کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5904608 | 1158021 | 2012 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation
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کلمات کلیدی
ECMGDF3RETNmetallopeptidaseCTSKTIMP1Egr2HDL-CLDL-CRT-PCRChitooligosaccharideFFAMMPmRNAcDNA - cDNAComplementary DNA - DNA تکمیلیmessenger RNA - RNA messengerAdipogenesis - آدیپوژنزFree fatty acid - اسید چرب آزادfatty acid synthase - اسید چرب سنتازinflammation - التهاب( توروم) FER - انجام دهیدGene expression - بیان ژنanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetriglyceride - تریگلیسریدResistin - رزیستینhigh-fat diet - رژیم غذایی با چربی بالاFasn - فسادhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالExtracellular matrix - ماتریکس خارج سلولیObesity - مرض چاقیTissue inhibitor of metalloproteinase 1 - مهار کننده بافت متالوپروتئیناز 1feed efficiency ratio - نسبت بازده خوراکReverse transcriptase-polymerase chain reaction - واکنش زنجیره ای واکنش زنجیره ای واکنش زنجیره ایEarly growth response 2 - پاسخ رشد اولیه 2high-fat - چربی بالاCathepsin K - کتهفسین کtotal cholesterol - کلسترول تامLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
Chitooligosaccharide (CO) has been reported to have potential antiobestic effects in a few studies, but the antiobesity properties of CO and its related mechanisms in models of dietary obesity remain unclear. We investigated the effect of CO on body weight gain, size of adipocytes, adipokines, and lipid profiles in high-fat (HF) diet-induced obese mice and on the gene expression in adipose tissue using a complementary DNA microarray approach to test the hypothesis that CO supplementation would alleviate HF diet-induced obesity by the alteration of adipose tissue-specific gene expression. Male C57BL/6N mice were fed a normal diet (control), HF diet, or CO-supplemented HF diet (1% or 3%) for 5 months. Compared with the HF diet mice, mice fed the 3% CO-supplemented diet gained 15% less weight but did not display any change in food and energy intake. Chitooligosaccharide supplementation markedly improved serum and hepatic lipid profiles. Histologic examination showed that epididymal adipocyte size was smaller in mice fed the HF + 3% CO. Microarray analysis showed that dietary CO supplementation modulated adipogenesis-related genes such as matrix metallopeptidases 3, 12, 13, and 14; tissue inhibitor of metalloproteinase 1; and cathepsin k in the adipose tissues. Twenty-five percent of the CO-responsive genes identified are involved in immune responses including the inflammatory response and cytokine production. These results suggest that CO supplementation may help ameliorate HF diet-induced weight gain and improve serum and liver lipid profile abnormalities, which are associated, at least in part, with altered adipose tissue gene expression involved in adipogenesis and inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 32, Issue 3, March 2012, Pages 218-228
Journal: Nutrition Research - Volume 32, Issue 3, March 2012, Pages 218-228
نویسندگان
Eun Hye Choi, Hyun Pil Yang, Hyang Sook Chun,