Keywords: MMR، تعمیر ناسازگاری; MMR, mismatch repair; GC, gastric cancer; Hp, Helicobacter pylori; MSI, microsatellite instability; MSS, microsatellite stability; LD, linkage disequilibrium; OR, odds ratios; CI, confidence intervalsPolymorphism; Mismatch repair genes; Gastric cancer; Mi
مقالات ISI MMR، تعمیر ناسازگاری (ترجمه نشده)
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Keywords: MMR، تعمیر ناسازگاری; Monoterpenes; Genotoxicity; Antigenotoxicity; Cytotoxicity; Escherichia coli; Colorectal carcinoma cellsCam, Camphor; Euc, Eucalyptol; MMR, mismatch repair; NER, nucleotide excision repair; 4NQO, 4-Nitroquinoline-1-oxide; Thu, Thujone
Keywords: MMR، تعمیر ناسازگاری; Cancer Risk; Familial Pancreatic Cancer; Pancreatic Cancer GeneticsGATK, Genome Analysis Toolkit; MMR, mismatch repair; NGS, next-generation sequencing; OPCS, Ontario Pancreas Cancer Study; PC, pancreatic cancer; VUS, variants of unknown significance
Keywords: MMR، تعمیر ناسازگاری; NER, nucleotide excision repair; GC, gastric cancer; BER, base excision repair; MMR, mismatch repair; DSBR, double-strand break repair; GGNER, global genome nucleotide excision repair; TCNER, transcription-coupled nucleotide excision repair; GCA, gastric
Prognostic Utility of Immunoprofiling in Colon Cancer: Results from a Prospective, Multicenter Nodal Ultrastaging Trial
Keywords: MMR، تعمیر ناسازگاری; AJCC, American Joint Committee on Cancer; DFS, disease-free survival; IHC, immunohistochemistry; IM, invasive margin; MMR, mismatch repair; TC, tumor center; TIL, tumor-infiltrating lymphocyte
The stem cell renewal and DNA damage response pathways are frequently altered in fibroepithelial tumors of breast in Indian patients
Keywords: MMR، تعمیر ناسازگاری; FA, fibroadenoma; PT, phyllode tumor; ADH, atypical ductal hyperplasia; BC, breast carcinoma; IDC, infiltrating ductal carcinoma; HR, homologous recombination; MMR, mismatch repair; NER, nucleotide excision repair; RFLP, restriction fragment length polymo
MSH2 role in BRCA1-driven tumorigenesis: A preliminary study in yeast and in human tumors from BRCA1-VUS carriers
Keywords: MMR، تعمیر ناسازگاری; BRCA1; MSH2; Hereditary breast and ovarian cancer; Yeast functional assay; Mutational analysisHBOC, hereditary breast and ovarian cancer; VUS, variants of unknown significance; MMR, mismatch repair; BASC complex, BRCA1-Associated Genome Surveillance Compl
DNA repair genes XPC, XPD, XRCC1, and XRCC3 are associated with risk and survival of squamous cell carcinoma of the head and neck
Keywords: MMR، تعمیر ناسازگاری; HNSCC, head and neck squamous cell carcinoma; HPV, human Papilloma Virus; BER, base-excision repair; NER, nucleotide-excision repair; DSB, double-strand break repair; MMR, mismatch repair; ROS, reactive oxygen species; SNP, single-nucleotide polymorphisms
Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines
Keywords: MMR، تعمیر ناسازگاری; MMR, mismatch repair; dNTP, deoxynucleotide triphosphate; BER, base excision repair; DSB, double strand break; HR, homologous recombination; NEHJ, non-homologous end-joining; NER, nucleotide excision repair; DDR, DNA damage repair; DDS, DNA damage signall
DNA damage response – A double-edged sword in cancer prevention and cancer therapy
Keywords: MMR، تعمیر ناسازگاری; DDR, DNA damage response; BER, base excision repair; MMR, mismatch repair; NER, nucleotide excision repair; TLS, translesion DNA synthesis; NHEJ, nonhomologous end joining; HR, homologous recombination; SSBs, single strand DNA breaks; DSBs, double strand
DNA methylation changes in epithelial ovarian cancer histotypes
Keywords: MMR، تعمیر ناسازگاری; EOC, epithelial ovarian cancer; EN, endometrioid; CC, clear cell; MC, mucinous; HG, high-grade; LG, low-grade; CGI, CpG Island; CIMP, CpG Island methylation phenotype; SBT, serous borderline tumor; TSG, tumor suppressor gene; MMR, mismatch repair; MSI, mi
Analysis of DNA repair gene polymorphisms in glioblastoma
Keywords: MMR، تعمیر ناسازگاری; NER, nucleotide excision repair; BER, base excision repair; DSBR, double-strand break repair; MMR, mismatch repair; ERCC1, excision repair cross-complementing rodent repair deficiency, complementation group 1; ERCC2, excision repair cross-complementing ro
A nonsense mutation in the Xeroderma pigmentosum complementation group F (XPF) gene is associated with gastric carcinogenesis
Keywords: MMR، تعمیر ناسازگاری; XPF, Xeroderma pigmentosum complementation group F; SNP, single nucleotide polymorphism; ERCC1, excision repair cross-complimentary group 1; NER, nucleotide excision repair; BER, base excision repair; MMR, mismatch repair; MTHFR, methylenetetrahydrofolate
Repair of endogenous DNA base lesions modulate lifespan in mice
Keywords: MMR، تعمیر ناسازگاری; 3meA, 3-methyladenine; Aag/Mpg, alkyladenine glycosylase; AP, abasic; Atm, ataxia telangiectasia mutated; BER, base excision repair; BM, bone marrow; CR, calorie restriction; Exo1, exonuclease 1; Mgmt, O6MeG DNA methyltransferase; MMR, mismatch repair; MM
Analysis of Ig gene hypermutation in Ung−/−Polh−/− mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions
Keywords: MMR، تعمیر ناسازگاری; Immunoglobulin gene hypermutation; Activation-induced cytidine deaminase; Uracil DNA glycosylase; DNA polymerase η; Cell cycleAID, activation-induced cytidine deaminase; GC, germinal center; MMR, mismatch repair; POLH, DNA polymerase η; SHM, somatic hyper
Tumor-specific microsatellite instability: Do distinct mechanisms underlie the MSI-L and EMAST phenotypes?
Keywords: MMR، تعمیر ناسازگاری; A-MSI, alternative microsatellite instability; EMAST, elevated microsatellite alterations at selected tetranucleotides; ESTR, expanded short tandem repeat; Indel, insertion/deletion; IDL, insertion/deletion loop; MMR, mismatch repair; MSI, microsatellite
Core promoter STRs: Novel mechanism for inter-individual variation in gene expression in humans
Keywords: MMR، تعمیر ناسازگاری; STR, short tandem repeat; MMR, mismatch repair; SOX5, SRY (sex determining region Y)-box 5; TSS, transcription start site; Caveolin 1, CAV1SOX5; Core promoter; Expression; GA-repeat; STR
Genetic polymorphisms in translesion synthesis genes are associated with colorectal cancer risk and metastasis in Han Chinese
Keywords: MMR، تعمیر ناسازگاری; CRC, colorectal carcinoma; TLS, translesion synthesis; SNP, single nucleotide polymorphism; PCR, polymerase chain reaction; BER, base excision repair; NER, nucleotide excision repair; MMR, mismatch repair; DSBR, double-strand break repair; REV3L, REV3-lik
Systematic Immunohistochemistry Screening for Lynch Syndrome in Early Age-of-Onset Colorectal Cancer Patients Undergoing Surgical Resection
Keywords: MMR، تعمیر ناسازگاری; CRC, colorectal cancer; IHC, immunohistochemistry; LS, Lynch syndrome; MSI, microsatellite instability; MMR, mismatch repair; MSKCC, Memorial Sloan-Kettering Cancer Center; SIFT, Sorts Intolerant From Tolerant Substitutions
The human MSH5 (MutSHomolog 5) protein localizes to mitochondria and protects the mitochondrial genome from oxidative damage
Keywords: MMR، تعمیر ناسازگاری; MSH5, MutS Homolog 5; mtDNA, mitochondrial DNA; PEO, progressive external ophtalmoplegia; MMR, mismatch repair; MSH1, MutS Homolog 1; MSH2, MutS Homolog 2; MSH3, MutS Homolog 3; MSH6, MutS Homolog 6; YB-1, Y-box binding protein; MSH4, MutS Homolog 4; hMSH
ATR–Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity
Keywords: MMR، تعمیر ناسازگاری; 5-FU, 5-fluorouracil; FUTP, fluorouridine triphosphate; FdUTP, fluorodeoxyuridine triphosphate; FdUMP, fluorodeoxyuridine monophosphate; TS, thymidylate synthase; BER, base excision repair; MMR, mismatch repair; DSB, double-strand break; HRR, homologous r
The generation of oxidative stress-induced rearrangements in Saccharomyces cerevisiae mtDNA is dependent on the Nuc1 (EndoG/ExoG) nuclease and is enhanced by inactivation of the MRX complex
Keywords: MMR، تعمیر ناسازگاری; BER, base excision repair; MMR, mismatch repair; mtDNA, mitochondrial DNA; ROS, reactive oxygen species; 8-oxoG, 8-oxo-7,8-dihydroguanine; HR, homologous recombinationMitochondrial genome; Oxidative lesions; MtDNA rearrangements; MRX; Nuc1
DNA repair in Corynebacterium model
Keywords: MMR، تعمیر ناسازگاری; 16S rDNA, 16S subunit ribosomal RNA coding gene; DNA, deoxyribonucleic acid; BER, base excision repair; DR, direct reversal; DDR, direct damage reversal; MMR, mismatch repair; NER, nucleotide excision repair; RR, recombination repairDNA repair; Bioinforma
The in vitro fidelity of yeast DNA polymerase δ and polymerase ɛ holoenzymes during dinucleotide microsatellite DNA synthesis
Keywords: MMR، تعمیر ناسازگاری; EF, error frequency; GD, gapped duplex; Indel, insertion/deletion; MF, mutant frequency; MMR, mismatch repair; Pol δ, yeast DNA polymerase delta holoenzyme; Pol ɛ, yeast DNA polymerase epsilon holoenzymeMicrosatellite instability; Indel mutation; DNA repl
Oxidized purine nucleotides, genome instability and neurodegeneration
Keywords: MMR، تعمیر ناسازگاری; 8-oxo-dG8, -oxoguanine; 8-oxo-dGTP, 8-oxo-2′-deoxyguanosine triphosphate; 2-OH-dATP, 2-hydroxy-2′-deoxyadenosine triphosphate; BER, base excision repair; MMR, mismatch repair; NER, nucleotide excision repair; PD, Parkinson's disease; HD, Huntington's dise
Lethal Mutagenesis: Targeting the Mutator Phenotype in Cancer
Keywords: MMR، تعمیر ناسازگاری; 5-OH-dC, 5-hydroxy-2′-deoxycytidine; AZT, azidothymidine; HBV, Hepatitis B virus; HCV, Hepatitis C virus; HCC, hepatocellular carcinoma; KP-1212, 5-aza-5,6,-dihydro-2′-deoxycytidine; MMR, mismatch repair; TCID50, 50% tissue culture infective doseLethal mu
Association of smoking and flat adenomas: results from an asymptomatic population screened with a high-definition colonoscope
Keywords: MMR، تعمیر ناسازگاری; COX2, cyclooxygenase-2; CRC, colorectal cancer; IQR, interquartile range; JRSC, Japanese Research Society Classification; MMR, mismatch repair; NSAIDs, nonsteroidal anti-inflammatory drugs; OR, odds ratio
The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound
Keywords: MMR، تعمیر ناسازگاری; CDK, cyclin-dependent kinase; RB, retinoblastoma protein; TMZ, temozolomide, i.e. 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; MMR, mismatch repair; CM, complete medium; MGM, melanocyte growth medium; BG, O6-benzylguanine; MGMT, O6-meth
Chromium genotoxicity: A double-edged sword
Keywords: MMR، تعمیر ناسازگاری; Cr(VI), hexavalent chromium; GSH, glutathione; ROS, reactive oxygen species; IN, intranasal; CHO, Chinese hamster ovary cells; Ni, nickel; ATM, ataxia telangiectasia mutated; BER, base excision repair; NER, nucleotide excision repair; MMR, mismatch repair
Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions
Keywords: MMR، تعمیر ناسازگاری; PAHs, polycyclic aromatic hydrocarbons; NER, nucleotide excision repair; MMR, mismatch repair; BER, base excision repair; GGR, global genomic repair; TCR, transcription coupled repair; AP, apurinic; XPA, xeroderma pigmentosum complementation group A; XPC,
Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome
Keywords: MMR، تعمیر ناسازگاری; CI, confidence interval; CRC, colorectal cancer; HNPCC, hereditary nonpolyposis colorectal cancer; HR, hazard ratio; HWE, Hardy–Weinberg equilibrium; kb, kilobase; LS, Lynch syndrome; MMR, mismatch repair; PCR, polymerase chain reaction
Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae
Keywords: MMR، تعمیر ناسازگاری; BER, base excision repair; ER, endoplasmic reticulum; MMR, mismatch repair; mtDNA, mitochondrial DNA; ROS, reactive oxygen species; 8-oxoG, 8-oxo-7,8-dihydroguaninemtDNA; Proteasome; Ump1p; Oxidative lesions
Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma
Keywords: MMR، تعمیر ناسازگاری; CI, confidence interval; CRC, colorectal cancer; DFS, disease-free survival; 5-FU, 5-fluorouracil; HR, hazard ratio; MMR, mismatch repair; MSI, microsatellite instability; OS, overall survival; TIL, tumor-infiltrating T lymphocyte; Treg, regulatory T cell
Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae
Keywords: MMR، تعمیر ناسازگاری; BER, base excision repair; MMR, mismatch repair; mtDNA, mitochondrial DNA; ROS, reactive oxygen species; 8-oxoG, 8-oxo-7,8-dihydroguaninemtDNA; Oxidative lesions; Msh1p; Recombination; Mitochondria
Double-strand break DNA repair genotype predictive of later mortality and cancer incidence in a cohort of non-smokers
Keywords: MMR، تعمیر ناسازگاری; NER, nucleotide excision repair; BER, base excision repair; DSBR, double-strand break repair; MMR, mismatch repair; DRR, direct reversal repair; EPIC, European prospective investigation into cancer and nutrition; SNP, single nucleotide polymorphism; XRCC,
P53 transcriptional activities: A general overview and some thoughts
Keywords: MMR، تعمیر ناسازگاری; EMSA, Electrophoresis Mobility Shift Assay; HR, Homologous Recombination; MMR, MisMatch Repair; NER, Nucleotide Excision Repair; NES, Nuclear Export Signal; NLS, Nuclear Localization Signal; NMR, nuclear magnetic resonance; RE, response element; ROS, Reac
Mouse Models of Colon Cancer
Keywords: MMR، تعمیر ناسازگاری; COX, cyclooxygenase; FAP, familial adenomatous polyposis; HNPCC, hereditary nonpolyposis colon cancer; IDL, insertion/deletion mutation; IL, interleukin; LOH, loss of heterozygosity; MMR, mismatch repair; MNNG, N-methyl-N′-nitro-N-nitrosoguanidine; MSI, m
Altered DNA Mismatch Repair Expression in Synchronous and Metachronous Colorectal Cancers
Keywords: MMR، تعمیر ناسازگاری; CI, confidence interval; CRC, colorectal cancer; MMR, mismatch repair
Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations
Keywords: MMR، تعمیر ناسازگاری; Aprt, adenine phosphoribosyltransferase; DSB, double-strand break; Hprt, hypoxanthineguanine phosphoribosyltransferase; IR, ionizing radiation; MF, mutant frequency; MMR, mismatch repair; MR, mitotic recombinationLoss of heterozygosity; Mismatch repair; M
Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: A case-control analysis
Keywords: MMR، تعمیر ناسازگاری; CI, confidential interval; EXO1, exonuclease 1; LD, linkage disequilibrium; MAF, minor allele frequency; MMR, mismatch repair; OR, odds ratio; SNPs, single nucleotide polymorphismsEXO1; MMR; Polymorphisms; Lung cancer; Susceptibility; Molecular epidemiolo
A Prospective, Multicenter, Population-Based Study of BRAF Mutational Analysis for Lynch Syndrome Screening
Keywords: MMR، تعمیر ناسازگاری; CRC, colorectal cancer; HNPCC, hereditary nonpolyposis colorectal cancer; MMR, mismatch repair; MSI, microsatellite instability; MSI-H, high-level microsatellite instability; MSI-L, low-level microsatellite instability
UvrD helicase of Plasmodium falciparum
Keywords: MMR، تعمیر ناسازگاری; BER, base excision repair; DSBR, double strand break repair; MMR, mismatch repair; NER, nucleotide excision repair; NTP, nucleoside triphosphate; SF, super-family.Helicase; Malaria; Plasmodium falciparum; UvrD
Overexpression of human NOX1 complex induces genome instability in mammalian cells
Keywords: MMR، تعمیر ناسازگاری; ROS, reactive oxygen species; RNS, reactive oxygen species; 8-oxoGua, 8-oxo-7,8dihydroguanine; MMR, mismatch repair; MEF, mouse embryo fibroblast; MSI, microsatelite instability; BER, base excision repair; SSB, single strand breakhNOX1; Reactive oxygen sp
DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae
Keywords: MMR، تعمیر ناسازگاری; ROS, reactive oxygen species; BER, base excision repair; NER, nucleotide excision repair; MMR, mismatch repair; TLS, translesion synthesis; REC, recombination; CPD, cyclobutane pyrimidine dimmer; 6–4 PP, 6–4 photoproduct; H2O2, hydrogen peroxide; MMS, met
Colorectal Cancer Risks in Relatives of Young-Onset Cases: Is Risk the Same Across All First-Degree Relatives?
Keywords: MMR، تعمیر ناسازگاری; CI, confidence interval; CRC, colorectal cancer; HNPCC, hereditary nonpolyposis colorectal cancer; MCSS, Minnesota Cancer Surveillance System; MMR, mismatch repair; MSI, microsatellite instability; MSS, microsatellite stable; NCI, National Cancer Institut
Homozygous PMS2 Deletion Causes a Severe Colorectal Cancer and Multiple Adenoma Phenotype Without Extraintestinal Cancer
Keywords: MMR، تعمیر ناسازگاری; aCGH, array-comparative genomic hybridization; FAP, familial adenomatous polyposis; HNPCC, hereditary nonpolyposis colorectal cancer; MAP, MUTYH-associated polyposis; MMR, mismatch repair; MSI, microsatellite instability; STS, sequence tagged site
Development of Colorectal Tumors in Colonoscopic Surveillance in Lynch Syndrome
Keywords: MMR، تعمیر ناسازگاری; CI, confidence interval; CRC, colorectal cancer; MMR, mismatch repair
The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites
Keywords: MMR، تعمیر ناسازگاری; MMR, mismatch repair; MSH, mutS homolog; MLH, mutL homolog; PlasmoDB, P. falciparum genome database; pBS-SK+, pBlueScript SK+ vector; gDNA, genomic DNA; SD, Sprague-Dawley; 5-FOA, 5-fluoroorotate; PCNA, proliferating cell nuclear antigenDNA mismatch repai
Methylation damage response in hematopoietic progenitor cells
Keywords: MMR، تعمیر ناسازگاری; HSCs, hematopoietic stem cells; MNU, N-methyl-N-nitrosourea; MMR, mismatch repair; BER, base excision repair; AML, acute myeloid leukaemia; NER, nucleotide excision repair; DSBs, double strand breaks; ENU, ethylnitrosourea; O6-meG, O6-methylguanine; O6MGM
Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles
Keywords: MMR، تعمیر ناسازگاری; Cm, Chloramphenicol; E. coli, Escherichia Coli; FUdR, 5-Fluoro-2′deoxyuridine; HSV-tk, Herpes Simplex Virus thymidine kinase; MMR, Mismatch repair; Pol, Polymerase; Rif, Rifampicin; STR, Short Tandem Repeat (microsatellite)Microsatellite mutation; dinB; D