Keywords: Glioblastoma; MGMT; Repositioning of drugs; Precision medicine; Biomarker; Radiomics; Treatment resistance; Immunotherapy;
مقالات ISI (ترجمه نشده)
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Keywords: Sporadic/hereditary pituitary tumors; Whole genome/exome sequencing; USP8 mutation; Pituitary adenoma progression; Pituitary carcinoma; Pituitary tumor senescence; AIP; aryl hydrocarbon-interacting protein; BC; bromocriptine; bFGF; basic fibroblast growth
Keywords: ABCB1; ATP-binding cassette sub-family B member 1; ABCG; ATP-binding cassette drug efflux transporters; ACD; autophagic cell death; AKT; alpha serine/threonine protein kinase; ALDH; aldehyde dehydrogenase; AMPK; AMP-activated protein kinase; AP; apurinic/
Keywords: Anticancer activity; Apoptosis; DNA repair; Glioblastoma; Seaweed compounds; Temozolomide; AIC; 5-aminoimidazole-4-carboxamide; Akt; Protein kinase B (PKB); AP site; apurinic/apyrimidinic site; AP-1; activator protein-1; APE-1; AP endonuclease; Bax; Bcl-2
Keywords: A; astrocytoma; AA; anaplastic astrocytoma; AO; anaplastic oligodendroglioma; AOA; anaplastic oligoastrocytoma; EGFR; epidermal growth factor receptor; FISH; fluorescence in situ hybridization; MGMT; O6-methylguanine-DNA methyltransferase; MMP9; matrix me
Keywords: ACSVL3; acyl-coA synthetase VL3; ALDH1; aldehyde dehydrogenase; ALDOA; aldolase A; ALDOC; aldolase C; AMPK; 5â² AMP-activated protein kinase; ASNS; asparagine synthetase; BTICs; brain tumor initiating cells; 3-BrOP; 3-bromo-2-oxopropionate-1-propyl ester
Keywords: Chemotherapy; Gliosarcoma; MGMT; Prognosis; Radiotherapy; GBM; Glioblastoma; KPS; Karnofsky Performance Scale; MGMT; Methylguanine DNA methyl transferase; OS; Overall survival; PFS; Progression-free survival;
Keywords: GBM; glioblastoma multiforme; TMZ; temozolomide; MGMT; O6 methylguanine- DNA methyltransferase; HDAC; histone deacetylase; HDACI; HDAC inhibitor; HMG-CoA; 3-hydroxy-3-methylglutaryl-CoA; VPA; valproic acid; ROS; reactive oxygen species; NaB; sodium butyra
Keywords: Age; Glioblastoma; Long-term survival; Loss of 19q; MGMT; Subventricular zone involvement; CAN; Copy number aberration; CGH; Comparative genomic hybridization; DNA; Deoxyribonucleic acid; FFPE; Formalin-fixed paraffin-embedded; GB; Glioblastoma; IDH; Isoc
Keywords: EORTC; European Organisation for Research and Treatment of Cancer; FDA; Food and Drug Administration; GBM; glioblastoma multiforme; GFR; growth factor receptor; IDH; isocitrate dehydrogenase gene; KPS; Karnofsky Performance Status; MGMT; O6-methylguanine-
Keywords: Recurrent malignant glioma; ATRX; Alpha thalassemia/mental retardation syndrome X-linked; Bev; Bevacizumab; CNS; Central nervous system; EGFR; Epidermal growth factor receptor; GBM; Glioblastoma multiforme; Gy; Gray; HRQoL; Health-related quality of life;
Keywords: BAL; bronchoalveolar lavage; ChIA-PET; chromatin interaction analysis with paired-end tag; ChIP-seq; chromatin inmunoprecipitation and massively parallel sequencing; circ-ncRNA; circulating noncoding RNA; CRC; colorectal cancer; CRISPR-Cas9; clustered, re
Keywords: Glioblastoma; Tumor recurrence pattern; 5-ALA; 5-Aminolevulinic acid; CR; Complete resection; EORTC; European Organisation for Research and Treatment of Cancer; MGMT; Methylguanine-deoxyribonucleic acid methyltransferase; MRI; Magnetic resonance imaging
Keywords: Extent of resection; Glioblastoma; Hydrocephalus; Overall survival; Prognosis; Tumor volume; Ventricle opening; CI; Confidence interval; CSF; Cerebrospinal fluid; EOR; Extent of resection; GBM; Glioblastoma; IDH; Isocitrate dehydrogenase; KPS; Karnofsky P
Anticancer properties of sodium selenite in human glioblastoma cell cluster spheroids
Keywords: 3D culture; Three dimension cell culture; ABC; ATP-binding cassette; ANOVA; analysis of variance; AOBS; Acousto-Optical Beam Splitter; APMA; amino-phenyl mercuric acetate; BBB; blood brain barrier; BSA; bovine serum albumin; CA9; carbonic anhydrase 9; DME
Keywords: Glioblastoma; Elderly; Geriatric assessment; Temozolomide; MGMT;
Keywords: High-grade gliomas; Seizure; MGMT; EGFR;
Keywords: LS; Lynch syndrome; CRC; colorectal cancer; HNPCC; hereditary non-polyposis colon cancer; MMR; mismatch repair; FAP; familial adenomatous polyposis; CFS; cancer family syndrome; MSI; microsatellite instability; IDL; insertion/deletion loop; MSH2; human mu
Keywords: Melanoma; Liquid biopsy; Circulating tumor cells; Cell-free circulating tumor DNA; Cell-free DNA; Cell-free microRNA; Ab; antibody; AIM1; absent in melanoma-1; AJCC; American Joint Committee on Cancer; BRAF; B-Raf proto-oncogene, serine/threonine kinase;
Keywords: High-grade glioma; Overall Survival; Recurrent; Re-do Craniotomy; ADLs; Activities of daily living; EOR; Extent of resection; GBM; World Health Organization grade IV glioblastoma; GTR; Gross total resection; IRB; Institutional Review Board; MGMT; O6-methy
Keywords: Glioblastoma; MGMT; Temozolomide; Nitrosourea; Bevacizumab; Immunotherapy;
Keywords: 1p19q; Anaplastic gliomas; IDH1; MGMT; Prognosis; Recurrence; Temozolomide
Keywords: CCA; cholangiocarcinoma; OS; overall survival; miRNA; microRNA; TSG; tumor suppressor genes; ICC; intrahepatic cholangiocarcinoma; OV; Opisthorchis viverrini; CpG; scytosine guanine dinucleotides; DNMT; DNA methyltransferases; EZH2; zeste homolog 2; RASSF
Keywords: AIC; Akaike information criterion; CI; confidence interval; EGFR; epidermal growth factor receptor; GBM; glioblastoma multiforme; HGG; high-grade glioma; HR; hazard ratio; IDH; isocitrate dehydrogenase; KPS; Karnofsky Performance Scale; MGMT; O-6-methylgu
Keywords: ABCB1; ATP-Binding Cassette, Sub-Family B; MDR; Multi Drug Resistance; DAPK; Death Associated Protein Kinase; APAF-1; Apoptotic Peptidase Activating Factor 1; MLH1; MutL Homolog 1; MGMT; O-6-Methylguanine-DNA Methyltransferase; KDM5A; Lysine (K)-Specific
Keywords: Base excision repair; Glioma resistance; MGMT; PARP; Temozolomide chemotherapy
Keywords: Carcinogens; Threshold; DNA repair; MGMT; Detoxification; Cell death; Apoptosis; PoD;
Keywords: Glioblastoma; Treatment; Review; Pharmacology; Targeted therapy; Stem cell; AKT; protein kinase B; BBB; blood-brain barrier; BCNU; carmustin; CCNU; lomustin; c-MET; hepatocyte growth factor receptor; EGF(R); epidermal growth factor (receptor); EGFRvIII; e
Keywords: ANXA 1; annexin A1; APA; aminopeptidase A; APN; aminopeptidase N; APP; aminopeptidase P; BBB; blood-brain barrier; CT; computed tomography; CREG1; cellular repressor of E1A-stimulated genes 1; DDL4; delta like ligand 4; DLP; dynamin-1 like protein; Eph-
Keywords: AD; Alzheimer's disease; AP site; apurinic/apyrimidinic site; APE1; apurinic/apyrimidinic endonuclease 1; Aβ; amyloid beta; BER; base excision repair; CaMKII; Ca2 +/Calmodulin-Dependent Protein Kinase II; CDK; cyclin-dependent kinase; CREB; cAMP respons
Keywords: AHR; aryl hydrocarbon receptor; AIP; aryl hydrocarbon receptor interacting protein; BMP-4; bone morphogenetic protein 4; CDK; cyclin-dependent kinases; CDKN1A; cyclin-dependent kinase inhibitor 1A; CDKN1B; cyclin-dependent kinase inhibitor 1B; CDKN2A; cyc
Keywords: ÎKG; α-ketoglutarate; AML; acute myeloid leukemia; BCAT1; branched-chain amino acid transporter 1; BRD4; bromodomain-containing protein 4; D-2HG; D-2-hydroxyglutarate or R-2-hydroxyglutarate; D-2HGA; D-2-hydroxyglutarate aciduria; D2HGDH; D-2-hydroxyglu
Keywords: AID; activation-induced cytidine deaminase; H. pylori; Helicobacter pylori; IARC; International Agency for Research on Cancer; GI; gastrointestinal; CI; confidence interval; KLF5; Krüppel-like factor 5; VCP; valosin-containing protein; OLGA; Operative Li
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif, 9; ARID1A; AT rich interactive domain 1A (SWI-like); AML; Acute myelocytic leukemia; ATBF1; A
Keywords: Glioblastoma; Malignant gliomas; MGMT; Temozolomide; Elderly; Radiotherapy; Cognitive dysfunction
Is MGMT promoter methylation to be considered in the decision making for recurrent surgery in glioblastoma patients?
Keywords: Recurrent glioblastoma; Overall survival; Progression free survival; Reoperation; MGMT; Gross total resection;
The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review
Keywords: Glioblastoma; MGMT; IDH1; IDH2; TERT; BRAF; High grade gliomas; Molecular biology;
Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma
Keywords: Rb; retinoblastoma-associated protein-1; CDK4/6; cyclin-dependent kinases 4 and 6; MGMT; O6-methylguanine-DNA-alkyltranferase; FEN1; flap endonuclease-1; PDAC; pancreatic ductal adenocarcinoma; DFS; disease-free survival; RFS; relapse-free survival; OS; o
Promoter methylation and expression of DNA repair genes MGMT and ERCC1 in tissue and blood of rectal cancer patients
Keywords: CRCs; colorectal cancers; MSP; methylation-specific PCR; MGMT; O6-methylguanine DNA methyltransferase; NER; Nucleotide excision repair; Rectal cancer; Methylation specific-PCR; DNA repair; MGMT gene; ERCC1 gene; Gene expression;
Prediction of DNA methylation in the promoter of gene suppressor tumor
Keywords: DNA; deoxyribonucleic acid; CpG; cytosine-phosphate-guanine; HMM; hidden Markov model; DNMTs; DNA méthyltransférase; CGI; CpG islands; bp; base pair; BRCA1; breast cancer 1; BRCA2; breast cancer 2; CHEK2; Checkpoint kinase 2; P53; tumor protein 53; PTEN
Value of 18F-FET PET in adult brainstem glioma
Keywords: ADC; apparent diffusion coefficient; BSG; brain stem glioma; Cho; choline; CT; computed tomography; DTI; diffusion tensor imaging; DWI; diffusion weighted imaging; FET; 18F-fluoro-ethyl-tyrosine; FLAIR; fluid-attenuated inversion recovery; GBM; glioblasto
X-inactive-specific transcript: A long noncoding RNA with complex roles in human cancers
Keywords: AR; androgen receptor; ATG7; autophagy related 7; Bcl2; B-cell lymphoma-2; BRCA1; breast cancer-associated protein 1; CCND1; cyclin D1; CDK4/6; cyclin dependent kinase 4/6; CDX1; caudal type homeobox 1; CRC; colorectal cancer; EMT; epithelial mesenchymal
Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2
Keywords: ABC; ATP-binding cassette; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; GBM; glioblastoma; MGMT; O6-methylguanine-DNA methyltransferase; MRI; magnetic resonance imaging; P-gp; P-glycoprotein; WT; wild-type;
S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells
Keywords: MGMT; O6-methylguanine DNA methyltransferase; PCNA; proliferating nuclear antigen; His Tag; Hexahistidine tag; DAPI; 4,6-Diamidino-2-phenylindole; rMGMT; recombinant MGMT protein; tet; tetracycline; IB; immunoblot; WB; western blot; LV; lenti-viral transf
Drug-induced xenogenization of tumors: A possible role in the immune control of malignant cell growth in the brain?
Keywords: Cyclophosphamide (PubChem CID: 2907); DTIC (Dacarbazine) (PubChem CID: 5353562); GPI 15427 (PubChem CID: 11739525); Lomeguatrib (PubChem CID: 3025944); NU 1025 (PubChem CID: 63306); Temozolomide (PubChem CID: 5394); BER; base excision repair; CD2F1; hybri
Stereotactic Brachytherapy with Iodine-125 Seeds Plus Temozolomide Induced Complete and Durable Remission in a Patient with Recurrent Primary Central Nervous System Lymphoma
Keywords: Iodine-125 seeds; Primary central nervous system lymphoma; Recurrent stereotactic brachytherapy; Temozolomide; 125-I; Iodine-125; DLBCL; Diffuse large B-cell lymphoma; HD-MTX; High-dose methotrexate; MGMT; O6-Methylguanine-DNA methyl-transferase; MRI; Mag
Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas
Keywords: BBB; blood-brain barrier; Br-Cn; bromoalkane; Br-C12; 1-bromododecane; Br-C14; 1-bromotetradecane; Br-C16; 1-bromohexadecane; Br-C18; 1-bromooctadecane; CHOL; cholesterol; DCM; dichloromethane; DLS; dynamic light scattering; DMEM; Dulbecco's modified Ea
Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy
Keywords: PARP; poly (ADP-ribose) polymerase; TMZ; temozolomide; BER; base-excision repair; MGMT; O-6-methylguanine-DNA methyltransferase; NHEJ; non-homologous end joining; HR; homologous recombination; 3-AB; 3-aminobenzamide; MTIC; 5-(3-methyltriazen-1-yl)imidazol
Inhibition of NF-κB results in anti-glioma activity and reduces temozolomide-induced chemoresistance by down-regulating MGMT gene expression
Keywords: Parthenolide; Temozolomide; Glioma; NF-κB; MGMT;
Comparative assessment of three methods to analyze MGMT methylation status in a series of 350 gliomas and gangliogliomas
Keywords: Methylation; MGMT; Glioma; Pyrosequencing; Immunohistochemistry;