acetylcholine receptor; inflammatory pain; complete Freund adjuvant–induced hyperalgesia; mecamylamine; methyllycaconitine
Pharmacological and immunological identification of native α7 nicotinic receptors: Evidence for homomeric and heteromeric α7 receptors
Keywords: متیل لیکاکونیتین; Nicotinic acetylcholine receptor; Binding; Adrenal medulla; Methyllycaconitine; α-Bungarotoxin; α7
Toxic Alkaloid Concentrations in Delphinium Nuttallianum, Delphinium Andersonii, and Delphinium Geyeri in the Intermountain Region
Keywords: متیل لیکاکونیتین; diterpenoid alkaloids; cattle; larkspur; poisonous plants; methyllycaconitine;
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs
Keywords: متیل لیکاکونیتین; Methyllycaconitine; α7 nAChR; Antagonist; MLA analogs
α7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation
Keywords: متیل لیکاکونیتین; α7 nicotinic receptors; recombinant adeno-associated virus; ACSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; FBS; fetal bovine serum; GFP; green fluorescent protein; gp; genomic particle; KO; knockout; KRH; Krebs Ringer buffer; MLA; methy