کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3062542 | 1187492 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Contribution of DNA repair mechanisms to determining chemotherapy response in high-grade glioma Contribution of DNA repair mechanisms to determining chemotherapy response in high-grade glioma](/preview/png/3062542.png)
Despite the existence of a well described, succinct pathological grading system for gliomas, tumour behaviour between individual patients varies widely. In addition, predictors of response to treatment in glioblastoma multiforme are lacking. The majority of chemotherapeutic agents currently employed exert their effect on DNA. As our understanding of DNA repair mechanisms improves and predictive markers are elucidated, this may allow treating clinicians to individualise treatment based on molecular markers. This review examines important DNA repair mechanisms and their application to glioblastoma multiforme. By improving understanding of these mechanisms, and particularly the variations that occur between tumours and individuals, it may be possible to adapt treatment to maximise effectiveness and minimise toxicity.
Journal: Journal of Clinical Neuroscience - Volume 15, Issue 1, January 2008, Pages 1–8