
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65
Keywords: MOI، چندگانگی عفونت; Ad-RPE65, adenovirus expressing RPE65; LCA, Leber congenital amaurosis; MOI, multiplicity of infection; RPE, retinal pigment epithelium; CHX, cycloheximideRPE65; Visual cycle; Isomerohydrolase; Leber congenital amaurosis; Retinoids