دانلود مقالات ISI درباره Mgmt + ترجمه فارسی

Comparative assessment of three methods to analyze MGMT methylation status in a series of 350 gliomas and gangliogliomas

Keywords: Methylation; MGMT; Glioma; Pyrosequencing; Immunohistochemistry;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

GlioblastomaNovel recursive partitioning analysis classification for newly diagnosed glioblastoma: A multi-institutional study highlighting the MGMT promoter methylation and IDH1 gene mutation status

Keywords: Glioblastoma; MGMT; Isocitrate dehydrogenase; Temozolomide; Recursive partitioning analysis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Formation and degradation of nitrogen mustard-induced MGMT-DNA crosslinking in 16HBE cells

Keywords: NM; nitrogen mustard; HN2; N-methyl-2,2-di(chloroethyl)amine; MGMT; O6-methylguanine-DNA methyltransferase; BAA; bifunctional alkylating agents; DPC; DNA-protein cross-link; O6BG; O6-benzylguanine; c-Myc; myelocytomatosis viral oncogene; SUMO; small ubi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Curcumin synergizes with the endocannabinoid reuptake inhibitor OMDM-2 in human MCF-7 breast cancer and U-87 glioblastoma cells

Keywords: Δ9-THC; Delta-9-tetrahydrocannabinol; 2-AG; 2-arachidonoylglycerol; AEA; Anandamide; BCL2; B-cell CLL/lymphoma 2; CB-1; Cannabinoid receptor 1; CB-2; Cannabinoid receptor 2; CI; Combination Index; CXCR4; chemokine receptor type 4; DDS; Drug delivery syst

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Original ResearchDigital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients

Keywords: MGMT; Immunohistochemistry; DNA methylation; Digital PCR; Metastatic colorectal cancer; Alkylating agent;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens

Keywords: Colon cancer; Carcinogens; Food; Heterocyclic amines; DNA repair; MGMT; AAG; Thresholds; Point of departure; Genotoxicity;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Methylation analysis of DNA repair genes in Alzheimer's disease

Keywords: DNA methylation; Alzheimer's disease; Epigenetics; DNA repair; OGG1; PARP1 BRCA1; MGMT; MLH1; MRE11A;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Akt and β-catenin contribute to TMZ resistance and EMT of MGMT negative malignant glioma cell line

Keywords: Gliomas; Temozolomide resistance; Epithelial-to-mesenchymal transition; MGMT; Akt; β-catenin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

IDH mutation and MGMT promoter methylation are associated with the pseudoprogression and improved prognosis of glioblastoma multiforme patients who have undergone concurrent and adjuvant temozolomide-based chemoradiotherapy

Keywords: Glioblastoma; Chemotherapy; Pseudoprogression; Molecular genetics; IDH mutation; MGMT;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

The combined EGFR protein expression analysis refines the prognostic value of the MGMT promoter methylation status in glioblastoma

Keywords: Prognostic markers; EGFR; MGMT; Glioblastoma; Radiotherapy; Temozolomide

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Bifunctional alkylating agent-mediated MGMT-DNA cross-linking and its proteolytic cleavage in 16HBE cells

Keywords: MGMT; DNA damage and repair; DNA-protein cross-link; Bifunctional alkylating agent; Nitrogen mustard; Proteolysis; NM; nitrogen mustard; MGMT; O6-methylguanine-DNA methyltransferase; BAA; bifunctional alkylating agents; DPC; DNA-protein cross-link; DSB;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

DNA-repair defects in pancreatic neuroendocrine tumors and potential clinical applications

Keywords: Neuroendocrine tumor; Carcinoid; DNA repair; MGMT; MMR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

High IFIT1 expression predicts improved clinical outcome, and IFIT1 along with MGMT more accurately predicts prognosis in newly diagnosed glioblastoma

Keywords: Glioblastoma; Prognosis; IFIT1; MGMT; IFN;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Guidelines, “minimal requirements” and standard of care in glioblastoma around the Mediterranean Area: A report from the AROME (Association of Radiotherapy and Oncology of the Mediterranean arEa) Neuro-Oncology working party

Keywords: OS; overall survival; PFS; progression-free survival; WHO; World Health Organization; MA; Mediterranean area; AROME; association of radiotherapy and oncology of the Mediterranean area; MTDs; multidisciplinary teams meetings; MRI; magnetic resonance imagin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Keywords: RBBP4; temozolomide; resistance; MGMT; glioblastoma

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents

Keywords: AAG; alkyladenine DNA glycosylase; ATM; ataxia telangiectasia mutated; BER; base excision repair; BPD; break point dose; BMD; benchmark dose; BMDL; benchmark dose lower confidence limit; CSBP; computational systems biology pathway; DSB; double strand brea

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Fractional Anisotropy Correlates with Overall Survival in Glioblastoma

Keywords: DTI; Fractional anisotropy; Glioblastoma; Outcome; Survival; ADC; Apparent diffusion coefficient; CEL; Contrast-enhancing lesions; CI; Confidence interval; CR; Central tumor regions; DTI; Diffusion tensor imaging; ECM; Extracellular matrix; FA; Fractional

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Keywords: Glioblastoma; Apoptosis resistance; Multidrug resistance; Translation inhibition; Lycorine; Haemanthamine; ATCC; American Type Culture Collection; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMF; dimethylformamide; DMS

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2016 سفارش ترجمه

MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel

Keywords: Gliadel; Glioblastoma multiforme; Methylation; MGMT; Outcome; Survival

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity

Keywords: Alkyltransferase; MGMT; ATL; O6MeG; Killing protection; Alkylating agents

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo

Keywords: CFA; colony formation assay; MGMT; O6-methylguanine-DNA methyltransferase; O6-BG; O6-benzylguanine; POH; perillyl alcohol; TMZ; temozolomide; NEO212; perillyl alcohol covalently linked to temozolomide (TMZ-POH); O6-methylguanine-DNA methyltransferase; MGM

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Hypermethylation in gastric cancer

Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; APC; adenomatosis polyposis coli; ATP; adenosine-triphosphate; BCL6B; B-Cell CLL/Lymphoma 6, Member B; BGS; bisulfite genomic sequencing; BMP-2; bone morphoge

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway

Keywords: ATG4d; autophagy-related gene 4d; ATG6; autophagy-related gene 6; ATG12; autophagy-related gene 12; BAX; BCL-2 Associated X Protein; BCL-2; B-cell lymphoma-2; BW; body weight; Bet; piglets born to sows supplemented with betaine diets; CCND2; cyclin D2; Co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines

Keywords: GBM; glioblastoma; MGMT; O6-methylguanine-DNA methyltransferase; TMX; tamoxifen; TMZ; temozolomide; PKC; protein kinase C; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; PGP; (P-glycoprotein ); SERM; non-steroidal selective estrogen r

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

MGMT enrichment and second gene co-expression in hematopoietic progenitor cells using separate or dual-gene lentiviral vectors

Keywords: O6-methylguanine-DNA methyltransferase; MGMT; P140K; IRES; F2A; Lentivirus; Gene therapy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Imaging Genomics of Glioblastoma

Keywords: Glioblastoma; Imaging genomics; Genetic biomarkers; Radiogenomics; MGMT; IDH1; EGFR; 1p/19q;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy

Keywords: GBM; glioblastoma multiforme; let-7a; lethal-7a; miRNA; microRNA; TCGA; The Cancer Genome Atlas; GLUT; glucose transporter; PKM2; pyruvate kinase M2; PDK; pyruvate dehydrogenase kinase; MGMT; O6-methylguanine-DNA methyltransferase; GSK3β; glycogen syntha

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

Targeting strategies on miRNA-21 and PDCD4 for glioblastoma

Keywords: GBM; glioblastoma multiforme; miRNAs; microRNAs; PDCD4; programmed cell death 4; EMT; epithelial-mesenchymal transition; JNK; Jun N-terminal protein kinase; PTEN; phosphatase and tensin homolog; PI3K/AKT; phosphatidylinositol-3 kinase/Akt; MAPK/ERK; mit

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

Trial of a 5-day dosing regimen of temozolomide in patients with relapsed small cell lung cancers with assessment of methylguanine-DNA methyltransferase

Keywords: Temozolomide; SCLC; MGMT; Biomarker; Alkylating agent; Chemotherapy;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

The anti-cancer actions of O6-methylguanine-DNA-methyltransferase in relation to colon polyps

Keywords: MGMT; Colon polyps; Genetic analysis; Colon cancer

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

ERCC1 expression and tumor regression predict survival in esophageal squamous cell carcinoma patients receiving combined trimodality therapy

Keywords: XRCC1; ERCC1; MGMT; Histopathologic response; Neoadjuvant chemoradiation; Esophagaeal cancer;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The contrasting epigenetic role of RUNX3 when compared with that of MGMT and TIMP3 in glioblastoma multiforme clinical outcomes

Keywords: Epigenetics; Glioblastoma; MGMT; TIMP3; RUNX3; Outcome;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Methylation and expression profiles of MGMT gene in thymic epithelial tumors

Keywords: MGMT; O6-methylguanine-DNA methyltransferase; TET; thymic epithelial tumors; MSP; methylation-specific PCR; MG; myasthenia gravis; M; methylated; NI; non-informative case; U; unmethylated; WHO; World Health Organization; MI; methylation index; O6-methylgu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Lentiviral MGMTP140K-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter

Keywords: Gene therapy; MGMT; UCOE; Lentiviral vector; In vivo selection;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Keep-ING balance: Tumor suppression by epigenetic regulation

Keywords: bp; base pair; CDK; cyclin-dependent kinase; DNA; desoxyribonucleic acid; DNMT; DNA methyltransferase; H; histone; HAT; histone acetyltransferase; H3K4me3; histone H3 trimethylated on lysine 4; HDAC; histone deacetylase; ING; Inhibitor of growth; mSin3; m

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine

Keywords: α-KG; α-ketoglutarate; AML; acute myeloid leukemia; APOBEC; apolipoprotein B mRNA-editing enzyme complex; ARP; aldehyde reactive probe; β-GT; β-glucosyl transferase; 5-caC; 5-carboxylcytosine; 5-cadCyd; 5-carboxyl-2′-deoxycytidine; C; cytosine; C5-M

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

A pilot study of glioblastoma multiforme in elderly patients: Treatments, O-6-methylguanine-DNA methyltransferase (MGMT) methylation status and survival

Keywords: Glioblastoma multiforme; Elderly; MGMT; Methylated; Unmethylated temozolamide; Survival;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours

Keywords: Bayesian analysis; Model selection; DNA methylation; MGMT; Lung cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Research ReportAcetylcholine esterase is a regulator of GFAP expression and a target of dichlorvos in astrocytic differentiation of rat glioma C6 cells

Keywords: GFAP; glial fibrillary acidic protein; ACh; acetylcholine; AChE; ACh esterase; DDVP; dichlorvos; OPIDN; organophosphate-induced delayed neuropathy; FAAH; fatty acid amide hydrolase; NTE; neuropathy target esterase; MGMT; methyl guanine methyl transferase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients

Keywords: MGMT; Methylation; Single nucleotide polymorphism; Glioblastoma; Temozolomide; Survival;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

A long non-coding RNA signature in glioblastoma multiforme predicts survival

Keywords: Glioblastoma; LncRNAs; Prognosis; Biomarkers; MGMT;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system

Keywords: DNA-protein crosslinks; Nucleotide excision repair; MGMT; Dibromoethane; Epibromohydrin; AGT (MGMT); O6-alkylguanine-DNA alkyltransferase; hAGT; human wild type AGT; NER; nucleotide excision repair; TC-NER; transcription-coupled NER; GC-NER; global geno

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Loss of O6-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells

Keywords: Triple negative breast cancer; Collateral sensitivity; TOP2A; MGMT;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of the mitochondrial Hsp90 chaperone network: A novel, efficient treatment strategy for cancer?

Keywords: 17-AAG; 17-N-Allylamino-17-demethoxygeldanamycin; AMPK; AMP-activated kinase; CCCP; carbonyl cyanide 3-chlorophenylhydrazone; CsA; Cyclosporin A; CyD; Cyclophilin-D; G-G4; Gamitrinib(s), Geldanamycin (GA), mitochondrial matrix inhibitors - Gamitrinib â€

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Oncogenic functions of the transcription factor Nrf2

Keywords: b-ZIP; leucine-zipper protein; ARE; antioxidant response element; PT; primary tumor; LOH; loss of heterogeneity; NSCLC; non-small-cell lung carcinoma; EOC; epithelial ovarian carcinoma; ESCC; esophagus squamous cell carcinoma; SCC; squamous cell carcinoma

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

DNA repair mechanisms in dividing and non-dividing cells

Keywords: DNA repair; Neural cells; Neurological disorder; Dividing and non-dividing; Endogenous DNA damage; AOA1; ataxia with ocular motor apraxia 1; AP; apurinic/apyrimidinic; APE1; AP endonuclease 1; APTX; aprataxin; ATM; ataxia telangiectasia mutated; CPDs; cyc

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Development of a new application of the comet assay to assess levels of O6-methylguanine in genomic DNA (CoMeth)

Keywords: BER; base excision repair; BG; O6-benzylguanine; Mx; methoxyamine; MMS; methyl methanesulfonate; MMR; mismatch repair; MNU; N-methyl-N-nitrosourea; MPG; N-methylpurine-DNA glycosylase; O6meG; O6-methylguanine; MGMT; O6-methylguanine-DNA methyltransferase;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis

Keywords: AOM, azoxymethane; O6-meG, O6-methylguanine; MGMT, O6-methylguanine DNA methyltransferase; DMH, 1,2-dimethylhydrazine; CRC, colorectal cancer; DSB, double-strand breakAzoxymethane; O6-meG adduct; DNA repair; MGMT; Apoptosis; Colon cancer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma

Keywords: Brain tumor; GBM; Temozolomide; MGMT

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Correlation of histomorphologic prognostic markers and proliferative index with loss of heterozygosity 1p/19q and MGMT status in diffusely infiltrating gliomas

Keywords: Diffusely infiltrating gliomas; LOH 1p/19q; MGMT; MIB-1LI

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه