Keywords: ALK; anaplastic lymphoma receptor tyrosine kinase; ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; APE1; apurinic/apyimidinic endonuclease 1; AKT; v-akt murine thymoma viral oncogene; BER; base excision repair; BRCA1; breast cancer 1; BRCA2
مقالات ISI (ترجمه نشده)
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The mre11A470T mutation and homeologous interactions increase error-prone BIR
Keywords: aa; amino acid; BIR; break-induced replication; CHEF electrophoresis; contour-clamped homogeneous electric field electrophoresis; d; deoxyribo-; ds; double-strand(ed); kb; kilobase(s) or 1000â¯bp; kan; kanamycin; kd; kilodalton(s); nt; nucleotides; oligo
Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair
Keywords: CDK4/6; cyclin-dependent kinases 4 and 6; CDK2; cyclin-dependent kinase 2; iCDK4/6; inhibitor of CDK4/6; LEE011; inhibitor of CDK4/6, ribociclib, Kisqali; PD0332991; inhibitor of CDK4/6, palbociclib, Imbrance; NU6140; cyclin-dependent kinase 2 (CDK2) inhi
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses
Keywords: DNA damage response; Mre11; SV40; Polyomavirus; BK polyomavirus; Polyamide; Antiviral;
Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?
Keywords: E3 ubiquitin ligase; Cullin RING ligase; Ubiquitin-proteasome system; Therapeutic targets; ASB; ankyrin repeat-containing proteins with a SOCS box; β-Trcp; β-transducin repeat-containing protein; BTB; bric-a-brac; CIS1; cytokine-inducible Src homology
Cancer TARGETases: DSB repair as a pharmacological target
Keywords: DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel
MR (Mre11-Rad50) complex in Giardia duodenalis: In vitro characterization and its response upon DNA damage
Keywords: Giardia duodenalis; DNA repair; Double strand breaks; Mre11; Rad50;
Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia
Keywords: Myoclonus; Progressive myoclonic ataxia; Tremor; Ataxia-telangiectasia-like disorder; Neurogenetics; MRE11;
Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells
Keywords: PARP inhibitors; MSI; MRE11; DNA damage; Colorectal cancer;
The MRE11 complex: An important source of stress relief
Keywords: DNA damage; DNA repair; Cell cycle checkpoint; Apoptosis; Genomic instability; Cancer; Replication fork; MRE11; RAD50; NBS1;
Phosphorylation of PTEN at STT motif is associated with DNA damage response
Keywords: Phosphatase and tensin homolog deleted from chromosome Ten (PTEN); Phosphorylation; DNA damage repair; Mre11; Ku70; γH2AX; Etoposide;
The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes
Keywords: Mre11; Rad50; Nbs1; DNA double-strand break repair;
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Studying the cerebellar DNA damage response in the tissue culture dish
Keywords: 53BP1; p53 binding protein 1; AOA1/2; ataxia with oculomotor apraxia type 1; A-T; ataxia-telangiectasia; A-TLD; ataxia-telangiectasia-like disorder/disease; ATM; ataxia-telangiectasia, mutated; ATR; ATM- and Rad3-related protein kinase; CaBP; calbindin pr
Influence of MRE11, RAD50 and NIBRIN protein expression on survival in pancreatic carcinoma after curative resection
Keywords: MRE11; RAD50; NIBRIN; Survival; Pancreatic carcinoma;
TIS21/BTG2/PC3 accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2T68-p53S20 pathway
Keywords: TIS21; TPA inducible sequence 21; DSBs; DNA double strand breaks; TIS21â/âMEF; TIS21 knockout mouse embryo fibroblast; wt-MEF; wild type mouse embryo fibroblast; PRMT1; protein arginine methyltransferase 1; Mre11; meiotic recombination 11; Chk2; check
Defective homologous recombination in human cancers
Keywords: Homologous recombination; DNA repair; BRCA; ATM; ATR; MRE11; RAD50; NSB1; RAD51; FANC
DNA end resection—Unraveling the tail
Keywords: Mre11; Sae2; Sgs1; Dna2; Exo1; Resection; Recombination
Brca2, Rad51 and Mre11: Performing balancing acts on replication forks
Keywords: DNA replication; Mre11; Rad51
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly
Keywords: Nijmegen breakage syndrome (NBS); Ataxia–telangiectasia-like disorder (ATLD); Nijmegen breakage syndrome-like disorder (NBSLD); ATM; MRE11; NBS1; Microcephaly
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
Keywords: Chk1; Chk2; Rad53; Rad9; Mre11; Nbs1; Rad50; ATR; ATM; Tel1; Cell cycle; Checkpoint; Transcription; Apoptosis; DNA repair; Recombination
DNA end resection: Many nucleases make light work
Keywords: Double-strand break; Repair; Recombination; Mre11; Sae2/CtIP; Exo1; Sgs1/BLM
Ku, Artemis, and ataxia-telangiectasia-mutated: Signalling networks in DNA damage
Keywords: AT; ataxia-telangiectasia; ATM; ataxia-telangiectasia-mutated; ATR; ataxia-telangiectasia and Rad3-related; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; catalytic subunit of DNA-dependent protein kinase; DSBs; double-strand breaks; ROS; reactive oxygen
Unique and overlapping functions of the Exo1, Mre11 and Pso2 nucleases in DNA repair
Keywords: Exo1; Mre11; Pso2; Interstrand cross-links; Homologous recombination
Deficient repair of particulate hexavalent chromium-induced DNA double strand breaks leads to neoplastic transformation
Keywords: Chromium; Lead chromate; Mre11; DNA double strand break; Neoplastic transformation
Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway
Keywords: Cadmium; DSB repair; NHEJ; DNA-PK; MRE11
The importance of making ends meet: Mutations in genes and altered expression of proteins of the MRN complex and cancer
Keywords: MRE11; RAD50; NBS1; Double-strand break repair; Carcinogenesis
Archaeal DNA helicase HerA interacts with Mre11 homologue and unwinds blunt-ended double-stranded DNA and recombination intermediates
Keywords: Helicase; HerA; Mre11; Archaea; Sulfolobus tokodaii; Homologous recombination
NBS1 and MRE11 associate for responses to DNA double-strand breaks
Keywords: NBS1; MRE11; Checkpoint; Homologous recombination
Radiosensitization of head/neck sqaumous cell carcinoma by adenovirus-mediated expression of the Nbs1 protein
Keywords: double-strand break; Mre11; Rad50; Nijmegen breakage syndrome;
Intact Mre11/Rad50/Nbs1 Complex Predicts Good Response to Radiotherapy in Early Breast Cancer
Keywords: Radiotherapy; Breast cancer; Mre11; Rad50; Nbs1;
The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication
Keywords: Adenovirus; E4 mutant; DNA replication; Double strand break repair; Mre11; Damage response; Mdc1
ATM signaling and 53BP1
Keywords: ATM; 53BP1; NBS1; MRE11; RAD50; DNA damage checkpoint;
Protein kinase CK2 interacts with Chk2 and phosphorylates Mre11 on serine 649
Keywords: Mre11; Protein kinase CK2; Chk2; Phosphorylation; DNA damage response pathway;
Analysis of ionizing radiation-induced foci of DNA damage repair proteins
Keywords: Homologous recombination; Non-homologous DNA end joining; Cell cycle; Rad51; Mre11;
The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae
Keywords: Non-homologous end joining; NHEJ; Mre11; Rad50; Xrs2; Double-strand break repair; Microhomology;