کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1980796 1061881 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
چکیده انگلیسی

The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon recognition of DNA damage by sensor proteins, an intricate signal transduction network is activated to coordinate diverse cellular outcomes that promote genome integrity. Key components of the DDR in mammalian cells are the checkpoint effector kinases Chk1 and Chk2 (referred to henceforth as the effector kinases; orthologous to spChk1 and spCds1 in the fission yeast S. pombe and scChk1 and scRad53 in the budding yeast S. cerevisiae). These evolutionarily conserved and structurally divergent kinases phosphorylate numerous substrates to regulate the DDR. This review will focus on recent advances in our understanding of the structure, regulation, and functions of the effector kinases in the DDR, as well as their potential roles in human disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 8, Issue 9, 2 September 2009, Pages 1047–1054
نویسندگان
, , ,