MGMT Promoter Methylation and Glioblastoma Prognosis: A Systematic Review and Meta-analysis
Keywords: MGMT; Promoter methylation; Glioblastoma prognosis; Meta-analysis
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Genetics and pharmacogenomics of diffuse gliomas
Keywords: Companion diagnostics; Glioma; 1p/19q co-deletion; IDH1; Pharmacogenomics; EGFRvIII; CGH; comparative genomic hybridization; CNA; copy number aberrations; CRC; colorectal carcinoma; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FF
FET-PET assessed recurrence pattern after radio-chemotherapy in newly diagnosed patients with glioblastoma is influenced by MGMT methylation status
Keywords: FET-PET; Recurrence pattern; Radio-chemotherapy; Glioblastoma; MGMT;
Prognostic significance of MGMT gene promoter methylation in differently treated metastatic melanomas
Keywords: Melanoma; metastasis; methylation; MGMT; prognosis; therapy;
MGMT and PTEN as potential prognostic markers in breast cancer
Keywords: MGMT; PTEN; Breast cancer; Prognosis; Basal-like carcinomas
Aberrant Promoter Methylation of CDH13 and MGMT Genes is Associated With Clinicopathologic Characteristics of Primary Non–Small-Cell Lung Carcinoma
Keywords: CDH13; Clinicopathologic characteristics; Methylation; MGMT; Non–small-cell lung carcinoma
EORTC topics in neurooncology: The long path from a focus on neurological complications of cancer towards molecularly defined trials and therapies in neurooncology
Keywords: Glioblastoma; MGMT; 1p/19q; IDH1; Neurocognition
Progress in high-throughput assays of MGMT and APE1 activities in cell extracts
Keywords: MGMT; O6-methylguanine; APE1; BER pathway; Phenotypic assay; Molecular epidemiology
Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas
Keywords: GBM; glioblastoma multiforme; MGMT; O6-methylguanine DNA methyltransferase; SVZ; subventricular zone; ADIFFI; Analysis of Differential Involvement; MR/MRI; magnetic resonance imaging; IDH1; isocitrate dehydrogenase 1; TMZ; temozolomide; MSP; methylation-s
Associations between maternal genotypes and metabolites implicated in congenital heart defects
Keywords: BHMT; betaine-homocysteine methyltransferase gene; CAT; catalase gene; CHDs; congenital heart defects; COMT; catechol-O-methyltransferase gene; FDR; false discovery rate; GluCys; glutamylcysteine; GPX3; glutathione peroxidase 3 gene; GPX6; glutathione per
Pathology: Commonly Monitored Glioblastoma Markers: EFGR, EGFRvIII, PTEN, and MGMT
Keywords: EGFR; EGFRvIII; PTEN; MGMT; Glioblastoma;
O6-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke
Keywords: MGMT; DNA repair; Cancer protection; Tobacco; Lung cancer; Biomarker
Unique biology of gliomas: challenges and opportunities
Keywords: glioma; clinical trial; glutamate; MGMT; bradykinin; ion channel
DNA methylation-based biomarkers in serum of patients with breast cancer
Keywords: 5-Aza-CdR; 5-aza-2â²-deoxycytidine; 5-Aza-CR; 5-azacytidine; 5mC; 5-methylcytidine; AIMS; amplification of inter-methylated sites; APC; adenomatous polyposis coli; BiMP; bisulfite methylation profiling; BRCA1; breast cancer gene 1; BsPP; bisulfite padloc
A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy
Keywords: Glioma; Melanoma; Gene therapy; TMZ; MGMT; Conditionally-replicating adenoviruses
SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study
Keywords: SMAD7; MGMT; Cancer; Genotype; Variants; EPIC-Norfolk study
Evaluation of O6-methylguanine-DNA methyltransferase by immunohistochemistry: Best clinical and research practices
Keywords: MGMT; Breast cancer; Immunohistochemistry; RT-PCR
Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP
Keywords: MGMT; DNA methylation; Mesothelioma; SMART-MSP
Biomarqueurs pronostiques et facteurs prédictifs de la réponse au traitement dans les gliomes de l'adulte
Keywords: Gliome; Codélétion 1p/19q; MGMT; Mutation IDH1; Glioma; 1p/19q codeletion; MGMT; IDH1;
Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators
Keywords: DNA repair; MGMT; PaTrin2; 5-Nitropyrimidine; Docking;
O6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry
Keywords: MGMT; O6-methylguanine-DNA methyltransferase; Alkyltransferase; Promoter methylation; DNA repair; Drug resistance;
Chemoradiotherapy of Newly Diagnosed Glioblastoma With Intensified Temozolomide
Keywords: Glioblastoma; indomethacin; O6-methylguanine-DNA methyltransferase; MGMT; radiotherapy; temozolomide;
MGMT expression levels predict disease stabilisation, progression-free and overall survival in patients with advanced melanomas treated with DTIC
Keywords: Melanoma; MGMT; p16INK4a; DTIC; Antineoplastic drug resistance; Drug response; Biomarkers; Prognosis
O6-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers
Keywords: Brain metastasis; O6-Methylguanine-DNA methyltransferase; MGMT; Immunohistochemistry
Deregulated signalling networks in human brain tumours
Keywords: GBM; glioblastoma multiforme; RTK; receptor tyrosine kinase; EGF(R); epidermal growth factor (receptor); PDGF(R); platelet-derived growth factor (receptor); VEGF(R); vascular endothelial growth factor (receptor); ERBB2; v-erb-b2 erythroblastic leukemia vi
Glioblastomes : oncogenèse et bases biologiques
Keywords: Glioblastoma; Cancer stem cell; IDH1; MGMT; Angiogenesis; Invasion; Glioblastome; Cellule souche cancéreuse; IDH1; MGMT; Angiogenèse; Invasion;
Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients
Keywords: Breast cancer; DNA methylation; BRCA1; GSTP1; MGMT; Gene silencing
Basic-Alimentary TractCpG Methylation and Reduced Expression of O6-Methylguanine DNA Methyltransferase Is Associated With Helicobacter pylori Infection
Keywords: Eradication; MGMT; O6-Methylguanine DNA Methyltransferase; DNA Repair; ACTB; β-actin; cDNA; complementary DNA; CT; threshold cycle; MGMT; O6-Methylguanine DNA methyltransferase; mRNA; messenger RNA; MSP; methylation-specific PCR; PCR; polymerase chain re
Absence of MGMT promoter methylation in endometrial cancer
Keywords: MGMT; Endometrial neoplasms; Methylation
Telomerase and DNA repair in glioma
Keywords: Glioma; hTERT; MGMT; Chemotherapy;
Identificación de alteraciones genéticas en oligodendrogliomas mediante amplificación dependiente de ligasa de múltiples sondas (MLPA) (multiple ligationdependent probe amplification)
Keywords: Oligodendrogliomas; Deleción lp/19q; MLPA; EGFR; CDKN2A; PTEN; Oligodendrogliomas; 1p/l9q deletion; MLPA; EGFR; CDKN2A; PTEN; ADN; ácido desoxirribonucleico; GAC1; repeticiones ricas en leucina del componente neuronal 2; CAMTA1; activador de la trascrip
Radiosensitizing Effects of Temozolomide Observed in vivo only in a Subset of O6-Methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts
Keywords: Radiation; Temozolomide; Glioblastoma; MGMT; Xenografts;
Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations
Keywords: MGMT; K-ras; Soft tissue sarcoma
MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma
Keywords: Extended dosing; High-grade glioma; MGMT; Recurrent; Temozolomide
Ethyl methanesulfonate toxicity in Viracept—A comprehensive human risk assessment based on threshold data for genotoxicity
Keywords: Viracept; Ethyl methanesulfonate; Contamination; Mutation threshold; Cancer; Birth defects; Patient exposure risk; Cmax; AUC; Ethyl valine adducts; DNA adducts; DNA repair; MGMT
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O6-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs
Keywords: Apoptosis; DNA double-strand breaks; Aberrations; SCEs; Brca2; XRCC2; NHEJ; MGMT; Homologous recombination; Temozolomide
Pragmatic classification of superficial neoplastic colorectal lesions
Keywords: ACF; aberrant crypt foci; CIMP; CpG island methylator phenotype; CIN; chromosomal instability; FAP; familial adenomatous polyposis; HNPCC; hereditary nonpolyposis colon cancer; HP; hyperplastic polyp; IEN; intraepithelial neoplasia; LST; laterally spreadi
Diet Synergistically Affects Helicobacter pylori-Induced Gastric Carcinogenesis in Nonhuman Primates
Keywords: ANOVA; analysis of variance; ENNG; ethyl-nitro-nitrosoguanidine; C; controls; H; H pylori-infected; E; receiving ENNG; EH; H pylori-infected receiving ENNG; IL; interleukin; MGMT; O6-methylguanine-DNA methyltransferase; rRNA; ribosomal RNA; RT-PCR; re
Detailed methylation patterns and protein expression profiles of MGMT in colorectal carcinoma surgical margins
Keywords: MGMT; Methylation; Immunohistochemistry; Colorectal carcinoma; Survival rate
Contribution of DNA repair mechanisms to determining chemotherapy response in high-grade glioma
Keywords: Glioma; DNA repair; MGMT; Mismatch repair; Topoisomerase; Base excision repair; Antineoplastic agents
Combination of O6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy
Keywords: MGMT; TS; Fluoropyrimidine; Colorectal cancer; Irinotecan;
Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma
Keywords: Glioblastoma; 5azadC; Telomerase; MGMT; Demethylation
Different initial steps of apoptosis induced by two types of antineoplastic drugs
Keywords: Apoptosis; DNA repair; MGMT; Temozolomide; ACNU
The Sodium Pump α1 Subunit as a Potential Target to Combat Apoptosis-Resistant Glioblastomas
Keywords: AMOG; adhesion molecule on glia; MGMT; methylguanine-DNA methyltransferase; mTOR; mammalian target of rapamycin; NF-κB; nuclear factor-kappa B; P13K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog on chromosome ten;
A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis
Keywords: Hypermethylation; Glioblastoma; Real-time PCR; MGMT; Promoter;
Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool?
Keywords: MGMT; Leukoplakia; Oral squamous cell carcinoma; Tobacco; Immunohistochemistry
In vitro studies of DNA damage and its repair in cells from NHL patients with different p53 mutant protein status, resistant (p53+) and sensitive (p53−) to cancer chemotherapy
Keywords: Chemoresistance; DNA repair capacity/kinetics; p53 mutant protein; MGMT; NHL
O6-methylguanine-DNA methyltransferase deficiency in developing brain: Implications for brain tumorigenesis
Keywords: MGMT; Brain development; Brain tumor; Alkylating agents
Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia
Keywords: IL-2; Leukaemia; Lomeguatrib; MGMT; MMR; Temozolomide