Pharmacological validation of a novel home cage activity counter in mice
Keywords: Locomotion; Home cage; Mice; Anxiety; MK-801; Diazepam; d-Amphetamine;
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Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis
Keywords: Schizophrenia; Network oscillations; MK-801; Hippocampus; IPSPs; Na+-K+-pump
Pain-related behavior following REM sleep deprivation in the rat: Influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide
Keywords: l-NAME, Nω-nitro-l-arginine methyl ester hydrochloride; mGluR5, metabotropic glutamate receptor 5; MPEP, 6-methyl-2-(phenylethynyl)pyridine; NMDA, N-methyl-d-aspartate; REM, rapid eye movement; REMSD, rapid eye movement sleep deprivationl-NAME; MK-801; MP
The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801
Keywords: Serotonin 5-HT1A receptors; 8-OH-DPAT; MK-801; PPI; Locomotor activity; Rats; Schizophrenia
Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques
Keywords: Cerebellar granule cells; Drug discovery; Fluorescence; Methods; NMDA; Calcium; Rat; MK-801; Ion channel block; Fura-2
Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT2A/2C receptors
Keywords: MK-801; Risperidone; Hyperlocomotion; Serotonin; (Mice)
Morphine-induced place preference: Involvement of the central amygdala NMDA receptors
Keywords: Morphine; Conditioned place preference; Central amygdala; NMDA; MK-801; Rat
Developmental lead (Pb) exposure reduces the ability of the NMDA antagonist MK-801 to suppress long-term potentiation (LTP) in the rat dentate gyrus, in vivo
Keywords: Dentate gyrus; Long-term potentiation; NMDA; MK-801; Glutamate; Lead; Pb; In vivo; Hippocampus; Rat; Neurotoxicity; Learning and memory
Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response
Keywords: Dizocilpine; MK-801; Nicotine; Clozapine; Pre-pulse inhibition; PPI; Tactile startle;
Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory
Keywords: psychostimulants; GluR2; NR1; NR2A; astrogliosis; AMPH; amphetamine; CA1; regio superior cornu ammonis; CA3; regio inferior cornu ammonis; DA; dopamine; ED; escalating dose/s; F-J C; Fluoro-Jade C; GFAP; glial fibrillary acidic protein; Glu; glutamate; LT
Activity-dependent reorganization of local circuitry in the developing visceral sensory system
Keywords: GABA; synapse; nucleus of tractus solitarius; MK-801; NMDA; critical periodAPV, d,l-2-amino-5-phosphovaleric acid; DAB, diaminobenzidine tetrahydrochloride; EPSC, excitatory postsynaptic current; GAD67, glutamic acid decarboxylase67; IPSC, inhibitory post
Mechanisms underlying the long-term behavioral effects of traumatic experience in rats: The role of serotonin/noradrenaline balance and NMDA receptors
Keywords: DSP-4; 5,7-DHT; Chemical lesion; MK-801; Social interaction; Anxiety;
Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia
Keywords: Endothelin-1 model of ischemia; MK-801; Electrophysiological outcome; Neurological deficit; Neuroprotection
7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats
Keywords: 7-Nitroindazole; MK-801; Learning-memory; Elevated plus-maze; Passive-avoidance; Rat
Translocation and activation of Rac in the hippocampus during associative contextual fear learning
Keywords: Learning and memory; Context fear; Hippocampus; MK-801; Small GTPases
Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism
Keywords: Schizophrenia; Limbic system; Interneurons; MK-801; Haloperidol
Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures
Keywords: AC; adenylyl cyclase; Bic; bicuculline; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; DIV; days in vitro; EHNA; erythro-9-(2-hydroxy-3-nonyl)-adenine; MK-801; dizocilpine hydrogen maleate; IFN; ifenprodil; TTX; tetrodotoxin;
Suppressive effect of clozapine but not haloperidol on the increases of neuropeptide-degrading enzymes and glial cells in MK-801-treated rat brain regions
Keywords: Glia; MK-801; Neuropeptidase; Neuroleptics; Schizophrenia-like psychosis
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion
Keywords: cerebral ischemia; GABA receptor; NMDA receptor; muscimol; baclofen; Src; CAMK II; CaM-dependent protein kinase II; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfoxide; EBSS; Earl's balanced salt solution; h-DMEM; high-glucos
Effect of chronic MK-801 and/or phenytoin on the acquisition of complex behaviors in rats
Keywords: MK-801; N-methyl-D-aspartate (NMDA) receptors; Operant behavior; Phenytoin; Sodium channels
Ethanol prevents NMDA receptor reduction by maternal separation in neonatal rat hippocampus
Keywords: Disorders of the nervous system, Developmental disordersFetal alcohol syndrome; FAS; AMPA receptor; MK-801
NMDA receptor antagonist MK-801 infused into the insular cortex prevents the attenuation of gustatory neophobia in rats
Keywords: Gustatory neophobia; MK-801; Insular cortex; NMDA receptor; Rat
Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia
Keywords: Heptamethoxyflavone; MK-801; Schizophrenia-like behavior; Locomotion; Y-maze test; Open field test;
Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats
Keywords: MK-801; NMDA; Subiculum; Schizophrenia; LTP
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test
Keywords: Nitric oxide; Indomethacin; MK-801; l-NAME; Formalin test; Hyperalgesia
Effect of Ocimum sanctum Linn. on cardiac changes in rats subjected to chronic restraint stress
Keywords: Chronic restraint stress; Myocardium; Oxidative stress; Ocimum sanctum (Labiatae); MK-801
Developmental Vitamin D Deficiency Alters MK 801-Induced Hyperlocomotion in the Adult Rat: An Animal Model of Schizophrenia
Keywords: Schizophrenia; vitamin D; neurodevelopment; MK-801; haloperidol; prepulse inhibition
Analysis of sensitivity to MK-801 treatment in a novel active allothetic place avoidance task and in the working memory version of the Morris water maze reveals differences between Long-Evans and Wistar rats
Keywords: Animal model of schizophrenia; MK-801; Strain differences; Spatial cognition; Active allothetic place avoidance; Working memory; Morris water maze
Effect of N-methyl-d-aspartate receptor blockade on caspase activation and neuronal death in the developing rat cerebellum
Keywords: Apoptosis; Cerebellar granule neurons; MK-801; Development; Glutamate;
Consolidation of auditory cortex-dependent memory requires N-methyl-d-aspartate receptor activation
Keywords: Auditory; Cortex; d-AP-5; Glutamate; Learning; MK-801
The connexin 36 blockers quinine, quinidine and mefloquine inhibit cortical spreading depression in a rat neocortical slice model in vitro
Keywords: Migraine aura; Gap junctions; Connexin 36; MK-801
Spontaneous alternation behaviour in rats: Kynurenic acid attenuated deficits induced by MK-801
Keywords: Kynurenic acid; Locomotor activity; MK-801; Rat; Spontaneous alternation;
Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior
Keywords: Glutamate; Ascorbic acid; MK-801; Microdialysis; Prefrontal cortex; Locomotion
NMDA receptor antagonists antagonize the facilitatory effects of post-training intra-basolateral amygdala NMDA and physostigmine on passive avoidance learning
Keywords: NMDA; DL-AP5; MK-801; Physostigmine; Passive avoidance learning; Retention; Basolateral amygdala; (Rats)
Creatine prevents behavioral alterations caused by methylmalonic acid administration into the hippocampus of rats in the open field task
Keywords: MMA; methylmalonic acid; MMAemia; methylmalonic acidemia; NMDA; N-methyl-d-aspartate; MK-801; dizocilpine maleate; ANOVA; analysis of variance; S.E.M.; standard error of the mean; SPSS; Statistical Package of the Social Sciences; NaCl; sodium chloride; Me
The evaluation of antimuscarinic-induced convulsions in fasted rats after food intake
Keywords: Muscarine receptor antagonist-induced convulsions; Anticonvulsants; Clonidine; Chlorpromazine; MK-801; Fasting;
Methotrexate induces seizure and decreases glutamate uptake in brain slices: Prevention by ionotropic glutamate receptors antagonists and adenosine
Keywords: Methotrexate; Neurotoxicity; Glutamate uptake; Seizure; MK-801; DNQX; Adenosine
NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats
Keywords: NMDA; MK-801; DL-AP5; Physostigmine; Passive avoidance learning; Retention; Dorsal hippocampus; Rat
Cognitive dysfunction induced by sequential injection of amyloid-β and ibotenate into the bilateral hippocampus; protection by memantine and MK-801
Keywords: Amyloid-β; Ibotenate; Hippocampus; Memantine; MK-801; Water maze
Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex
Keywords: N-Methyl-d-aspartate receptor; PCP binding site; MK-801; TetrahydroisoquinolinesCC, column chromatography; GP, general procedure; NMDA, N-methyl-d-aspartate; PCP, phencyclidine; S.E.M., standard error of the means
Co-administration of MK-801 and morphine attenuates neuropathic pain in rat
Keywords: Neuropathic pain; CCI; Pre-emptive; MK-801; Morphine; Compound action potential
A Pharmacological Model for Psychosis Based on N-methyl-D-aspartate Receptor Hypofunction: Molecular, Cellular, Functional and Behavioral Abnormalities
Keywords: Psychosis; NMDA; MK-801; animal model; glutamate; hippocampus
Distinct gene expression profiles in adult rat brains after acute MK-801 and cocaine treatments
Keywords: MK-801; Cocaine; Gene expression; Microarray; Glutamate; Dopamine; Addiction
Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions
Keywords: Taste aversion; UCS preexposure; Tolerance; Morphine; Proglumide; MK-801; Naloxone; NMDA; CCK;
Nitrous Oxide and Xenon Prevent Amphetamine-Induced Carrier-Mediated Dopamine Release in a Memantine-Like Fashion and Protect Against Behavioral Sensitization
Keywords: Amphetamine; dopamine release; locomotor sensitization; memantine; MK-801; nitrous oxide; xenon
SCH 23390 in the prefrontal cortex enhances the effect of apomorphine on prepulse inhibition of rats
Keywords: Dopamine; Frontal cortex; Prepulse inhibition; Apomorphine; MK-801
Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation
Keywords: 7-nitroindazole; hippocampus; proliferation; MK-801; NMDA receptorsBrdU, 5-bromodeoxyuridine; BrdU+, 5-bromodeoxyuridine positive; cAMP, cyclic AMP; CBP, cyclic AMP response element binding protein-binding protein; CREB, cyclic AMP response element bindin
Glutamate-dependent translational regulation in cultured Bergmann glia cells: Involvement of p70S6K
Keywords: p70S6K; glutamate receptors; Bergmann glia; mTOR; translational control; Akt I; 1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate; AMPA; amino α-3-hydroxy-5-methyl-4-isoaxazolepropionate; ANOVA; analysis of variance; BAPTA-AM; 1,2
Hypoxia in presence of blockers of excitotoxicity induces a caspase-dependent neuronal necrosis
Keywords: apoptosis; cytochrome c; MK-801; NBQX; ATP; mitochondrial membrane potentialCB, cacodylate buffer; CHX, cycloheximide; DAB, diaminobenzidine; DG, dentate gyrus; EM, electron microscopy; FBS, fetal bovine serum; LDH, lactate dehydrogenase; NEH, non-excitot
Differential effects of classical neuroleptics and a newer generation antipsychotics on the MK-801 induced behavioural primitivization in mouse
Keywords: AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; CCD, charge-coupled device; 5-HT, serotonin; NMDA, N-methyl-d-aspartate; PLS, Partial Least Square; PLS-DA, Partial Least Square Discriminant AnalysisCognition; Mice; MK-801; Schizophrenia; Video