Multifunctional triblock copolymers for intracellular messenger RNA delivery
Keywords: mRNA; Gene therapy; Copolymer; Micelle; Immune response;
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The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts
Keywords: mRNA; Reprogramming; Lipofection; Transfection; Immune response
The identification and oxidative stress response of a zeta class glutathione S-transferase (GSTZ1) gene from Apis cerana cerana
Keywords: ROS; reactive oxygen species; GSTs; glutathione S-transferases; cDNA; complementary DNA; bp; base pair(s); UTR; untranslated region; ORF; open reading frame; mRNA; messenger ribonucleic acid; RACE; rapid amplification of cDNA ends; RT-PCR; reverse transcr
Treadmill training stimulates brain-derived neurotrophic factor mRNA expression in motor neurons of the lumbar spinal cord in spinally transected rats
Keywords: BDNF; brain-derived neurotrophic factor; DIG; Digoxigenin; HSP27; heat shock protein 27; ISH; in situ hybridization; mRNA; messenger ribonucleic acid; ST; spinally transected; ST100; spinally transected + treadmill training for 100 steps/session; ST1000
Developmental alterations in CNS stress-related gene expression following postnatal immune activation
Keywords: 5-HT; serotonin; 5-HT2A; serotonin receptor 2A; 5-HT2C; serotonin receptor 2C; ACTH; adrenocorticotropic releasing hormone; BLA; basolateral amygdala; CA1; cornuammonis 1; CA3; cornuammonis 3; CeA; central amygdala; CNS; central nervous system; CORT; cort
Molecular and physiological responses to long-term sublethal ammonia exposure in Atlantic salmon (Salmo salar)
Keywords: TAN; total ammonia nitrogen; plasma [Tamm]; plasma ammonia levels; Rh; Rhesus glycoprotein; UT; urea transporter; Aqp; aquaporin; H+-ATPase; V-type H+-ATPase; mRNA; messenger RNA; Gln; glutamine; Glu; glutamate; Gsase; glutamine synthetase; HEA; high envi
A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
Keywords: cDNA; Complementary DNA; CHE; Cholesteryl hexadecyl ether; Chol; Cholesterol; DMEM; Dulbecco's modified Eagle medium; DMG; Dimyristoyl-sn-glycerol; DSG; Distearoyl-sn-glycerol; DODAP; 1,2-Dioleoyl-3-dimethylammonium propane; DOPC; 1,2-Dioleoyl-sn-glycero-
Analysis of the 5′ untranslated region (5′UTR) of the alcohol oxidase 1 (AOX1) gene in recombinant protein expression in Pichia pastoris
Keywords: AOX1, alcohol oxidase 1; UTR, untranslated region; nt, nucleotides; eIF, eukaryotic initiation factorPichia pastoris; Recombinant protein expression; Translational regulation; Untranslated regions; mRNA
Enhanced Expression and Shedding of Tumor Necrosis Factor (TNF) Receptors from Mononuclear Leukocytes in Human Heart Failure
Keywords: TNF receptor; Flow cytometry; mRNA; Shedding; Heart failure; Matrix metalloproteinase.
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models
Keywords: AUC; area under the curve; CH; compound heterozygote; CS; Cockayne syndrome; GG-NER; global genome NER; IGF-1; insulin-like growth factor 1; IGF-1R; insulin-like growth factor receptor; IR; ionizing radiation; MDF; mouse dermal fibroblast; MEF; mouse embr
Inferring functional miRNA–mRNA regulatory modules in epithelial–mesenchymal transition with a probabilistic topic model
Keywords: miRNA; mRNA; Functional regulatory modules; Epithelial–mesenchymal transition; Probabilistic topic model
The effects of sub-lethal concentrations of silver nanoparticles on inflammatory and stress genes in human macrophages using cDNA microarray analysis
Keywords: Nanoparticle; Silver; Macrophage; Interleukin; mRNA
Cloning and functional expression of novel cholesterol transporters ABCG1 and ABCG4 in gonadotropin-releasing hormone neurons of the tilapia
Keywords: ABCG transporters; teleost; GnRH; lipid; cholesterol; ABC; ATP-binding cassette; AP; adapter primer; apoE; apolipoprotein E; AUAP; abridged universal amplification primer; BSA; bovine serum albumin; Cb; Cerebellum; cDNA; complementary DNA; dNTP; deoxyribo
Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampus
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; amyg nu; amygdala nucleus; BCA; bicinchoninic acid; cc; corpus callosum; cDNA; complementary deoxyribonucleic acid; ChAT; choline acetyltransferase; CHT1; high affinity choline transporter; CP; crossing poin
Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions
Keywords: microRNA; mRNA; milk; bovine;
Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation
Keywords: ANOVA; analysis of variance; cDNA; complementary DNA; Ctsk; cathepsin K; CO; chitooligosaccharide; ECM; extracellular matrix; Egr2; early growth response 2; Fasn; fatty acid synthase; FER; feed efficiency ratio; FFA; free fatty acid; Gdf3; growth differen
Effects of a putative antidepressant with a rapid onset of action in defeated mice with different coping strategies
Keywords: 5-HT1A; 5-hydroxytryptamine 1A; 5-HT4; 5-hydroxytryptamine 4; CEBA; Ethical Committee for animal welfare; cDNA; complementary deoxyribonucleic acid; DNA; deoxyribonucleic acid; Dnase; deoxyribonuclease; FST; forced swimming test; GAPDH; glyceraldehyde-6-p
Systemic inflammation and priming of peripheral blood leukocytes persist during clinical remission in horses with heaves
Keywords: BAL; bronchoalveolar lavage; CD; cluster of differentiation; fMLP; Nformyl-Met-Leu-Phe; LPS; lipopolysaccharide; mRNA; messenger RNA; NF-κB; nuclear factor-kappaB; PAMPS; pathogen-associated molecular patterns; PBMC; peripheral blood mononuclear cells; P
In vitro and in vivo bioactivity of CoBlast hydroxyapatite coating and the effect of impaction on its osteoconductivity
Keywords: Biomaterial; Hydroxyapatite coating; CoBlast; Mesenchymal stem cells; Osteoconduction; Osseointegration; mRNA; PCR
β-Catenin Regulates Deiodinase Levels and Thyroid Hormone Signaling in Colon Cancer Cells
Keywords: Thyroid Receptor; Intestinal Epithelium; Colorectal Cancer; Hypothalamus; bp; base pair; CMV; Cytomegalovirus; D3; type 3 deiodinase; DIO3; Type 3 deiodinase gene; EMSA; electrophoretic mobility shift assay; miRCâ; negative control miR microRNA; miRD3;
Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia
Keywords: Alternative splicing; Genetics; mRNA; Postmortem brain; Schizophrenia; Transcriptomics;
Biological effects of the anti-parasitic chemotherapeutant emamectin benzoate on a non-target crustacean, the spot prawn (Pandalus platyceros Brandt, 1851) under laboratory conditions
Keywords: Pandalus platyceros; Emamectin benzoate; mRNA; Real-time quantitative polymerase chain reaction; Spot prawn; Subtractive hybridization
Internalization and induction of antioxidant messages by microvesicles contribute to the antiapoptotic effects on human endothelial cells
Keywords: Act D; actinomycin D; ATP; adenosine triphosphate; BSA; bovine serum albumin; CMH; 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine; Cu/Zn-SOD; copper/zinc superoxide dismutase; CUR61414; N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazi
Sexual Dimorphism in Urinary Angiotensinogen Excretion During Chronic Angiotensin II−Salt Hypertension
Keywords: angiotensinogen; intrarenal RAS; mRNA; proteinuria; sex differences; Sprague-Dawley rats; systolic blood pressure
Comparison of propidium monoazide-quantitative PCR and reverse transcription quantitative PCR for viability detection of fresh Cryptosporidium oocysts following disinfection and after long-term storage in water samples
Keywords: Cryptosporidium parvum; PMA; mRNA; Water concentrate; Disinfection; Long-term storage
Hypothalamic vasopressin system regulation by maternal separation: Its impact on anxiety in rats
Keywords: 3hMS; procedure of maternal separation for 3Â h; AFR; animal facility-reared pups; AVP; arginine vasopressin; DEPC; diethyl pyrocarbonate; ELISA; Enzyme linked ImmunoSorbent Assay; EPM; elevated plus maze test; ISH; in situ hybridization; mRNA; messenger
Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E
Keywords: Mouse Model; Carcinogenesis; shRNA; CCK-8; AFP; α-fetoprotein; ChIP; chromatin immunoprecipitation; CHO; Chinese hamster ovary; EGFP; enhanced green fluorescent protein; GPC3; glypican 3; HA; hemagglutinin; HCC; hepatocellular carcinoma; mRNA; messenger
Pharmacologic magnetic resonance imaging (phMRI): Imaging drug action in the brain
Keywords: 7-NI; 7-nitroindazole; BBB; blood brain barrier; BOLD; blood oxygenation level dependent; CBF; cerebral blood flow; CBV; cerebral blood volume; CFT; ((2β-carbomethoxy-3β-(4-fluorophenyl) tropane); CMRglc; cerebral metabolic rate glucose; DA; dopamine; f
Dynamic expression profiles of virus-responsive and putative antimicrobial peptide-encoding transcripts during Atlantic cod (Gadus morhua) embryonic and early larval development
Keywords: ADAM; A disintegrin and metalloproteinase domain; AMP; Antimicrobial peptide; ARPC4; Actin-related protein 2/3 complex subunit 4; ATF; Activating transcription factor; BLAST; Basic local alignment search tool; C; Celsius; cAMP; Cyclic adenosine monophosph
Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice
Keywords: Mouse Model; Immune Response; Bone Marrow-Derived Macrophages; Myofibroblast; aHSCs; activated HSCs; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; BM; bone marrow; CCl4; carbon tetrachloride; Col-GFP mice; collagen-α1(I)-GFP mice; EC; endothel
Liver Failure After Extended Hepatectomy in Mice Is Mediated by a p21-Dependent Barrier to Liver Regeneration
Keywords: Liver Regeneration; Small-For-Size Syndrome; Extended Hepatectomy; Liver Regeneration Failure; ATP; adenosine triphosphate; eHx; extended 86% hepatectomy; LW/BW; liver weight to body weight ratio; mRNA; messenger RNA; PCNA; proliferating cell nuclear anti
Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells
Keywords: Chemoprevention; Colon Cancer; Oncogene; Tumor Suppressor; ACC; acetyl-CoA carboxylase; ADP; adenosine diphosphate; AMPK; adenosine monophosphate-activated protein kinase; ATP; adenosine triphosphate; CRC; colorectal cancer; eIF4E; eukaryotic translatio
Interferon-γ-Stimulated Genes, but Not USP18, Are Expressed in Livers of Patients With Acute Hepatitis C
Keywords: HCV; Jak-STAT Signaling; Host-Virus Interaction; Immune Response; AHC; acute hepatitis C; CHC; chronic hepatitis C; CHC-NR; CHC nonresponder; CHC-R; CHC responder; HCV; hepatitis C virus; HPF; high-power field; ISG; interferon-stimulated gene; JAK; Ja
Expression of vasa and nanos3 during primordial germ cell formation and migration in Atlantic cod (Gadus morhua L.)
Keywords: Embryogenesis; mRNA; Nanos; ISH; primordial germ cells; Vasa;
ReviewAdvances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders
Keywords: CNS; central nervous system; GOI; gene of interest; mRNA; messenger RNA; siRNA; short interfering RNA; miRNA; microRNA; pri-miRNA; primary microRNA; pre-miRNA; microRNA precursor; AD; Alzheimer disease; Aβ; amyloid-β; APP; amyloid-β precursor protein;
Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice
Keywords: Genetically Engineered Mouse Model; Notch Activation; Gene Expression Profiling; AFP; α-fetoprotein; GFP; green fluorescent protein; GSI; γ-secretase inhibitor; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; Igf2; insulin-like growth factor 2; I
Devil's Claw-A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens
Keywords: 5-LOX; 5-lipo-oxygenase; 6â²-PCHG; 6â²-O-p-coumaroylharpagide; 8-PCHG; 8-p-coumaroylharpagide; BCL; Bicuculline; COX-2; cyclooxygenase-2; CREB; cAMP response element-binding; CYP; cytochrome P450; DAD; diode array detection; DPPH; 2, 2-diphenyl-1-picryl
Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies
Keywords: Enterohepatic Circulation; Cholehepatic Shunt; Bicarbonate Secretion; Bile Acid Transporters; Asbt; apical sodium-dependent bile salt transporter; BA; bile acid; cAMP; adenosine 3â²,5â²-cyclic monophosphate; Cck; cholecystokinin; CF; cystic fibrosis; CF
Neurodegeneration the RNA way
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; Aβ42; amyloid β - 42 amino acids; CUGBP1; CUG binding protein 1; DM1; myotonic dystrophy type 1; DM2; myotonic dystrophy type 2; FTD; frontotemporal dementia;
miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions
Keywords: Liver Cancer; mRNA Processing; Gene Expression; Cell Death; GFP; green fluorescent protein; HCC; hepatocellular carcinoma; mRNA; messenger RNA; miRNA; microRNA; mTOR; mammalian target of rapamycin; PCR; polymerase chain reaction; PDK1; 3â²-phosphoinositi
Stress and animal models of inflammatory bowel disease-An update on the role of the hypothalamo-pituitary-adrenal axis
Keywords: AA; acetic acid; ACTH; adrenocorticotrope hormone; ADX; adrenalectomy; ANS; autonomic nervous system; AVP; arginine vasopressin; CD; Crohn's disease; CD; cluster of differentiation; CRC; colorectal cancer; CRH; corticotrophin releasing hormone; CSC; chron
Farnesoid X Receptor Protects Hepatocytes From Injury by Repressing miR-199a-3p, Which Increases Levels of LKB1
Keywords: Nuclear Receptor; Noncoding RNA; Mitochondrial Protection; Fibrotic Liver Injury; AA; arachidonic acid; AMPK; AMP-activated protein kinase; ASO; antisense oligonucleotide; CAB39; calcium binding protein 39; CDCA; chenodeoxycholic acid; DCFH-DA; 2â²,7â²-
Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease
Keywords: Inflammatory Bowel Disease; IAP; 17-AAG; Immune Regulation; AAG; N-Allylamino-17-Demethoxygeldanamycin; CD; Crohn's disease; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HSP; heat shock protein; IBD; inflammatory bowel disease; IL; interleukin; LPT; l
Glucocorticoids Promote Hepatic Cholestasis in Mice by Inhibiting the Transcriptional Activity of the Farnesoid X Receptor
Keywords: Bile Acid Metabolism; Small Heterodimer Partners; Liver Disease; Nuclear Receptor; ALT; alanine aminotransferase; BA; bile acid; BMI; body mass index; ChIP; chromatin immunoprecipitation; CtBP; C-terminal binding protein; Cyp7A1; cytochrome P450, family 7
MicroRNA-26a Promotes Cholangiocarcinoma Growth by Activating β-catenin
Keywords: Biliary Tract; Prostaglandin; COX-2; Post-Transcription Gene Regulation; COX-2; cyclooxygenase-2; CTD; C-terminal domain; GSK-3β; glycogen synthase kinase-3β; LEF; lymphoid enhancer factor; miRNA; microRNA; mRNA; messenger RNA; 15-PGDH; 15-hydroxyprosta
The RNA-Binding Protein RBPMS2 Regulates Development of Gastrointestinal Smooth Muscle
Keywords: Developmental Biology; RNA-Binding Protein; Gastrointestinal Tract; Smooth Muscle Contraction; αSMA; α-smooth muscle actin; BMP; bone morphogenetic protein; CIPO; chronic intestinal pseudo-obstruction; DMEM; Dulbecco's modified Eagle medium; E; embryoni
Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer Cells
Keywords: Transcript Regulation; Gene; RNA Processing; CRC; colorectal cancer; miRNA; microRNA; MSS; microsatellite stable; mRNA; messenger RNA; MSI; microsatellite unstable; PCR; polymerase chain reaction; SCR; scrambled negative control; PARP1; poly(adenosine dip
Pan-Histone Deacetylase Inhibitor Panobinostat Sensitizes Gastric Cancer Cells to Anthracyclines via Induction of CITED2
Keywords: Cancer Treatment; Stomach; Chemotherapeutic Agent; cDNA; complementary DNA; CEA/Tag; transgenic CEA424/SV40 T-antigen mouse line; ChIP; chromatin immunoprecipitation; CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxyterminal domain 2;
Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival
Keywords: Liver Cancer; Tumor Profiling; Cancer Driver Genes; arrayCGH; array-based comparative genomic hybridization; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; LCI; Liver Cancer Institute; LEC; Laboratory of Experimental Carcinogenesis; mRNA; messenge
Igf2bp1 Is Required for Full Induction of Ptgs2 mRNA in Colonic Mesenchymal Stem Cells in Mice
Keywords: Cox-2; Imp-1; ZBP1; Colorectal Cancer; Inflammatory Bowel Disease; α-SMA; α-smooth muscle actin; ARE; AU-rich elements; cDNA; complementary DNA; cMSC; colonic mesenchymal stem cell; GFP; green fluorescent protein; Igf2bp1; insulin-like growth factor 2 b