Telmisartan pharmacokinetics in Japanese renal transplant recipients
Keywords: Telmisartan; UGT; OATP; MRP2; Pharmacokinetics
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Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease
Keywords: Bile; Liver; MRP2; Multidrug-resistance-associated protein; Gene variant; ABCC2; Fatty liver disease; NASH
In vivo evaluation of thiolated poly(acrylic acid) as a drug absorption modulator for MRP2 efflux pump substrates
Keywords: Poly(acrylic acid); Thiomers; MRP2; MRP2 inhibition; Sulforhodamine;
Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513
Keywords: P-glycoprotein; BCRP; MRP2; LS513; ABC transporters
Influence of luminal monosaccharides on secretion of glutathione conjugates from rat small intestine in vitro
Keywords: Glutathione conjugates; MRP2; Hypoosmolarity; Glucose; SGLT
The patient presenting with isolated hyperbilirubinemia
Keywords: Bilirubin; Crigler-Najjar syndrome; Dubin-Johnson syndrome; Gilbert syndrome; MRP2; UDP-GT
Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
Keywords: BCRP; MRP2; ERCC1; BRCA1; Stage IV; Non-small-cell lung cancer
Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose
Keywords: Acetaminophen; Liver toxicity; Mrp2; Mrp3; Enterohepatic recirculation
Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp
Keywords: Astilbin; Taxifolin; P-gp; MRP2; Caco-2 cell; Absorption
Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2
Keywords: Boswellic acids; Permeability; P-glycoprotein; OATP1B3; MRP2; Caco-2; Absorption;
Effect of ursodeoxycholic acid treatment on the expression and function of multidrug resistance-associated protein 2 in rat intestine
Keywords: UDCA; Mrp2; DNP-SG; methotrexate; intestine;
Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures
Keywords: ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ASBT; apical sodium-dependent bile acid transporter; AUC; area under the curve; BS; bile salts; BSEP; bile salt export pump; CH; cholesterol; FI; fold induction; γ
Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy
Keywords: ICP, intrahepatic cholestasis of pregnancy; MRP2, multidrug-resistance-associated protein; SNPs, single nucleotide polymorphisms; ALT, alanine aminotransferase; AST, aspartate aminotransferaseBile; Liver; MRP2; Multidrug-resistance-associated protein; Gen
Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether
Keywords: Deuxemether; Pharmacokinetics; Tissue distribution; Protein binding; Elimination; MRP2
Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system
Keywords: MRP2; ABCC2; CMFDA; Fluorescence assay; ABC-protein
Molecular cloning and functional characterization of cynomolgus monkey multidrug resistance-associated protein 2 (MRP2)
Keywords: ABC; ATP-binding cassette; MRP; multidrug resistance-associated protein; CMV; canalicular membrane vesicles; E2-17βG; 17β-estradiol 17-(β-d-glucuronide); DNP-SG; 2,4-dinitrophenyl-S-glutathione; LTC4; leukotriene C4; ABC transporter; MRP2; Cynomolgus m
Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats
Keywords: Arsenite; Mrp2; Liver functionMrp2, multidrug resistance protein 2; HGAAS, hydride generation atomic absorption spectrometry; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GSH-PX, glutathione peroxidase; MDA, malon dialdehyde; ATP, adeno
The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
Keywords: ABC transporters; MRP1; MRP2; Quercetin; Flavonoids; Phase II metabolism
Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3
Keywords: ERM, ezrin/radixin/moesin; mAb, monoclonal antibody; pAb, polyclonal antibody; Mrp, multidrug resistance protein; Rdx, radixin; Bsep, bile salt export pump; P-gps, P-glycoprotein; EMB, early mixed background; LMB, late mixed backgroundERM; Mrp2; Mrp3; Hyp
Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell
Keywords: Hyaluronate; Non-small cell lung cancer; Chemoresistance; CD44s; MRP2
RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells
Keywords: RNAi; ABCC2; MRP2; cMOAT; ABC-transporter; Cisplatin; Paclitaxel; Drug resistance
Cytoprotective responses in the Mediterranean mussel exposed to Hg2+ and CH3Hg+
Keywords: HSP70; HSC70; PgP; Mrp2; Mvp; Mytilus galloprovincialis; Mussel; Gene expression; Mercury; Methyl-mercury
Radixin Is Required to Maintain Apical Canalicular Membrane Structure and Function in Rat Hepatocytes
Keywords: Ad-siRadixin; adenovirus-mediated short interfering RNA for radixin; Bsep; bile salt export pump; CGamF; cholylglycylamido-fluorescein; CMFDA; 5-chloromethylfluorescein diacetate; ERM; ezrin-radixin-moesin; MOI; multiplicity of infection; Mrp2; multidrug-
Naproxen-induced oxidative stress in the isolated perfused rat liver
Keywords: TBARS; thiobarbituric acid reactive substances; GSH; glutathione; GSSG; oxidized glutathione; KHBB; Krebs-Henseleit bicarbonate buffer; MDA; malondialdehyde; TBA; thiobarbituric acid; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophores
Involvement of the multidrug resistance transporters in cisplatin-induced neuropathy in rats. Comparison with the chronic constriction injury model and monoarthritic rats
Keywords: mdr1a; mdr1b; mrp2; Cisplatin; Neuropathy; Mononeuropathy;
Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis
Keywords: Polarized hepatocyte culture model; Bile secretion; Membrane transport; Bsep; Mrp2; Oatp; ATP; Glutathione
Dual Hereditary Jaundice: Simultaneous Occurrence of Mutations Causing Gilbert's and Dubin-Johnson Syndrome
Keywords: ABCC2; ATP-binding cassette protein C2; BSP; bromosulphthalein; CEACAM1; CEA-related adhesion molecule 1; DAPI; 4',6-diamidino-2-phenylindole; DJS; Dubin-Johnson syndrome; GS; Gilbert's syndrome; HIDA; 2,6-dimethylacetanilido-iminodiacetic acid; MRP2;
Developmental expression of canalicular transporter genes in human liver
Keywords: Cholestasis; BSEP; MDR3; MRP2; Ontogeny;
Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids
Keywords: Multidrug resistance; MRP2; MRP3; Glucocorticoids; Transcriptional regulation; Dexamethasone; Hydrocortisone; Prednisone;
Characterization of Secretory Intestinal Transport of Phenolsulfonphthalein
Keywords: PSP; organic anion; intestinal secretion; Mrp2; pravastatin;
Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TRâ rats
Keywords: Mrp; multidrug resistance-associated protein; TRâ; transport-deficient rat; UGT; UDP-glucuronosyltransferase; bDNA; branched DNA; PAH; p-aminohippurate; CYP; cytochrome P450; Mrp4; Mrp2; TRâ rat; Kidney; Up-regulation; Gunn rat;
Transport deficient (TRâ) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity
Keywords: TRâ; transport deficient hyperbilirubinemic rats; Mrp; multidrug resistance-associated protein; APAP; acetaminophen; APAP-GSH; acetaminophen glutathione; APAP-GLUC; acetaminophen glucuronide; ICG; indocyanine green; NAPQI; N-acetyl-p-benzoquinoneimine;
Hyperbilirubinemia in the setting of antiviral therapy
Keywords: AIDS; acquired immunodeficiency syndrome; CMV; cytomegalovirus; HIV; human immunodeficiency virus; MRP2; multidrug resistance-associated protein 2; NIAID; National Institute of Allergy and Infectious Diseases; NRTI; nucleoside reverse transcriptase inhibi
A novel ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients
Keywords: DJS; Dubin-Johnson syndrome; MRP2; multidrug resistance protein 2; Conjugated hyperbilirubinemia; Familial jaundice; Founder effect; Cryptic splice site;
Short-term oral exposure to aluminium decreases glutathione intestinal levels and changes enzyme activities involved in its metabolism
Keywords: Aluminium; Glutathione; GSH-synthase; γ-Glutamyltranspeptidase; Mrp2; Lipid peroxidation;
Mechanisms involved in spironolactone-induced choleresis in the rat
Keywords: AE2; anionic exchanger 2; BSDF; bile salt-dependent bile flow; Bsep; bile salt export pump; BSIF; bile salt-independent bile flow; CDNB; 1-chloro-2,4-dinitrobenzene; DNP-SG; dinitrophenyl S-glutathione; GSH; reduced glutathione; GSSG; oxidized glutathione
Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells
Keywords: Akt; protein kinase B; ERKs; extracellular signal-regulated kinases; ITCs; isothiocyanates; JNK; c-Jun N-terminal kinase; MAPKs; mitogen-activated protein kinases; MRP2; multidrug resistance-associated protein 2; NF-κB; nuclear factor-kappa B; NQO1; NADP
Dapsone impairs the bile salt-independent fraction of bile flow in rats: Possible involvement of its N-hydroxylated metabolite
Keywords: Dapsone; Cholestasis; Bile salt independent fraction of bile flow; Bicarbonate; Mrp2; AE2;
Mrp2/Abcc2 transport activity is stimulated by protein kinase Cα in a baculo virus co-expression system
Keywords: Mrp2; Phosphorylation; PKC;
Regulated vesicle trafficking of membrane transporters in hepatic epithelia
Keywords: Ntcp; Na+/bile salt co-transporter; Bsep; bile salt export pump; Mrp2; multi-drug resistance-related protein 2; Mdr1; multi-drug resistance P-glycoprotein 1; Mdr2; multi-drug resistance P-glycoprotein 2; AQP-8; aquaporin-8 water channels; ASBT; Na+/bile s