کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3303961 | 1210325 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Association of smoking and flat adenomas: results from an asymptomatic population screened with a high-definition colonoscope Association of smoking and flat adenomas: results from an asymptomatic population screened with a high-definition colonoscope](/preview/png/3303961.png)
BackgroundFlat adenomas represent a morphologically distinct class of polyps that may be difficult to detect, and little is known regarding risk factors for these lesions. Identification of risk factors for these lesions may aid in colorectal cancer (CRC) screening, because patients at risk for these lesions may require special imaging techniques. Smoking, an important risk factor for CRC, may be associated with molecular changes that increase the risk for flat adenomas.ObjectiveThe aim of this study was to examine the association between smoking and flat adenomas.DesignProspective cross-sectional study.SettingUniversity hospital endoscopy center.PatientsWe enrolled asymptomatic patients presenting for CRC screening.InterventionsWe screened patients with a high-definition (1080i signal) wide-angle (170° field of view) Olympus 180-series colonoscope. We collected demographics, medication use, family history of CRC, diet history, and smoking history.Main Outcome MeasurementsPolyp morphology, assessed by using the Japanese Research Society Classification (JRSC).ResultsA total of 600 patients were enrolled. We observed that smoking was associated with having a flat adenoma of any size (adjusted odds ratio [OR], 2.53; 95% CI, 1.60-4.00), having only flat adenomas that were ≥6 mm in diameter (adjusted OR, 3.84; 95% CI, 2.02-7.32), as well as flat advanced adenomas (adjusted OR, 2.81; 95% CI, 1.08-7.30).LimitationsThe study design may not account for some confounding variables and provides no information regarding smoking status at the time of initiation of flat adenomas.ConclusionSmoking was associated with flat adenomas in our population. Our findings may explain the earlier onset of CRC in smokers as well as the advanced stage with which they present, with compared with nonsmokers. Smokers may require screening with high-definition colonoscopes to detect flat adenomas.
Journal: Gastrointestinal Endoscopy - Volume 71, Issue 7, June 2010, Pages 1234–1240